The effect of propofol on effective brain networks
CONCLUSIONS: Our findings suggest that the number of effective network connections decreases, but network measures are only marginally affected.SIGNIFICANCE: The primary network topology is preserved under propofol.PMID:38522268 | DOI:10.1016/j.clinph.2024.01.012 (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - March 24, 2024 Category: Neurology Authors: D van Blooijs S Blok G J M Huiskamp P van Eijsden H G E Meijer F S S Leijten Source Type: research
The effect of propofol on effective brain networks
CONCLUSIONS: Our findings suggest that the number of effective network connections decreases, but network measures are only marginally affected.SIGNIFICANCE: The primary network topology is preserved under propofol.PMID:38522268 | DOI:10.1016/j.clinph.2024.01.012 (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - March 24, 2024 Category: Neurology Authors: D van Blooijs S Blok G J M Huiskamp P van Eijsden H G E Meijer F S S Leijten Source Type: research
The effect of propofol on effective brain networks
CONCLUSIONS: Our findings suggest that the number of effective network connections decreases, but network measures are only marginally affected.SIGNIFICANCE: The primary network topology is preserved under propofol.PMID:38522268 | DOI:10.1016/j.clinph.2024.01.012 (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - March 24, 2024 Category: Neurology Authors: D van Blooijs S Blok G J M Huiskamp P van Eijsden H G E Meijer F S S Leijten Source Type: research
Molecules, Vol. 29, Pages 1445: Rearrangement of Arylsulfamates and Sulfates to Para-Sulfonyl Anilines and Phenols
nes
The C(sp2)-aryl sulfonate functional group is found in bioactive molecules, but their synthesis can involve extreme temperatures (>190 °C or flash vacuum pyrolysis) and strongly acidic reaction conditions. Inspired by the 1917 Tyrer industrial process for a sulfa dye that involved an aniline N(sp2)-SO3 intermediate en route to a C(sp2)-SO3 rearranged product, we investigated tributylsulfoammonium betaine (TBSAB) as a milder N-sulfamation to C-sulfonate relay reagent. Initial investigations of a stepwise route involving TBSAB on selected anilines at room temperature enabled the isolation of N(...
Source: Molecules - March 23, 2024 Category: Chemistry Authors: Yifei Zhou Alan M. Jones Tags: Article Source Type: research
The Effectiveness of Low-dose Esmketamine Versus Remifentanil Adjunct to Propofol for Sedation in Patients Undergoing Radiofrequency Thermocoagulation for Trigeminal Neuralgia
CONCLUSIONS: Low-dose esketamine reduces the total amount of propofol necessary for sedation and incidence of respiratory depression during RFT of gasserian ganglion in American Society of Anesthesiologists I to III patients without affecting recovery time, satisfaction of surgeons and patients, cardiovascular adverse events, when compared with remifentanil.PMID:38518157 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: An Xie Jia Han Feng Ju Yukai Zhou Dan Wu Xianjie Zhang Source Type: research
The Effectiveness of Low-dose Esmketamine Versus Remifentanil Adjunct to Propofol for Sedation in Patients Undergoing Radiofrequency Thermocoagulation for Trigeminal Neuralgia
CONCLUSIONS: Low-dose esketamine reduces the total amount of propofol necessary for sedation and incidence of respiratory depression during RFT of gasserian ganglion in American Society of Anesthesiologists I to III patients without affecting recovery time, satisfaction of surgeons and patients, cardiovascular adverse events, when compared with remifentanil.PMID:38518157 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: An Xie Jia Han Feng Ju Yukai Zhou Dan Wu Xianjie Zhang Source Type: research
The Effectiveness of Low-dose Esmketamine Versus Remifentanil Adjunct to Propofol for Sedation in Patients Undergoing Radiofrequency Thermocoagulation for Trigeminal Neuralgia
CONCLUSIONS: Low-dose esketamine reduces the total amount of propofol necessary for sedation and incidence of respiratory depression during RFT of gasserian ganglion in American Society of Anesthesiologists I to III patients without affecting recovery time, satisfaction of surgeons and patients, cardiovascular adverse events, when compared with remifentanil.PMID:38518157 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: An Xie Jia Han Feng Ju Yukai Zhou Dan Wu Xianjie Zhang Source Type: research
The Effectiveness of Low-dose Esmketamine Versus Remifentanil Adjunct to Propofol for Sedation in Patients Undergoing Radiofrequency Thermocoagulation for Trigeminal Neuralgia
CONCLUSIONS: Low-dose esketamine reduces the total amount of propofol necessary for sedation and incidence of respiratory depression during RFT of gasserian ganglion in American Society of Anesthesiologists I to III patients without affecting recovery time, satisfaction of surgeons and patients, cardiovascular adverse events, when compared with remifentanil.PMID:38518157 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: An Xie Jia Han Feng Ju Yukai Zhou Dan Wu Xianjie Zhang Source Type: research
The Effectiveness of Low-dose Esmketamine Versus Remifentanil Adjunct to Propofol for Sedation in Patients Undergoing Radiofrequency Thermocoagulation for Trigeminal Neuralgia
CONCLUSIONS: Low-dose esketamine reduces the total amount of propofol necessary for sedation and incidence of respiratory depression during RFT of gasserian ganglion in American Society of Anesthesiologists I to III patients without affecting recovery time, satisfaction of surgeons and patients, cardiovascular adverse events, when compared with remifentanil.PMID:38518157 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: An Xie Jia Han Feng Ju Yukai Zhou Dan Wu Xianjie Zhang Source Type: research
Sensors, Vol. 24, Pages 2031: Development, Validation, and Comparison of a Novel Nociception/Anti-Nociception Monitor against Two Commercial Monitors in General Anesthesia
Martine Neckebroek
In this paper, we present the development and the validation of a novel index of nociception/anti-nociception (N/AN) based on skin impedance measurement in time and frequency domain with our prototype AnspecPro device. The primary objective of the study was to compare the Anspec-PRO device with two other commercial devices (Medasense, Medstorm). This comparison was designed to be conducted under the same conditions for the three devices. This was carried out during total intravenous anesthesia (TIVA) by investigating its outcomes related to noxious stimulus. In a carefully designed clinical protocol...
Source: Sensors - March 22, 2024 Category: Biotechnology Authors: Clara M. Ionescu Dana Copot Erhan Yumuk Robin De Keyser Cristina Muresan Isabela Roxana Birs Ghada Ben Othman Hamed Farbakhsh Amani R. Ynineb Martine Neckebroek Tags: Article Source Type: research
Ferritinophagy-Mediated Hippocampus Ferroptosis is Involved in Cognitive Impairment in Immature Rats Induced by Hypoxia Combined with Propofol
In this study, our in vivo experiments found that immature rats exposed to hypoxia combined with propofol (HCWP) could develop cognitive impairment. We performed the RNA-seq analysis of its hippocampal tissues and found that autophagy and ferroptosis may play a role in our model. Next, we verified the participation of the two modes of death by detecting the expression of autophagy-related indexes Sequestosome 1 (SQSTM1) and Beclin1, and ferroptosis-related indicators Fe2+, reactive oxygen species (ROS) and glutathione peroxidase 4 (GPX4). Meanwhile, we found that ferrostatin-1 (Fer-1), an inhibitor of ferroptosis, could im...
Source: Neurochemical Research - March 21, 2024 Category: Neuroscience Authors: Ling Liu Wen Gao Shun Yang Fei Yang Shangyingying Li Yaqiong Tian Li Yang Qianyu Deng Zhengwei Gan Shengfen Tu Source Type: research
Comparison of Deep and Moderate Neuromuscular Blockade for Major Laparoscopic Surgery in Children: A Randomized Controlled Trial
CONCLUSIONS: A deep NMB provided better operative conditions and similar recovery profiles compared with a moderate NMB as reversed with sugammadex in children undergoing major laparoscopic surgery.CLINICAL TRIAL REGISTRATION: Chinese Clinical Trial Registry, No. ChiCTR2100053821.PMID:38512578 | DOI:10.1007/s40272-024-00622-0 (Source: Paediatric Drugs)
Source: Paediatric Drugs - March 21, 2024 Category: Pediatrics Authors: Guo Wei Yong-Xin Li Ying Chen Mei Diao John Wei Zhong Shou-Dong Pan Source Type: research
Ferritinophagy-Mediated Hippocampus Ferroptosis is Involved in Cognitive Impairment in Immature Rats Induced by Hypoxia Combined with Propofol
In this study, our in vivo experiments found that immature rats exposed to hypoxia combined with propofol (HCWP) could develop cognitive impairment. We performed the RNA-seq analysis of its hippocampal tissues and found that autophagy and ferroptosis may play a role in our model. Next, we verified the participation of the two modes of death by detecting the expression of autophagy-related indexes Sequestosome 1 (SQSTM1) and Beclin1, and ferroptosis-related indicators Fe2+, reactive oxygen species (ROS) and glutathione peroxidase 4 (GPX4). Meanwhile, we found that ferrostatin-1 (Fer-1), an inhibitor of ferroptosis, could im...
Source: Neurochemical Research - March 21, 2024 Category: Neuroscience Authors: Ling Liu Wen Gao Shun Yang Fei Yang Shangyingying Li Yaqiong Tian Li Yang Qianyu Deng Zhengwei Gan Shengfen Tu Source Type: research
Dexmedetomidine Alleviates Propofol Infusion Syndrome-Induced Myocardial Injury through Inhibiting Ferroptosis Associated with Accumulation of Reactive Oxygen Species
CONCLUSIONS: Dex could alleviate PRIS-induced myocardial injury by inhibiting ferroptosis associated with accumulation of ROS. Combined sedation using propofol and Dex might be a potential strategy for the prevention and treatment of PRIS-induced cardiotoxicity.PMID:38514063 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Jinhui Sun Bing Zhang Qiang Geng Jiayinati Halimujiang Chang Song Min Xi Ting Wang Source Type: research
