Factors associated with adherence to medications for lowering breast cancer risk between female Medicare beneficiaries in Alabama and nationwide
ConclusionOur findings highlight the importance of access to preventive services such as mammography to better adherence to BC preventive treatments among female Medicare beneficiaries. (Source: Cancer Causes and Control)
Source: Cancer Causes and Control - September 8, 2023 Category: Cancer & Oncology Source Type: research
Advantage of ostarine over raloxifene and their combined treatments for muscle of estrogen-deficient rats
ConclusionOST had beneficial effects on muscle in OVX rats. Side effects of OST on the uterus and serum electrolytes should be considered before using it for therapeutic purposes. RAL and RAL + OST had less effect on muscle and showed endocrinological side effects on pituitary–gonadal axis. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 6, 2023 Category: Endocrinology Source Type: research
Comparative Pharmacokinetic Profiles of a Novel Low ‐Dose Micronized Formulation of Raloxifene 45 mg (AD‐101) and the Conventional Raloxifene 60 mg in Healthy Subjects
This study was designed as an open-label, randomized, 2-treatment-period, crossover study with a 2-week washout period. Two treatments consisted of micronized raloxifene 45 mg daily; and conventional raloxifene 60 mg daily administered in fasting conditions. Plasma raloxifene concentrations were determined by a validated method using ultra-fast liquid chromatography–tandem mass spectrometry, and pharmacokinetic parameters were calculated using a noncompartmental m odel. In total, 49 subjects completed the study. The geometric mean ratio (micronized/conventional) of the maximum concentration and the area under the plas...
Source: Clinical Pharmacology in Drug Development - August 26, 2023 Category: Drugs & Pharmacology Authors: Hae Won Lee,
Woo Youl Kang,
Mi ‐Ri Gwon,
Soo‐Jin Park,
Kyunghee Cho,
Sook Jin Seong,
Young‐Ran Yoon Tags: Original Article Source Type: research
Hormone therapy for sexual function in perimenopausal and postmenopausal women
CONCLUSIONS: Hormone therapy treatment with estrogen alone probably slightly improves the sexual function composite score in women with menopausal symptoms or in early postmenopause (within five years of amenorrhoea), and in unselected postmenopausal women, especially in the lubrication, pain, and satisfaction domains. We are uncertain whether estrogen combined with progestogens improves the sexual function composite score in unselected postmenopausal women. Evidence regarding other hormone therapies (synthetic steroids and SERMs) is of very low quality and we are uncertain of their effect on sexual function. The current e...
Source: Cochrane Database of Systematic Reviews - August 24, 2023 Category: General Medicine Authors: Lucia A Lara Denisse Cartagena-Ramos Jaqueline Bp Figueiredo Ana Carolina Js Rosa-E-Silva Rui A Ferriani Wellington P Martins Miguel Fuentealba-Torres Source Type: research
Hormone therapy for sexual function in perimenopausal and postmenopausal women
CONCLUSIONS: Hormone therapy treatment with estrogen alone probably slightly improves the sexual function composite score in women with menopausal symptoms or in early postmenopause (within five years of amenorrhoea), and in unselected postmenopausal women, especially in the lubrication, pain, and satisfaction domains. We are uncertain whether estrogen combined with progestogens improves the sexual function composite score in unselected postmenopausal women. Evidence regarding other hormone therapies (synthetic steroids and SERMs) is of very low quality and we are uncertain of their effect on sexual function. The current e...
Source: Cochrane Database of Systematic Reviews - August 24, 2023 Category: General Medicine Authors: Lucia A Lara Denisse Cartagena-Ramos Jaqueline Bp Figueiredo Ana Carolina Js Rosa-E-Silva Rui A Ferriani Wellington P Martins Miguel Fuentealba-Torres Source Type: research
Hormone therapy for sexual function in perimenopausal and postmenopausal women
CONCLUSIONS: Hormone therapy treatment with estrogen alone probably slightly improves the sexual function composite score in women with menopausal symptoms or in early postmenopause (within five years of amenorrhoea), and in unselected postmenopausal women, especially in the lubrication, pain, and satisfaction domains. We are uncertain whether estrogen combined with progestogens improves the sexual function composite score in unselected postmenopausal women. Evidence regarding other hormone therapies (synthetic steroids and SERMs) is of very low quality and we are uncertain of their effect on sexual function. The current e...
Source: Cochrane Database of Systematic Reviews - August 24, 2023 Category: General Medicine Authors: Lucia A Lara Denisse Cartagena-Ramos Jaqueline Bp Figueiredo Ana Carolina Js Rosa-E-Silva Rui A Ferriani Wellington P Martins Miguel Fuentealba-Torres Source Type: research
Synthesis of raloxifene-like quinoxaline derivatives by intramolecular electrophilic cyclization with disulfides
Bioorg Med Chem Lett. 2023 Jul 31:129415. doi: 10.1016/j.bmcl.2023.129415. Online ahead of print.ABSTRACTThe intramolecular electrophilic cyclization of alkynes with disulfides to form thieno[2,3-b]quinoxaline structures and to introduce thioether substituents afforded quinoxaline derivatives (7a-7d, 8a-8d). Among obtained eight derivatives, the raloxifene analogues (7c, 8b) showed specifically high cytotoxicity against breast cancer cells (SK-BR-3), and raloxifene analogues (8a) showed the highest cytotoxicity against human leukemia cells (HL-60). None of the raloxifene analogues (7a-7d, 8a-8d) showed cytotoxicity against...
Source: Bioorganic and Medicinal Chemistry Letters - August 2, 2023 Category: Chemistry Authors: Yuhi Umezu Eito Horiyama Yuto Nakai Masayuki Ninomiya Atsuyoshi Nishina Mamoru Koketsu Source Type: research
Synthesis of raloxifene-like quinoxaline derivatives by intramolecular electrophilic cyclization with disulfides
Bioorg Med Chem Lett. 2023 Jul 31:129415. doi: 10.1016/j.bmcl.2023.129415. Online ahead of print.ABSTRACTThe intramolecular electrophilic cyclization of alkynes with disulfides to form thieno[2,3-b]quinoxaline structures and to introduce thioether substituents afforded quinoxaline derivatives (7a-7d, 8a-8d). Among obtained eight derivatives, the raloxifene analogues (7c, 8b) showed specifically high cytotoxicity against breast cancer cells (SK-BR-3), and raloxifene analogues (8a) showed the highest cytotoxicity against human leukemia cells (HL-60). None of the raloxifene analogues (7a-7d, 8a-8d) showed cytotoxicity against...
Source: Bioorganic and Medicinal Chemistry Letters - August 2, 2023 Category: Chemistry Authors: Yuhi Umezu Eito Horiyama Yuto Nakai Masayuki Ninomiya Atsuyoshi Nishina Mamoru Koketsu Source Type: research
Synthesis of raloxifene-like quinoxaline derivatives by intramolecular electrophilic cyclization with disulfides
Bioorg Med Chem Lett. 2023 Jul 31:129415. doi: 10.1016/j.bmcl.2023.129415. Online ahead of print.ABSTRACTThe intramolecular electrophilic cyclization of alkynes with disulfides to form thieno[2,3-b]quinoxaline structures and to introduce thioether substituents afforded quinoxaline derivatives (7a-7d, 8a-8d). Among obtained eight derivatives, the raloxifene analogues (7c, 8b) showed specifically high cytotoxicity against breast cancer cells (SK-BR-3), and raloxifene analogues (8a) showed the highest cytotoxicity against human leukemia cells (HL-60). None of the raloxifene analogues (7a-7d, 8a-8d) showed cytotoxicity against...
Source: Bioorganic and Medicinal Chemistry Letters - August 2, 2023 Category: Chemistry Authors: Yuhi Umezu Eito Horiyama Yuto Nakai Masayuki Ninomiya Atsuyoshi Nishina Mamoru Koketsu Source Type: research
