Development of Subdermal Implants Using Direct Powder Extrusion 3D Printing and Hot-Melt Extrusion Technologies
This study further evaluated the impact of different processing techniques, viz., hot-melt extrusion (HME) technology vs. DPE 3D printing technique, on the release of RFH from the implants fabricated by each processing technique. All the fabricated implants were characterized by XRD, DSC, SEM, and FTIR, and evaluated for their water uptake, mass loss, and in vitro RFH release. The current study successfully demonstrated a great opportunity of controlling and/or tuning the release of RFH from the subdermal implants by altering the implant shape, and hence surface area, and could be a great contribution and/or addition to th...
Source: AAPS PharmSciTech - October 19, 2023 Category: Drugs & Pharmacology Authors: Derick Muhindo Eman A Ashour Mashan Almutairi Michael A Repka Source Type: research
Development of Subdermal Implants Using Direct Powder Extrusion 3D Printing and Hot-Melt Extrusion Technologies
This study further evaluated the impact of different processing techniques, viz., hot-melt extrusion (HME) technology vs. DPE 3D printing technique, on the release of RFH from the implants fabricated by each processing technique. All the fabricated implants were characterized by XRD, DSC, SEM, and FTIR, and evaluated for their water uptake, mass loss, and in vitro RFH release. The current study successfully demonstrated a great opportunity of controlling and/or tuning the release of RFH from the subdermal implants by altering the implant shape, and hence surface area, and could be a great contribution and/or addition to th...
Source: AAPS PharmSciTech - October 19, 2023 Category: Drugs & Pharmacology Authors: Derick Muhindo Eman A Ashour Mashan Almutairi Michael A Repka Source Type: research
Development of Subdermal Implants Using Direct Powder Extrusion 3D Printing and Hot-Melt Extrusion Technologies
This study further evaluated the impact of different processing techniques, viz., hot-melt extrusion (HME) technology vs. DPE 3D printing technique, on the release of RFH from the implants fabricated by each processing technique. All the fabricated implants were characterized by XRD, DSC, SEM, and FTIR, and evaluated for their water uptake, mass loss, and in vitro RFH release. The current study successfully demonstrated a great opportunity of controlling and/or tuning the release of RFH from the subdermal implants by altering the implant shape, and hence surface area, and could be a great contribution and/or addition to th...
Source: AAPS PharmSciTech - October 19, 2023 Category: Drugs & Pharmacology Authors: Derick Muhindo Eman A Ashour Mashan Almutairi Michael A Repka Source Type: research
Development of Subdermal Implants Using Direct Powder Extrusion 3D Printing and Hot-Melt Extrusion Technologies
This study further evaluated the impact of different processing techniques, viz., hot-melt extrusion (HME) technology vs. DPE 3D printing technique, on the release of RFH from the implants fabricated by each processing technique. All the fabricated implants were characterized by XRD, DSC, SEM, and FTIR, and evaluated for their water uptake, mass loss, and in vitro RFH release. The current study successfully demonstrated a great opportunity of controlling and/or tuning the release of RFH from the subdermal implants by altering the implant shape, and hence surface area, and could be a great contribution and/or addition to th...
Source: AAPS PharmSciTech - October 19, 2023 Category: Drugs & Pharmacology Authors: Derick Muhindo Eman A Ashour Mashan Almutairi Michael A Repka Source Type: research
Adjunctive agents to antipsychotics in schizophrenia: a systematic umbrella review and recommendations for amino acids, hormonal therapies and anti-inflammatory drugs
Conclusions
The results of this umbrella review should be interpreted with caution as the number of RCTs included in the meta-analyses was generally small and the effect sizes were weak or medium. For NAC, two RCTs with low risk of bias have provided conflicting results and the WFSBP-grade recommendation included also the results of meta-analyses. These drugs could be provisionally prescribed for patients for whom no other treatments have been effective, but they should be discontinued if they prove ineffective. (Source: Evidence-Based Mental Health)
Source: Evidence-Based Mental Health - October 18, 2023 Category: Psychiatry & Psychology Authors: Fond, G., Mallet, J., Urbach, M., Benros, M. E., Berk, M., Billeci, M., Boyer, L., Correll, C. U., Fornaro, M., Kulkarni, J., Leboyer, M., Llorca, P.-M., Misdrahi, D., Rey, R., Schürhoff, F., Solmi, M., Sommer, I. E. C., Stahl, S. M., Pignon, B., Tags: Open access Adult mental health Source Type: research
Molecular Investigation of the Antitumor Effects of Monoamine Oxidase Inhibitors in Breast Cancer Cells
This study is aimed at evaluating the effect of different monoamine oxidase A inhibitors (MAO-AIs) on the proliferation and progression of breast cancer cell lines. The cell viability assay was used to evaluate the antiproliferative and combined effects of MAO-AIs. Cell migration was evaluated using wound healing, invasion, and colony formation assays. The underlying mechanism of cell death was studied using flow cytometry. The real-time polymerase chain reaction was used to determine the relative gene expression. Finally, MAO-A activity in breast cancer cells was evaluated using an MAO-A activity assay. According to the r...
Source: Biomed Res - October 16, 2023 Category: Research Authors: Aseel Alkhawaldeh Sanaa Bardaweel Source Type: research
SGX523 causes renal toxicity through aldehyde oxidase-mediated less-soluble metabolite formation in chimeric mice with humanized livers
This study investigated the metabolism and renal toxicity of SGX523 in chimeric mice with humanized livers (humanized-liver mice). The 2-quinolinone-SGX523 formation activity was higher in humanized-liver mouse and human hepatocytes than in mouse hepatocytes. Additionally, this activity in the liver cytosolic fraction from humanized-liver mice was inhibited by the AOX inhibitors raloxifene and hydralazine. After oral SGX523 administration, higher maximum concentrations, larger areas under the plasma concentration versus time curves, and higher urinary concentrations of 2-quinolinone-SGX523 were observed in humanized-liver ...
Source: Toxicology Letters - October 8, 2023 Category: Toxicology Authors: Shotaro Uehara Masahiko Yasuda Yuichiro Higuchi Nao Yoneda Kenji Kawai Masami Suzuki Hiroshi Yamazaki Hiroshi Suemizu Source Type: research
SGX523 causes renal toxicity through aldehyde oxidase-mediated less-soluble metabolite formation in chimeric mice with humanized livers
This study investigated the metabolism and renal toxicity of SGX523 in chimeric mice with humanized livers (humanized-liver mice). The 2-quinolinone-SGX523 formation activity was higher in humanized-liver mouse and human hepatocytes than in mouse hepatocytes. Additionally, this activity in the liver cytosolic fraction from humanized-liver mice was inhibited by the AOX inhibitors raloxifene and hydralazine. After oral SGX523 administration, higher maximum concentrations, larger areas under the plasma concentration versus time curves, and higher urinary concentrations of 2-quinolinone-SGX523 were observed in humanized-liver ...
Source: Toxicology Letters - October 8, 2023 Category: Toxicology Authors: Shotaro Uehara Masahiko Yasuda Yuichiro Higuchi Nao Yoneda Kenji Kawai Masami Suzuki Hiroshi Yamazaki Hiroshi Suemizu Source Type: research
The comparison of alendronate and raloxifene after denosumab (CARD) study: A comparative efficacy trial
ConclusionsThese results suggest that after one year of denosumab, one year of alendronate is better able to maintain the inhibition of bone remodeling and BMD gains than raloxifene. (Source: Osteoporosis International)
Source: Osteoporosis International - October 6, 2023 Category: Orthopaedics Source Type: research
The antifracture efficacy of vitamin D in adults - are we assessing it reliably? A systematic review
CONCLUSIONS: The analysed studies did not conclusively assess the vitamin D antifracture efficacy in patients with prestudy low serum vitamin levels, due to the lack of assessment of whether sufficient doses of vitamin D were used. They informed about the relevant doses and preparations of vitamin D in particular groups (specific fracture risk, age, place of residence) only.PMID:37779375 | DOI:10.5603/ep.95639 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - October 2, 2023 Category: Endocrinology Authors: Jerzy Przedlacki Urszula O łdakowska-Jedynak Source Type: research
The antifracture efficacy of vitamin D in adults - are we assessing it reliably? A systematic review
CONCLUSIONS: The analysed studies did not conclusively assess the vitamin D antifracture efficacy in patients with prestudy low serum vitamin levels, due to the lack of assessment of whether sufficient doses of vitamin D were used. They informed about the relevant doses and preparations of vitamin D in particular groups (specific fracture risk, age, place of residence) only.PMID:37779375 | DOI:10.5603/ep.95639 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - October 2, 2023 Category: Endocrinology Authors: Jerzy Przedlacki Urszula O łdakowska-Jedynak Source Type: research
The antifracture efficacy of vitamin D in adults - are we assessing it reliably? A systematic review
CONCLUSIONS: The analysed studies did not conclusively assess the vitamin D antifracture efficacy in patients with prestudy low serum vitamin levels, due to the lack of assessment of whether sufficient doses of vitamin D were used. They informed about the relevant doses and preparations of vitamin D in particular groups (specific fracture risk, age, place of residence) only.PMID:37779375 | DOI:10.5603/ep.95639 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - October 2, 2023 Category: Endocrinology Authors: Jerzy Przedlacki Urszula O łdakowska-Jedynak Source Type: research
The antifracture efficacy of vitamin D in adults - are we assessing it reliably? A systematic review
CONCLUSIONS: The analysed studies did not conclusively assess the vitamin D antifracture efficacy in patients with prestudy low serum vitamin levels, due to the lack of assessment of whether sufficient doses of vitamin D were used. They informed about the relevant doses and preparations of vitamin D in particular groups (specific fracture risk, age, place of residence) only.PMID:37779375 | DOI:10.5603/ep.95639 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - October 2, 2023 Category: Endocrinology Authors: Jerzy Przedlacki Urszula O łdakowska-Jedynak Source Type: research
The antifracture efficacy of vitamin D in adults - are we assessing it reliably? A systematic review
CONCLUSIONS: The analysed studies did not conclusively assess the vitamin D antifracture efficacy in patients with prestudy low serum vitamin levels, due to the lack of assessment of whether sufficient doses of vitamin D were used. They informed about the relevant doses and preparations of vitamin D in particular groups (specific fracture risk, age, place of residence) only.PMID:37779375 | DOI:10.5603/ep.95639 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - October 2, 2023 Category: Endocrinology Authors: Jerzy Przedlacki Urszula O łdakowska-Jedynak Source Type: research
