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‘Jelly in the skull’: Ancient brains are preserved more often than you think
In 1982, construction workers uncovered dozens of 8000-year-old human skeletons in a pond on the edge of Titusville, Florida. Archaeologists excavating the waterlogged site—now known as Windover Archeological Site—were shocked to discover intact brain tissue inside 91 of the skulls, with some brains intact enough to identify contours and extract ancient DNA. University of Oxford forensic anthropologist Alexandra Morton-Hayward was also surprised when, as a Ph.D. student, she read about Windover as she set out to study the decomposition of what she assumed was the body’s most ephemeral organ. As a former underta...
Source: Science of Aging Knowledge Environment - March 20, 2024 Category: Geriatrics Source Type: research

Molecules, Vol. 29, Pages 1377: Unveiling the Chemical Composition, Bioactive Profile and Antioxidant Capacity of Dried Egyptian Jew & rsquo;s Mallow Stems as a Promising Anticancer Agent
Molecules, Vol. 29, Pages 1377: Unveiling the Chemical Composition, Bioactive Profile and Antioxidant Capacity of Dried Egyptian Jew’s Mallow Stems as a Promising Anticancer Agent Molecules doi: 10.3390/molecules29061377 Authors: Marwa Rashad Ali Huda Hassan Ibrahim Aziza Ali Salah-Eldin Phytochemicals from waste materials generated by agricultural and industrial processes have become globally significant due to their accessibility and potential effectiveness with few side effects. These compounds have essential implications in both medicine and the economy. Therefore, a quantitative analysis of the p...
Source: Molecules - March 20, 2024 Category: Chemistry Authors: Marwa Rashad Ali Huda Hassan Ibrahim Aziza Ali Salah-Eldin Tags: Article Source Type: research

An approach to understand the uranium ’s concentration variance on the eastern and western sides of the Nile Valley phosphorites, Egypt
AbstractThe Nile Valley is a main area for Egyptian phosphorites. The studied samples from the eastern and western sides of the Nile Valley showed similarities in their characteristics, suggesting one depositional basin, but they varied in their uranium content, with averages recorded at 91.7 and 44.83 ppm on the eastern and western sides, respectively. The evidence pointed out that initially the uranium was formed by adsorption onto the iron oxides and organic matter surfaces, then it was partially removed under the effect of groundwater, and the removal was deeper in the western phosphorites than the eastern ones. (Sourc...
Source: Journal of Radioanalytical and Nuclear Chemistry - March 20, 2024 Category: Nuclear Medicine Source Type: research

The role of point-of-care ultrasound in the assessment of schistosomiasis-induced liver fibrosis: A systematic scoping review
ConclusionsThe exclusive use of the image patterns in many studies despite lack of specific acquisition guidance, the increasing number of studies over time that conduct ultrasound staging of schistosomal PPF, and the advances in ultrasound technology used since 2000 all indicate a need to consider an update to the Niamey protocol. The protocol update should simplify and prioritise what is to be assessed, advise on who is to conduct the ultrasound examination, and procedures for improved standardisation and external reproducibility. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - March 20, 2024 Category: Tropical Medicine Authors: Eloise S. Ockenden Source Type: research

Molecules, Vol. 29, Pages 1360: Variation in the Composition and Quality of Nigella sativa L. Seed Oils & mdash;The Underestimated Impact on Possible Health-Promoting Properties
Molecules, Vol. 29, Pages 1360: Variation in the Composition and Quality of Nigella sativa L. Seed Oils—The Underestimated Impact on Possible Health-Promoting Properties Molecules doi: 10.3390/molecules29061360 Authors: Grzegorz Dąbrowski Sylwester Czaplicki Iwona Konopka Nigella sativa L. (black cumin) is one of the most investigated medicinal plants in recent years. Volatile compounds like thymoquinone and unsaponifiable lipid compounds are crucial functional components of this oil. Unfortunately, the composition of oils and their quality indicators are ambiguous both in terms of identified compoun...
Source: Molecules - March 19, 2024 Category: Chemistry Authors: Grzegorz D ąbrowski Sylwester Czaplicki Iwona Konopka Tags: Article Source Type: research

The effect of lacosamide on calcitonin gene-related peptide serum level in episodic migraine patients: a randomized, controlled trial
ConclusionThe daily use of lacosamide 50 mg Bid for three months in episodic migraine patients was associated with a significant reduction in serum CGRP-LI, better clinical outcomes regarding frequency and duration of migraine attacks, and was well tolerated by patients. These results were derived from an open-label pilot study that need ed to be thoroughly investigated by a large-scale, randomized, double-blinded, placebo-controlled study.Trial registration: We registered our trial on ClinicalTrials.gov, named after"The Lacosamide's Effect on Calcitonin Gene-related Peptide in Migraine Patients," and with a c...
Source: Acta Neurologica Belgica - March 19, 2024 Category: Neurology Source Type: research

IJERPH, Vol. 21, Pages 364: Bullying in the Arab World: Definition, Perception, and Implications for Public Health and Interventions
Hisham Morsi The present research aimed to examine bullying among diverse Arab nationalities residing in Qatar across two separate studies. Study 1 examined how Arabic-speaking adolescents and adults describe and perceive bullying, participants (N = 36) from different Arab nationalities (i.e., Egyptians, Qataris, Syrians, and other Arabs) were presented with three tasks in a focus group where they were asked questions about how they describe and perceive three scenarios without reference to the term &ldquo;bullying&rdquo;. Findings indicated that (1) the majority of participants referred to the intenti...
Source: International Journal of Environmental Research and Public Health - March 19, 2024 Category: Environmental Health Authors: Muthanna Samara Nura Alkathiri Mahitab Sherif Aiman El-Asam Sara Hammuda Peter K. Smith Hisham Morsi Tags: Article Source Type: research

CircMCTP2 enhances the progression of bladder cancer by regulating the miR-99a-5p/FZD8 axis
CONCLUSIONS: This novel signaling could regulate the biological behaviours of bladder cancer cells, and these findings highlighted circMCTP2 as a critical target for treating bladder cancer.PMID:38494582 | DOI:10.1186/s43046-024-00206-6 (Source: J Egypt Natl Canc In...)
Source: J Egypt Natl Canc In... - March 18, 2024 Category: Cancer & Oncology Authors: Yan Liu Kexin Zhang Xianxu Yang Source Type: research

Emergence of pandrug-resistant carbapenemase-producing Enterobacterales in dogs and cats: a cross-sectional study in Egypt
This study provides evidence of colonization with PDR CPE in dogs and cats. To manage the infection or colonization of pets in veterinary clinical settings, extended surveillance systems should be considered, and the use of critical antibiotics should be strictly controlled. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - March 18, 2024 Category: Microbiology Source Type: research

Effects of Pharmacogenetics on Pharmacokinetics and Toxicity of Doxorubicin in Egyptian Breast Cancer Patients
This study investigates the impact of single nucleotide polymorphisms in genes (SLC22A16 and CBR1) involved in the pharmacokinetics and toxicity of doxorubicin (DOX) in Egyptian female patients with breast cancer.2. Patients administered DOX (60 mg/m2) for 4 cycles every 3 weeks. The peak DOX plasma concentration was measured using a validated chromatographic method. The genotyping for the selected SNPs, SLC22A16 T > C (rs714368) and CBR1 C > T (rs20572), was performed by RT-PCR. Patients were monitored for hematological and cardiac toxicities.3. The variant carriers of CBR1 C > T (rs20572) exhibited significantly...
Source: Xenobiotica - March 16, 2024 Category: Research Authors: N F Ebaid K S Abdelkawy M A Shehata H F Salem G Magdy R R S Hussein F Elbarbry Source Type: research