Long-Term Survival after Primary Ewing's Sarcoma of the Skull with Intracranial Extension
Conclusion The presented case is the longest surviving patient after treatment of primary Ewing's sarcoma of the skull bone. This rare type of tumor may allow better survival rates under adequate management than sarcoma elsewhere in the body. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Journal of Neurological Surgery Part A: Central European Neurosurgery)
Source: Journal of Neurological Surgery Part A: Central European Neurosurgery - November 8, 2023 Category: Neurosurgery Authors: Rainov, Nikolai G. Haritonov, Dimitar Heidecke, Volkmar Tags: Case Report Source Type: research
The value of GLI1 and p16 immunohistochemistry in the premolecular screening for GLI1-altered mesenchymal neoplasms
In conclusion, we confirm that GLI1 IHC represents a good, quick, and cheap helpful screening tool. The inclusion of p16 may aid in pre-screening for potentialGLI1-amplified neoplasms and provide insights on which tumors warrant further molecular testing. (Source: Virchows Archiv)
Source: Virchows Archiv - November 8, 2023 Category: Pathology Source Type: research
ASO Visual Abstract: Prognostic Factors and Clinical Outcomes in Extraskeletal Ewing Sarcoma —A Cohort Study
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - November 6, 2023 Category: Cancer & Oncology Source Type: research
The expression of neuraminidase-1 in Ewing sarcoma and its impact on sarcoma cell proliferation and migration
Conclusion: NEU1 may be a prognostic factor in ES, and its abnormal expression in ES can affect the proliferation and migration ability of the ES cells, leading to poor prognosis in ES patients.PMID:37926573 | DOI:10.3760/cma.j.cn112137-20230411-00580 (Source: Cancer Control)
Source: Cancer Control - November 5, 2023 Category: Cancer & Oncology Authors: B F Liu Y Z Gao Source Type: research
Detection of early prognostic biomarkers for metastasis of Ewing's sarcoma in pediatric patients
This study presented potential empirical predictive circulating biomarkers for determining the disease status of pediatric Ewing's sarcoma, which is vital for early prediction.PMID:37926299 | DOI:10.1016/j.lfs.2023.122237 (Source: Cancer Control)
Source: Cancer Control - November 5, 2023 Category: Cancer & Oncology Authors: Shahd Ezzeldin Aya Osama Ali Mostafa Anwar Sebaey Mahgoub Eman A Ahmed Nesma Farid Manal Zamzam Ahmed El Ghoneimy Sameh Magdeldin Source Type: research
Regorafenib in patients with advanced Ewing sarcoma: results of a non-comparative, randomised, double-blind, placebo-controlled, multicentre Phase II study
British Journal of Cancer, Published online: 01 November 2023; doi:10.1038/s41416-023-02413-9Regorafenib in patients with advanced Ewing sarcoma: results of a non-comparative, randomised, double-blind, placebo-controlled, multicentre Phase II study (Source: British Journal of Cancer)
Source: British Journal of Cancer - November 1, 2023 Category: Cancer & Oncology Authors: Florence Duffaud Jean-Yves Blay Axel Le Cesne Christine Chevreau Pascaline Boudou-Rouquette Elsa Kalbacher Nicolas Penel Christophe Perrin Val érie Laurence Emmanuelle Bompas Esma Saada-Bouzid Corinne Delcambre Fran çois Bertucci Mathilde Cancel Camille Source Type: research
Cancers, Vol. 15, Pages 5225: Carbonic Anhydrase Inhibitors Induce Ferroptosis through Inhibition of AKT/FTH1 Signaling in Ewing Sarcoma Tumor Cells
roeder
Ilya V. Ulasov
Ewing sarcoma (ES) is one of the most frequent types of malignant tumors among children. The active metabolic state of ES cells presents a new potential target for therapeutic interventions. As a primary regulator of cellular homeostasis, carbonic anhydrases (CAs; EC 4.2.1.1) have emerged as promising molecular targets for the development of anticancer drugs. Within the present study, we tested the commercial drug acetazolamide and our previously discovered inhibitors to target the CAII isoform, which was overexpressed and positively correlated with ES patient relapse. We employed molecular biol...
Source: Cancers - October 31, 2023 Category: Cancer & Oncology Authors: Darya Fayzullina Semyn Yakushov Kamilla Kantserova Elizaveta Belyaeva Denis Aniskin Sergey Tsibulnikov Nafisa Fayzullina Stanislav Kalinin Olga Romantsova Peter S. Timashev Brett A. Schroeder Ilya V. Ulasov Tags: Article Source Type: research
Inducing Mitotic Catastrophe as a Therapeutic Approach to Improve Outcomes in Ewing Sarcoma
Cancers (Basel). 2023 Oct 10;15(20):4911. doi: 10.3390/cancers15204911.ABSTRACTEwing sarcoma (EWS) is an aggressive pediatric malignancy of the bone and soft tissues in need of novel therapeutic options. To identify potential therapeutic targets, we focused on essential biological pathways that are upregulated by EWS-FLI1, the primary oncogenic driver of EWS, including mitotic proteins such as Aurora kinase A (AURKA) and kinesin family member 15 (KIF15) and its binding partner, targeting protein for Xklp2 (TPX2). KIF15/TPX2 cooperates with KIF11, a key mitotic kinesin essential for mitotic spindle orientation. Given the la...
Source: Cancer Control - October 28, 2023 Category: Cancer & Oncology Authors: Soumya M Turaga Vikalp Vishwakarma Stacey L Hembruff Benjamin K Gibbs Priya Sabu Rajni V Puri Harsh B Pathak Glenson Samuel Andrew K Godwin Source Type: research
Intracranial extraosseous Ewing's sarcoma with glioma
Asian J Surg. 2023 Oct 23:S1015-9584(23)01644-5. doi: 10.1016/j.asjsur.2023.10.032. Online ahead of print.NO ABSTRACTPMID:37879980 | DOI:10.1016/j.asjsur.2023.10.032 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - October 25, 2023 Category: Surgery Authors: Yu Shang Lina Song Junjie Liu Peng An Source Type: research
Intracranial extraosseous Ewing's sarcoma with glioma
Asian J Surg. 2023 Oct 23:S1015-9584(23)01644-5. doi: 10.1016/j.asjsur.2023.10.032. Online ahead of print.NO ABSTRACTPMID:37879980 | DOI:10.1016/j.asjsur.2023.10.032 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - October 25, 2023 Category: Surgery Authors: Yu Shang Lina Song Junjie Liu Peng An Source Type: research
Intracranial extraosseous Ewing's sarcoma with glioma
Asian J Surg. 2023 Oct 23:S1015-9584(23)01644-5. doi: 10.1016/j.asjsur.2023.10.032. Online ahead of print.NO ABSTRACTPMID:37879980 | DOI:10.1016/j.asjsur.2023.10.032 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - October 25, 2023 Category: Surgery Authors: Yu Shang Lina Song Junjie Liu Peng An Source Type: research
Does primary tumor resection improve survival for patients with sarcomas of pelvic bones, sacrum, and coccyx who have metastasis at diagnosis ?
ConclusionPrimary lesion resection may provide a survival benefit for metastatic chondrosarcoma, but not for osteosarcoma and Ewing sarcoma of pelvic bones, sacrum, and coccyx. This population-based study recommends an active surgical intervention for metastatic chondrosarcoma while non-surgical treatment for metastatic osteosarcoma and Ewing sarcoma of the pelvis in terms of survival improvement. (Source: European Spine Journal)
Source: European Spine Journal - October 23, 2023 Category: Orthopaedics Source Type: research
