The S1 spike protein of SARS-CoV-2 upregulates the ERK/MAPK signaling pathway in DC-SIGN-expressing THP-1 cells
In this study, we report that the S1 spike protein of SARS-CoV-2 induces the phosphorylation of ERKs in THP-1 cells, a DC-SIGN-expressing human monocytic leukemic cell line. On the other hand, the phosphorylation level of NF-κB remained unchanged under the same conditions. These data suggest that the major cell signaling pathway regulated by S1 spike protein is the ERK pathway, which is superior to the NF-κB pathway in these DC-SIGN-expressing THP-1 cells and may contribute to immune hyperactivation in SARS-CoV-2 infections. Additionally, several glycans such as mannans, mannosylated BSA, the serum amyloid beta protein, ...
Source: Cell Stress and Chaperones - March 7, 2024 Category: Cytology Authors: Emma Lee Johnson Yuki Ohkawa Noriko Kanto Reiko Fujinawa Taiki Kuribara Eiji Miyoshi Naoyuki Taniguchi Source Type: research
The S1 spike protein of SARS-CoV-2 upregulates the ERK/MAPK signaling pathway in DC-SIGN-expressing THP-1 cells
In this study, we report that the S1 spike protein of SARS-CoV-2 induces the phosphorylation of ERKs in THP-1 cells, a DC-SIGN-expressing human monocytic leukemic cell line. On the other hand, the phosphorylation level of NF-κB remained unchanged under the same conditions. These data suggest that the major cell signaling pathway regulated by S1 spike protein is the ERK pathway, which is superior to the NF-κB pathway in these DC-SIGN-expressing THP-1 cells and may contribute to immune hyperactivation in SARS-CoV-2 infections. Additionally, several glycans such as mannans, mannosylated BSA, the serum amyloid beta protein, ...
Source: Cell Stress and Chaperones - March 7, 2024 Category: Cytology Authors: Emma Lee Johnson Yuki Ohkawa Noriko Kanto Reiko Fujinawa Taiki Kuribara Eiji Miyoshi Naoyuki Taniguchi Source Type: research
The Current Pathogenicity and Potential Risk Evaluation of Marburg Virus to Cause Mysterious "Disease X"-An Update on Recent Evidences
Environ Health Insights. 2024 Mar 4;18:11786302241235809. doi: 10.1177/11786302241235809. eCollection 2024.ABSTRACTThe World Health Organization (WHO) defined Disease X as an upcoming disease with the potential to cause a pandemic. Pathogen X is responsible for Disease X. Marburg virus disease (MVD) is one of the diseases from the priority disease list published by WHO. Marburg virus is a filamentous, negative-sense RNA virus that belongs to the same filovirus family as the lethal Ebola virus. Since the first discovery of this virus in 1967, 17 outbreaks occurred sporadically till 2023. Rousettus aegyptiacus acts as the na...
Source: Environmental Health Insights - March 5, 2024 Category: Environmental Health Authors: Rahima Akter Mitu Md Rabiul Islam Source Type: research
The Current Pathogenicity and Potential Risk Evaluation of Marburg Virus to Cause Mysterious "Disease X"-An Update on Recent Evidences
Environ Health Insights. 2024 Mar 4;18:11786302241235809. doi: 10.1177/11786302241235809. eCollection 2024.ABSTRACTThe World Health Organization (WHO) defined Disease X as an upcoming disease with the potential to cause a pandemic. Pathogen X is responsible for Disease X. Marburg virus disease (MVD) is one of the diseases from the priority disease list published by WHO. Marburg virus is a filamentous, negative-sense RNA virus that belongs to the same filovirus family as the lethal Ebola virus. Since the first discovery of this virus in 1967, 17 outbreaks occurred sporadically till 2023. Rousettus aegyptiacus acts as the na...
Source: Environmental Health Insights - March 5, 2024 Category: Environmental Health Authors: Rahima Akter Mitu Md Rabiul Islam Source Type: research
18 The role of social science and transdisciplinarity in disease outbreaks in Africa over the last decade
ConclusionThis research offers insights into the importance of strengthening transdisciplinary collaboration, communication, data integration, and policy to enhance preparedness and response for future pandemics by learning from experiences over the last decade. (Source: BMJ Open)
Source: BMJ Open - March 3, 2024 Category: General Medicine Authors: Grant, C. Tags: Open access Source Type: research
Correction: Impact of Ebola and COVID ‑19 on maternal, neonatal, and child health care among populations affected by conflicts: a scoping review exploring demand and supply‑side barriers and solutions
(Source: Conflict and Health)
Source: Conflict and Health - March 1, 2024 Category: International Medicine & Public Health Authors: Yasir Shafiq, Elena Rubini, Zoha Zahid Fazal, Muhammad Murtaza Bukhari, Maheen Zakaria, Noor ul Huda Zeeshan, Ameer Muhammad, Luca Ragazzoni, Francesco Barone ‑Adesi and Martina Valente Tags: Correction Source Type: research
IJERPH, Vol. 21, Pages 286: Towards Resilient Healthcare Systems: A Framework for Crisis Management
This study addresses the crucial need for resilient healthcare systems, highlighted by recent global health emergencies such as the Ebola and COVID-19 crises. It identifies a significant gap in the current literature: a lack of practical, actionable frameworks for healthcare resilience. To bridge this gap, the research introduces an innovative framework that blends theoretical resilience concepts with heuristic approaches. This framework, rooted in the principles of monitoring, anticipation, recognition, and learning, is designed to enhance the crisis management capabilities of healthcare systems. The methodology involves ...
Source: International Journal of Environmental Research and Public Health - February 29, 2024 Category: Environmental Health Authors: Seyedeh Gelareh Emami Valentina Lorenzoni Giuseppe Turchetti Tags: Article Source Type: research
Ebola virus VP35 interacts non-covalently with ubiquitin chains to promote viral replication
In conclusion, we identified a novel role of unanchored polyUb in regulating Ebola virus polymerase function and discovered compounds that have promising anti-Ebola virus activity. (Source: PLoS Biology: Archived Table of Contents)
Source: PLoS Biology: Archived Table of Contents - February 29, 2024 Category: Biology Authors: Carlos A. Rodr íguez-Salazar Source Type: research
Effects of Shock and Vibration on Product Quality during Last-Mile Transportation of Ebola Vaccine under Refrigerated Conditions
L. Bus-Jacobs et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - February 28, 2024 Category: Infectious Diseases Source Type: research
Role of phosphatidic acid lipids on plasma membrane association of the Ebola virus matrix protein VP40
Biochim Biophys Acta Mol Cell Biol Lipids. 2024 Feb 13:159464. doi: 10.1016/j.bbalip.2024.159464. Online ahead of print.ABSTRACTThe Ebola virus matrix protein VP40 is responsible for the formation of the viral matrix by localizing at the inner leaflet of the human plasma membrane (PM). Various lipid types, including PI(4,5)P2 (i.e. PIP2) and phosphatidylserine (PS), play active roles in this process. Specifically, the negatively charged headgroups of both PIP2 and PS interact with the basic residues of VP40 and stabilize it at the membrane surface, allowing for eventual egress. Phosphatidic acid (PA), resulting from the en...
Source: Biochimica et Biophysica Acta - February 15, 2024 Category: Biochemistry Authors: Michael D Cioffi Monica L Husby Bernard S Gerstman Robert V Stahelin Prem P Chapagain Source Type: research
Role of phosphatidic acid lipids on plasma membrane association of the Ebola virus matrix protein VP40
Biochim Biophys Acta Mol Cell Biol Lipids. 2024 Feb 13:159464. doi: 10.1016/j.bbalip.2024.159464. Online ahead of print.ABSTRACTThe Ebola virus matrix protein VP40 is responsible for the formation of the viral matrix by localizing at the inner leaflet of the human plasma membrane (PM). Various lipid types, including PI(4,5)P2 (i.e. PIP2) and phosphatidylserine (PS), play active roles in this process. Specifically, the negatively charged headgroups of both PIP2 and PS interact with the basic residues of VP40 and stabilize it at the membrane surface, allowing for eventual egress. Phosphatidic acid (PA), resulting from the en...
Source: Mol Biol Cell - February 15, 2024 Category: Molecular Biology Authors: Michael D Cioffi Monica L Husby Bernard S Gerstman Robert V Stahelin Prem P Chapagain Source Type: research
Role of phosphatidic acid lipids on plasma membrane association of the Ebola virus matrix protein VP40
Biochim Biophys Acta Mol Cell Biol Lipids. 2024 Feb 13:159464. doi: 10.1016/j.bbalip.2024.159464. Online ahead of print.ABSTRACTThe Ebola virus matrix protein VP40 is responsible for the formation of the viral matrix by localizing at the inner leaflet of the human plasma membrane (PM). Various lipid types, including PI(4,5)P2 (i.e. PIP2) and phosphatidylserine (PS), play active roles in this process. Specifically, the negatively charged headgroups of both PIP2 and PS interact with the basic residues of VP40 and stabilize it at the membrane surface, allowing for eventual egress. Phosphatidic acid (PA), resulting from the en...
Source: Biochimica et Biophysica Acta - February 15, 2024 Category: Biochemistry Authors: Michael D Cioffi Monica L Husby Bernard S Gerstman Robert V Stahelin Prem P Chapagain Source Type: research
Role of phosphatidic acid lipids on plasma membrane association of the Ebola virus matrix protein VP40
Biochim Biophys Acta Mol Cell Biol Lipids. 2024 Feb 13:159464. doi: 10.1016/j.bbalip.2024.159464. Online ahead of print.ABSTRACTThe Ebola virus matrix protein VP40 is responsible for the formation of the viral matrix by localizing at the inner leaflet of the human plasma membrane (PM). Various lipid types, including PI(4,5)P2 (i.e. PIP2) and phosphatidylserine (PS), play active roles in this process. Specifically, the negatively charged headgroups of both PIP2 and PS interact with the basic residues of VP40 and stabilize it at the membrane surface, allowing for eventual egress. Phosphatidic acid (PA), resulting from the en...
Source: Mol Biol Cell - February 15, 2024 Category: Molecular Biology Authors: Michael D Cioffi Monica L Husby Bernard S Gerstman Robert V Stahelin Prem P Chapagain Source Type: research
Viruses, Vol. 16, Pages 279: Bivalent VSV Vectors Mediate Rapid and Potent Protection from Andes Virus Challenge in Hamsters
nz Feldmann
Orthohantaviruses may cause hemorrhagic fever with renal syndrome or hantavirus cardiopulmonary syndrome. Andes virus (ANDV) is the only orthohantavirus associated with human–human transmission. Therefore, emergency vaccination would be a valuable public health measure to combat ANDV-derived infection clusters. Here, we utilized a promising vesicular stomatitis virus (VSV)-based vaccine to advance the approach for emergency applications. We compared monovalent and bivalent VSV vectors containing the Ebola virus (EBOV), glycoprotein (GP), and ANDV glycoprotein precursor (GPC) for protective eff...
Source: Viruses - February 11, 2024 Category: Virology Authors: Joshua Marceau David Safronetz Cynthia Martellaro Andrea Marzi Kyle Rosenke Heinz Feldmann Tags: Article Source Type: research
The economic burden of Ebola virus disease: a review and recommendations for analysis
CONCLUSIONS: The severe impact of EVD puts pressure on governments and the international community for better resource utilization and re-allocation. Several technical and methodological issues related to economic evaluation of EVD remain to be addressed, especially for LMICs. We recommend conducting cost-of-sequelae and cost-of-distribution analyses in addition to adapting existing economic analytical methods to EVD. Characteristics of the affected regions should be considered to provide evidence-based economic plans and economic-evaluation of mitigations that enhance resource allocation for prevention and treatment.PMID:...
Source: Journal of Medical Economics - February 1, 2024 Category: Health Management Authors: Mavis Obeng-Kusi Jennifer Martin Ivo Abraham Source Type: research
