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Efficacy of Sevoflurane and Propofol Anesthesia on Perioperative Adverse Cardiovascular Events and Hemodynamics in Elderly Patients With Diabetes
This study was undertaken to compare the effects of sevoflurane and propofol anesthesia on perioperative hemodynamics and perioperative adverse cardiovascular events (PACE) in elderly patients with diabetes undergoing general anesthesia for noncardiac surgery.METHODS: According to the random number table (n = 40), 80 patients with diabetes undergoing noncardiac general anesthesia were divided into a control group and an observation group. In the control group, the patients were given propofol 4 to 6 mg/(kg·h), continuously pumped to maintain anesthesia. In the observation group, the patients were given maintained concentr...
Source: Clinical Therapeutics - February 13, 2024 Category: Drugs & Pharmacology Authors: Liling Jia Hongfeng Li Tuping Li Source Type: research

Propofol anesthesia improves stroke outcomes over isoflurane anesthesia —a longitudinal multiparametric MRI study in a rodent model of transient middle cerebral artery occlusion
General anesthesia is routinely used in endovascular thrombectomy procedures, for which volatile gas and/or intravenous propofol are recommended. Emerging evidence suggests propofol may have superior effects on disability and/or mortality rates, but a mode-of-action underlying these class-specific effects remains unknown. Here, a moderate isoflurane or propofol dosage on experimental stroke outcomes was retrospectively compared using serial multiparametric MRI and behavioral testing. Adult male rats (N = 26) were subjected to 90-min filament-induced transient middle cerebral artery occlusion. Diffusion-, T2- and perfus...
Source: Frontiers in Neurology - February 13, 2024 Category: Neurology Source Type: research

Comparison of remimazolam-based and propofol-based total intravenous anesthesia on hemodynamics during anesthesia induction in patients undergoing transcatheter aortic valve replacement: a randomized controlled trial
ConclusionRemimazolam-based total intravenous anesthesia resulted in a lower hypotension rate than propofol-based total intravenous anesthesia during induction in patients undergoing TAVR. Remimazolam-based total intravenous anesthesia can be used safely during anesthetic induction in patients with severe aortic stenosis. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - February 12, 2024 Category: Anesthesiology Source Type: research

General purpose propofol target-controlled infusion using the marsh model with adjusted weight input
We report a simple method for adjusting the weight input of the Marsh target-controlled infusion (TCI) model such that the resulting infusion regime closely mimics the behaviour of the Eleveld model, thereby making the Marsh model more precise for patients at the extremes of age and body mass index. To assess the performance of our method, we simulated 2768 subjects with diverse combinations of age, weight, height and sex undergoing a hypothetical four-hour propofol TCI using both the Marsh model with our weight adjustment and the Eleveld model. The weight adjusted Marsh model produced infusion regimes and corresponding ef...
Source: Journal of Anesthesia - February 11, 2024 Category: Anesthesiology Source Type: research

Propofol Modulates Gallbladder Cancer Progression via miR-4430/SLC19A3 Axis
CONCLUSION: Propofol changed the cell behaviors of GBC by modulating the miR-4430/SLC19A3 axis.PMID:38330587 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - February 8, 2024 Category: Complementary Medicine Authors: Hui Zhang Bei Zhang Source Type: research

Postanesthesia Care Unit and Anesthetic Management Outcomes Among Patients Undergoing Noncardiac Surgery: Differences by Race and Ethnicity
CONCLUSIONS: The rate of appropriate number of PONV prophylactic medications as well as the incidence of PONV were similar in patients from racial and ethnic minority populations compared to non-Hispanic White patients. However, there was a lower use of PROP in racial and ethnic minority patients. It is important to have a health equity lens to identify differences in management that may contribute to disparities within each phase of perioperative care.PMID:38323973 | DOI:10.1016/j.jopan.2023.11.011 (Source: Journal of Perianesthesia Nursing)
Source: Journal of Perianesthesia Nursing - February 7, 2024 Category: Nursing Authors: Steven B Porter Yvette Martin-McGrew Catherine Njathi-Ori Danette L Bruns Allison M LeMahieu Carlos B Mantilla Adam J Milam Beth L Ladlie Source Type: research

Electroconvulsive therapy (ECT) with ketamine induction for catatonia in an HIV positive patient
Conclusion and contributions: This case report suggests that ketamine may be a viable induction agent for ECT in this clinical setting. (Source: South African Journal of Psychiatry)
Source: South African Journal of Psychiatry - February 7, 2024 Category: Psychiatry Authors: Yvette Nel, Craig A. Bracken Source Type: research

Comparing the Analgesic Effects Between the Pre- and Post-costal Cartilage Harvest Cohorts Using Ultrasound-Guided Deep Serratus Anterior Plane Block in Children with Microtia Undergoing Auricular Reconstruction: A Randomized Clinical Trial
ConclusionThe analgesic effect of the SAPB-pre-cohort was better than the SAPB-post-cohort suggesting both efficacy and feasibility of preemptive analgesia.Level of Evidence IIThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authorswww.springer.com/00266. (Source: Aesthetic Plastic Surgery)
Source: Aesthetic Plastic Surgery - February 7, 2024 Category: Cosmetic Surgery Source Type: research

Comparison of remimazolam and propofol combined with low dose esketamine for pediatric same-day painless bidirectional endoscopy: a randomized, controlled clinical trial
Conclusion: Remimazolam combined with low dose esketamine has a non-inferior sedative effect than propofol for pediatric BDE, with no injection pain, less respiratory depression, more stable hemodynamics. Moreover, early detection of the decline in PI may avoid harmful stimulation under light anesthesia.Clinical trial registration:https://www.clinicaltrials.gov/study/NCT05686863?id=NCT05686863&rank=1, NCT05686863 (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - February 5, 2024 Category: Drugs & Pharmacology Source Type: research