Therapeutic Hope on the Surface of Ewing Sarcoma
Clin Cancer Res. 2023 Dec 19. doi: 10.1158/1078-0432.CCR-23-3138. Online ahead of print.ABSTRACTA detailed analysis of the Ewing sarcoma surfacesome has arrived. Robust expression of surface CDH11 and ENPP1 was identified. This "comprehensive catalogue" of the Ewing surfacesome serves as a fresh roadmap to development of new therapeutic approaches, including immunotherapies and multi-modality therapeutic combinations, to target aggressive Ewing tumor subpopulations.PMID:38113033 | DOI:10.1158/1078-0432.CCR-23-3138 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - December 19, 2023 Category: Cancer & Oncology Authors: Kelly M Bailey Source Type: research
Sarcoma of the Lung and Mediastinum
Primary sarcoma of the lung and mediastinum is rare. The diagnosis requires careful exclusion of sarcomatoid carcinoma, sarcomatoid mesothelioma, and metastases from extra-thoracic sites. This review summarizes the key morphologic, immunohistochemical, and molecular characteristics of sarcomas that are encountered in the lung and mediastinum. The tumor types discussed are synovial sarcoma, well-differentiated/dedifferentiated liposarcoma, myxoid pleomorphic liposarcoma, intimal sarcoma of the pulmonary artery, inflammatory myofibroblastic tumor, epithelioid hemangioendothelioma, primary pulmonary myxoid sarcoma, malignant ...
Source: Surgical Pathology Clinics - December 15, 2023 Category: Pathology Authors: Ken-ichi Yoshida, Akihiko Yoshida Source Type: research
Sequential treatments with TRK inhibitors in a patient with NTRK fusion-positive sarcoma: A case report
In this report, we present a patient with NTRK fusion-positive sarcoma arising from the anterior mediastinum, with tumor progression after 4 months of entrectinib use. The patient took larotrectinib subsequently and maintained disease control for more than 21 months.PATIENT CONCERNS: A 48-year-old female visited a physician because she experienced difficulty in breathing and chest and back pain with no obvious cause 2 months ago. Computed tomography (CT)-guided biopsy was performed at a district general hospital, and histopathological examination revealed a small round cell tumor. She was referred to our hospital, and a se...
Source: Pain Physician - December 8, 2023 Category: Anesthesiology Authors: Yuta Kubota Masanori Kawano Tatsuya Iwasaki Ichiro Itonaga Hiroshi Tsumura Nobuhiro Kaku Kazuhiro Tanaka Source Type: research
Cancers, Vol. 15, Pages 5750: EWSR1::ATF1 Orchestrates the Clear Cell Sarcoma Transcriptome in Human Tumors and a Mouse Genetic Model
in B. Jones
Clear cell sarcoma (CCS) is a rare, aggressive malignancy that most frequently arises in the soft tissues of the extremities. It is defined and driven by expression of one member of a family of related translocation-generated fusion oncogenes, the most common of which is EWSR1::ATF1. The EWSR1::ATF1 fusion oncoprotein reprograms transcription. However, the binding distribution of EWSR1::ATF1 across the genome and its target genes remain unclear. Here, we interrogated the genomic distribution of V5-tagged EWSR1::ATF1 in tumors it had induced upon expression in mice that also recapitulated the transcriptome o...
Source: Cancers - December 8, 2023 Category: Cancer & Oncology Authors: Benjamin B. Ozenberger Li Li Emily R. Wilson Alexander J. Lazar Jared J. Barrott Kevin B. Jones Tags: Article Source Type: research
Engagement of CD99 activates distinct programs in Ewing sarcoma and macrophages
In this study, we analyzed CD99 expression and functions on macrophages and investigated whether the concomitant targeting of CD99 on both tumor and macrophages could explain the inhibitory effect of this approach against EWS. Targeting CD99 on EWS cells downregulated expression of the "don't eat-me" CD47 molecule but increased levels of the "eat-me" phosphatidyl serine and calreticulin molecules on the outer leaflet of the tumor cell membrane, triggering phagocytosis and digestion of EWS cells by macrophages. In addition, CD99 ligation induced reprogramming of undifferentiated M0 macrophages and M2-like macrophages toward...
Source: Cell Research - December 5, 2023 Category: Cytology Authors: Maria Cristina Manara Cristina Manferdini Camilla Cristalli Marianna Carrabotta Spartaco Santi Alessandra De Feo Giulia Caldoni Michela Pasello Lorena Landuzzi Pier-Luigi Lollini Francesca Salamanna Sabrina Dominici Valentina Fiori Mauro Magnani Gina Lisi Source Type: research
A case of primary retroperitoneal Ewing's sarcoma in a young woman
Asian J Surg. 2023 Nov 27:S1015-9584(23)01802-X. doi: 10.1016/j.asjsur.2023.11.067. Online ahead of print.NO ABSTRACTPMID:38016832 | DOI:10.1016/j.asjsur.2023.11.067 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - November 28, 2023 Category: Surgery Authors: Li Kong Xinsheng Zhang Ying Zhang Zixuan Kong Source Type: research
A case of primary retroperitoneal Ewing's sarcoma in a young woman
Asian J Surg. 2023 Nov 27:S1015-9584(23)01802-X. doi: 10.1016/j.asjsur.2023.11.067. Online ahead of print.NO ABSTRACTPMID:38016832 | DOI:10.1016/j.asjsur.2023.11.067 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - November 28, 2023 Category: Surgery Authors: Li Kong Xinsheng Zhang Ying Zhang Zixuan Kong Source Type: research
The DNA/RNA helicase DHX9 orchestrates the KDM2B-mediated transcriptional regulation of YAP1 in Ewing sarcoma
Oncogene, Published online: 28 November 2023; doi:10.1038/s41388-023-02894-1The DNA/RNA helicase DHX9 orchestrates the KDM2B-mediated transcriptional regulation of YAP1 in Ewing sarcoma (Source: Oncogene)
Source: Oncogene - November 28, 2023 Category: Cancer & Oncology Authors: Lidia Chellini Marzia Scarf ò Davide Bonvissuto Claudio Sette Maria Paola Paronetto Source Type: research
One ‐stage combined approach en bloc vertebrectomy for primary Ewing's sarcoma of mobile spine in an adult patient: 3 years following aggressive surgery for a rare entity
We report a case of thoracic spine EWS in an adult treated by combined approach en bloc vertebrectomy. (Source: Clinical Case Reports)
Source: Clinical Case Reports - November 16, 2023 Category: General Medicine Authors: Mohamed Amine Gharbi,
Houssem Eddine Chahed,
Sana Ben Slama,
Anis Teborbi,
Ramzi Bouzidi,
Mouadh Nefiss Tags: CASE REPORT Source Type: research
The chromatin remodeler CHD4 sustains Ewing Sarcoma cell survival by controlling global chromatin architecture
Cancer Res. 2023 Nov 14. doi: 10.1158/0008-5472.CAN-22-3950. Online ahead of print.ABSTRACTEwing sarcoma is an aggressive cancer with a defective response to DNA damage leading to an enhanced sensitivity to genotoxic agents. Mechanistically, Ewing sarcoma is driven by the fusion transcription factor EWS-FLI1 which reprograms the tumor cell epigenome. The NuRD complex is an important regulator of chromatin function, controlling both gene expression and DNA damage repair, and has been associated with EWS-FLI1 activity. Here, a NuRD-focused CRISPR/Cas9 inactivation screen identified the helicase CHD4 as essential for Ewing sa...
Source: Cell Research - November 14, 2023 Category: Cytology Authors: Joana G Marques Blaz Pavlovic Quy A Ngo Gloria Pedot Michaela Roemmele Larissa Volken Samanta Kisele Romain Perbet Marco Wachtel Beat W Schafer Source Type: research
Ewing's Sarcoma of the Orbit: A Case Report and Literature Review
Cureus. 2023 Nov 10;15(11):e48592. doi: 10.7759/cureus.48592. eCollection 2023 Nov.ABSTRACTEwing's sarcoma (ES) is a malignant small round cell neuroectodermal tumour primarily affecting children in the first and second decade of life. Since ES is difficult to control, early diagnosis is crucial, and the treatment requires a multimodality approach constituting chemotherapy, surgery and radiotherapy. Here, we present a case of ES of orbit in a 17-year-old female diagnosed in 2021. This case report focuses on the clinicopathological presentation and management principles of this rare manifestation of the disease that unilate...
Source: Cancer Control - November 13, 2023 Category: Cancer & Oncology Authors: Jahnabi Das Jyotiman Nath Chandramouli R Mostafijur Rahaman Shiraj Ahmed Source Type: research
Extraosseous Ewing sarcoma in the fossa jugular: A rare case report
CONCLUSION: EES rarely occurs in the head and neck. This may manifest as a solid mass with bleeding components that destroy the nearby bones, with exophytic mass. Imaging is important for early finding and detecting complications of EES.PMID:37941635 | PMC:PMC10629324 | DOI:10.25259/SNI_638_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - November 9, 2023 Category: Neurosurgery Authors: Suga Marthawati Widiana Ferriastuti Suresh K Mukherji Artono Artono Source Type: research
