Effects of Pharmacogenetics on Pharmacokinetics and Toxicity of Doxorubicin in Egyptian Breast Cancer Patients
This study investigates the impact of single nucleotide polymorphisms in genes (SLC22A16 and CBR1) involved in the pharmacokinetics and toxicity of doxorubicin (DOX) in Egyptian female patients with breast cancer.2. Patients administered DOX (60 mg/m2) for 4 cycles every 3 weeks. The peak DOX plasma concentration was measured using a validated chromatographic method. The genotyping for the selected SNPs, SLC22A16 T > C (rs714368) and CBR1 C > T (rs20572), was performed by RT-PCR. Patients were monitored for hematological and cardiac toxicities.3. The variant carriers of CBR1 C > T (rs20572) exhibited significantly...
Source: Xenobiotica - March 16, 2024 Category: Research Authors: N F Ebaid K S Abdelkawy M A Shehata H F Salem G Magdy R R S Hussein F Elbarbry Source Type: research
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) gene polymorphisms in a cohort of Egyptian patients with immune thrombocytopenia (ITP)
CONCLUSION: CTLA-4 CT 60 A/G may affect the susceptibility of ITP, but both CTLA-4 + 49 A/G and CT60 A/G did not impact the response of patients with ITP to different lines of therapy.PMID:38485815 | DOI:10.1007/s44313-024-00011-z (Source: Blood Research)
Source: Blood Research - March 15, 2024 Category: Hematology Authors: Doaa Mohamed El Demerdash Maha Mohamed Saber Alia Ayad Kareeman Gomaa Mohamed Abdelkader Morad Source Type: research
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) gene polymorphisms in a cohort of Egyptian patients with immune thrombocytopenia (ITP)
CONCLUSION: CTLA-4 CT 60 A/G may affect the susceptibility of ITP, but both CTLA-4 + 49 A/G and CT60 A/G did not impact the response of patients with ITP to different lines of therapy.PMID:38485815 | PMC:PMC10917709 | DOI:10.1007/s44313-024-00011-z (Source: Blood Research)
Source: Blood Research - March 15, 2024 Category: Hematology Authors: Doaa Mohamed El Demerdash Maha Mohamed Saber Alia Ayad Kareeman Gomaa Mohamed Abdelkader Morad Source Type: research
Dithiocarbamate functionalised crosslinked polyacrylamide for separation and pre-concentration of uranium (VI) ions from sulphate medium
. (Source: International Journal of Environmental Analytical Chemistry)
Source: International Journal of Environmental Analytical Chemistry - March 15, 2024 Category: Chemistry Authors: Ahmed M. MasoudMahmoud M. El-MaadawyMohamed H. TahaAhmed A. Younesa Department of chemistry, Nuclear Materials Authority, El-Maadi, Cairo, Egyptb Department of Chemistry, Faculty of Science, Helwan University, Cairo, Egypt Source Type: research
Production, characterization and biomedical potential of biosurfactants produced by haloalkaliphilic archaea from Wadi El-Natrun, Egypt
This study delves into the fascinating field of halophilic archaea an... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - March 14, 2024 Category: Microbiology Authors: Basma T. Alghamrawy, Ghada E. Hegazy, Soraya A. Sabry and Hanan Ghozlan Tags: Research Source Type: research
Gamma irradiation and ozone application as preservation methods for longer-term storage of bee pollen
Environ Sci Pollut Res Int. 2024 Mar 11. doi: 10.1007/s11356-024-32801-4. Online ahead of print.ABSTRACTBee pollen is a healthy product with a good nutritional profile and therapeutic properties. Its high moisture content, however, promotes the growth of bacteria, molds, and yeast during storage commonly result in product degradation. Therefore, the aim of this study is to assess the effectiveness of gamma irradiation (GI) and ozone (OZ) as bee pollen preservation methods for longer storage time, as well as whether they are influenced by pollen species. To do that, GI at a dosage of 2.5, 5.0, and 7.5 kGy was applied at a r...
Source: Environmental Science and Pollution Research International - March 11, 2024 Category: Environmental Health Authors: Yahya Al Naggar Ibrahim M Taha El-Kazafy A Taha Ayman Zaghlool Ali Nasr Ashraf Nagib Sam M Elhamamsy Gomaa Abolaban Alaa Fahmy Eslam Hegazy Khaled H Metwaly Abdullah A Zahra Source Type: research
Molecular perspectives on systemic priming and concomitant immunity in colorectal carcinoma
J Egypt Natl Canc Inst. 2024 Mar 11;36(1):7. doi: 10.1186/s43046-024-00211-9.ABSTRACTThe progression of metastasis, a complex systemic disease, is facilitated by interactions between tumor cells and their isolated microenvironments. Over the past few decades, researchers have investigated the metastatic spread of cancer extensively, identifying multiple stages in the process, such as intravasation, extravasation, tumor latency, and the development of micrometastasis and macrometastasis. The premetastatic niche is established in target organs by the accumulation of aberrant immune cells and extracellular matrix proteins. Th...
Source: J Egypt Natl Canc In... - March 11, 2024 Category: Cancer & Oncology Authors: Suman Kumar Ray Sukhes Mukherjee Source Type: research
Gamma irradiation and ozone application as preservation methods for longer-term storage of bee pollen
Environ Sci Pollut Res Int. 2024 Mar 11. doi: 10.1007/s11356-024-32801-4. Online ahead of print.ABSTRACTBee pollen is a healthy product with a good nutritional profile and therapeutic properties. Its high moisture content, however, promotes the growth of bacteria, molds, and yeast during storage commonly result in product degradation. Therefore, the aim of this study is to assess the effectiveness of gamma irradiation (GI) and ozone (OZ) as bee pollen preservation methods for longer storage time, as well as whether they are influenced by pollen species. To do that, GI at a dosage of 2.5, 5.0, and 7.5 kGy was applied at a r...
Source: Environmental Science and Pollution Research International - March 11, 2024 Category: Environmental Health Authors: Yahya Al Naggar Ibrahim M Taha El-Kazafy A Taha Ayman Zaghlool Ali Nasr Ashraf Nagib Sam M Elhamamsy Gomaa Abolaban Alaa Fahmy Eslam Hegazy Khaled H Metwaly Abdullah A Zahra Source Type: research
Molecular perspectives on systemic priming and concomitant immunity in colorectal carcinoma
J Egypt Natl Canc Inst. 2024 Mar 11;36(1):7. doi: 10.1186/s43046-024-00211-9.ABSTRACTThe progression of metastasis, a complex systemic disease, is facilitated by interactions between tumor cells and their isolated microenvironments. Over the past few decades, researchers have investigated the metastatic spread of cancer extensively, identifying multiple stages in the process, such as intravasation, extravasation, tumor latency, and the development of micrometastasis and macrometastasis. The premetastatic niche is established in target organs by the accumulation of aberrant immune cells and extracellular matrix proteins. Th...
Source: J Egypt Natl Canc In... - March 11, 2024 Category: Cancer & Oncology Authors: Suman Kumar Ray Sukhes Mukherjee Source Type: research
