Cancers, Vol. 16, Pages 1685: Feasibility and Acute Toxicity of Hypo-Fractionated Radiotherapy on 0.35T MR-LINAC: The First Prospective Study in Spain
i
Lopez-Campos
Alongi
Couñago
This observational, descriptive, longitudinal, and prospective basket-type study (Registry #5289) prospectively evaluated the feasibility and acute toxicity of hypo-fractionated radiotherapy on the first 0.35T MR-LINAC in Spain. A total of 37 patients were included between August and December 2023, primarily with prostate tumors (59.46%), followed by pancreatic tumors (32.44%). Treatment regimens typically involved extreme hypo-fractionated radiotherapy, with precise dose delivery verified through quality assurance measures. Acute toxicity assessment at treatment completion revea...
Source: Cancers - April 26, 2024 Category: Cancer & Oncology Authors: Gonsalves Ocanto Meilan Gomez Dominguez Torres Pascual Teja Linde Guijarro Rivas Begara Gonz ález Andreescu Holgado Alcaraz L ópez Dzhugashvli Lopez-Campos Alongi Cou ñago Tags: Article Source Type: research
PD-L1 Expression in Nonbacterial Chronic Cystitis and Bladder Cancer
CONCLUSIONS: Expression of PD-L1 was detected in a cohort of NCC patients, although the PD-L1 positivity rate was lower than that in BC. Our results demonstrate that the degree of PD-L1 expression in bladder tissue is associated with the presence of viral infections and with the degree of inflammatory infiltration of the bladder wall in both NCC and BC.PMID:38662109 | DOI:10.1007/s00192-024-05782-8 (Source: Herpes)
Source: Herpes - April 25, 2024 Category: Infectious Diseases Authors: Inga Kosova Vagan Barsegian Lyudmila Gundorova Dmitriy Kolbasov Source Type: research
PD-L1 Expression in Nonbacterial Chronic Cystitis and Bladder Cancer
ConclusionsExpression of PD-L1 was detected in a cohort of NCC patients, although the PD-L1 positivity rate was lower than that in BC. Our results demonstrate that the degree of PD-L1 expression in bladder tissue is associated with the presence of viral infections and with the degree of inflammatory infiltration of the bladder wall in both NCC and BC. (Source: International Urogynecology Journal and Pelvic Floor Dysfunction)
Source: International Urogynecology Journal and Pelvic Floor Dysfunction - April 25, 2024 Category: OBGYN Source Type: research
High prevalence of plasmid-mediated quinolone resistance in escherichia coli strains producing extended-spectrum beta-lactamases isolated from faeces and urine of pregnant women with acute cystitis
CONCLUSION: This study revealed a high rate of resistance to the quinolone nalidixic acid and a widespread distribution of PMQR genes in MDR E. coli strains producing ESBLs. The strains represented virulence factors and phylogenetic group B2 are closely associated with abundance in UTI and faeces. However, the predominant clones in faeces were not found in UTIs and it is possible that rep-PCR is not sufficiently discriminating clones.PMID:38656625 | DOI:10.1007/s11033-024-09491-9 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 24, 2024 Category: Molecular Biology Authors: Maryam Sohrabi Javad Fathi Samane Mohebi Zahra Hashemizadeh Soudeh Kholdi Mahtab Hadadi Kowsar Keshavarz Zahra Darvishvand Source Type: research
Current updates relating to treatment for interstitial cystitis/bladder pain syndrome: systematic review and network meta-analysis
Despite the publication of several meta-analyses regarding the efficacy of certain therapies in helping individuals with interstitial cystitis (IC) / bladder pain syndrome (BPS), these have not provided a comp... (Source: BMC Urology)
Source: BMC Urology - April 24, 2024 Category: Urology & Nephrology Authors: Jae Joon Park, Kwang Taek Kim, Eun Ji Lee, Joey Chun, Serin Lee, Sung Ryul Shim and Jae Heon Kim Tags: Research Source Type: research
Risk Classification for Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) Using Machine Learning Based Predictions
To improve diagnosis of IC/BPS(IC) we hereby developed an improved IC risk classification using machine learning algorithms. (Source: Urology)
Source: Urology - April 24, 2024 Category: Urology & Nephrology Authors: Laura E. Lamb, Joseph J. Janicki, Sarah N. Bartolone, Elijah P. Ward, Nitya Abraham, Melissa Laudano, Christopher P. Smith, Kenneth M. Peters, Bernadette M.M. Zwaans, Michael B. Chancellor Source Type: research
Immune reconstitution in children after haploidentical haematopoietic stem cell transplantation
CONCLUSION: Paediatric patients who undergo haploidentical HSCT with PTCy are likely to have delayed IR and an increased risk of viral reactivation/infection compared with HLA-matched HSCT. The addition of ATG to PTCy delayed T cell recovery and increased risk of BKV reactivation.PMID:38646695 | DOI:10.1111/ijlh.14290 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - April 22, 2024 Category: Hematology Authors: Saranthorn Apasuthirat Nopporn Apiwattanakul Usanarat Anurathapan Nintita Sripaiboonkij Thokanit Karan Paisooksantivatana Ekawat Pasomsub Suradej Hongeng Samart Pakakasama Source Type: research
Immune reconstitution in children after haploidentical haematopoietic stem cell transplantation
CONCLUSION: Paediatric patients who undergo haploidentical HSCT with PTCy are likely to have delayed IR and an increased risk of viral reactivation/infection compared with HLA-matched HSCT. The addition of ATG to PTCy delayed T cell recovery and increased risk of BKV reactivation.PMID:38646695 | DOI:10.1111/ijlh.14290 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - April 22, 2024 Category: Hematology Authors: Saranthorn Apasuthirat Nopporn Apiwattanakul Usanarat Anurathapan Nintita Sripaiboonkij Thokanit Karan Paisooksantivatana Ekawat Pasomsub Suradej Hongeng Samart Pakakasama Source Type: research
Randomized clinical trial of non-antibiotic prophylaxis with d-Mannose plus Proanthocyanidins vs. Proanthocyanidins alone for urinary tract infections and asymptomatic bacteriuria in de novo kidney transplant recipients: The Manotras study
CONCLUSIONS: Non-antibiotic therapy is an unmet need to prevent UTI after kidney transplantation; however, the use of d-Mannose plus PAC does not seem capable to prevent it.PMID:38637262 | DOI:10.1016/j.nefroe.2024.02.011 (Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia)
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - April 18, 2024 Category: Urology & Nephrology Authors: Melissa Rau Adrian Santelli Sara Mart í Mar ía Isabel Díaz Nuria Sab é Mar ía Fiol Luis Riera Bego ña Etcheverry Sergi Codina Ana Coloma Anna Carreras-Salinas Carmen Ardanuy Josep M Cruzado Edoardo Melilli Source Type: research
Cystitis glandularis with concomitant Crohn ’s disease leading to a paroxysm of Crohn’s disease with ulcerated external iliac vessels
•we report the case of a 36-year-old female patient who presented to our hospital with a diagnosis of cystitis glandularis manifesting as a vesicovaginal fistula. She underwent cystoscopic biopsy at a local ho... (Source: BMC Urology)
Source: BMC Urology - April 17, 2024 Category: Urology & Nephrology Authors: Wu Ronghua, Zheng Ji, Liu Gang, Zhang Yun and Nie Xubiao Tags: Case Report Source Type: research
Hemorrhagic cystitis induced by JC polyomavirus infection following COVID-19: a case report
JC polyomavirus (JCPyV) is a human polyomavirus that can establish lifelong persistent infection in the majority of adults. It is typically asymptomatic in immunocompetent individuals. However, there is a risk... (Source: BMC Urology)
Source: BMC Urology - April 16, 2024 Category: Urology & Nephrology Authors: Yuanjie Lv and Xiaoping Liu Tags: Case Report Source Type: research
Impact of BK polyomavirus viremia on the outcomes of allogeneic hematopoietic stem cell transplantation
AbstractAlthough it is known that BK polyomavirus (BKPyV) causes hemorrhagic cystitis (HC) after allogeneic hematopoietic stem cell transplantation (HSCT), the clinical significance of BKPyV viremia has not been fully evaluated. We retrospectively analyzed the results of quantitative polymerase chain reaction (PCR) evaluations for detecting BKPyV in the whole blood samples of patients undergoing allogeneic HSCT during the period from January 2010 to June 2020 at a single institute, Tokyo Medical and Dental University. BKPyV was detected in the blood of 28 of the 107 evaluated patients, and the cumulative incidence of was 2...
Source: Annals of Hematology - April 12, 2024 Category: Hematology Source Type: research
Experimental Animal Models for IC/BPS
AbstractPurpose of ReviewInterstitial cystitis/bladder pain syndrome (IC/BPS) is a disease that causes bladder symptoms such as pelvic pain and frequent urination and is often an intractable disease affecting a patient ’s quality of life. The etiology of IC/BPS remains elusive, and treatment strategies are still not fully established. To better understand the underlying pathophysiology, many studies have strived to recreate an animal model of IC/BPS to help further expand the treatment options of this difficult disease.Recent FindingsBasic animal studies of IC/BPS have often been conducted by provoking inflammation in th...
Source: Current Bladder Dysfunction Reports - April 12, 2024 Category: Urology & Nephrology Source Type: research
POU2F3-expressing intraepithelial small-cell carcinoma with mixed small-cell carcinoma and conventional-type urothelial carcinoma of the urinary bladder
AbstractBased on lineage-specific transcription factors, small-cell neuroendocrine carcinoma (SmCC) of the urinary bladder has recently been subtyped into three molecular subtypes: ASCL1, NEUROD1 and POU2F3. The latter is a master transcriptional regulator of tuft cells (TCs) which are rare solitary cells found in various mucosal epithelia such as the gastrointestinal tract, but which have not been reported in the bladder. The POU2F3 subtype shows low or absent neuroendocrine marker expression. A case of mixed SmCC and conventional-type urothelial carcinoma (CUC) of the urinary bladder with POU2F3-expressing intraepithelia...
Source: Virchows Archiv - April 11, 2024 Category: Pathology Source Type: research
