Endocrine Therapy for Primary and Secondary Prevention After Diagnosis of High-Risk Breast Lesions or Preinvasive Breast Cancer
J Clin Oncol. 2023 May 1:JCO2300455. doi: 10.1200/JCO.23.00455. Online ahead of print.ABSTRACTThe Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice.Patients with high...
Source: Clinical Genitourinary Cancer - May 1, 2023 Category: Cancer & Oncology Authors: Alison Laws Rinaa S Punglia Source Type: research
Global epidemiology of hip fractures: secular trends in incidence rate, post ‐fracture treatment, and all‐cause mortality
AbstractIn this international study, we examined the incidence of hip fractures, post-fracture treatment, and all-cause mortality following hip fractures, based on demographics, geography, and calendar year. We used patient-level healthcare data from 19 countries and regions to identify patients aged 50 years and older hospitalized with a hip fracture from 2005 to 2018. The age- and sex-standardized incidence rates of hip fractures, post-hip fracture treatment (defined as the proportion of patients receiving anti-osteoporosis medication with various mechanisms of action [bisphosphonates, denosum ab, raloxifene, strontiu...
Source: Journal of Bone and Mineral Research - April 30, 2023 Category: Orthopaedics Authors: Chor ‐Wing Sing,
Tzu‐Chieh Lin,
Sharon Bartholomew,
Simon Bell J,
Corina Bennett,
Kebede Beyene,
Pauline Bosco‐Levy,
Brian D Bradbury,
Amy Hai Yan Chan,
Manju Chandran,
Cyrus Cooper,
Maria Ridder,
Caroline Doyon Y,
Cécile Droz‐Perrot Tags: Research Article Source Type: research
Quality by Design (QbD)-Steered Development and Validation of Analytical and Bioanalytical Methods for Raloxifene: Application of Monte Carlo Simulations and Variance Inflation Factor
Biomed Chromatogr. 2023 Apr 11:e5641. doi: 10.1002/bmc.5641. Online ahead of print.ABSTRACTA sensitive, rapid, reproducible and economical high-performance liquid chromatographic (HPLC) method is reported for the quantification of raloxifene hydrochloride employing QbD principles. Factor screening studies, employing Taguchi design, indicated buffer volume percentage and isocratic flow rate as the critical method parameters (CMPs), which significantly influence the chosen critical analytical attributes, i.e., tailing factor and theoretical plate number. Method conditions were subsequently optimized using face-centered cubic...
Source: Biomedical Chromatography : BMC - April 11, 2023 Category: Biomedical Science Authors: Anjali Pant Gajanand Sharma Sumant Saini Atul Jain Ravi Pratap Barnwal Gurpal Singh Bhupinder Singh Source Type: research
HPV16 status predicts potential protein biomarkers and therapeutics in head and neck squamous cell carcinoma
Virology. 2023 Apr 7;582:90-99. doi: 10.1016/j.virol.2023.03.013. Online ahead of print.ABSTRACTHuman papillomavirus (HPV) infection, especially HPV16, is one of the causative factors for the development of head and neck squamous cell (HNSC) carcinoma. HPV-positive and HPV-negative HNSC patients differ significantly in their molecular profiles and clinical features, so they should be evaluated differently depending on their HPV status. Given the tremendous variation in HNSC cancers depending on HPV, our goal in this study was to present biomarkers and treatment options tailored to the patient's HPV status. Gene expression ...
Source: Virology - April 9, 2023 Category: Virology Authors: Medi Kori Kazim Yalcin Arga Source Type: research
HPV16 status predicts potential protein biomarkers and therapeutics in head and neck squamous cell carcinoma
Virology. 2023 Apr 7;582:90-99. doi: 10.1016/j.virol.2023.03.013. Online ahead of print.ABSTRACTHuman papillomavirus (HPV) infection, especially HPV16, is one of the causative factors for the development of head and neck squamous cell (HNSC) carcinoma. HPV-positive and HPV-negative HNSC patients differ significantly in their molecular profiles and clinical features, so they should be evaluated differently depending on their HPV status. Given the tremendous variation in HNSC cancers depending on HPV, our goal in this study was to present biomarkers and treatment options tailored to the patient's HPV status. Gene expression ...
Source: Virology - April 9, 2023 Category: Virology Authors: Medi Kori Kazim Yalcin Arga Source Type: research
HPV16 status predicts potential protein biomarkers and therapeutics in head and neck squamous cell carcinoma
Virology. 2023 Apr 7;582:90-99. doi: 10.1016/j.virol.2023.03.013. Online ahead of print.ABSTRACTHuman papillomavirus (HPV) infection, especially HPV16, is one of the causative factors for the development of head and neck squamous cell (HNSC) carcinoma. HPV-positive and HPV-negative HNSC patients differ significantly in their molecular profiles and clinical features, so they should be evaluated differently depending on their HPV status. Given the tremendous variation in HNSC cancers depending on HPV, our goal in this study was to present biomarkers and treatment options tailored to the patient's HPV status. Gene expression ...
Source: Virology - April 9, 2023 Category: Virology Authors: Medi Kori Kazim Yalcin Arga Source Type: research
HPV16 status predicts potential protein biomarkers and therapeutics in head and neck squamous cell carcinoma
Virology. 2023 Apr 7;582:90-99. doi: 10.1016/j.virol.2023.03.013. Online ahead of print.ABSTRACTHuman papillomavirus (HPV) infection, especially HPV16, is one of the causative factors for the development of head and neck squamous cell (HNSC) carcinoma. HPV-positive and HPV-negative HNSC patients differ significantly in their molecular profiles and clinical features, so they should be evaluated differently depending on their HPV status. Given the tremendous variation in HNSC cancers depending on HPV, our goal in this study was to present biomarkers and treatment options tailored to the patient's HPV status. Gene expression ...
Source: Virology - April 9, 2023 Category: Virology Authors: Medi Kori Kazim Yalcin Arga Source Type: research
Hyaluronated nanoparticles deliver raloxifene to CD44-expressed colon cancer cells and regulate lncRNAs/miRNAs epigenetic cascade
ConclusionsWe may conclude that the RX NP effectively targets CRC cells in vitro via altering lncRNAs and miRNAs epigenetic cascade as well as cellular uptake through CD44-expressed CRC cells. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - April 7, 2023 Category: Cancer & Oncology Source Type: research
The Clinical Effectiveness of Denosumab (Prolia ®) for the Treatment of Osteoporosis in Postmenopausal Women, Compared to Bisphosphonates, Selective Estrogen Receptor Modulators (SERM), and Placebo: A Systematic Review and Network Meta-Analysis
AbstractTo assess the effectiveness and safety of denosumab (Prolia ®) compared to bisphosphonates (alendronate, ibandronate, risedronate, zoledronate), selective estrogen receptor modulators (SERMs; bazedoxifene, raloxifene) or placebo, for the treatment of osteoporosis in postmenopausal women (PMW). Systematic searches were run in PubMed, Embase& Cochrane Library on 27-April-2022. Randomized controlled trials (RCTs) that included osteoporotic PMW allocated to denosumab, SERMs, bisphosphonates, or placebo were eligible for inclusion. RCTs were appraised using Cochrane Risk of Bias 2.0. Bayesian network and/or pairwis...
Source: Calcified Tissue International - April 5, 2023 Category: Orthopaedics Source Type: research
Pan-cancer analysis of ADAMs: A promising biomarker for prognosis and response to chemotherapy and immunotherapy
Conclusion: This study elucidates the importance of ADAMs in cancer progression and lays a foundation for further exploration of ADAMs as potential pan-cancer targets. (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - April 4, 2023 Category: Genetics & Stem Cells Source Type: research
Weak Inhibitory Effects of Anthocyanins on Human Aldehyde Oxidase Activity: An In Vitro Study
J Nutr Sci Vitaminol (Tokyo). 2023;69(1):71-75. doi: 10.3177/jnsv.69.71.ABSTRACTAldehyde oxidase (AO) plays an important role in the metabolism of antitumor and antiviral drugs, including methotrexate, favipiravir, and acyclovir. The consumption of blueberry fruits or their extracts, which contain large amounts of anthocyanins, has recently increased. The intake of large amounts of anthocyanins occurs through the frequent consumption of blueberries or their functional foods, which may result in unwanted interactions between anthocyanins and medicinal drugs. Therefore, the present study examined the inhibition of AO by anth...
Source: Journal of Nutritional Science and Vitaminology - March 1, 2023 Category: Nutrition Authors: Yuma Shibata Kaori Matsumoto Tetsuya Hasegawa Kosuke Ohara Masayuki Akimoto Source Type: research
