Effect of dexmedetomidine on dynamic cerebral autoregulation and carbon dioxide reactivity during sevoflurane anesthesia in healthy patients.
Conclusions: Dexmedetomidine administration does not impair dCA and CO2 reactivity in patients undergoing spine surgery under sevoflurane anesthesia. PMID: 32209963 [PubMed - as supplied by publisher] (Source: Korean Journal of Anesthesiology)
Source: Korean Journal of Anesthesiology - March 28, 2020 Category: Anesthesiology Tags: Korean J Anesthesiol Source Type: research

Emergence agitation: current knowledge and unresolved questions.
Authors: Lee SJ, Sung TY Abstract Emergence agitation (EA), which is also referred to as emergence delirium, can lead to clinically significant consequences. The mechanism of EA remains unclear. Proposed contributors to EA include age, male sex, type of surgery, emergency operation, use of inhalational anesthetics with low blood-gas partition coefficients, long duration of surgery, anticholinergics, premedication with benzodiazepines, voiding urgency, postoperative pain, and the presence of invasive devices. If pre- or intraoperative objective monitoring could predict the occurrence of agitation during emergence, t...
Source: Korean Journal of Anesthesiology - March 28, 2020 Category: Anesthesiology Tags: Korean J Anesthesiol Source Type: research

The effect of different factors on partitioning of propofol between aqueous and organic phases of microemulsions
Publication date: Available online 27 March 2020Source: Journal of Molecular LiquidsAuthor(s): Zahra Nadeloo, Ali Shayanfar, Parvin Zakeri-Milani, Hadi Valizadeh (Source: Journal of Molecular Liquids)
Source: Journal of Molecular Liquids - March 27, 2020 Category: Molecular Biology Source Type: research

Propofol inhibited apoptosis of hippocampal neurons in status epilepticus through miR-15a-5p/NR2B/ERK1/2 pathway
. (Source: Cell Cycle)
Source: Cell Cycle - March 26, 2020 Category: Cytology Authors: Xing Liu Jiefeng Geng Haiming Guo Huaping Zhao Yanqiu Ai Source Type: research

Dexmedetomidine in the  prevention of postoperative delirium in elderly patients following non-cardiac surgery: a systematic review and meta-analysis.
Dexmedetomidine in the prevention of postoperative delirium in elderly patients following non-cardiac surgery: a systematic review and meta-analysis. Clin Exp Pharmacol Physiol. 2020 Mar 25;: Authors: Shen QH, Li HF, Zhou XY, Yuan XZ Abstract The efficacy of dexmedetomidine in the prevention of postoperative delirium (POD) remains ambiguous, however, it has been used to reduce the incidence of delirium in elderly patients. Here, we conducted a meta-analysis study for assessing the effects of dexmedetomidine on POD among elderly patients following non-cardiac surgery. A systematic l...
Source: Clinical and Experimental Pharmacology and Physiology - March 25, 2020 Category: Drugs & Pharmacology Authors: Shen QH, Li HF, Zhou XY, Yuan XZ Tags: Clin Exp Pharmacol Physiol Source Type: research

External Validation of a Pharmacokinetic Model of Propofol for Target-Controlled Infusion in Children under Two Years Old.
CONCLUSION: The pooled bias and inaccuracy of the pharmacokinetic predictions are clinically acceptable. Therefore, our external validation of the Kim model indicated that the model can be applicable to target-controlled infusion of propofol in children younger than 2 years, with the recommended use of actual bispectral index monitoring in clinical settings that remifentanil is present. Trial Registration Clinical Research Information Service Identifier. TRIAL REGISTRATION: Clinical Research Information Service Identifier: KCT0001752. PMID: 32193901 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - March 21, 2020 Category: General Medicine Authors: Ji SH, Lee JH, Cho JY, Kim HS, Jang YE, Kim EH, Kim JT, Kim HS Tags: J Korean Med Sci Source Type: research

Anesthetic Management of a Patient With a Vagal Nerve Stimulator.
This report describes the successful anesthetic management of a 28-year-old woman with a VNS device who underwent dental treatment under general anesthesia. She was morbidly obese and had undergone placement of a VNS device secondary to drug-resistant epilepsy 2 years prior but continued to experience daily epileptic seizures. Because of concerns about the risk of perioperative epileptic seizures and apneic events, use of the dedicated VNS device magnet was planned if such complications occurred. Total intravenous anesthesia was induced with propofol and remifentanil and a bispectral index sensor was used to help monitor b...
Source: Anesthesia Progress - March 21, 2020 Category: Anesthesiology Tags: Anesth Prog Source Type: research

Hypnosis regulation in propofol anaesthesia employing super-twisting sliding mode control to compensate variability dynamics
This study focuses on regulation of the hypnosis level in the presence of surgical stimulus including skin incision, surgical diathermy and laryngoscopy as well as inter-patient variability by designing super-twisting sliding mode control (STSMC). The depth of the hypnosis level is maintained to 50 on the BIS level in the maintenance phase after improving the induction phase to 60 s using the conventional sliding mode control and 30 s with STSMC. The proposed scheme also compensates the inter-patient variability dynamics including height, age and weight of the different silico patients. Moreover, the surgical stimuli d...
Source: IET Systems Biology - March 20, 2020 Category: Biology Source Type: research

Effect of subarachnoid anesthesia combined with propofol target-controlled infusion on blood loss and transfusion for posterior total hip arthroplasty in elderly patients.
This study was aimed to evaluate the effect of subarachnoid anesthesia combined with propofol target-controlled infusion (TCI) on blood loss and transfusion for total hip arthroplasty (THA) in elderly patients in comparison with combined spinal-epidural anesthesia (CSEA) or GA. METHODS: Totally, 240 patients (aged ≥65 years, American Society of Anesthesiologists [ASA] I-III) scheduled for posterior THA were enrolled from September 1st, 2017 to March 1st, 2018. All cases were randomly divided into three groups to receive CSEA (group C, n = 80), GA (group G, n = 80), or subarachnoid anesthesia and propofol TC...
Source: Chinese Medical Journal - March 20, 2020 Category: General Medicine Authors: Xu CS, Qu XD, Qu ZJ, Wang G, Wang HJ Tags: Chin Med J (Engl) Source Type: research

Emergency airway management: A look into the practice, rate of success, and adverse events of 94 endotracheal intubations
Conclusions: This study provides an overview of the intubation practices in a single-center ED. Non-ED physicians perform the majority of intubations, with a variety of induction and paralyzing agents being used. It adds to the growing call for better standardization and provision of care to patients with a deteriorating airway and the continued auditing of practice. (Source: Journal of Emergencies, Trauma and Shock)
Source: Journal of Emergencies, Trauma and Shock - March 19, 2020 Category: Emergency Medicine Authors: Fiqry Fadhlillah Sarah Bury Ewa Grocholski Mike Dean Ali Refson Source Type: research

A survey of emergency providers regarding the current management of anterior shoulder dislocations
Conclusions: To our knowledge, this is the first study of its kind on ASD management by emergency practitioners. Our results indicate that Dutch emergency practitioners employ all three classes of reduction techniques: traction-countertraction most commonly, closely followed by biomechanical techniques. Medication use during repositioning varied widely. Per our survey, emergency practitioners are desirous of an evidence-based guideline for ASD management. (Source: Journal of Emergencies, Trauma and Shock)
Source: Journal of Emergencies, Trauma and Shock - March 19, 2020 Category: Emergency Medicine Authors: DN Baden MH Roetman T Boeije N Mullaart-Jansen MD Burg Source Type: research

Pharmacodynamic modelling of the effect of remifentanil using the Pupillary Pain Index
AbstractUsing a targeted controlled infusion of remifentanil during total intravenous anesthesia, we investigated the effect-site concentrations of remifentanil that correlate with different values of the Pupillary Pain Index and which concentrations were necessary for achieving a Pupillary Pain Index  ≤ 4 and its usefulness in titrating opioids. The Pupillary Pain Index was measured in 54 patients prior to surgery under different remifentanil effect-site concentrations and subsequently modeled. One hundred and twenty-eight measurements were taken at different remifentanil concentrations wh ile titrating p...
Source: Journal of Clinical Monitoring and Computing - March 18, 2020 Category: Information Technology Source Type: research

Comparison of Biochemical Recurrence After Robot-assisted Laparoscopic Radical Prostatectomy with Volatile and Total Intravenous Anesthesia.
Conclusions: Our findings demonstrate that both TIVA with propofol/remifentanil and VA with sevoflurane or desflurane/remifentanil have comparable effects on oncologic outcomes in patients undergoing RALP. PMID: 32174775 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - March 18, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

The effect of repetitive exposure to intravenous anesthetic agents on the immunity in mice.
This study was designed to assess the effect of repetitive exposure to intravenous anesthetic agents on the immunity in mice. Materials and Methods: The mice were divided into six groups: three intravenous anesthetic agents groups (dexmedetomidine, midazolam and propofol groups), and three corresponding control groups (CD, CM, and CP groups). The intravenous injections were administered once per day for 5 days. The immunity of mice was checked after the last intravenous injection. Histopathology and immunochemistry of liver and kidneys were evaluated. Cytokine levels in the blood was also checked. vs. evaluated with cytoki...
Source: International Journal of Medical Sciences - March 18, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Propofol alleviates ventilator-induced lung injury through regulating the Nrf2/NLRP3 signaling pathway.
Abstract Ventilator-induced lung injury (VILI) causes problems during acute lung injury treatment, and propofol is a well-known drug to prevent VILI. Herein, we discussed how propofol protects against VILI-induced inflammation with the interaction of nuclear factor E2-related factor 2 (Nrf2)/NOD-like receptor protein 3 (NLRP3). We established VILI mouse models for collecting lung tissues, and these mice were later treated with propofol and Nrf2/NLRP3 activator or inhibitor to observe their effects on VILI with inflammatory factors, 8-hydroxy-2 deoxyguanosine, malondialchehyche level, mitochondrial reactive oxygen ...
Source: Experimental and Molecular Pathology - March 18, 2020 Category: Pathology Authors: Ruan H, Li W, Wang J, Chen G, Xia B, Wang Z, Zhang M Tags: Exp Mol Pathol Source Type: research

In reply: Potential statistical issues in a study comparing postoperative hunger in patients anesthetized with propofol or sevoflurane.
PMID: 32180177 [PubMed - as supplied by publisher] (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - March 16, 2020 Category: Anesthesiology Authors: Gillibert A, Besnier E Tags: Can J Anaesth Source Type: research

Nasal high flow improves ventilation during propofol sedation: A randomized cross-over study in healthy volunteers
Publication date: Available online 12 March 2020Source: Respiratory Physiology & NeurobiologyAuthor(s): Gaku Mishima, Takuro Sanuki, James Revie, Max Pinkham, Toshihiro Watanabe, Shinji Kurata, Stanislav Tatkov, Takao Ayuse (Source: Respiratory Physiology and Neurobiology)
Source: Respiratory Physiology and Neurobiology - March 14, 2020 Category: Respiratory Medicine Source Type: research

Implementation of a protocol using ketamine-propofol ( ‘ketofol’) in a 1 to 4 ratio for procedural sedation in adults at a university hospital emergency department – report on safety and effectiveness
. (Source: Acta Clinica Belgica)
Source: Acta Clinica Belgica - March 14, 2020 Category: General Medicine Authors: Stig Walravens Walter Buylaert Evi Steen Peter De Paepe Source Type: research

A comparison of respiratory function in pigs anaesthetised by propofol or alfaxalone in combination with dexmedetomidine and ketamine
General anaesthesia in pigs maintained with intravenous drugs such as propofol may cause respiratory depression. Alfaxalone gives less respiratory depression than propofol in some species. The aim of the inves... (Source: Acta Veterinaria Scandinavica)
Source: Acta Veterinaria Scandinavica - March 12, 2020 Category: Veterinary Research Authors: Andreas Lervik, Simen Forr Toverud, Randi Krontveit and Henning Andreas Haga Tags: Research Source Type: research

Propofol Causes Consciousness Loss by Affecting GABA-A Receptor in the Nucleus Basalis of Rats.
Abstract Objective: Propofol is a classical anesthetic and induces consciousness loss, and gamma-aminobutyric-acid-type-A (GABA-A) receptor is its target. Righting reflex is associated with conscious response. The nucleus basalis (NB) acts as a major relay between the reticular activating system and the frontal cortex (FC). Propofol may mediate righting reflex by affecting GABA-A receptor in NB. Methods: Fifty male SD rats (250-350 g) were divided into parts I and II. In part I, 20 male SD rats were randomly divided into control group (CG) and NB-lesion group (NG, ibotenic acid-induced NB lesion). In p...
Source: Behavioural Neurology - March 11, 2020 Category: Neurology Authors: Xing Y, Li K, Jiao Y, Li Z Tags: Behav Neurol Source Type: research

The role of propofol hydroxyl group in 5-lipoxygenase recognition.
Abstract Propofol is a clinically important intravenous anesthetic. We previously reported that it directly inhibited 5-lipoxygenase (5-LOX), a key enzyme for leukotriene biosynthesis. Because the hydroxyl group in propofol (propofol 1-hydroxyl) is critical for its anesthetic effect, we examined if its presence would be inevitable for 5-lipoxygenase recognition. Fropofol is developed by substituting the hydroxy group in propofol with fluorine. We found that propofol 1-hydroxyl was important for 5-lipoxygenase recognition, but it was not absolutely necessary. Azi-fropofol bound to 5-LOX at one of the two propofol b...
Source: Biochemical and Biophysical Research communications - March 11, 2020 Category: Biochemistry Authors: Yuki K, Bu W, Eckenhoff RG, Yokomizo T, Okuno T Tags: Biochem Biophys Res Commun Source Type: research

Dynamics of Ketamine-induced Loss and Return of Consciousness across Primate Neocortex
Conclusions Ketamine generates unique intracortical dynamics during its altered states of consciousness, suggesting fundamentally different neuronal processes from propofol. The gradually shifting dynamics suggest a continuously conscious or dreaming state while unresponsive under ketamine until its deeper stage with the slow-delta oscillations. Somatosensory processing is preserved during ketamine anesthesia, but multisensory processing appears to be diminished under ketamine and through recovery.Editor ’s PerspectiveWhat We Already Know about This TopicKetamine increases both fast and slow oscillations in the prima...
Source: Anesthesiology - March 10, 2020 Category: Anesthesiology Source Type: research

Predictive Factors for Hypotension Associated With Supine-to-Prone Positional Change in Patients Undergoing Spine Surgery
The objective of this retrospective study was to determine predictive factors for hypotension associated with supine-to-prone positional change in spinal surgery patients. Materials and Methods: Data on demographics, current medications, comorbidity, intraoperative mean arterial pressure (MAP), heart rate, pulse pressure variation, tidal volume, peak inspiratory pressure, and propofol and remifentanil effect-site concentrations were collected from 179 patients undergoing elective spine surgery. Hypotension associated with supine-to-prone positional change was defined as>20% reduction in MAP during positional change. ...
Source: Journal of Neurosurgical Anesthesiology - March 10, 2020 Category: Anesthesiology Tags: Clinical Investigations Source Type: research

Propofol TCI Reductions Do Not Attenuate Significant Falls in Cardiac Output Associated With Anesthesia Induction and Knee-Chest Positioning in Spinal Surgery
Background: Induction of anesthesia and the knee-chest position are associated with hemodynamic changes that may impact patient outcomes. The aim of this study was to assess whether planned reductions in target-controlled infusion propofol concentrations attenuate the hemodynamic changes associated with anesthesia induction and knee-chest position. Materilas and Methods: A total of 20 patients scheduled for elective lumbar spinal surgery in the knee-chest position were included. In addition to standard anesthesia monitoring, bispectral index and noninvasive cardiac output (CO) monitoring were undertaken. The study was...
Source: Journal of Neurosurgical Anesthesiology - March 10, 2020 Category: Anesthesiology Tags: Clinical Investigations Source Type: research

Propofol post-conditioning lessens Renal Ischemia/Reperfusion-Induced Acute Lung Injury associated with autophagy and apoptosis through MAPK signals in Rats.
The objective of the current study was to explore the defensive roles of propofol (Pro), an intravenous anesthetic, on rI/R-induced ALI through mitogen-activated protein kinase (MAPK) signaling. Rats were divided into Sham, Pro (10 mg/kg), rI/R, rI/R + Pro (5 mg/kg), and rI/R + Pro (10 mg/kg) groups. Rats were treated with Pro at 1 h after rI/R treatment. Serum and lung tissues at 24 h after rI/R were collected to evaluate morphological changes and the expression of myeloperoxidase (MPO), inflammatory cytokines, and crucial proteins in the MAPK pathway. Pro attenuated the production of mediators, resulting in reduced level...
Source: Gene - March 10, 2020 Category: Genetics & Stem Cells Authors: Liu Z, Zhang J, Zhang F, Chang Y Tags: Gene Source Type: research

A Single Prophylactic Dose of Ondansetron Given at Cessation of Postoperative Propofol Sedation Decreases Postoperative Nausea and Vomiting in Cardiac Surgery Patients: A Randomized Controlled Trial.
CONCLUSIONS: These findings support the routine administration of ondansetron prophylaxis at the time of discontinuation of postoperative propofol sedation before extubation in patients following cardiac surgery. Further research is warranted to optimize PONV prophylaxis in cardiac surgery patients. PMID: 32167974 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 9, 2020 Category: Anesthesiology Authors: Wang EHZ, Sunderland S, Edwards NY, Chima NS, Yarnold CH, Schwarz SKW, Coley MA Tags: Anesth Analg Source Type: research

Propofol sedation with a target-controlled infusion pump in elderly patients undergoing ERCP
This study aimed to evaluate the safety and efficacy of nonanesthesiologist-administered propofol (NAAP) sedation with a target-controlled infusion (TCI) system in elderly patients during ERCP. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - March 8, 2020 Category: Gastroenterology Authors: Taiji Ogawa, Takeshi Tomoda, Hironari Kato, Yutaka Akimoto, Shoichi Tanaka, Hiroyuki Okada Source Type: research

Anxiety Administrated by Dexmedetomidine to Prevent New-Onset of Postoperative Atrial Fibrillation in Patients Undergoing Off-Pump Coronary Artery Bypass Graft.
This study aims to evaluate the effect of dexmedetomidine (DEX) sedation for relieving anxiety and the incidence of atrial fibrillation (AF) after off-pump coronary artery bypass graft (OPCABG).This randomized, double-blind, controlled trial was conducted on 196 patients who underwent OPCABG in Shandong Provincial Hospital from July 2017 to June 2018. The patients were randomly assigned to two groups, intervention of DEX group and Propofol (PROP) group. Episodes of postoperative AF (POAF) were identified within 5 days after OPCABG. Perioperative anxiety status was assessed using Zung's Self-Rating Anxiety Scale (SAS). The ...
Source: International Heart Journal - March 7, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Efficacy and safety of intravenous lidocaine in propofol-based sedation for ERCP procedures: a prospective, randomized, double-blinded, controlled trial
The objective of this study was to assess the efficacy and safety of intravenous lidocaine on propofol requirements during ERCP procedures. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - March 7, 2020 Category: Gastroenterology Authors: Jing Liu, Xiaoping Liu, Li-ping Peng, Rui Ji, Chao Liu, Yan-Qing Li Source Type: research

Sedation with remifentanil or propofol for flexible bronchoscopy: A randomised controlled trial
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - March 6, 2020 Category: Anesthesiology Tags: Correspondence Source Type: research

Desflurane anesthesia compared with total intravenous anesthesia on anesthesia-controlled operating room time in ambulatory surgery following strabotomy: a randomized controlled study.
This study was aimed to compare the ACT of desflurane with that of propofol-remifentanil in strabismus ambulatory surgery. METHODS: From November 2016 to December 2017, a total of 200 strabismus patients (aged 18-60 years old, and scheduled for elective ambulatory surgery at Zhongshan Ophthalmic Center) were randomly assigned to receive either propofol-based TIVA (group TIVA) or desflurane anesthesia (group DES) for maintenance of anesthesia. The primary outcome was the extubation time. Secondary outcomes included surgical time, anesthetic time, OR exit time, and Phase I and II recovery time. The intraoperative incide...
Source: Chinese Medical Journal - March 6, 2020 Category: General Medicine Authors: Zhu YL, Shen WH, Chen QR, Ye HJ, Huang JX, Kang Y, Chi W, Gan XL Tags: Chin Med J (Engl) Source Type: research

Anesthetic care for patients with anti-NMDA receptor encephalitis
Discussion: Multisystem involvement in anti-NMDA receptor encephalitis includes memory loss, behavior irregularity, psychosis, arrhythmias, blood pressure (BP) instability, and hypoventilation. In our study cohort, we noted no intraoperative issues and deterioration in clinical status following the use of volatile anesthetic agents, opioids, dexmedetomidine, and propofol for general anesthesia (GA) or sedation. As ketamine, xenon, and N2O mediate their anesthetic effects, primarily, through antagonism of NMDA receptors, theoretical concerns suggest that they should be avoided. (Source: Saudi Journal of Anaesthesia)
Source: Saudi Journal of Anaesthesia - March 5, 2020 Category: Anesthesiology Authors: Faris Al Ghamdi Joshua C Uffman Stephani S Kim Olubukola O Nafiu Joseph D Tobias Source Type: research

A prospective observational study to evaluate the magnitude of temperature changes in children undergoing elective MRI under general anesthesia
Conclusion: Vigilant temperature preservation strategies have to be maintained during the time the anesthetized child is present in the MRI suite. MRI compatible active warming devices are warranted especially in high turnover centers. (Source: Saudi Journal of Anaesthesia)
Source: Saudi Journal of Anaesthesia - March 5, 2020 Category: Anesthesiology Authors: Merlin S Ruth Nivetha Sridharan Ekta Rai Anita S Joselyn Source Type: research

Continuous infusion versus intermittent bolus injection of propofol during endoscopic retrograde cholangiopancreatography.
Abstract Background/Aims: It is unclear whether continuous infusion or intermittent bolus injection of propofol is better for achieving adequate sedation in endoscopic retrograde cholangiopancreatography (ERCP). We aimed to compare the efficacy and safety of continuous infusion and intermittent bolus injection of propofol during therapeutic ERCP. Methods: In this prospective study, we randomly assigned 232 patients undergoing therapeutic ERCP to either continuous infusion (CI group, n = 113) or intermittent bolus injection (BI group, n = 119) of propofol. The primary outcome was the quality of sedation as ass...
Source: The Korean Journal of Internal Medicine - March 5, 2020 Category: Internal Medicine Authors: Lee JG, Yoo KS, Byun YJ Tags: Korean J Intern Med Source Type: research

Volatile Anesthetic Sevoflurane Attenuates Toll-Like Receptor 1/2 Activation.
CONCLUSIONS: We found that TLR1/TLR2 activation was attenuated by sevoflurane, but we found no evidence for attenuation by isoflurane, propofol, or dexmedetomidine at clinically relevant concentrations. Our structural analysis and competition assay supported that sevoflurane directly bound to TLR2 at the interphase of the TLR1/TLR2 complex. Sevoflurane attenuated neutrophil L-selectin shedding, an important step for neutrophil migration. PMID: 32149756 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 5, 2020 Category: Anesthesiology Authors: Mitsui Y, Hou L, Huang X, Odegard KC, Pereira LM, Yuki K Tags: Anesth Analg Source Type: research

The Influence of Hemorrhagic Shock on the Disposition and Effects of Intravenous Anesthetics: A Narrative Review.
Abstract The need to reduce the dose of intravenous anesthetic in the setting of hemorrhagic shock is a well-established clinical dogma. Considered collectively,; the body of information concerning the behavior of intravenous anesthetics during hemorrhagic shock, drawn from animal and human data, confirms that clinical dogma and informs the rational selection and administration of intravenous anesthetics in the setting of hemorrhagic shock. The physiologic changes during hemorrhagic shock can alter pharmacokinetics and pharmacodynamics of intravenous anesthetics. Decreased size of the central compartment and centr...
Source: Anesthesia and Analgesia - March 5, 2020 Category: Anesthesiology Authors: Egan ED, Johnson KB Tags: Anesth Analg Source Type: research

Connexin 32 deficiency protects the liver against ischemia/reperfusion injury.
In conclusion Cx32 is a novel regulator of hepatic I/R injury through the modulation of hepatocyte apoptosis and damage, largely via the p53/puma signaling pathway. PMID: 32147436 [PubMed - as supplied by publisher] (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - March 5, 2020 Category: Drugs & Pharmacology Authors: Wu S, Yao W, Chen C, Chen H, Huang F, Liu Y, Cai J, Yuan D, Hei Z Tags: Eur J Pharmacol Source Type: research

Propofol Reduces Epithelial to Mesenchymal Transition, Invasion and Migration of Gastric Cancer Cells through the MicroRNA-195-5p/Snail Axis.
CONCLUSIONS Our study found that propofol could inhibit EMT, invasion, and migration of GC cells by promoting miR-195-5p expression and suppressing Snail expression. This study may provide novel insights in GC treatment. PMID: 32115570 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

[Propofol: From white to green].
ias D PMID: 32146145 [PubMed - as supplied by publisher] (Source: Anales de Pediatria)
Source: Anales de Pediatria - March 4, 2020 Category: Pediatrics Authors: Arlabán Carpintero L, Hidalgo Sanz J, Pinilla Borobia J, Palanca Arias D Tags: An Pediatr (Barc) Source Type: research

[The effects of cannabis and cannabinoids on anesthesia and analgesia during the perioperative period].
Abstract Cannabis is the most frequently used recreational drug worldwide. Moreover, the use of cannabinoids for medical purposes is also constantly growing and medical cannabis products are legalised by an increasing number of countries. First clinical reports have shown enhanced requirements for propofol and analgesics used for general anesthesia and perioperative pain management in cannabis users. Therefore, this article discusses the potential impact of medical or recreational cannabis use on patients with regard to the recent literature. Besides the significantly increased requirement for propofol and fentany...
Source: Schmerz - March 3, 2020 Category: Anesthesiology Authors: Kraft B, Stromer W Tags: Schmerz Source Type: research

Propofol protects human cardiac cells against chemical hypoxiainduced injury by regulating the JNK signaling pathways.
Authors: Han L, Zhuo Q, Zhou Y, Qian Y Abstract Propofol is a widely used intravenous anesthetic shown to exert a cardioprotective role against oxidative stress and ischemia/reperfusion injury in rat cardiac H9c2 cells. However, the regulatory mechanisms and functions of propofol in human cardiomyocytes remain unknown. The present study chemically induced hypoxia with cobalt chloride (CoCl2) to mimic cardiomyocyte ischemic injury in human cardiac AC16 and HCM cells. To investigate its underlying mechanisms, propofol was added to the cells before the chemical hypoxia phase. The present results suggested that, in res...
Source: Experimental and Therapeutic Medicine - February 29, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

The immunosuppressive effects of volatile versus intravenous anesthesia combined with epidural analgesia on kidney cancer: a pilot randomized controlled trial.
Conclusions: The results of the current pilot study did not support the hypothesis that the suppression of the cell-mediated immunity is worse under the use of inhalational anesthesia as compared to total intravenous anesthesia, in patients undergoing kidney cancer surgery under combined low thoracic epidural analgesia and general anesthesia. PMID: 32098012 [PubMed - as supplied by publisher] (Source: Korean Journal of Anesthesiology)
Source: Korean Journal of Anesthesiology - February 28, 2020 Category: Anesthesiology Tags: Korean J Anesthesiol Source Type: research

Statistical analysis plan for the Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients with Acute Respiratory Failure trial.
CONCLUSION: This study will compare the effects of two sedatives in mechanically ventilated severely septic patients. In keeping with the guidance on statistical principles for clinical trials, we have developed a comprehensive statistical analysis plan by which we will adhere, as this will avoid bias and support transparency and reproducibility. TRIAL REGISTRATION: ClinicalTrials.gov (NCT01739933). PMID: 32102644 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - February 28, 2020 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Propofol: an intravenous anesthetic suitable for pediatric age.
Authors: Gentili A PMID: 32100518 [PubMed - as supplied by publisher] (Source: Minerva Anestesiologica)
Source: Minerva Anestesiologica - February 28, 2020 Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research

MicroRNA-20b-5p regulates propofol-preconditioning-induced inhibition of autophagy in hypoxia-and-reoxygenation-stimulated endothelial cells.
In conclusion, our results indicate that propofol inhibits autophagic cell death via the miR-20b-5p-ULKI axis and that ULK1 may be a therapeutic target for cardiovascular IR injury. PMID: 32098914 [PubMed - in process] (Source: Journal of Biosciences)
Source: Journal of Biosciences - February 28, 2020 Category: Biomedical Science Authors: Zhen W, Hui D, Wenying S, Yulong S Tags: J Biosci Source Type: research

Usefulness of ANI (analgesia nociception index) monitoring for outpatient saphenectomy surgery outcomes: an observational study
AbstractThe Analgesia Nociception Index (ANI), derived from heart rate variability is a proposed guide to obtain an adequate control of the analgesic component during anaesthesia. This single blind observational study was designed to evaluate the relationship between intraoperative ANI values and length of stay in Day Surgery Units (DSU) in patients undergoing varicose vein intervention. 131 patients (ASA I-II) scheduled for elective varicose vein surgery were studied. A propofol closed-loop TCI was used to maintain a specific level of BIS. To control analgesia, a remifentanil TCI was used, modifying the target according t...
Source: Journal of Clinical Monitoring and Computing - February 28, 2020 Category: Information Technology Source Type: research

Comparison of intubating conditions after induction with propofol and remifentanil or sufentanil : Randomized controlled REMIDENT trial for  surgical tooth extraction.
CONCLUSION: When intubation without muscle relaxants is required, intubating conditions are much better when a remifentanil bolus is used compared to a sufentanil bolus. The remifentanil/propofol rapid induction technique is a valuable technique to quickly intubate and achieve good conditions. PMID: 32112114 [PubMed - as supplied by publisher] (Source: Der Anaesthesist)
Source: Der Anaesthesist - February 28, 2020 Category: Anesthesiology Authors: Dolsan A, Bruneteau L, Roche C, Ferré F, Labaste F, Sommet A, Conil JM, Minville V Tags: Anaesthesist Source Type: research

Monitoring of anesthetic depth and EEG band power using phase lag entropy during propofol anesthesia
Phase lag entropy (PLE) is a novel anesthetic depth indicator that uses four-channel electroencephalography (EEG) to measure the temporal pattern diversity in the phase relationship of frequency signals in the... (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - February 26, 2020 Category: Anesthesiology Authors: Hye Won Shin, Hyun Jung Kim, Yoo Kyung Jang, Hae Sun You, Hyub Huh, Yoon Ji Choi, Seung Uk Choi and Ji Su Hong Tags: Research article Source Type: research

Adult Mild Encephalitis With Reversible Splenial Lesion Associated With Delirious Mania: A Case Report
Mild encephalitis with reversible splenial lesion is a rare clinic-radiological entity presenting with neurological and neuropsychiatric symptoms associated with cerebral lesion/s. Delirious mania is a severe psychiatric syndrome characterized by acute onset of delirium, excitement, and psychosis with a high mortality rate. In this paper, we present a case report of mild encephalitis with reversible splenial lesion clinically presenting as delirious mania and evolving into life-threatening multi-organ failure. The patient was treated with aripiprazole and benzodiazepine with poor effect and, after 4 days, the patient's con...
Source: Frontiers in Psychiatry - February 26, 2020 Category: Psychiatry Source Type: research

Batten disease and perioperative complications: a retrospective descriptive study
ConclusionsThe majority of these patients were managed without clinically significant perioperative complications. As previously reported, bradycardia, hypotension, and hypothermia were the most common adverse events. Routine avoidance of propofol in patients with Batten disease does not appear warranted. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - February 25, 2020 Category: Anesthesiology Source Type: research