Utilizing targeted integration CHO pools to potentially accelerate the GMP manufacturing of monoclonal and bispecific antibodies
AbstractMonoclonal antibodies (mAbs) are effective therapeutic agents against many acute infectious diseases including COVID-19, Ebola, RSV,Clostridium difficile, and Anthrax. mAbs can therefore help combat a future pandemic. Unfortunately, mAb development typically takes years, limiting its potential to save lives during a pandemic. Therefore “pandemic mAb” timelines need to be shortened. One acceleration tool is “deferred cloning” and leverages new Chinese hamster ovary (CHO) technology based on targeted gene integration (TI). CHO pools, instead of CHO clones, can be used for Phase I/II clinical material producti...
Source: Biotechnology Progress - October 25, 2023 Category: Biotechnology Authors: Gavin C. Barnard,
Michelle Zhou,
Amy Shen,
Inn H. Yuk,
Michael W. Laird Tags: RESEARCH ARTICLE Source Type: research
Antiviral Effects of Micafungin against Pteropine Orthoreovirus, an Emerging Zoonotic Virus Carried by Bats
Virus Res. 2023 Oct 17:199248. doi: 10.1016/j.virusres.2023.199248. Online ahead of print.ABSTRACTBat-borne emerging zoonotic viruses cause major outbreaks, such as the Ebola virus, Nipah virus, and/or beta coronavirus. Pteropine orthoreovirus (PRV), whose spillover event occurred from fruits bats to humans, causes respiratory syndrome in humans widely in South East Asia. Repurposing approved drugs against PRV is an effective tool to confront future PRV pandemics. We screened 2,943 compounds in an FDA-approved drug library and identified eight hit compounds that reduce viral cytopathic effects on cultured Vero cells. Real-...
Source: Virus Research - October 20, 2023 Category: Virology Authors: Eiichi Hondo Tetsufumi Katta Ayato Sato Naoya Kadofusa Tomoki Ishibashi Hiroshi Shimoda Atsuo Iida Source Type: research
Antiviral Effects of Micafungin against Pteropine Orthoreovirus, an Emerging Zoonotic Virus Carried by Bats
Virus Res. 2023 Oct 17:199248. doi: 10.1016/j.virusres.2023.199248. Online ahead of print.ABSTRACTBat-borne emerging zoonotic viruses cause major outbreaks, such as the Ebola virus, Nipah virus, and/or beta coronavirus. Pteropine orthoreovirus (PRV), whose spillover event occurred from fruits bats to humans, causes respiratory syndrome in humans widely in South East Asia. Repurposing approved drugs against PRV is an effective tool to confront future PRV pandemics. We screened 2,943 compounds in an FDA-approved drug library and identified eight hit compounds that reduce viral cytopathic effects on cultured Vero cells. Real-...
Source: Virus Research - October 20, 2023 Category: Virology Authors: Eiichi Hondo Tetsufumi Katta Ayato Sato Naoya Kadofusa Tomoki Ishibashi Hiroshi Shimoda Atsuo Iida Source Type: research
Cost-effectiveness of incorporating Ebola prediction score tools and rapid diagnostic tests into a screening algorithm: A decision analytic model
ConclusionsFindings from this study showed that prediction scores and RDT could improve Ebola screening. The use of the ECPS as a conditional test algorithm and the dual ECPS as a conditional test and then the QuickNavi ™-Ebola RDT algorithm are the best screening choices because they are more efficient and lower the number of confirmation tests and overall care costs during an EBOV epidemic. (Source: PLoS One)
Source: PLoS One - October 17, 2023 Category: Biomedical Science Authors: Antoine Oloma Tshomba Source Type: research
Post-epidemic health system recovery: A comparative case study analysis of routine immunization programs in the Republics of Haiti and Liberia
This study suggests that embedding in-country expertise within outbreak response structures, respecting governmental autonomy, aligning post-epidemic recovery plans and policies, and integrating outbreak response assets into robust systems of primary care contribute to higher, more equitable levels of routine immunization coverage in resource-constrained settings recovering from epidemics. (Source: PLoS One)
Source: PLoS One - October 17, 2023 Category: Biomedical Science Authors: Sanjana J. Ravi Source Type: research
Viruses, Vol. 15, Pages 2077: Effect of Interferon Gamma on Ebola Virus Infection of Primary Kupffer Cells and a Kupffer Cell Line
ndy J. Maury
Ebola virus disease (EVD) represents a global health threat. The etiological agents of EVD are six species of Orthoebolaviruses, with Orthoebolavirus zairense (EBOV) having the greatest public health and medical significance. EVD pathogenesis occurs as a result of broad cellular tropism of the virus, robust viral replication and a potent and dysregulated production of cytokines. In vivo, tissue macrophages are some of the earliest cells infected and contribute significantly to virus load and cytokine production. While EBOV is known to infect macrophages and to generate high titer virus in the liver, EBOV i...
Source: Viruses - October 11, 2023 Category: Virology Authors: Jos é A. Aguilar-Briseño Jonah M. Elliff Justin J. Patten Lindsay R. Wilson Robert A. Davey Adam L. Bailey Wendy J. Maury Tags: Article Source Type: research
A decentralized public-permissioned blockchain framework for enhanced security of health records in fog computing
Comput Methods Biomech Biomed Engin. 2023 Oct 9:1-13. doi: 10.1080/10255842.2023.2262664. Online ahead of print.ABSTRACTMedical health records comprise sensitive patient data for precise diagnosis and successive treatment. However, it must be stored and shared securely to protect data privacy. Generally, health records are kept on centralized servers, which raise the risk of security breaches and involve trust in a single authority that cannot efficiently defend data from internal attacks. Blockchain (BC) is extensively used in medical health records management because of its decentralized and tamper-proof properties. This...
Source: Computer Methods in Biomechanics and Biomedical Engineering - October 9, 2023 Category: Biomedical Engineering Authors: Ramaiah Challa Kiran Kumar Kothamasu Source Type: research
Communication to promote and support physical distancing for COVID-19 prevention and control
CONCLUSIONS: Implications for practice Evidence highlights the critical role of communication throughout a public health emergency. Like any intervention, communication can be done well or poorly, but the consequences of poor communication during a pandemic may mean the difference between life and death. The approaches to effective communication identified in this review can be used by policymakers and decision-makers, working closely with communication teams, to plan, implement and adjust public communications over the course of a public health emergency like the COVID-19 pandemic. Implications for research Despite massiv...
Source: Cochrane Database of Systematic Reviews - October 9, 2023 Category: General Medicine Authors: Rebecca E Ryan Charlotte Silke Anne Parkhill Ariane Virgona Bronwen Merner Shauna Hurley Louisa Walsh Caroline de Moel-Mandel Lina Schonfeld Adrian Gk Edwards Jessica Kaufman Alison Cooper Rachel Kar Yee Chung Karla Solo Margaret Hellard Gian Luca Di Tann Source Type: research
A decentralized public-permissioned blockchain framework for enhanced security of health records in fog computing
Comput Methods Biomech Biomed Engin. 2023 Oct 9:1-13. doi: 10.1080/10255842.2023.2262664. Online ahead of print.ABSTRACTMedical health records comprise sensitive patient data for precise diagnosis and successive treatment. However, it must be stored and shared securely to protect data privacy. Generally, health records are kept on centralized servers, which raise the risk of security breaches and involve trust in a single authority that cannot efficiently defend data from internal attacks. Blockchain (BC) is extensively used in medical health records management because of its decentralized and tamper-proof properties. This...
Source: Computer Methods in Biomechanics and Biomedical Engineering - October 9, 2023 Category: Biomedical Engineering Authors: Ramaiah Challa Kiran Kumar Kothamasu Source Type: research
Communication to promote and support physical distancing for COVID-19 prevention and control
CONCLUSIONS: Implications for practice Evidence highlights the critical role of communication throughout a public health emergency. Like any intervention, communication can be done well or poorly, but the consequences of poor communication during a pandemic may mean the difference between life and death. The approaches to effective communication identified in this review can be used by policymakers and decision-makers, working closely with communication teams, to plan, implement and adjust public communications over the course of a public health emergency like the COVID-19 pandemic. Implications for research Despite massiv...
Source: Cochrane Database of Systematic Reviews - October 9, 2023 Category: General Medicine Authors: Rebecca E Ryan Charlotte Silke Anne Parkhill Ariane Virgona Bronwen Merner Shauna Hurley Louisa Walsh Caroline de Moel-Mandel Lina Schonfeld Adrian Gk Edwards Jessica Kaufman Alison Cooper Rachel Kar Yee Chung Karla Solo Margaret Hellard Gian Luca Di Tann Source Type: research
A decentralized public-permissioned blockchain framework for enhanced security of health records in fog computing
Comput Methods Biomech Biomed Engin. 2023 Oct 9:1-13. doi: 10.1080/10255842.2023.2262664. Online ahead of print.ABSTRACTMedical health records comprise sensitive patient data for precise diagnosis and successive treatment. However, it must be stored and shared securely to protect data privacy. Generally, health records are kept on centralized servers, which raise the risk of security breaches and involve trust in a single authority that cannot efficiently defend data from internal attacks. Blockchain (BC) is extensively used in medical health records management because of its decentralized and tamper-proof properties. This...
Source: Computer Methods in Biomechanics and Biomedical Engineering - October 9, 2023 Category: Biomedical Engineering Authors: Ramaiah Challa Kiran Kumar Kothamasu Source Type: research
Continuity and Rupture in Crisis: from Ebola to COVID-19 in Sierra Leone and the eastern Democratic Republic of the Congo
Volume 18, Issue 1, January 2023 . (Source: Global Public Health)
Source: Global Public Health - October 3, 2023 Category: International Medicine & Public Health Authors: Myfanwy JamesAnthony MansarayFrederic Omega ThigeMabel MafindaKennedy Kambale KasoniaJoel Kahehero PalukuAlie D. TimboLina KarenziFerdinand NtabalaDaniel TindanbilBailah LeighHugo Kavunga-MemboDeborah Watson-JonesKatherine GallagherLuisa Enriaa London Sch Source Type: research
Adaptation of an rVSV Ebola vaccine purification process for rapid development of a viral vaccine candidate for SARS-CoV-2
This article is protected by copyright. All rights reserved.PMID:37766672 | DOI:10.1002/biot.202300041 (Source: Biotechnology Journal)
Source: Biotechnology Journal - September 28, 2023 Category: Biotechnology Authors: Laura E Kuczynski James R Shallow Matthew P Watson Michael L Homsy Thomas Svab Ashley Gruber Richard R Rustandi Jianfang Hu Michael A Winters Source Type: research
Anthony Fauci on becoming the ‘devil’ and a warning for his successor
Last Wednesday afternoon, Anthony Fauci, one of the world’s most famous scientists, answered the door of his Washington, D.C., house in jeans and a T-shirt, apologizing for the boxes in his living room. Although he retired in December 2022 from directing the National Institute of Allergy and Infectious Diseases (NIAID), he has just recently finished deciding what should go to archives at the National Institutes of Health (NIH) and what to keep from the abundant memorabilia he had collected from his
38 years in that job
.
An immunologist by training, Fauci spent much of his career overseeing the world’s ...
Source: Science of Aging Knowledge Environment - September 25, 2023 Category: Geriatrics Source Type: research
