Wisconsin bill to restrict pathogen studies worries scientists
A hearing this week in Wisconsin on a proposal to bar research that may make human pathogens more dangerous has scientists worried that such state bans would hamper a broad range of microbiology studies. Bills like Wisconsin’s could also conflict with or exceed new federal restrictions on so-called gain-of-function (GOF) research, due out any moment.
The Wisconsin bill is still early in the legislative process, and its prospects are uncertain. But the hearing gave a platform to a small, vocal group of scientists who want to forbid certain GOF studies. Several hold the controversial view that such research is to bla...
Source: Science of Aging Knowledge Environment - January 12, 2024 Category: Geriatrics Source Type: research
GSE232633 Identification of early gene expression profiles governing long-lasting antibody responses to the Ebola vaccine Ad26.ZEBOV/MVA-BN-Filo
In this study, we comprehensively investigated transcriptome profiles at 0, 3 hours, 1 and 7 days after vaccination with Ad26.ZEBOV and MVA-BN-Filo. Three hours after Ad26.ZEBOV injection, we observed an increase in gene abundance related to antigen presentation, sensing, and T- and B-cell receptors. The highest response occurred one day after Ad26.ZEBOV injection, with an increase in the expression of genes for interferon-induced antiviral molecules, monocyte activation, and sensing receptors. This response was mainly shaped by the HESX1, ATF3, ANKRD22, and ETV7 transcription factors. A plasma-cell signature was observed ...
Source: GEO: Gene Expression Omnibus - January 11, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Patient level barriers to accessing TB care services during the COVID-19 pandemic in Uganda, a mixed methods study
Lockdown measure has been utilized widely to mitigate COVID-19 pandemic transmission and recently during the 2022 Sudan Ebola Virus Disease outbreak in Uganda. These have setback effects on the continuity of e... (Source: BMC Health Services Research)
Source: BMC Health Services Research - January 10, 2024 Category: General Medicine Authors: Mudarshiru Bbuye, Stella Zawedde Muyanja, Isaac Sekitoleko, Roma Padalkar, Nicole Robertson, Madeline Helwig, Dennis Hopkinson, Trishul Siddharthan and Peter Jackson Tags: Research Source Type: research
Investing in Africa ’s scientific future | Science
Africa bears a disproportionate burden of infectious diseases, accounting for a substantial percentage of global cases. Malaria, HIV/AIDS, tuberculosis, cholera, Ebola, Lassa fever, and other tropical diseases, such as dengue and chikungunya, have had a ... (Source: Science: Current Issue)
Source: Science: Current Issue - January 4, 2024 Category: Science Source Type: research
Refined innate plasma signature after rVSV ΔG-ZEBOV-GP immunization is shared among adult cohorts in Europe and North America
ConclusionEleven additional biomarkers refined the previously found 5-biomarker Geneva signature. The refined signature better discriminated between different doses, was strongly associated with the risk of adverse events and with antibody responses and was validated in a separate cohort. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - January 3, 2024 Category: Allergy & Immunology Source Type: research
Longitudinal assessment of an Ebola vaccine trial understanding among healthcare providers in the Democratic Republic of the Congo
CONCLUSION: We observed a significant decline in the informational knowledge of informed consent, specifically in terms of basic knowledge on the study vaccine and trial procedures. As participant safety and understanding is a paramount ethical concern for researchers, it is crucial for participants to fully comprehend the study's objectives and potential risks. Therefore, our findings suggest the need for clinical researchers to re-explain participants to optimize the protection of their rights and wellbeing during the research.PMID:38163747 | DOI:10.1016/j.vaccine.2023.12.076 (Source: Vaccine)
Source: Vaccine - January 1, 2024 Category: Allergy & Immunology Authors: Tr ésor Zola Matuvanga Ynke Larivi ère Gwen Lemey Bernard Isekah Osang'ir Joachim Mari ën Solange Milolo Rachel Meta Junior Matangila Vivi Maketa Patrick Mitashi Jean-Pierre Van Geertruyden Hypolite Muhindo-Mavoko Pierre Van Damme Source Type: research
Longitudinal assessment of an Ebola vaccine trial understanding among healthcare providers in the Democratic Republic of the Congo
CONCLUSION: We observed a significant decline in the informational knowledge of informed consent, specifically in terms of basic knowledge on the study vaccine and trial procedures. As participant safety and understanding is a paramount ethical concern for researchers, it is crucial for participants to fully comprehend the study's objectives and potential risks. Therefore, our findings suggest the need for clinical researchers to re-explain participants to optimize the protection of their rights and wellbeing during the research.PMID:38163747 | DOI:10.1016/j.vaccine.2023.12.076 (Source: Vaccine)
Source: Vaccine - January 1, 2024 Category: Allergy & Immunology Authors: Tr ésor Zola Matuvanga Ynke Larivi ère Gwen Lemey Bernard Isekah Osang'ir Joachim Mari ën Solange Milolo Rachel Meta Junior Matangila Vivi Maketa Patrick Mitashi Jean-Pierre Van Geertruyden Hypolite Muhindo-Mavoko Pierre Van Damme Source Type: research
GSE83565 mRNA and miRNA profiling of patients infected with Ebola virus compared with healthy adult
Series Type : Expression profiling by high throughput sequencing ; Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - December 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
GSE83564 miRNA profiling in the blood of patitents infected with Ebola virus
Contributors : Hui Wang ; Tao LiSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensEbola virus can cause a severe and often fatal hemorrhagic fever in humans and other mammals, known as Ebola virus disease (EVD),the mechanism of how this pathogenesis comes about is not well understood, It is assumed that miRNA may have important roles in virus infection response. To better understand the function of miRNA in EBOV infection disease, we undertook a miRNA profiling analysis using the whole blood of EBOV infection patients. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - December 31, 2023 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
GSE83563 mRNA profiling of patients infected with Ebola virus compared with healthy adult
Contributors : Hui Wang ; Tao LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEbola virus can cause a severe and often fatal hemorrhagic fever in humans and other mammals, known as Ebola virus disease (EVD),the mechanism of how this pathogenesis comes about is not well understood, but it is well accepted that pathogenesis is significantly driven by a hyperactive immune response. To better understand the overall response to Ebola virus challenge, we undertook a transcriptomic analysis using the whole blood of EBOV infection patients. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - December 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Markers of antroponotic viral infections in vervet monkeys arrived from their natural habitat (Tanzania)
CONCLUSION: When importing monkeys from different regions of the world, an expanded screening for viral infections is needed considering the epidemiological situation both in the country of importation and in the country of destination.PMID:38156576 | DOI:10.36233/0507-4088-188 (Source: Herpes)
Source: Herpes - December 29, 2023 Category: Infectious Diseases Authors: D I Dogadov K K Kyuregyan G M Alexandra A A Minosyan A A Kochkonyan A A Karlsen O I Vyshemirsky D D Karal-Ogly M I Mikhailov Source Type: research
Markers of antroponotic viral infections in vervet monkeys arrived from their natural habitat (Tanzania)
CONCLUSION: When importing monkeys from different regions of the world, an expanded screening for viral infections is needed considering the epidemiological situation both in the country of importation and in the country of destination.PMID:38156576 | DOI:10.36233/0507-4088-188 (Source: Herpes)
Source: Herpes - December 29, 2023 Category: Infectious Diseases Authors: D I Dogadov K K Kyuregyan G M Alexandra A A Minosyan A A Kochkonyan A A Karlsen O I Vyshemirsky D D Karal-Ogly M I Mikhailov Source Type: research
Markers of antroponotic viral infections in vervet monkeys arrived from their natural habitat (Tanzania)
CONCLUSION: When importing monkeys from different regions of the world, an expanded screening for viral infections is needed considering the epidemiological situation both in the country of importation and in the country of destination.PMID:38156576 | DOI:10.36233/0507-4088-188 (Source: Herpes)
Source: Herpes - December 29, 2023 Category: Infectious Diseases Authors: D I Dogadov K K Kyuregyan G M Alexandra A A Minosyan A A Kochkonyan A A Karlsen O I Vyshemirsky D D Karal-Ogly M I Mikhailov Source Type: research
Markers of antroponotic viral infections in vervet monkeys arrived from their natural habitat (Tanzania)
CONCLUSION: When importing monkeys from different regions of the world, an expanded screening for viral infections is needed considering the epidemiological situation both in the country of importation and in the country of destination.PMID:38156576 | DOI:10.36233/0507-4088-188 (Source: Herpes)
Source: Herpes - December 29, 2023 Category: Infectious Diseases Authors: D I Dogadov K K Kyuregyan G M Alexandra A A Minosyan A A Kochkonyan A A Karlsen O I Vyshemirsky D D Karal-Ogly M I Mikhailov Source Type: research
GSE242207 Global blood miRNA profiling unravels early signatures of immunogenicity of Ebola vaccine rVSV ΔG-ZEBOV-GP
Contributors : Eleonora Vianello ; Josefine Persson ; Bj örn Andersson ; Suzanne van Veen ; Thomaz Lüscher Dias ; Francesco Santoro ; Malin Östensson ; Ogonna Obudulu ; Christopher Agbajogu ; Sara Torkzadeh ; Helder Nakaya ; Donata Medaglini ; Claire-Anne Siegrist ; Tom M Ottenhoff ; Ali M HarandiSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensWe characterized the extracellular miRNAs, isolated from serum-derived extracellular vesicles (EV), induced by vaccination against Ebola.We identified early miRNA signatures associated with the ZEBOV-specific IgG antibody res...
Source: GEO: Gene Expression Omnibus - December 18, 2023 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
