Are noscapine and raloxifene ligands of the bradykinin B < sub > 2 < /sub > receptor? An assessment based on the human umbilical vein contractility assay
Int Immunopharmacol. 2022 Jun 30;110:108984. doi: 10.1016/j.intimp.2022.108984. Online ahead of print.ABSTRACTThe centrally acting antitussive opiate derivative, noscapine, has been claimed to be a non-competitive bradykinin B2 receptor antagonist. Raloxifene, a selective estrogen receptor modulator, was predicted to bind the bradykinin B2 receptor and to exert a partial agonist activity. These intriguing claims suggest that new molecular scaffolds ("chemotypes") may be identified for small molecule ligands of kinin receptors and that some off-target effects of noscapine or raloxifene may be mediated by bradykinin B2 recep...
Source: International Immunopharmacology - July 3, 2022 Category: Allergy & Immunology Authors: H élène Bachelard Fran çois Marceau Source Type: research
Are noscapine and raloxifene ligands of the bradykinin B < sub > 2 < /sub > receptor? An assessment based on the human umbilical vein contractility assay
Int Immunopharmacol. 2022 Jun 30;110:108984. doi: 10.1016/j.intimp.2022.108984. Online ahead of print.ABSTRACTThe centrally acting antitussive opiate derivative, noscapine, has been claimed to be a non-competitive bradykinin B2 receptor antagonist. Raloxifene, a selective estrogen receptor modulator, was predicted to bind the bradykinin B2 receptor and to exert a partial agonist activity. These intriguing claims suggest that new molecular scaffolds ("chemotypes") may be identified for small molecule ligands of kinin receptors and that some off-target effects of noscapine or raloxifene may be mediated by bradykinin B2 recep...
Source: International Immunopharmacology - July 3, 2022 Category: Allergy & Immunology Authors: H élène Bachelard Fran çois Marceau Source Type: research
Frontal Fibrosing Alopecia - a review and a practical guide for clinicians
Ann Agric Environ Med. 2022 Jun 24;29(2):169-184. doi: 10.26444/aaem/141324. Epub 2021 Aug 31.ABSTRACTDespite a significant increase in reported cases of frontal fibrosing alopecia (FFA) in literature, discussion about the possible role of environmental factors, instruction for diagnosis and guideline for treatment, are limited. The review aims to provide a detailed synthesis of this condition that could be used by clinicians in their practise. Whether single-centre or multi-centre, studies of more than 60 cases less than 5 years old were mainly taken into consideration. Results obtained were that FFA affects mainly postme...
Source: Annals of Agricultural and Environmental Medicine : AAEM - June 29, 2022 Category: Environmental Health Authors: Klementyna K ępińska Magdalena Ja łowska Monika Bowszyc-Dmochowska Source Type: research
Frontal Fibrosing Alopecia - a review and a practical guide for clinicians
Ann Agric Environ Med. 2022 Jun 24;29(2):169-184. doi: 10.26444/aaem/141324. Epub 2021 Aug 31.ABSTRACTDespite a significant increase in reported cases of frontal fibrosing alopecia (FFA) in literature, discussion about the possible role of environmental factors, instruction for diagnosis and guideline for treatment, are limited. The review aims to provide a detailed synthesis of this condition that could be used by clinicians in their practise. Whether single-centre or multi-centre, studies of more than 60 cases less than 5 years old were mainly taken into consideration. Results obtained were that FFA affects mainly postme...
Source: Annals of Agricultural and Environmental Medicine : AAEM - June 29, 2022 Category: Environmental Health Authors: Klementyna K ępińska Magdalena Ja łowska Monika Bowszyc-Dmochowska Source Type: research
Frontal Fibrosing Alopecia - a review and a practical guide for clinicians
Ann Agric Environ Med. 2022 Jun 24;29(2):169-184. doi: 10.26444/aaem/141324. Epub 2021 Aug 31.ABSTRACTDespite a significant increase in reported cases of frontal fibrosing alopecia (FFA) in literature, discussion about the possible role of environmental factors, instruction for diagnosis and guideline for treatment, are limited. The review aims to provide a detailed synthesis of this condition that could be used by clinicians in their practise. Whether single-centre or multi-centre, studies of more than 60 cases less than 5 years old were mainly taken into consideration. Results obtained were that FFA affects mainly postme...
Source: Annals of Agricultural and Environmental Medicine : AAEM - June 29, 2022 Category: Environmental Health Authors: Klementyna K ępińska Magdalena Ja łowska Monika Bowszyc-Dmochowska Source Type: research
Frontal Fibrosing Alopecia - a review and a practical guide for clinicians
Ann Agric Environ Med. 2022 Jun 24;29(2):169-184. doi: 10.26444/aaem/141324. Epub 2021 Aug 31.ABSTRACTDespite a significant increase in reported cases of frontal fibrosing alopecia (FFA) in literature, discussion about the possible role of environmental factors, instruction for diagnosis and guideline for treatment, are limited. The review aims to provide a detailed synthesis of this condition that could be used by clinicians in their practise. Whether single-centre or multi-centre, studies of more than 60 cases less than 5 years old were mainly taken into consideration. Results obtained were that FFA affects mainly postme...
Source: Annals of Agricultural and Environmental Medicine : AAEM - June 29, 2022 Category: Environmental Health Authors: Klementyna K ępińska Magdalena Ja łowska Monika Bowszyc-Dmochowska Source Type: research
Frontal Fibrosing Alopecia - a review and a practical guide for clinicians
Ann Agric Environ Med. 2022 Jun 24;29(2):169-184. doi: 10.26444/aaem/141324. Epub 2021 Aug 31.ABSTRACTDespite a significant increase in reported cases of frontal fibrosing alopecia (FFA) in literature, discussion about the possible role of environmental factors, instruction for diagnosis and guideline for treatment, are limited. The review aims to provide a detailed synthesis of this condition that could be used by clinicians in their practise. Whether single-centre or multi-centre, studies of more than 60 cases less than 5 years old were mainly taken into consideration. Results obtained were that FFA affects mainly postme...
Source: Annals of Agricultural and Environmental Medicine : AAEM - June 29, 2022 Category: Environmental Health Authors: Klementyna K ępińska Magdalena Ja łowska Monika Bowszyc-Dmochowska Source Type: research
Frontal Fibrosing Alopecia - a review and a practical guide for clinicians
Ann Agric Environ Med. 2022 Jun 24;29(2):169-184. doi: 10.26444/aaem/141324. Epub 2021 Aug 31.ABSTRACTDespite a significant increase in reported cases of frontal fibrosing alopecia (FFA) in literature, discussion about the possible role of environmental factors, instruction for diagnosis and guideline for treatment, are limited. The review aims to provide a detailed synthesis of this condition that could be used by clinicians in their practise. Whether single-centre or multi-centre, studies of more than 60 cases less than 5 years old were mainly taken into consideration. Results obtained were that FFA affects mainly postme...
Source: Annals of Agricultural and Environmental Medicine : AAEM - June 29, 2022 Category: Environmental Health Authors: Klementyna K ępińska Magdalena Ja łowska Monika Bowszyc-Dmochowska Source Type: research
Frontal Fibrosing Alopecia - a review and a practical guide for clinicians
Ann Agric Environ Med. 2022 Jun 24;29(2):169-184. doi: 10.26444/aaem/141324. Epub 2021 Aug 31.ABSTRACTDespite a significant increase in reported cases of frontal fibrosing alopecia (FFA) in literature, discussion about the possible role of environmental factors, instruction for diagnosis and guideline for treatment, are limited. The review aims to provide a detailed synthesis of this condition that could be used by clinicians in their practise. Whether single-centre or multi-centre, studies of more than 60 cases less than 5 years old were mainly taken into consideration. Results obtained were that FFA affects mainly postme...
Source: Annals of Agricultural and Environmental Medicine : AAEM - June 29, 2022 Category: Environmental Health Authors: Klementyna K ępińska Magdalena Ja łowska Monika Bowszyc-Dmochowska Source Type: research
Frontal Fibrosing Alopecia - a review and a practical guide for clinicians
Ann Agric Environ Med. 2022 Jun 24;29(2):169-184. doi: 10.26444/aaem/141324. Epub 2021 Aug 31.ABSTRACTDespite a significant increase in reported cases of frontal fibrosing alopecia (FFA) in literature, discussion about the possible role of environmental factors, instruction for diagnosis and guideline for treatment, are limited. The review aims to provide a detailed synthesis of this condition that could be used by clinicians in their practise. Whether single-centre or multi-centre, studies of more than 60 cases less than 5 years old were mainly taken into consideration. Results obtained were that FFA affects mainly postme...
Source: Annals of Agricultural and Environmental Medicine : AAEM - June 29, 2022 Category: Environmental Health Authors: Klementyna K ępińska Magdalena Ja łowska Monika Bowszyc-Dmochowska Source Type: research
Frontal Fibrosing Alopecia - a review and a practical guide for clinicians
Ann Agric Environ Med. 2022 Jun 24;29(2):169-184. doi: 10.26444/aaem/141324. Epub 2021 Aug 31.ABSTRACTDespite a significant increase in reported cases of frontal fibrosing alopecia (FFA) in literature, discussion about the possible role of environmental factors, instruction for diagnosis and guideline for treatment, are limited. The review aims to provide a detailed synthesis of this condition that could be used by clinicians in their practise. Whether single-centre or multi-centre, studies of more than 60 cases less than 5 years old were mainly taken into consideration. Results obtained were that FFA affects mainly postme...
Source: Annals of Agricultural and Environmental Medicine : AAEM - June 29, 2022 Category: Environmental Health Authors: Klementyna K ępińska Magdalena Ja łowska Monika Bowszyc-Dmochowska Source Type: research
Frontal Fibrosing Alopecia - a review and a practical guide for clinicians
Ann Agric Environ Med. 2022 Jun 24;29(2):169-184. doi: 10.26444/aaem/141324. Epub 2021 Aug 31.ABSTRACTDespite a significant increase in reported cases of frontal fibrosing alopecia (FFA) in literature, discussion about the possible role of environmental factors, instruction for diagnosis and guideline for treatment, are limited. The review aims to provide a detailed synthesis of this condition that could be used by clinicians in their practise. Whether single-centre or multi-centre, studies of more than 60 cases less than 5 years old were mainly taken into consideration. Results obtained were that FFA affects mainly postme...
Source: Annals of Agricultural and Environmental Medicine : AAEM - June 29, 2022 Category: Environmental Health Authors: Klementyna K ępińska Magdalena Ja łowska Monika Bowszyc-Dmochowska Source Type: research
Frontal Fibrosing Alopecia - a review and a practical guide for clinicians
Ann Agric Environ Med. 2022 Jun 24;29(2):169-184. doi: 10.26444/aaem/141324. Epub 2021 Aug 31.ABSTRACTDespite a significant increase in reported cases of frontal fibrosing alopecia (FFA) in literature, discussion about the possible role of environmental factors, instruction for diagnosis and guideline for treatment, are limited. The review aims to provide a detailed synthesis of this condition that could be used by clinicians in their practise. Whether single-centre or multi-centre, studies of more than 60 cases less than 5 years old were mainly taken into consideration. Results obtained were that FFA affects mainly postme...
Source: Annals of Agricultural and Environmental Medicine : AAEM - June 29, 2022 Category: Environmental Health Authors: Klementyna K ępińska Magdalena Ja łowska Monika Bowszyc-Dmochowska Source Type: research
Frontal Fibrosing Alopecia - a review and a practical guide for clinicians
Ann Agric Environ Med. 2022 Jun 24;29(2):169-184. doi: 10.26444/aaem/141324. Epub 2021 Aug 31.ABSTRACTDespite a significant increase in reported cases of frontal fibrosing alopecia (FFA) in literature, discussion about the possible role of environmental factors, instruction for diagnosis and guideline for treatment, are limited. The review aims to provide a detailed synthesis of this condition that could be used by clinicians in their practise. Whether single-centre or multi-centre, studies of more than 60 cases less than 5 years old were mainly taken into consideration. Results obtained were that FFA affects mainly postme...
Source: Annals of Agricultural and Environmental Medicine : AAEM - June 29, 2022 Category: Environmental Health Authors: Klementyna K ępińska Magdalena Ja łowska Monika Bowszyc-Dmochowska Source Type: research
Frontal Fibrosing Alopecia - a review and a practical guide for clinicians
Ann Agric Environ Med. 2022 Jun 24;29(2):169-184. doi: 10.26444/aaem/141324. Epub 2021 Aug 31.ABSTRACTDespite a significant increase in reported cases of frontal fibrosing alopecia (FFA) in literature, discussion about the possible role of environmental factors, instruction for diagnosis and guideline for treatment, are limited. The review aims to provide a detailed synthesis of this condition that could be used by clinicians in their practise. Whether single-centre or multi-centre, studies of more than 60 cases less than 5 years old were mainly taken into consideration. Results obtained were that FFA affects mainly postme...
Source: Annals of Agricultural and Environmental Medicine : AAEM - June 29, 2022 Category: Environmental Health Authors: Klementyna K ępińska Magdalena Ja łowska Monika Bowszyc-Dmochowska Source Type: research
