Immune reconstitution in children after haploidentical haematopoietic stem cell transplantation
CONCLUSION: Paediatric patients who undergo haploidentical HSCT with PTCy are likely to have delayed IR and an increased risk of viral reactivation/infection compared with HLA-matched HSCT. The addition of ATG to PTCy delayed T cell recovery and increased risk of BKV reactivation.PMID:38646695 | DOI:10.1111/ijlh.14290 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - April 22, 2024 Category: Hematology Authors: Saranthorn Apasuthirat Nopporn Apiwattanakul Usanarat Anurathapan Nintita Sripaiboonkij Thokanit Karan Paisooksantivatana Ekawat Pasomsub Suradej Hongeng Samart Pakakasama Source Type: research
Immune reconstitution in children after haploidentical haematopoietic stem cell transplantation
CONCLUSION: Paediatric patients who undergo haploidentical HSCT with PTCy are likely to have delayed IR and an increased risk of viral reactivation/infection compared with HLA-matched HSCT. The addition of ATG to PTCy delayed T cell recovery and increased risk of BKV reactivation.PMID:38646695 | DOI:10.1111/ijlh.14290 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - April 22, 2024 Category: Hematology Authors: Saranthorn Apasuthirat Nopporn Apiwattanakul Usanarat Anurathapan Nintita Sripaiboonkij Thokanit Karan Paisooksantivatana Ekawat Pasomsub Suradej Hongeng Samart Pakakasama Source Type: research
Randomized clinical trial of non-antibiotic prophylaxis with d-Mannose plus Proanthocyanidins vs. Proanthocyanidins alone for urinary tract infections and asymptomatic bacteriuria in de novo kidney transplant recipients: The Manotras study
CONCLUSIONS: Non-antibiotic therapy is an unmet need to prevent UTI after kidney transplantation; however, the use of d-Mannose plus PAC does not seem capable to prevent it.PMID:38637262 | DOI:10.1016/j.nefroe.2024.02.011 (Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia)
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - April 18, 2024 Category: Urology & Nephrology Authors: Melissa Rau Adrian Santelli Sara Mart í Mar ía Isabel Díaz Nuria Sab é Mar ía Fiol Luis Riera Bego ña Etcheverry Sergi Codina Ana Coloma Anna Carreras-Salinas Carmen Ardanuy Josep M Cruzado Edoardo Melilli Source Type: research
Cystitis glandularis with concomitant Crohn ’s disease leading to a paroxysm of Crohn’s disease with ulcerated external iliac vessels
•we report the case of a 36-year-old female patient who presented to our hospital with a diagnosis of cystitis glandularis manifesting as a vesicovaginal fistula. She underwent cystoscopic biopsy at a local ho... (Source: BMC Urology)
Source: BMC Urology - April 17, 2024 Category: Urology & Nephrology Authors: Wu Ronghua, Zheng Ji, Liu Gang, Zhang Yun and Nie Xubiao Tags: Case Report Source Type: research
Hemorrhagic cystitis induced by JC polyomavirus infection following COVID-19: a case report
JC polyomavirus (JCPyV) is a human polyomavirus that can establish lifelong persistent infection in the majority of adults. It is typically asymptomatic in immunocompetent individuals. However, there is a risk... (Source: BMC Urology)
Source: BMC Urology - April 16, 2024 Category: Urology & Nephrology Authors: Yuanjie Lv and Xiaoping Liu Tags: Case Report Source Type: research
Impact of BK polyomavirus viremia on the outcomes of allogeneic hematopoietic stem cell transplantation
AbstractAlthough it is known that BK polyomavirus (BKPyV) causes hemorrhagic cystitis (HC) after allogeneic hematopoietic stem cell transplantation (HSCT), the clinical significance of BKPyV viremia has not been fully evaluated. We retrospectively analyzed the results of quantitative polymerase chain reaction (PCR) evaluations for detecting BKPyV in the whole blood samples of patients undergoing allogeneic HSCT during the period from January 2010 to June 2020 at a single institute, Tokyo Medical and Dental University. BKPyV was detected in the blood of 28 of the 107 evaluated patients, and the cumulative incidence of was 2...
Source: Annals of Hematology - April 12, 2024 Category: Hematology Source Type: research
Experimental Animal Models for IC/BPS
AbstractPurpose of ReviewInterstitial cystitis/bladder pain syndrome (IC/BPS) is a disease that causes bladder symptoms such as pelvic pain and frequent urination and is often an intractable disease affecting a patient ’s quality of life. The etiology of IC/BPS remains elusive, and treatment strategies are still not fully established. To better understand the underlying pathophysiology, many studies have strived to recreate an animal model of IC/BPS to help further expand the treatment options of this difficult disease.Recent FindingsBasic animal studies of IC/BPS have often been conducted by provoking inflammation in th...
Source: Current Bladder Dysfunction Reports - April 12, 2024 Category: Urology & Nephrology Source Type: research
POU2F3-expressing intraepithelial small-cell carcinoma with mixed small-cell carcinoma and conventional-type urothelial carcinoma of the urinary bladder
AbstractBased on lineage-specific transcription factors, small-cell neuroendocrine carcinoma (SmCC) of the urinary bladder has recently been subtyped into three molecular subtypes: ASCL1, NEUROD1 and POU2F3. The latter is a master transcriptional regulator of tuft cells (TCs) which are rare solitary cells found in various mucosal epithelia such as the gastrointestinal tract, but which have not been reported in the bladder. The POU2F3 subtype shows low or absent neuroendocrine marker expression. A case of mixed SmCC and conventional-type urothelial carcinoma (CUC) of the urinary bladder with POU2F3-expressing intraepithelia...
Source: Virchows Archiv - April 11, 2024 Category: Pathology Source Type: research
Antibiotic-Sparing Prevention of Urinary Tract Infections
Approximately half of women experience a urinary tract infection (UTI) in their lifetime, and at least 1 in 4 women who experience an initial episode of UTI go on to have a recurrent infection. While antibiotics are the mainstay of treatment for isolated episodes of cystitis as well as suppression of recurrent episodes, much effort has been directed at identifying potential antibiotic-sparing strategies to prevent recurrent UTIs due to concern about the rise of antimicrobial-resistant organisms and adverse effects associated with antibiotics. Although guidelines from professional societies encourage the use of vaginal estr...
Source: JAMA Internal Medicine - April 8, 2024 Category: Internal Medicine Source Type: research
Prolonged suppressive antibiotic therapy for inferior vena cava filter infection following emphysematous pyelonephritis and cystitis: a case report
CONCLUSION: Infections of implanted devices, such as IVC filters, secondary to severe infections can cause persistent bacteremia. PSAT may be an alternative option to treat IVC filter infection, when the IVC filter is considered difficult to remove.PMID:38576969 | PMC:PMC10990323 | DOI:10.1097/MS9.0000000000001886 (Source: Annals of Medicine)
Source: Annals of Medicine - April 5, 2024 Category: Internal Medicine Authors: Yasuhiro Suzuki Akira Kuriyama Source Type: research
The Critical Role of Intracellular Bacterial Communities in Uncomplicated Recurrent Urinary Cystitis: A Comprehensive Review of Detection Methods and Diagnostic Potential
Int Neurourol J. 2024 Mar;28(1):4-10. doi: 10.5213/inj.2448066.033. Epub 2024 Mar 31.ABSTRACTUrinary tract infections (UTIs) are among the most common bacterial infections worldwide and are particularly prevalent in women. Recurrent UTIs significantly diminish quality of life due to their symptoms and frequent relapses. Patients often experience immediate relapse following slightly strenuous activities or intense psychological stress. In this review, we explore why infections persist despite the advent of various treatments and suggest strategies to manage recurrent cystitis by targeting the mechanisms of adhesion and infe...
Source: International Neurourology Journal - April 3, 2024 Category: Urology & Nephrology Authors: Yeonjoo Kwak Hyeong Gon Kim Jaekwon Seok Sehwan Kim Eun-Mee Kim Aram Kim Source Type: research
