Effect of Bone Resorption Inhibitors on Serum Cholesterol Level and Fracture Risk in Osteoporosis: Randomized Comparative Study Between Minodronic Acid and Raloxifene
AbstractThe positive link between osteoporosis and hypercholesterolemia has been documented, and bone resorption inhibitors, such as nitrogen-containing bisphosphonates (N-BP) and selective estrogen receptor modulators (SERMs), are known to reduce serum cholesterol levels. However, the relationship between the baseline cholesterol level and incident fracture rate under the treatment using the bone resorption inhibitors has not been documented. We investigated the relation between vertebral fracture incident and the baseline cholesterol levels and cholesterol-lowering effect of N-BP and SERM in osteoporosis through a prospe...
Source: Calcified Tissue International - January 28, 2023 Category: Orthopaedics Source Type: research
Specific gene module pair-based target identification and drug discovery
Identification of the biological targets of a compound is of paramount importance for the exploration of the mechanism of action of drugs and for the development of novel drugs. A concept of the Connectivity Map (CMap) was previously proposed to connect genes, drugs, and disease states based on the common gene-expression signatures. For a new query compound, the CMap-based method can infer its potential targets by searching similar drugs with known targets (reference drugs) and measuring the similarities into their specific transcriptional responses between the query compound and those reference drugs. However, the availab...
Source: Frontiers in Pharmacology - January 16, 2023 Category: Drugs & Pharmacology Source Type: research
The contribution of larval zebrafish transcriptomics to chemical risk assessment
Regul Toxicol Pharmacol. 2023 Jan 12:105336. doi: 10.1016/j.yrtph.2023.105336. Online ahead of print.ABSTRACTIn Canada, the Canadian Environmental Protection Act (1999) requires human health and environmental risk assessments be conducted for new substances prior to their manufacture or import. While this toxicity data is historically obtained using rodents, in response to the international effort to eliminate animal testing, Health Canada is collaborating with the National Research Council (NRC) of Canada to develop a New Approach Method by refining existing NRC zebrafish models. The embryo/larval zebrafish model evaluate...
Source: Regulatory Toxicology and Pharmacology : RTP - January 15, 2023 Category: Toxicology Authors: Michael G Morash Morgan W Kirzinger J C Achenbach Anand Venkatachalam Jo ëlle Pinsonnault Cooper Deborah E Ratzlaff Cindy L A Woodland Lee D Ellis Source Type: research
The contribution of larval zebrafish transcriptomics to chemical risk assessment
Regul Toxicol Pharmacol. 2023 Jan 12:105336. doi: 10.1016/j.yrtph.2023.105336. Online ahead of print.ABSTRACTIn Canada, the Canadian Environmental Protection Act (1999) requires human health and environmental risk assessments be conducted for new substances prior to their manufacture or import. While this toxicity data is historically obtained using rodents, in response to the international effort to eliminate animal testing, Health Canada is collaborating with the National Research Council (NRC) of Canada to develop a New Approach Method by refining existing NRC zebrafish models. The embryo/larval zebrafish model evaluate...
Source: Regulatory Toxicology and Pharmacology : RTP - January 15, 2023 Category: Toxicology Authors: Michael G Morash Morgan W Kirzinger J C Achenbach Anand Venkatachalam Jo ëlle Pinsonnault Cooper Deborah E Ratzlaff Cindy L A Woodland Lee D Ellis Source Type: research
Cancers, Vol. 15, Pages 456: Targeting Interleukin-6/Glycoprotein-130 Signaling by Raloxifene or SC144 Enhances Paclitaxel Efficacy in Pancreatic Cancer
In conclusion, raloxifene or SC144 can enhance the anti-tumorigenic effects of paclitaxel, suggesting that paclitaxel doses might also be reduced in combined chemotherapy to lessen paclitaxel side effects. (Source: Cancers)
Source: Cancers - January 11, 2023 Category: Cancer & Oncology Authors: Nina A. Hering Emily G ünzler Marco Arndt Miriam Zibell Johannes C. Lauscher Martin E. Kreis Katharina Beyer Hendrik Seeliger Ioannis Pozios Tags: Article Source Type: research
