Recurring cystitis cystica and cystitis glandularis masquerading as urothelial carcinoma
We report a rare case of cystitis cystica and glandularis mimicking low-grade urothelial carcinoma that was found incidentally and treated with resection and fulguration via transurethral resection of bladder tumor (TURBT). When early recurrence was found on surveillance cystoscopy 3 months later, the patient was treated with repeat TURBT and intravesical gemcitabine. Surveillance cystoscopy 4 months later revealed cystitis cystica and cystitis glandularis yet again. We highlight the diagnosis and management of multiple early recurrences of cystitis cystica in this patient, particularly our treatment with gemcitabine and c...
Source: Canadian Journal of Urology - December 17, 2023 Category: Urology & Nephrology Authors: Kerith R Wang Rishabh K Simhal Gabriel G Dinatale Li Li Thenappan Chandrasekar Source Type: research
Re: Pentosan polysulfate and a pigmentary maculopathy: causation versus correlation?
Can J Urol. 2023 Dec;30(6):11740.ABSTRACTHow should a conscientious physician advise patients with Interstitial Cystitis /Bladder Pain Syndrome (IC/BPS) when they want to know if taking Pentosan Polysulfate Sodium (PPS) will lead to loss of vision? Ever since the initial report from Pearce et al in 2018 suggesting that PPS usage can lead to the development of pigmented maculopathy (PM), my patients have been inundated with solicitations from attorneys looking to sign up clients for class action lawsuits.1 While there have been additional reports suggesting a relationship between PPS exposure and the development of PM, Ludw...
Source: Canadian Journal of Urology - December 17, 2023 Category: Urology & Nephrology Authors: Robert J Evans Raymond Xu Source Type: research
Pentosan polysulfate and a pigmentary maculopathy: causation versus correlation?
CONCLUSIONS: After an analysis of the literature describing a pigmentary maculopathy in IC patients on long term PPS, a causal relationship does not appear to be present. An alternate model is proposed postulating that the causative factor for the pigmentary maculopathy is the underlying inflammatory state associated with IC and not PPS use.PMID:38104330 (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - December 17, 2023 Category: Urology & Nephrology Authors: Jeffrey G Proctor Source Type: research
Recurring cystitis cystica and cystitis glandularis masquerading as urothelial carcinoma
We report a rare case of cystitis cystica and glandularis mimicking low-grade urothelial carcinoma that was found incidentally and treated with resection and fulguration via transurethral resection of bladder tumor (TURBT). When early recurrence was found on surveillance cystoscopy 3 months later, the patient was treated with repeat TURBT and intravesical gemcitabine. Surveillance cystoscopy 4 months later revealed cystitis cystica and cystitis glandularis yet again. We highlight the diagnosis and management of multiple early recurrences of cystitis cystica in this patient, particularly our treatment with gemcitabine and c...
Source: Canadian Journal of Urology - December 17, 2023 Category: Urology & Nephrology Authors: Kerith R Wang Rishabh K Simhal Gabriel G Dinatale Li Li Thenappan Chandrasekar Source Type: research
Re: Pentosan polysulfate and a pigmentary maculopathy: causation versus correlation?
Can J Urol. 2023 Dec;30(6):11740.ABSTRACTHow should a conscientious physician advise patients with Interstitial Cystitis /Bladder Pain Syndrome (IC/BPS) when they want to know if taking Pentosan Polysulfate Sodium (PPS) will lead to loss of vision? Ever since the initial report from Pearce et al in 2018 suggesting that PPS usage can lead to the development of pigmented maculopathy (PM), my patients have been inundated with solicitations from attorneys looking to sign up clients for class action lawsuits.1 While there have been additional reports suggesting a relationship between PPS exposure and the development of PM, Ludw...
Source: Canadian Journal of Urology - December 17, 2023 Category: Urology & Nephrology Authors: Robert J Evans Raymond Xu Source Type: research
Pentosan polysulfate and a pigmentary maculopathy: causation versus correlation?
CONCLUSIONS: After an analysis of the literature describing a pigmentary maculopathy in IC patients on long term PPS, a causal relationship does not appear to be present. An alternate model is proposed postulating that the causative factor for the pigmentary maculopathy is the underlying inflammatory state associated with IC and not PPS use.PMID:38104330 (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - December 17, 2023 Category: Urology & Nephrology Authors: Jeffrey G Proctor Source Type: research
Recurring cystitis cystica and cystitis glandularis masquerading as urothelial carcinoma
We report a rare case of cystitis cystica and glandularis mimicking low-grade urothelial carcinoma that was found incidentally and treated with resection and fulguration via transurethral resection of bladder tumor (TURBT). When early recurrence was found on surveillance cystoscopy 3 months later, the patient was treated with repeat TURBT and intravesical gemcitabine. Surveillance cystoscopy 4 months later revealed cystitis cystica and cystitis glandularis yet again. We highlight the diagnosis and management of multiple early recurrences of cystitis cystica in this patient, particularly our treatment with gemcitabine and c...
Source: Canadian Journal of Urology - December 17, 2023 Category: Urology & Nephrology Authors: Kerith R Wang Rishabh K Simhal Gabriel G Dinatale Li Li Thenappan Chandrasekar Source Type: research
Re: Pentosan polysulfate and a pigmentary maculopathy: causation versus correlation?
Can J Urol. 2023 Dec;30(6):11740.ABSTRACTHow should a conscientious physician advise patients with Interstitial Cystitis /Bladder Pain Syndrome (IC/BPS) when they want to know if taking Pentosan Polysulfate Sodium (PPS) will lead to loss of vision? Ever since the initial report from Pearce et al in 2018 suggesting that PPS usage can lead to the development of pigmented maculopathy (PM), my patients have been inundated with solicitations from attorneys looking to sign up clients for class action lawsuits.1 While there have been additional reports suggesting a relationship between PPS exposure and the development of PM, Ludw...
Source: Canadian Journal of Urology - December 17, 2023 Category: Urology & Nephrology Authors: Robert J Evans Raymond Xu Source Type: research
Pentosan polysulfate and a pigmentary maculopathy: causation versus correlation?
CONCLUSIONS: After an analysis of the literature describing a pigmentary maculopathy in IC patients on long term PPS, a causal relationship does not appear to be present. An alternate model is proposed postulating that the causative factor for the pigmentary maculopathy is the underlying inflammatory state associated with IC and not PPS use.PMID:38104330 (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - December 17, 2023 Category: Urology & Nephrology Authors: Jeffrey G Proctor Source Type: research
Recurring cystitis cystica and cystitis glandularis masquerading as urothelial carcinoma
We report a rare case of cystitis cystica and glandularis mimicking low-grade urothelial carcinoma that was found incidentally and treated with resection and fulguration via transurethral resection of bladder tumor (TURBT). When early recurrence was found on surveillance cystoscopy 3 months later, the patient was treated with repeat TURBT and intravesical gemcitabine. Surveillance cystoscopy 4 months later revealed cystitis cystica and cystitis glandularis yet again. We highlight the diagnosis and management of multiple early recurrences of cystitis cystica in this patient, particularly our treatment with gemcitabine and c...
Source: Canadian Journal of Urology - December 17, 2023 Category: Urology & Nephrology Authors: Kerith R Wang Rishabh K Simhal Gabriel G Dinatale Li Li Thenappan Chandrasekar Source Type: research
Re: Pentosan polysulfate and a pigmentary maculopathy: causation versus correlation?
Can J Urol. 2023 Dec;30(6):11740.ABSTRACTHow should a conscientious physician advise patients with Interstitial Cystitis /Bladder Pain Syndrome (IC/BPS) when they want to know if taking Pentosan Polysulfate Sodium (PPS) will lead to loss of vision? Ever since the initial report from Pearce et al in 2018 suggesting that PPS usage can lead to the development of pigmented maculopathy (PM), my patients have been inundated with solicitations from attorneys looking to sign up clients for class action lawsuits.1 While there have been additional reports suggesting a relationship between PPS exposure and the development of PM, Ludw...
Source: Canadian Journal of Urology - December 17, 2023 Category: Urology & Nephrology Authors: Robert J Evans Raymond Xu Source Type: research
Pentosan polysulfate and a pigmentary maculopathy: causation versus correlation?
CONCLUSIONS: After an analysis of the literature describing a pigmentary maculopathy in IC patients on long term PPS, a causal relationship does not appear to be present. An alternate model is proposed postulating that the causative factor for the pigmentary maculopathy is the underlying inflammatory state associated with IC and not PPS use.PMID:38104330 (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - December 17, 2023 Category: Urology & Nephrology Authors: Jeffrey G Proctor Source Type: research
Recurring cystitis cystica and cystitis glandularis masquerading as urothelial carcinoma
We report a rare case of cystitis cystica and glandularis mimicking low-grade urothelial carcinoma that was found incidentally and treated with resection and fulguration via transurethral resection of bladder tumor (TURBT). When early recurrence was found on surveillance cystoscopy 3 months later, the patient was treated with repeat TURBT and intravesical gemcitabine. Surveillance cystoscopy 4 months later revealed cystitis cystica and cystitis glandularis yet again. We highlight the diagnosis and management of multiple early recurrences of cystitis cystica in this patient, particularly our treatment with gemcitabine and c...
Source: Canadian Journal of Urology - December 17, 2023 Category: Urology & Nephrology Authors: Kerith R Wang Rishabh K Simhal Gabriel G Dinatale Li Li Thenappan Chandrasekar Source Type: research
Re: Pentosan polysulfate and a pigmentary maculopathy: causation versus correlation?
Can J Urol. 2023 Dec;30(6):11740.ABSTRACTHow should a conscientious physician advise patients with Interstitial Cystitis /Bladder Pain Syndrome (IC/BPS) when they want to know if taking Pentosan Polysulfate Sodium (PPS) will lead to loss of vision? Ever since the initial report from Pearce et al in 2018 suggesting that PPS usage can lead to the development of pigmented maculopathy (PM), my patients have been inundated with solicitations from attorneys looking to sign up clients for class action lawsuits.1 While there have been additional reports suggesting a relationship between PPS exposure and the development of PM, Ludw...
Source: Canadian Journal of Urology - December 17, 2023 Category: Urology & Nephrology Authors: Robert J Evans Raymond Xu Source Type: research
