Cardioprotective effect of tamoxifen and raloxifene: Preventing proteoglycan synthesis by modulating non-canonical TGF- β signalling through NADPH oxidase and ERK phosphorylation
This study sought to investigate the impact of tamoxifen and raloxifene on TGF-β-induced CHSY1 expression and Smad2 linker region phosphorylation in VSMCs and to elucidate the role of reactive oxygen species (ROS), NADPH oxidase (NOX), and kinase pathways in mediating these effects. Employing a comprehensive experimental strategy, VSMCs were treated with TGF-β in the presence or absence of tamoxifen, raloxifene, and various pharmacological inhibitors. Subsequently, CHSY1 mRNA expression, Smad2C and Smad2L phosphorylation, ROS production, p47phox and ERK 1/2 phosphorylation were assessed. Our results revealed that tamoxif...
Source: Atherosclerosis - June 12, 2023 Category: Cardiology Authors: Vahid Zarezade Narges Mohammadtaghvaei Mojtaba Rashidi Hossein Babaahmadi-Rezaei Source Type: research
Cardioprotective effect of tamoxifen and raloxifene: Preventing proteoglycan synthesis by modulating non-canonical TGF- β signalling through NADPH oxidase and ERK phosphorylation
This study sought to investigate the impact of tamoxifen and raloxifene on TGF-β-induced CHSY1 expression and Smad2 linker region phosphorylation in VSMCs and to elucidate the role of reactive oxygen species (ROS), NADPH oxidase (NOX), and kinase pathways in mediating these effects. Employing a comprehensive experimental strategy, VSMCs were treated with TGF-β in the presence or absence of tamoxifen, raloxifene, and various pharmacological inhibitors. Subsequently, CHSY1 mRNA expression, Smad2C and Smad2L phosphorylation, ROS production, p47phox and ERK 1/2 phosphorylation were assessed. Our results revealed that tamoxif...
Source: Biochemical and Biophysical Research communications - June 12, 2023 Category: Biochemistry Authors: Vahid Zarezade Narges Mohammadtaghvaei Mojtaba Rashidi Hossein Babaahmadi-Rezaei Source Type: research
The real-world adherence of the first-line anti-osteoporosis medications in Taiwan: Visualize the gap between reality and expectations
CONCLUSION: The initial AOMs and the observed adherence may provide clues for optimizing patient treatment. The real-world adherence in Taiwan was far from satisfactory in our study.PMID:37302970 | DOI:10.1016/j.jfma.2023.05.022 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - June 11, 2023 Category: General Medicine Authors: Chia-Che Lee Shau-Huai Fu Ho-Min Chen Jou-Wei Lin Chih-Cheng Hsu Sheng-Chieh Lin Jawl-Shan Hwang Rong-Sen Yang Chih-Hsing Wu Chen-Yu Wang Source Type: research
The real-world adherence of the first-line anti-osteoporosis medications in Taiwan: Visualize the gap between reality and expectations
CONCLUSION: The initial AOMs and the observed adherence may provide clues for optimizing patient treatment. The real-world adherence in Taiwan was far from satisfactory in our study.PMID:37302970 | DOI:10.1016/j.jfma.2023.05.022 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - June 11, 2023 Category: General Medicine Authors: Chia-Che Lee Shau-Huai Fu Ho-Min Chen Jou-Wei Lin Chih-Cheng Hsu Sheng-Chieh Lin Jawl-Shan Hwang Rong-Sen Yang Chih-Hsing Wu Chen-Yu Wang Source Type: research
Mechanisms underlying the therapeutic effects of isoflavones isolated from chickpea sprouts in treating osteoporosis based on network pharmacology
Biochem Biophys Res Commun. 2023 May 29;671:26-37. doi: 10.1016/j.bbrc.2023.05.090. Online ahead of print.ABSTRACTOsteoporosis is a systemic bone disease that is caused by multiple factors that lead to an imbalance in bone metabolism. Isoflavones can prevent and treat osteoporosis by regulating bone metabolism through a variety of pathways. The germination of chickpeas can significantly increase their isoflavone contents. However, the use of isoflavones isolated from chickpea sprouts (ICS) to prevent and treat osteoporosis by regulating bone metabolism has not been widely studied. In vivo experimental studies in ovariectom...
Source: Biochemical and Biophysical Research communications - June 8, 2023 Category: Biochemistry Authors: Jinyong Huang Xin Wang Jingjie Zheng Qiyu Jia Xi Wang Zengru Xie Hairong Ma Source Type: research
Mechanisms underlying the therapeutic effects of isoflavones isolated from chickpea sprouts in treating osteoporosis based on network pharmacology
Biochem Biophys Res Commun. 2023 May 29;671:26-37. doi: 10.1016/j.bbrc.2023.05.090. Online ahead of print.ABSTRACTOsteoporosis is a systemic bone disease that is caused by multiple factors that lead to an imbalance in bone metabolism. Isoflavones can prevent and treat osteoporosis by regulating bone metabolism through a variety of pathways. The germination of chickpeas can significantly increase their isoflavone contents. However, the use of isoflavones isolated from chickpea sprouts (ICS) to prevent and treat osteoporosis by regulating bone metabolism has not been widely studied. In vivo experimental studies in ovariectom...
Source: Biochemical and Biophysical Research communications - June 8, 2023 Category: Biochemistry Authors: Jinyong Huang Xin Wang Jingjie Zheng Qiyu Jia Xi Wang Zengru Xie Hairong Ma Source Type: research
The role of SERMs in menopausal hormonal treatment
Selective Estrogen Receptor Modulators (SERMs) are synthetic molecules that bind to the estrogen receptor and can have agonistic activity in some tissues while being antagonistic in others. While most clinicians are very familiar with older SERMs like tamoxifen and raloxifene, newer agents such as ospemifene and bazedoxifene offer other beneficial properties that should encourage their more widespread use to treat menopausal symptoms. (Source: Maturitas)
Source: Maturitas - June 8, 2023 Category: Primary Care Authors: Steven R. Goldstein Tags: Abstract ID: 102 Source Type: research
11 years secular trend of the initiation of anti-osteoporosis medications and subsequent fractures in Taiwan: From 2008 to 2018
CONCLUSION: This study showed an immediate drop in AOMs prescription after the implementation of a new stricter reimbursement policy. It took 5 years to return the annual prescription number.PMID:37280138 | DOI:10.1016/j.jfma.2023.05.023 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - June 6, 2023 Category: General Medicine Authors: Tsung-Han Yang Chen-Yu Wang Shau-Huai Fu Ding-Cheng Chan Ho-Min Chen Jou-Wei Lin Chun-Feng Huang Jen-Jia Yang Chih-Hsing Wu Jawl-Shan Hwang Rong-Sen Yang Source Type: research
Constraining in reimbursement criteria and the adherence to anti-osteoporosis medications (AOMs) in Taiwan: Urbanization makes the difference
CONCLUSION: The implementation of new reimbursement criteria in 2011 was associated with increased adherence to AOMs and the increase was most apparent in high-urbanization areas.PMID:37271714 | DOI:10.1016/j.jfma.2023.05.012 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - June 4, 2023 Category: General Medicine Authors: Chen-Yu Wang Tsung-Han Yang Shau-Huai Fu Jawl-Shan Hwang Ho-Min Chen Jou-Wei Lin Chih-Cheng Hsu Yin-Fan Chang Chih-Hsing Wu Ding-Cheng Chan Rong-Sen Yang Source Type: research
Constraining in reimbursement criteria and the adherence to anti-osteoporosis medications (AOMs) in Taiwan: Urbanization makes the difference
CONCLUSION: The implementation of new reimbursement criteria in 2011 was associated with increased adherence to AOMs and the increase was most apparent in high-urbanization areas.PMID:37271714 | DOI:10.1016/j.jfma.2023.05.012 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - June 4, 2023 Category: General Medicine Authors: Chen-Yu Wang Tsung-Han Yang Shau-Huai Fu Jawl-Shan Hwang Ho-Min Chen Jou-Wei Lin Chih-Cheng Hsu Yin-Fan Chang Chih-Hsing Wu Ding-Cheng Chan Rong-Sen Yang Source Type: research
Global Epidemiology of Hip Fractures: Secular Trends in Incidence Rate, Post ‐Fracture Treatment, and All‐Cause Mortality
ABSTRACTIn this international study, we examined the incidence of hip fractures, postfracture treatment, and all-cause mortality following hip fractures, based on demographics, geography, and calendar year. We used patient-level healthcare data from 19 countries and regions to identify patients aged 50 years and older hospitalized with a hip fracture from 2005 to 2018. The age- and sex-standardized incidence rates of hip fractures, post-hip fracture treatment (defined as the proportion of patients receiving anti-osteoporosis medication with various mechanisms of action [bisphosphonates, denosum ab, raloxifene, strontium...
Source: Journal of Bone and Mineral Research - May 29, 2023 Category: Orthopaedics Authors: Chor ‐Wing Sing,
Tzu‐Chieh Lin,
Sharon Bartholomew,
J Simon Bell,
Corina Bennett,
Kebede Beyene,
Pauline Bosco‐Levy,
Brian D. Bradbury,
Amy Hai Yan Chan,
Manju Chandran,
Cyrus Cooper,
Maria Ridder,
Caroline Y. Doyon,
Cécile Droz‐Perr Tags: Research Article Source Type: research
Raloxifene and bazedoxifene as selective ALDH1A1 inhibitors to ameliorate cyclophosphamide resistance: A drug repurposing approach
Int J Biol Macromol. 2023 May 7:124749. doi: 10.1016/j.ijbiomac.2023.124749. Online ahead of print.ABSTRACTCyclophosphamide (CP) is one of the most widely used anticancer drugs for various malignancies. However, its long-term use leads to ALDH1A1-mediated inactivation and subsequent resistance which necessitates the development of potential ALDH1A1 inhibitors. Currently, ALDH1A1 inhibitors from different chemical classes have been reported, but these failed to reach the market due to safety and efficacy problems. Developing a new treatment from the ground requires a huge amount of time, effort, and money, therefore it is w...
Source: International Journal of Biological Macromolecules - May 9, 2023 Category: Biochemistry Authors: Gera Narendra Baddipadige Raju Himanshu Verma Manoj Kumar Subheet Kumar Jain Gurleen Kaur Tung Shubham Thakur Rasdeep Kaur Satwinderjeet Kaur Bharti Sapra Pankaj Kumar Singh Om Silakari Source Type: research
Endocrine Therapy for Primary and Secondary Prevention After Diagnosis of High-Risk Breast Lesions or Preinvasive Breast Cancer
J Clin Oncol. 2023 May 1:JCO2300455. doi: 10.1200/JCO.23.00455. Online ahead of print.ABSTRACTThe Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice.Patients with high...
Source: Clinical Breast Cancer - May 1, 2023 Category: Cancer & Oncology Authors: Alison Laws Rinaa S Punglia Source Type: research
Endocrine Therapy for Primary and Secondary Prevention After Diagnosis of High-Risk Breast Lesions or Preinvasive Breast Cancer
J Clin Oncol. 2023 May 1:JCO2300455. doi: 10.1200/JCO.23.00455. Online ahead of print.ABSTRACTThe Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice.Patients with high...
Source: Clinical Genitourinary Cancer - May 1, 2023 Category: Cancer & Oncology Authors: Alison Laws Rinaa S Punglia Source Type: research
Endocrine Therapy for Primary and Secondary Prevention After Diagnosis of High-Risk Breast Lesions or Preinvasive Breast Cancer
J Clin Oncol. 2023 May 1:JCO2300455. doi: 10.1200/JCO.23.00455. Online ahead of print.ABSTRACTThe Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice.Patients with high...
Source: Clinical Breast Cancer - May 1, 2023 Category: Cancer & Oncology Authors: Alison Laws Rinaa S Punglia Source Type: research
