A Rotational Study of 2-tert-Butylphenol and Its 1:1 Argon Complex
Chemphyschem. 2024 Mar 19:e202400089. doi: 10.1002/cphc.202400089. Online ahead of print.ABSTRACTThe chirped-pulse Fourier Transform microwave spectrum of 2-tert-butylphenol, an industrial intermediate for the production of antioxidants, has been investigated in the 2-8 GHz frequency range. The spectral analysis has allowed obtaining precise structural information on the most stable conformer and its complex with argon. The conformation of the monomer reveals that the hydroxyl group is coplanar with the ring but points in the opposite direction to the tert-butyl group, reducing steric interactions. In the terbutyl group on...
Source: Chemphyschem - March 19, 2024 Category: Chemistry Authors: Wenqin Li Domingo Heras Assimo Maris Sonia Melandri Alberto Lesarri Luca Evangelisti Source Type: research
A Rotational Study of 2-tert-Butylphenol and Its 1:1 Argon Complex
Chemphyschem. 2024 Mar 19:e202400089. doi: 10.1002/cphc.202400089. Online ahead of print.ABSTRACTThe chirped-pulse Fourier Transform microwave spectrum of 2-tert-butylphenol, an industrial intermediate for the production of antioxidants, has been investigated in the 2-8 GHz frequency range. The spectral analysis has allowed obtaining precise structural information on the most stable conformer and its complex with argon. The conformation of the monomer reveals that the hydroxyl group is coplanar with the ring but points in the opposite direction to the tert-butyl group, reducing steric interactions. In the terbutyl group on...
Source: Chemphyschem - March 19, 2024 Category: Chemistry Authors: Wenqin Li Domingo Heras Assimo Maris Sonia Melandri Alberto Lesarri Luca Evangelisti Source Type: research
An atypical case of bilateral optic neuritis after strabismus surgery under general anesthesia
This report also highlights IOP monitoring in pediatric patients receiving systemic steroids to prevent loss of vision due to steroid-induced glaucoma.PMID:38494633 | DOI:10.1080/09273972.2024.2324166 (Source: Strabismus)
Source: Strabismus - March 18, 2024 Category: Research Authors: Himani Pal Anupam Singh Sandhya Shrestha Indar Kumar Sharawat Prateek Kumar Panda Barun Kumar Source Type: research
Reducing hydrophobic drug adsorption in an in-vitro extracorporeal membrane oxygenation model
Eur J Pharm Biopharm. 2024 Mar 13:114261. doi: 10.1016/j.ejpb.2024.114261. Online ahead of print.ABSTRACTExtracorporeal membrane oxygenation (ECMO) is a life-saving cardiopulmonary bypass technology for critically ill patients with heart and lung failure. Patients treated with ECMO receive a range of drugs that are used to treat underlying diseases and critical illnesses. However, the dosing guidelines for these drugs used in ECMO patients are unclear. Mortality rate for patients on ECMO exceeds 40% partly due to inaccurate dosing information, caused in part by the adsorption of drugs in the ECMO circuit and its components...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 15, 2024 Category: Drugs & Pharmacology Authors: Nitish Khurana Kamiya Watkins Debika Ghatak Jane Staples Oliver Hubbard Venkata Yellepeddi Kevin Watt Hamidreza Ghandehari Source Type: research
Reducing hydrophobic drug adsorption in an in-vitro extracorporeal membrane oxygenation model
Eur J Pharm Biopharm. 2024 Mar 13:114261. doi: 10.1016/j.ejpb.2024.114261. Online ahead of print.ABSTRACTExtracorporeal membrane oxygenation (ECMO) is a life-saving cardiopulmonary bypass technology for critically ill patients with heart and lung failure. Patients treated with ECMO receive a range of drugs that are used to treat underlying diseases and critical illnesses. However, the dosing guidelines for these drugs used in ECMO patients are unclear. Mortality rate for patients on ECMO exceeds 40% partly due to inaccurate dosing information, caused in part by the adsorption of drugs in the ECMO circuit and its components...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 15, 2024 Category: Drugs & Pharmacology Authors: Nitish Khurana Kamiya Watkins Debika Ghatak Jane Staples Oliver Hubbard Venkata Yellepeddi Kevin Watt Hamidreza Ghandehari Source Type: research
Neuropsychological follow-up of isoflurane sedated intensive care patients: a substudy of a randomized trial
CONCLUSIONS: Isoflurane sedation leads to more delirium free days during the ICU treatment and more factual memories of the ICU stay one year after the ICU stay. However long-term outcome of ventilated ICU patients is poor, and there were no differences between isoflurane and propofol sedation.PMID:38482637 | DOI:10.23736/S0375-9393.24.17834-0 (Source: Minerva Anestesiologica)
Source: Minerva Anestesiologica - March 14, 2024 Category: Anesthesiology Authors: Verena F Fuchs Henrik V Simon Nina Soldinger Thomas Volk Andreas Meiser Source Type: research
Adverse Drug Events Observed with the Newly Approved Remimazolam in Comparison to Propofol for General Anesthesia in Patients Undergoing Surgery: A Meta-analysis
CONCLUSION: Our current analysis showed that the newly approved remimazolam was apparently associated with significantly fewer adverse drug events in comparison to propofol for GA in patients undergoing surgery. Therefore, this new drug should be further studied and more research with larger population sizes should be carried out to confirm this hypothesis.PMID:38480661 | DOI:10.1007/s12325-024-02820-1 (Source: Adv Data)
Source: Adv Data - March 14, 2024 Category: Epidemiology Authors: Lidan Huang Hong Liu Xue Zou Jiawang Ding Song Tao Source Type: research
Neuropsychological follow-up of isoflurane sedated intensive care patients: a substudy of a randomized trial
CONCLUSIONS: Isoflurane sedation leads to more delirium free days during the ICU treatment and more factual memories of the ICU stay one year after the ICU stay. However long-term outcome of ventilated ICU patients is poor, and there were no differences between isoflurane and propofol sedation.PMID:38482637 | DOI:10.23736/S0375-9393.24.17834-0 (Source: Minerva Anestesiologica)
Source: Minerva Anestesiologica - March 14, 2024 Category: Anesthesiology Authors: Verena F Fuchs Henrik V Simon Nina Soldinger Thomas Volk Andreas Meiser Source Type: research
Propofol modulates Nrf2/NLRP3 signaling to ameliorate cigarette smoke-induced damage in human bronchial epithelial cells
This study aimed to elucidate the protective mechanisms of propofol against CSE-induced damage in human bronchial epithelial 16HBE cells. In CSE-induced 16HBE cells treated by propofol with or without transfection of nuclear factor erythroid 2-related factor 2 (Nrf2) interference plasmids, CCK-8 assay and lactate dehydrogenase (LDH) assay evaluated cytotoxicity. TUNEL assay and Western blot appraised cell apoptosis. ELISA and relevant assay kits severally measured inflammatory and oxidative stress levels. DCFH-DA fluorescent probe detected intracellular reactive oxygen species (ROS) activity. Immunofluorescence staining an...
Source: Tissue and Cell - March 13, 2024 Category: Cytology Authors: Linmei Xu Yanbin Wang Qumin Chen Xiaolei Zhu Jiageng Hong Source Type: research
Propofol modulates Nrf2/NLRP3 signaling to ameliorate cigarette smoke-induced damage in human bronchial epithelial cells
This study aimed to elucidate the protective mechanisms of propofol against CSE-induced damage in human bronchial epithelial 16HBE cells. In CSE-induced 16HBE cells treated by propofol with or without transfection of nuclear factor erythroid 2-related factor 2 (Nrf2) interference plasmids, CCK-8 assay and lactate dehydrogenase (LDH) assay evaluated cytotoxicity. TUNEL assay and Western blot appraised cell apoptosis. ELISA and relevant assay kits severally measured inflammatory and oxidative stress levels. DCFH-DA fluorescent probe detected intracellular reactive oxygen species (ROS) activity. Immunofluorescence staining an...
Source: Tissue and Cell - March 13, 2024 Category: Cytology Authors: Linmei Xu Yanbin Wang Qumin Chen Xiaolei Zhu Jiageng Hong Source Type: research
Propofol modulates Nrf2/NLRP3 signaling to ameliorate cigarette smoke-induced damage in human bronchial epithelial cells
This study aimed to elucidate the protective mechanisms of propofol against CSE-induced damage in human bronchial epithelial 16HBE cells. In CSE-induced 16HBE cells treated by propofol with or without transfection of nuclear factor erythroid 2-related factor 2 (Nrf2) interference plasmids, CCK-8 assay and lactate dehydrogenase (LDH) assay evaluated cytotoxicity. TUNEL assay and Western blot appraised cell apoptosis. ELISA and relevant assay kits severally measured inflammatory and oxidative stress levels. DCFH-DA fluorescent probe detected intracellular reactive oxygen species (ROS) activity. Immunofluorescence staining an...
Source: Tissue and Cell - March 13, 2024 Category: Cytology Authors: Linmei Xu Yanbin Wang Qumin Chen Xiaolei Zhu Jiageng Hong Source Type: research
