Stilbenes: a promising small molecule modulator for epigenetic regulation in human diseases
Stilbenes are characterized by a vinyl group connecting two benzene rings to form the basic parent nucleus. Hydrogen atoms on different positions of the benzene rings can be substituted with hydroQxyl groups. These unique structural features confer anti-inflammatory, antibacterial, antiviral, antioxidant, anticancer, cardiovascular protective, and neuroprotective pharmacological effects upon these compounds. Numerous small molecule compounds have demonstrated these pharmacological activities in recent years, including Resveratrol, and Pterostilbene, etc. Tamoxifen and Raloxifene are FDA-approved commonly prescribed synthet...
Source: Frontiers in Pharmacology - December 12, 2023 Category: Drugs & Pharmacology Source Type: research
The potential renoprotective effect of Raloxifene in renal ischemia-reperfusion injury in a male rat model
This study aimed to investigate the potential renoprotective effects of Raloxifene on bilateral renal ischemia-reperfusion injury in rats by looking into kidney function biomarkers, urea and creatinine, inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β). Additionally, antioxidant markers such as total antioxidant capacity (TAC) and the pro-apoptotic marker caspase-3 were assessed. Histopathological scores were also employed for evaluation. Our experimental design involved 20 rats divided into four groups: the sham group underwent median laparotomy without ischemia induction...
Source: Journal of Medicine and Life - November 29, 2023 Category: General Medicine Authors: Raghad Abdul Hameed Ali Murooj Altimimi Najah Rayish Hadi Source Type: research
