Prognostic value of < i > PRR11 < /i > and immune cell infiltration in Ewing sarcoma
by Jian Wen, Lijia Wan, Xieping Dong
Ewing’s sarcoma (ES) is the second most common bone and soft tissue malignancy in children and adolescents with a poor prognosis. The identification of genes with prognostic value may contribute to the prediction and treatment of this disease. The GSE17679, GSE68776, GSE63155, and GSE63156 datas ets were downloaded from the Gene Expression Omnibus database and qualified. Prognostic value of differentially expressed genes (DEGs) between the normal and tumor groups and immune cell infiltration were explored by several algorithms. A prognostic model was established and validated. Finall...
Source: PLoS One - March 1, 2024 Category: Biomedical Science Authors: Jian Wen Source Type: research
Unusual case presentation associated with impacted mandibular molars: Clinicopathological correlation and immunohistochemical analysis
J Cancer Res Ther. 2023 Jan 1;19(Suppl 2):S986-S990. doi: 10.4103/jcrt.jcrt_591_22. Epub 2023 Apr 30.ABSTRACTEwing's sarcoma of bone is a rare malignant round cell tumor of the head and neck. The jaw, particularly the mandible, accounts for 3% of occurrences in the head and neck area. These tumors have been reported more frequently in men than in women, and they are usually between 5- and 20-year-old. It is difficult for clinicians and pathologists to make a diagnosis based solely on clinical and microscopic findings. Immunohistochemistry presents a plausible tool that can help the pathologist to arrive at a confirmatory d...
Source: Cell Research - February 22, 2024 Category: Cytology Authors: Karthikeya Patil Vidya G Doddawad C J Sanjay S Shivananda Source Type: research
Ewing's sarcoma masquerading as an odontogenic infection
We report an unusual case of ES in a 13-year-old female treated for an odontogenic infection before a diagnosis of ES was finally made to make the clinicians aware of this rare entity. Emphasis is also given that ES and odontogenic infections/tumors can masquerade each other with delays in diagnosis and the possibility of devastating results.PMID:38384088 | DOI:10.4103/jcrt.jcrt_1133_22 (Source: Cell Research)
Source: Cell Research - February 22, 2024 Category: Cytology Authors: Rizwan Hamid Ambika Gaur Sunita Gupta Ritu Garg Source Type: research
Machine learning-supported diagnosis of small blue round cell sarcomas using targeted RNA sequencing
Small blue round cell sarcomas (SBRCSs) are a heterogeneous group of tumors with overlapping morphologic features but markedly varying prognosis. They are characterized by distinct chromosomal alterations, particularly rearrangements leading to gene fusions, whose detection currently represents the most reliable diagnostic marker. Ewing sarcomas (ESs) are the most common SBRCSs, defined by gene fusions involving EWSR1 and transcription factors of the ETS gene family, while the most frequent non-EWSR1-rearranged SBRCSs harbor a CIC rearrangement. (Source: Journal of Molecular Diagnostics)
Source: Journal of Molecular Diagnostics - February 21, 2024 Category: Pathology Authors: Lea Dewi Schlieben, Maria Giulia Carta, Evgeny A. Moskalev, Robert St öhr, Markus Metzler, Manuel Besendörfer, Norbert Meidenbauer, Sabine Semrau, Rolf Janka, Robert Grützmann, Stefan Wiemann, Arndt Hartmann, Abbas Agaimy, Florian Haller, Fulvia Ferraz Tags: Regular Article Source Type: research
Machine Learning –Supported Diagnosis of Small Blue Round Cell Sarcomas Using Targeted RNA Sequencing
Small blue round cell sarcomas (SBRCSs) are a heterogeneous group of tumors with overlapping morphologic features but markedly varying prognosis. They are characterized by distinct chromosomal alterations, particularly rearrangements leading to gene fusions, whose detection currently represents the most reliable diagnostic marker. Ewing sarcomas are the most common SBRCSs, defined by gene fusions involving EWSR1 and transcription factors of the ETS gene family, and the most frequent non –EWSR1-rearranged SBRCSs harbor a CIC rearrangement. (Source: Journal of Molecular Diagnostics)
Source: Journal of Molecular Diagnostics - February 21, 2024 Category: Pathology Authors: Lea Dewi Schlieben, Maria Giulia Carta, Evgeny A. Moskalev, Robert St öhr, Markus Metzler, Manuel Besendörfer, Norbert Meidenbauer, Sabine Semrau, Rolf Janka, Robert Grützmann, Stefan Wiemann, Arndt Hartmann, Abbas Agaimy, Florian Haller, Fulvia Ferraz Tags: Regular article Source Type: research
Apremilast for the treatment of pustular psoriasis induced by neoadjuvant ifosfamide + etoposide chemotherapy for Ewing Sarcoma: a case report
J Dermatolog Treat. 2024 Dec;35(1):2319303. doi: 10.1080/09546634.2024.2319303. Epub 2024 Feb 20.NO ABSTRACTPMID:38378173 | DOI:10.1080/09546634.2024.2319303 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - February 20, 2024 Category: Dermatology Authors: Mario Valenti Luigi Gargiulo Luciano Ibba Alexia Bertuzzi Sofia Manara Francesco Toso Antonio Costanzo Alessandra Narcisi Source Type: research
Translocated sinonasal tumors
Ann Pathol. 2024 Feb 13:S0242-6498(24)00007-5. doi: 10.1016/j.annpat.2023.12.013. Online ahead of print.ABSTRACTIn recent years, several nasal cavity and sinus entities have been described with fusion genes. Salivary gland tumors with fusion genes will not be discussed in this article, but it should be kept in mind that accessory salivary glands are present in the nasal cavity and sinuses and can therefore lead to tumoral lesions. Entities with specific or more frequently described rearrangements in the nasal cavities and sinuses are DEK::AFF2 squamous cell carcinomas,;non-intestinal and non-salivary nasosinusal adenocarci...
Source: Annales de Pathologie - February 14, 2024 Category: Pathology Authors: Charles L épine Aude Trinquet Marick La é Val érie Costes-Martineau Source Type: research
Translocated sinonasal tumors
Ann Pathol. 2024 Feb 13:S0242-6498(24)00007-5. doi: 10.1016/j.annpat.2023.12.013. Online ahead of print.ABSTRACTIn recent years, several nasal cavity and sinus entities have been described with fusion genes. Salivary gland tumors with fusion genes will not be discussed in this article, but it should be kept in mind that accessory salivary glands are present in the nasal cavity and sinuses and can therefore lead to tumoral lesions. Entities with specific or more frequently described rearrangements in the nasal cavities and sinuses are DEK::AFF2 squamous cell carcinomas,;non-intestinal and non-salivary nasosinusal adenocarci...
Source: Annales de Pathologie - February 14, 2024 Category: Pathology Authors: Charles L épine Aude Trinquet Marick La é Val érie Costes-Martineau Source Type: research
Translocated sinonasal tumors
Ann Pathol. 2024 Feb 13:S0242-6498(24)00007-5. doi: 10.1016/j.annpat.2023.12.013. Online ahead of print.ABSTRACTIn recent years, several nasal cavity and sinus entities have been described with fusion genes. Salivary gland tumors with fusion genes will not be discussed in this article, but it should be kept in mind that accessory salivary glands are present in the nasal cavity and sinuses and can therefore lead to tumoral lesions. Entities with specific or more frequently described rearrangements in the nasal cavities and sinuses are DEK::AFF2 squamous cell carcinomas,;non-intestinal and non-salivary nasosinusal adenocarci...
Source: Annales de Pathologie - February 14, 2024 Category: Pathology Authors: Charles L épine Aude Trinquet Marick La é Val érie Costes-Martineau Source Type: research
Translocated sinonasal tumors
Ann Pathol. 2024 Feb 13:S0242-6498(24)00007-5. doi: 10.1016/j.annpat.2023.12.013. Online ahead of print.ABSTRACTIn recent years, several nasal cavity and sinus entities have been described with fusion genes. Salivary gland tumors with fusion genes will not be discussed in this article, but it should be kept in mind that accessory salivary glands are present in the nasal cavity and sinuses and can therefore lead to tumoral lesions. Entities with specific or more frequently described rearrangements in the nasal cavities and sinuses are DEK::AFF2 squamous cell carcinomas,;non-intestinal and non-salivary nasosinusal adenocarci...
Source: Annales de Pathologie - February 14, 2024 Category: Pathology Authors: Charles L épine Aude Trinquet Marick La é Val érie Costes-Martineau Source Type: research
Translocated sinonasal tumors
Ann Pathol. 2024 Feb 13:S0242-6498(24)00007-5. doi: 10.1016/j.annpat.2023.12.013. Online ahead of print.ABSTRACTIn recent years, several nasal cavity and sinus entities have been described with fusion genes. Salivary gland tumors with fusion genes will not be discussed in this article, but it should be kept in mind that accessory salivary glands are present in the nasal cavity and sinuses and can therefore lead to tumoral lesions. Entities with specific or more frequently described rearrangements in the nasal cavities and sinuses are DEK::AFF2 squamous cell carcinomas,;non-intestinal and non-salivary nasosinusal adenocarci...
Source: Annales de Pathologie - February 14, 2024 Category: Pathology Authors: Charles L épine Aude Trinquet Marick La é Val érie Costes-Martineau Source Type: research
The significance of surveillance imaging in children with Ewing sarcoma and osteosarcoma
. (Source: Pediatric Hematology and Oncology)
Source: Pediatric Hematology and Oncology - February 12, 2024 Category: Pediatrics Authors: Scott Greve BrekkeArne LuckeHenrik HasleThomas Baad-Hansena Department of Pediatrics, Aarhus University Hospital, Aarhus N, Denmarkb Department of Radiology, Aarhus University Hospital, Aarhus N, Denmarkc Department of Orthopedic Surgery, Aarhus Universit Source Type: research
Small cell osteosarcoma versus fusion-driven round cell sarcomas of bone: retrospective clinical, radiological, pathological, and (epi)genetic comparison with clinical implications
In conclusion, discrimination of SCOS, epigenetically related to COS, versus FDRCS of bone can be challenging but is important due to different biology and therefore therapeutic strategies. Methylation profiling is a reliable and robust diagnostic test especially on decalcified FFPE material. Subsequent fusion gene analysis and/or use of specific immunohistochemical surrogate markers can be used to substantiate the diagnosis. (Source: Virchows Archiv)
Source: Virchows Archiv - February 9, 2024 Category: Pathology Source Type: research
Association of MiRNA and Bone Tumors: Future Therapeutic Inroads
Curr Med Chem. 2024 Jan 30. doi: 10.2174/0109298673284932231226110754. Online ahead of print.ABSTRACTSmall endogenous non-coding RNA molecules known as micro-ribonucleic acids (miRNAs) control post-transcriptional gene regulation. A change in miRNA expression is related to various diseases, including bone tumors. Benign bone tumors are categorized based on matrix production and predominant cell type. Osteochondromas and giant cell tumors are among the most common bone tumors. Interestingly, miRNAs can function as either tumor suppressor genes or oncogenes, thereby determining the fate of a tumor. In the present review, we ...
Source: Current Medicinal Chemistry - February 1, 2024 Category: Chemistry Authors: Rashid Al-Shibli Mohammed AlSuleimani Ibrahim Ahmed Abdullah Al Lawati Srijit Das Source Type: research
