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Two classes of GGAA-microsatellites in a Ewing sarcoma context
(Nationwide Children's Hospital) In a study published in PLOS ONE, researchers describe two types of GGAA-microsatellites and their roles in EWS/FLI binding and gene regulation in Ewing sarcoma. Ewing sarcoma is the second most common pediatric bone malignancy. It is initiated by chromosomal translocation t(11;22)(q24;q12), which creates the fusion protein and oncogenic driver EWS/FLI. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 1, 2017 Category: Cancer & Oncology Source Type: news

Living With Cancer: Cancer Humor
Cracking up may be a better option than breaking down, or so three recent books by young people with cancer suggest. (Source: NYT Health)
Source: NYT Health - October 12, 2017 Category: Consumer Health News Authors: SUSAN GUBAR Tags: Breast Cancer Books and Literature Ewing's Sarcoma (Disease) Comedy and Humor Riggs, Nina (1977-2017) Harrison, Teva (1976- ) Ritvo, Max (1990-2016) Source Type: news

Two agents deliver knockout punches to Ewing sarcoma
(Georgetown University Medical Center) When combined with an already FDA-approved chemotherapy, a novel agent developed by researchers at Georgetown Lombardi Comprehensive Cancer Center, appears to halt the ability of Ewing sarcoma to grow and progress. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 3, 2017 Category: Cancer & Oncology Source Type: news

Inhibition of the oncogenic fusion protein EWS-FLI1 causes G2-M cell cycle arrest and enhanced vincristine sensitivity in Ewings sarcoma
Ewing’s sarcoma (ES) is a rare and highly malignant cancer that grows in the bones or surrounding tissues mostly affecting adolescents and young adults. A chimeric fusion between the RNA binding protein EWS and the ETS family transcription factor FLI1 (EWS-FLI1), which is generated from a chromosomal translocation, is implicated in driving most ES cases by modulation of transcription and alternative splicing. The small-molecule YK-4-279 inhibits EWS-FLI1 function and induces apoptosis in ES cells. We aimed to identify both the underlying mechanism of the drug and potential combination therapies that might enhance its...
Source: Signal Transduction Knowledge Environment - October 3, 2017 Category: Science Authors: Zöllner, S. K., Selvanathan, S. P., Graham, G. T., Commins, R. M. T., Hong, S. H., Moseley, E., Parks, S., Haladyna, J. N., Erkizan, H. V., Dirksen, U., Hogarty, M. D., Üren, A., Toretsky, J. A. Tags: STKE Research Articles Source Type: news

Leicester cancer boy heading home after treatment in US
Alex Goodwin, from Rugby, England, was diagnosed with Ewing's Sarcoma last year after months of agony in his joints and muscles. He finished treatment earlier this month and is headed home in August. (Source: the Mail online | Health)
Source: the Mail online | Health - July 28, 2017 Category: Consumer Health News Source Type: news

A protein, a 'molecular staple' and CRISPR to develop an Ewing sarcoma model
(Centro Nacional de Investigaciones Oncol ó gicas (CNIO)) A team from the Spanish National Cancer Research Centre (CNIO) has optimized a system capable of generating a cellular model of Ewing sarcoma. The technique, based on CRISPR and described in the pages of Stem Cell Reports, makes it possible to generate cellular models to analyze the mechanisms underlying the origin and progression of this and other diseases, as well as the search for new treatments. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 10, 2017 Category: International Medicine & Public Health Source Type: news

' Jumonji' protein key to Ewing's sarcoma rampage
A new study pinpoints a protein that may be essential to Ewing's sarcoma metastasis -- when researchers knocked down the protein KDM3A in Ewing's sarcoma tumor cells, one of a family known as Jumonji proteins, they also inhibited the cancer's metastatic ability. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - March 24, 2017 Category: Science Source Type: news

'Jumonji' protein key to Ewing's sarcoma rampage
(University of Colorado Anschutz Medical Campus) A University of Colorado Cancer Center study published in the journal Oncogene pinpoints a protein that may be essential to Ewing's sarcoma metastasis -- when researchers knocked down the protein KDM3A in Ewing's sarcoma tumor cells, one of a family known as Jumonji proteins, they also inhibited the cancer's metastatic ability. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 24, 2017 Category: Cancer & Oncology Source Type: news

Make the Diagnosis: High-Tech Cancer Care
(MedPage Today) -- Case Findings: A 22-year-old male patient faces a total femur amputation after a diagnosis of Ewing's sarcoma. However, a surgeon was able to preserve his ability to walk. What was the strategy? (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - March 6, 2017 Category: Hematology Source Type: news

Ewing Sarcoma Survivors At Increased Risk for Subsequent Malignancies
Survivors of childhood Ewing sarcoma have substantial risk for late mortality and subsequent neoplasms, according to a long-term follow-up study. (Source: CancerNetwork)
Source: CancerNetwork - March 3, 2017 Category: Cancer & Oncology Authors: Dave Levitan Tags: News Sarcoma Source Type: news

British boy with cancer could be forced to leave US early
Alex Goodwin, from Rugby, England, was diagnosed with Ewing's Sarcoma last year after months of agony in his joints and muscles. He is mid treatment in Kansas - but may be forced home. (Source: the Mail online | Health)
Source: the Mail online | Health - February 24, 2017 Category: Consumer Health News Source Type: news

Tissue-engineered model developed to study bone-invading tumor
(Mary Ann Liebert, Inc./Genetic Engineering News) Researchers have used tissue engineering to create models for studying the bone-destroying activity of tumors such as the aggressive pediatric cancer Ewing's sarcoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 24, 2017 Category: Cancer & Oncology Source Type: news

A 5-Question Quiz on Sarcoma
Are you up to date on adverse prognostic factors for Ewing sarcoma? Do you know the latest drug approved for metastatic soft-tissue sarcoma? Test your knowledge on sarcoma in our latest quiz. (Source: CancerNetwork)
Source: CancerNetwork - February 5, 2017 Category: Cancer & Oncology Authors: Debra Hughes Tags: Quiz Source Type: news

Epigenetic diversity in childhood cancer
Tumors of the elderly carry many DNA mutations that can influence disease course. In contrast, much fewer genetic variants exist in childhood cancers, leaving their clinical diversity unexplained. This conundrum has now been addressed for Ewing sarcoma: researchers observed unexpected variety in the epigenome of these tumors. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - January 30, 2017 Category: Science Source Type: news

Epigenetic diversity in childhood cancer
(CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences) Tumors of the elderly carry many DNA mutations that can influence disease course. In contrast, much fewer genetic variants exist in childhood cancers, leaving their clinical diversity unexplained. This conundrum has now been addressed for Ewing sarcoma: researchers at St. Anna Children's Cancer Research Institute and CeMM Research Center for Molecular Medicine observed unexpected variety in the epigenome of these tumors. This finding, published in Nature Medicine, provides new perspectives for developing personalized therapies. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 30, 2017 Category: Cancer & Oncology Source Type: news

Little Girl Who Battled Pediatric Cancer Sends Message To Trump
Eight-year-old Abriel Bentley knows what it’s like to fight for your life. She was diagnosed with a form of bone cancer called Ewing Sarcoma in Sept. 2015, and after undergoing chemotherapy and surgery on her leg, she went into remission this past summer. Now the little girl from Scottsdale, Arizona has a new mission: raising awareness around pediatric cancer and helping other kids in this fight. On Jan. 21, her family posted a video on her Facebook page, “Team Abri.” In the video, Abriel issues a plea to President Donald Trump: “Please help us beat the odds against childhood cancer,” she...
Source: Healthy Living - The Huffington Post - January 26, 2017 Category: Consumer Health News Source Type: news

British boy receives lifesaving surgery for rare cancer in Kansas
Alex Goodwin, from Rugby, England, was diagnosed with Ewing's Sarcoma last year after months of agony in his joints and muscles. (Source: the Mail online | Health)
Source: the Mail online | Health - January 13, 2017 Category: Consumer Health News Source Type: news

British boy, 9, receives lifesaving surgery for rare cancer in Kansas after being dismissed by UK doctors for five months - even though he couldn't walk
Alex Goodwin, from Rugby, England, was diagnosed with Ewing's Sarcoma last year after months of agony in his joints and muscles. (Source: the Mail online | Health)
Source: the Mail online | Health - January 12, 2017 Category: Consumer Health News Source Type: news

Top Sarcoma News in 2016
In this slide show we highlight some of the top news on sarcoma in 2016, including the first frontline FDA approval in 40 years, and studies on imaging in Ewing sarcoma, maintenance chemotherapy in osteosarcoma, and more. (Source: CancerNetwork)
Source: CancerNetwork - December 14, 2016 Category: Cancer & Oncology Authors: Cancer Network Editors Tags: Conferences/Sarcoma Year In Review 2016 Source Type: news

The first analysis of Ewing's sarcoma methyloma opens doors to new treatments
(IDIBELL-Bellvitge Biomedical Research Institute) IDIBELL researchers describe the Ewing's sarcoma (ES) methylation profile for the first time.The methylation profile unveils the potential of the PTRF gene as a prognostic marker of the disease.The reestablishment of PTRF expression could serve as a therapeutic option in the future. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 1, 2016 Category: Cancer & Oncology Source Type: news

The dark side of 'junk' DNA
(UNC Lineberger Comprehensive Cancer Center) Researchers at the University of North Carolina Lineberger Comprehensive Cancer Center report in the journal Cell Reports that certain short, repetitive sequences of DNA, or 'junk,' play an important role in the development of Ewing sarcoma, a rare bone and soft tissue cancer that occurs most commonly in children and adolescents. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 1, 2016 Category: Cancer & Oncology Source Type: news

Cancer or no cancer — Carlie will sing!
Her voice at first sings softly, then gradually gains intensity and rises to a crescendo as she belts out the refrain of a tune she and her dad co-wrote: “You’re not standing alone!” Fifteen-year-old Carlie Gonzalez has been singing and making music for as long as she can remember. But these days singing has new meaning. After eight months of intensive treatment for Ewing sarcoma, a type of bone cancer, her powerful voice is also a symbol of her physical and emotional strength. Three weeks after school started in September 2015, Carlie began to feel a pain in her collarbone. Since she also played volleyba...
Source: Thrive, Children's Hospital Boston - September 1, 2016 Category: Pediatrics Authors: Linda Watts Tags: Our Patients’ Stories Dana-Farber/Boston Children's Cancer and Blood Disorders Center Ewing Sarcoma Source Type: news

Oncternal Therapeutics begins dosing in Phase I trial of TK216 to treat Ewing sarcoma
US-based clinical-stage biotechnology company Oncternal Therapeutics has begun dosing patients in its Phase I clinical trial of TK216 to treat Ewing sarcoma. (Source: Drug Development Technology)
Source: Drug Development Technology - August 31, 2016 Category: Pharmaceuticals Source Type: news

A new animal model to understand metastasis in sarcomas
Researchers have developed a modified version of an orthotopic model to recreate the metastatic steps in Ewing sarcoma, the second most common bone tumor in children and adolescents. This new model may become a valuable experimental tool to analyze metastatic potential in different kinds of sarcomas. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - August 30, 2016 Category: Science Source Type: news

A new animal model to understand metastasis in sarcomas
(IDIBELL-Bellvitge Biomedical Research Institute) Researchers from IDIBELL have developed a modified version of an orthotopic model to recreate the metastatic steps in Ewing sarcoma, the second most common bone tumor in children and adolescents. This new model may become a valuable experimental tool to analyze metastatic potential in different kinds of sarcomas. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 30, 2016 Category: Cancer & Oncology Source Type: news

Better Imaging Method for Ewing Sarcoma Response Assessment
Functional imaging using FDG-positron emission tomography (FDG-PET) was able to predict response to treatment in Ewing sarcoma patients, and was superior to other anatomic imaging criteria. (Source: CancerNetwork)
Source: CancerNetwork - August 29, 2016 Category: Cancer & Oncology Authors: Dave Levitan Tags: News Sarcoma Source Type: news

What Are The Most Common Pediatric Cancers?
Discussion Cancer occurs in all ages including children. Fortunately cancer is much less common in the pediatric age group accounting for
Source: PediatricEducation.org - July 4, 2016 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Pharma company to relocate to Houston following CPRIT grant
Salt Lake City-based Salarius Pharmaceuticals LLC will relocate to Houston following an $18.69 million grant from the Cancer Prevention and Research Institute of Texas. CPRIT awarded Salarius and Pelican Therapeutics two grants totaling nearly $34 million to recruit both of the companies to the Lone Star State. Pelican will be located in Austin, according to a statement. Salarius is developing a drug that will target Ewings Sarcoma, a pediatric bone cancer with no targeted therapies. Currently… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - May 19, 2016 Category: Biotechnology Authors: Joe Martin Source Type: news

Scientists uncover novel therapeutic targets and candidate biomarkers in childhood cancers
(Write Science Right) Brazilian scientists have obtained evidence suggesting that neurotrophins, which are well-known signaling molecules in normal brain development and function, may be useful biomarkers and therapeutic targets in childhood cancers. Blockade of the receptors that mediate neurotrophin signaling, namely TrkA and TrkB, have been shown to produce anticancer effects in both Ewing sarcoma and medulloblastoma. Additionally, levels of a neurotrophin have been associated with leukemia prognosis. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 18, 2016 Category: Cancer & Oncology Source Type: news

Ewing Sarcoma: New compounds may aid in development of targeted therapies for a rare pediatric cancer
Two recently discovered compounds have shown promise in preclinical studies for treating Ewing sarcoma, a rare cancer that predominantly affects children and adolescents. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - March 30, 2016 Category: Science Source Type: news

New compounds may aid in development of targeted therapies for a rare pediatric cancer
(Van Andel Research Institute) Two recently discovered compounds have shown promise in preclinical studies for treating Ewing sarcoma, a rare cancer that predominantly affects children and adolescents. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 30, 2016 Category: Cancer & Oncology Source Type: news

Living With Cancer: Tips on Dating, New Relationships
Tips for cancer survivors on dating, new relationships A new relationship is challenging for anyone. A cancer diagnosis adds physical and emotional changes to the situation. Video: Myelofibrosis See how having myelofibrosis — a form of leukemia — touched one woman's life and how she's found ways to cope. Ewing's sarcoma Learn about Ewing's sarcoma [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - February 12, 2016 Category: Databases & Libraries Source Type: news

Ewing's Sarcoma of the Cervix, a Diagnostic DilemmaEwing's Sarcoma of the Cervix, a Diagnostic Dilemma
This case of Ewing's sarcoma of the cervix, initially misdiagnosed as small cell carcinoma, highlights the diagnostic challenges due to their overlapping clinical and histopathological features. Journal of Medical Case Reports (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - January 14, 2016 Category: Pathology Tags: Hematology-Oncology Journal Article Source Type: news

Kids with cancer make “Fight Song” their fight song with new music video
Led by two teenaged patients, the kids in the outpatient clinic of Dana-Farber/Boston Children’s Cancer and Blood Disorders Center infused the place with levity earlier this month and made Rachel Platten’s “Fight Song” their fight song in a lively music video. The idea came from Maddie Carlson, a 16-year-old Goffstown, NH, girl being treated for Ewing sarcoma, a bone cancer. “I wanted to do something in the clinic that would be fun for me and the kids and give me a reason to get up every morning and go get chemotherapy,” Maddie says. “People always listen to the song and say it re...
Source: Thrive, Children's Hospital Boston - October 20, 2015 Category: Pediatrics Authors: Irene Sege Tags: Cancer Our patients’ stories bone cancer Dana-Farber/Boston Children's Cancer and Blood Disorders Center Ewing Sarcoma Hodgkin lymphoma Source Type: news

Novel compound turns off mutant cancer gene in animals with leukemia
(Georgetown University Medical Center) A compound discovered and developed by a team of Georgetown Lombardi Comprehensive Cancer Center researchers that halts cancer in animals with Ewing sarcoma and prostate cancer appears to work against some forms of leukemia, too. That finding and the team's latest work was published in Oncotarget. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 9, 2015 Category: Global & Universal Source Type: news

Jack Wells told his shoulder pain was a pulled muscle but it was cancer
EXCLUSIVE: Jack Wells, 23, from London, was diagnosed with Ewing's sarcoma, a rare form of bone cancer which is now incurable as it has spread to his lungs, spine and arm. (Source: the Mail online | Health)
Source: the Mail online | Health - September 30, 2015 Category: Consumer Health News Source Type: news

Baldwinsville girl who created fund at Upstate to help kids with cancer to appear on TV’s The View Friday, Sept. 25
Alexa Bolton is fighting her own cancer battle, having been diagnosed with Ewing Sarcoma in 2014. Her fund provides soft, comfy towels for pediatric cancer patients being treated at Upstate. (Source: SUNY Upstate Medical)
Source: SUNY Upstate Medical - September 24, 2015 Category: Universities & Medical Training Source Type: news

How my brave son struggled with cancer
Daniel Thomas was diagnosed with a rare cancer, Ewing's sacroma, at 17. His father, David Thomas, tells the story (Source: Telegraph Health)
Source: Telegraph Health - September 6, 2015 Category: Consumer Health News Tags: child cancer dealing with child cancer ewings sarcoma Source Type: news

How my brave son struggled with cancer
Daniel Thomas was diagnosed with a rare cancer, Ewing's sacroma, at 17. His father, David Thomas, tells the story (Source: The Telegraph : Health Advice)
Source: The Telegraph : Health Advice - September 6, 2015 Category: Consumer Health News Tags: child cancer dealing with child cancer ewings sarcoma Source Type: news

Bike crash saved father's life after a tumour the size of MELON grew days later
Simon Nutting, 39, from Walsall, flew head first over his handle bars while cycling home. Within a week a lump had grown and he was diagnosed with the soft tissue cancer Ewing's sarcoma. (Source: the Mail online | Health)
Source: the Mail online | Health - September 3, 2015 Category: Consumer Health News Source Type: news

Bike crash saved father's life after a deadly tumour the size of MELON grew just days later
Simon Nutting, 39, from Walsall, flew head first over his handle bars while cycling home. Within a week a lump had grown and he was diagnosed with the soft tissue cancer Ewing's sarcoma. (Source: the Mail online | Health)
Source: the Mail online | Health - September 2, 2015 Category: Consumer Health News Source Type: news

Rochdale teenager diagnosed 10 times for pulled muscle discovers it is bone cancer
Melissa Sutton, 16, from Rochdale, Lancashire, was diagnosed with Ewing's Sarcoma. She had an operation to remove four ribs and is currently undergoing chemotherapy and radiotherapy. (Source: the Mail online | Health)
Source: the Mail online | Health - August 14, 2015 Category: Consumer Health News Source Type: news

Ewing's sarcoma: A dangerous liaison
(Ludwig-Maximilians-Universität München) Researchers from Ludwig-Maximilians-Universitaet in Munich have elucidated at the molecular level how an otherwise innocuous inherited mutation that is quite common in European populations interacts with a spontaneous somatic mutation to promote the development of Ewing's sarcoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 28, 2015 Category: Cancer & Oncology Source Type: news

Medical News Today: Drug combo shows promise against rare bone cancer
Tests on cells and mice suggest a combination of the anti-cancer drugs Trabectedin and Olaparib offers a promising treatment for children with Ewing sarcoma - a rare bone cancer. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 7, 2015 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Potential treatment option for children with Ewing's sarcoma
A new therapeutic alternative for children who suffer from a malignant pediatric tumor bone and soft tissue called Ewing's sarcoma has been discovered by a research consortium. Ewing's sarcoma is the second most common bone cancer and affects children and youth. Currently, if diagnosed early and there is no metastasis it can be cured in 80% of cases but between 25% and 30% of cases are diagnosed when it has metastasized and survival drops to 20%. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - July 6, 2015 Category: Science Source Type: news

Doctors reveal woman's back pain was actually an aggressive bone cancer
Claire Burgess, 25, from Accrington, Lancashire, was diagnosed with Ewing's Sarcoma and given a 40 per cent chance of survival. She managed to beat the cancer and is now planning her wedding. (Source: the Mail online | Health)
Source: the Mail online | Health - July 6, 2015 Category: Consumer Health News Source Type: news

Discovered a potential treatment option for children with Ewing's sarcoma
(IDIBELL-Bellvitge Biomedical Research Institute) A research consortium made up of the Virgen del Rocio hospital in Seville, Sant Joan de Deu and the Bellvitge Biomedical Research Institute in Barcelona, has found a new therapeutic alternative for children who suffer from a malignant pediatric tumor bone and soft tissue called Ewing's sarcoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 6, 2015 Category: Cancer & Oncology Source Type: news

EORTC and Univ Oxford launch EUROSARC trial for patients with advanced Ewing Sarcoma
(European Organisation for Research and Treatment of Cancer) EUROSARC, European Clinical trials in Rare Sarcomas within an integrated translational trial network, has launched a phase II trial of Linsitinib for patients with relapsed and/or refractory Ewing Sarcoma. The trial, EORTC 1225 / OCTO 038, aims to establish pharmacodynamic responses in Ewing sarcoma tumors to Linsitinib using functional imaging and biopsies, and toxicity and clinical outcomes. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 8, 2015 Category: Global & Universal Source Type: news

How My Husband Transformed My Son's MRI Scans Into Incredible Adventures
My son was 2 years old when he had his first MRI scan. After a long, painful night in the emergency room, a CT scan confirmed what we feared: Andrew had a tumor behind his left eye. An MRI was needed to get a clearer and more detailed picture of the horror we were facing. On that first occasion, the MRI tech took him out of my arms and I listened to my son shriek my name over and over again with his arms flailing as he was carried down a very long, very white hallway. "Maaaama!! Maaaama!!! Mamaaaa!!!" Hearing his screams left me heartbroken and incredulous. It seemed like unnecessary trauma for a child who had ...
Source: Healthy Living - The Huffington Post - March 31, 2015 Category: Consumer Health News Source Type: news

Ruth Pearcey diagnosed with bone cancer says amputation means she is finally free
Ruth Pearcey, 21, from Leeds, had her leg amputated to beat Ewing's sarcoma, a rare form of bone cancer. Now, ten years later, she says losing her leg gave her her life back. (Source: the Mail online | Health)
Source: the Mail online | Health - February 11, 2015 Category: Consumer Health News Source Type: news