Exploring the Role of Sodium-Glucose Cotransporter as a New Target for Cancer Therapy
CONCLUSION: SGLT2 inhibitors have antiproliferation, anti-tumorigenesis, and anti-migration effects and may induce apoptosis in cancer cells. In addition, treatment with SGLT2 inhibitors resulted in the downregulation of selected genes in the Du-145 cell line.PMID:35977549 | DOI:10.18433/jpps32879 (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - August 17, 2022 Category: Drugs & Pharmacology Authors: Sanaa Bardaweel Ahmad Issa Source Type: research
Exploring the Role of Sodium-Glucose Cotransporter as a New Target for Cancer Therapy
CONCLUSION: SGLT2 inhibitors have antiproliferation, anti-tumorigenesis, and anti-migration effects and may induce apoptosis in cancer cells. In addition, treatment with SGLT2 inhibitors resulted in the downregulation of selected genes in the Du-145 cell line.PMID:35977549 | DOI:10.18433/jpps32879 (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - August 17, 2022 Category: Drugs & Pharmacology Authors: Sanaa Bardaweel Ahmad Issa Source Type: research
Exploring the Role of Sodium-Glucose Cotransporter as a New Target for Cancer Therapy
CONCLUSION: SGLT2 inhibitors have antiproliferation, anti-tumorigenesis, and anti-migration effects and may induce apoptosis in cancer cells. In addition, treatment with SGLT2 inhibitors resulted in the downregulation of selected genes in the Du-145 cell line.PMID:35977549 | DOI:10.18433/jpps32879 (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - August 17, 2022 Category: Drugs & Pharmacology Authors: Sanaa Bardaweel Ahmad Issa Source Type: research
Exploring the Role of Sodium-Glucose Cotransporter as a New Target for Cancer Therapy
CONCLUSION: SGLT2 inhibitors have antiproliferation, anti-tumorigenesis, and anti-migration effects and may induce apoptosis in cancer cells. In addition, treatment with SGLT2 inhibitors resulted in the downregulation of selected genes in the Du-145 cell line.PMID:35977549 | DOI:10.18433/jpps32879 (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - August 17, 2022 Category: Drugs & Pharmacology Authors: Sanaa Bardaweel Ahmad Issa Source Type: research
Exploring the Role of Sodium-Glucose Cotransporter as a New Target for Cancer Therapy
CONCLUSION: SGLT2 inhibitors have antiproliferation, anti-tumorigenesis, and anti-migration effects and may induce apoptosis in cancer cells. In addition, treatment with SGLT2 inhibitors resulted in the downregulation of selected genes in the Du-145 cell line.PMID:35977549 | DOI:10.18433/jpps32879 (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - August 17, 2022 Category: Drugs & Pharmacology Authors: Sanaa Bardaweel Ahmad Issa Source Type: research
Exploring the Role of Sodium-Glucose Cotransporter as a New Target for Cancer Therapy
CONCLUSION: SGLT2 inhibitors have antiproliferation, anti-tumorigenesis, and anti-migration effects and may induce apoptosis in cancer cells. In addition, treatment with SGLT2 inhibitors resulted in the downregulation of selected genes in the Du-145 cell line.PMID:35977549 | DOI:10.18433/jpps32879 (Source: J Pharm Pharm Sci)
Source: J Pharm Pharm Sci - August 17, 2022 Category: Drugs & Pharmacology Authors: Sanaa Bardaweel Ahmad Issa Source Type: research
Exploring the Role of Sodium-Glucose Cotransporter as a New Target for Cancer Therapy
CONCLUSION: SGLT2 inhibitors have antiproliferation, anti-tumorigenesis, and anti-migration effects and may induce apoptosis in cancer cells. In addition, treatment with SGLT2 inhibitors resulted in the downregulation of selected genes in the Du-145 cell line.PMID:35977549 | DOI:10.18433/jpps32879 (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - August 17, 2022 Category: Drugs & Pharmacology Authors: Sanaa Bardaweel Ahmad Issa Source Type: research
Insilico Docking Study of Isoxazole Indole Linked Resorcinol
Derivatives as Promising Selective Estrogen Receptor Modulators &
Anticancer Drugs
Drug Res (Stuttg) DOI: 10.1055/a-1888-4684A series of 9 compounds with isoxazole-indole-γ-resorcylic acid scaffold,
segregated into B1 & A1 series, wherein, B1 comprises compounds:1,3,4,5,
& 9 and A1comprises compounds: 2,6,7, & 8 , on the basis of
variable substituents at the indole , resorcinol and isoxazole end of the
scaffold as in Fig. 1, were designed and docked with human estrogen
receptor:1ERRα. The binding affinity (BA) and the interacting amino
acids compared with reference selective estrogen receptor modulators (SERMs)
such as Ra...
Source: Drug Research - August 11, 2022 Category: Drugs & Pharmacology Authors: Iyer, Jayashree Monikanta Khare, Aradhana Pandey, Jaya Tags: Original Article Source Type: research
Qualitative analysis of shared decision-making for chemoprevention in the primary care setting: provider-related barriers
Chemoprevention with anti-estrogens, such as tamoxifen, raloxifene or aromatase inhibitors, have been shown to reduce breast cancer risk in randomized controlled trials; however, uptake among women at high-ris... (Source: BMC Medical Informatics and Decision Making)
Source: BMC Medical Informatics and Decision Making - August 4, 2022 Category: Information Technology Authors: Tarsha Jones, Thomas Silverman, Ashlee Guzman, Julia E. McGuinness, Meghna S. Trivedi, Rita Kukafka and Katherine D. Crew Tags: Research Source Type: research
A combined treatment with selective androgen and estrogen receptor modulators prevents bone loss in orchiectomized rats
ConclusionThe EN + RAL treatment appeared to be promising in preventing male osteoporosis, but given the observed side effects on liver, kidney, and prostate weights, it requires further investigation. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - July 22, 2022 Category: Endocrinology Source Type: research
Raloxifene HCl - Quercetin Co-amorphous System: Preparation, Characterization, and Investigation of its Behavior in Phosphate Buffer
Conclusion: RQ(SE) formed a stable CAM; though the solubility of RLX in presence of QCT reduced, from the drug release study, it was apparent that the co-amorphous technique improved the concentration of RLX.PMID:35852408 | DOI:10.1080/03639045.2022.2104308 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - July 19, 2022 Category: Drugs & Pharmacology Authors: Navya Sree K S Swapnil J Dengale Srinivas Mutalik Krishnamurthy Bhat Source Type: research
Anti-fibrotic effect of a selective estrogen receptor modulator in systemic sclerosis
CONCLUSIONS: This study reveals that a disease model of systemic sclerosis generated using iPSCs-derived skin organoid is a novel tool for in vitro and in vivo dermatologic research. Since raloxifene and bazedoxifene are well-tolerated anti-osteoporotic drugs, our findings suggest that selective estrogen receptor modulator (SERM)-class drugs could treat SSc fibrosis.PMID:35841004 | DOI:10.1186/s13287-022-02987-w (Source: Cell Research)
Source: Cell Research - July 15, 2022 Category: Cytology Authors: Yena Kim Yoojun Nam Yeri Alice Rim Ji Hyeon Ju Source Type: research
Treatment patterns of long-dose-interval medication for persistent management of osteoporosis in Taiwan
ConclusionThe real-world data reveal long-dose-interval therapy as an initial treatment or at the first switch stage may improve management of persistent AOM treatment. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - July 15, 2022 Category: Orthopaedics Source Type: research
