Chronic Eosinophilic Cystitis: Up to Date Evidence Review
AbstractPurpose of ReviewEosinophilic cystitis is a rare condition of unknown etiology. However, many factors can trigger such pathology, its symptoms may mimic many other clinical situations. In this article, the author is aiming to illustrate and summarize the up-to-date evidence about this disorder.Recent FindingsThe latest published evidence about eosinophilic cystitis was reviewed and data about different triggers was collected. Different treatment modalities ranging from medications such as steroids to surgical interventions were mentioned in this review.SummaryThere are different recommended treatments owing to diff...
Source: Current Bladder Dysfunction Reports - February 1, 2024 Category: Urology & Nephrology Source Type: research
The Impact of Sulfa Allergy Label on Clinical Outcomes of Patients with Acute Cystitis
Sulfonamide (sulfa) allergy is the second most common allergy label in electronic health records. The impact of having sulfa allergy on clinical outcomes is not yet characterized. We investigate the impact of Sulfa allergy labels in patients with acute cystitis. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Ray Moussa, Taha Al-Shaikhly Source Type: research
Single Cell Rnaseq Identifies Chemokine Responses to BK Polyomavirus Infection and Novel Contribution of MAIT Cells
In this study, we hypothesized that differences in endothelial cell and host immune responses to BKPyV viremia influence BKPyV disease. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Nathan Luebbering, Sheyar Abdullah, Krishna Roskin, Aaron Webster, Jason T Blackard, Elizabeth Odegard, Benjamin Laskin, Alix E. Seif, Sonata Jodele, Stella M. Davies, Dr. Anthony Sabulski Tags: 100 Source Type: research
Riding the Wave: Risk Factors for Acute Kidney Injury in Patients Receiving Ptcy with Hyperhydration
Post-transplant cyclophosphamide has gained widespread use as GVHD prophylaxis due to superior outcomes in overall survival as well as decreased rate of acute and chronic GVHD as compared to ATG and methotrexate-based GVHD prophylaxis. To avoid the risk of hemorrhagic cystitis associated with cyclophosphamide, various hyperhydration protocols have been used to dilute acrolein, the toxic metabolite excreted in the urine. These protocols vary from 3-6L of IV hydration per day +/- diuresis and may carry risk of volume overload and renal . (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Anne Wofford, Mrs. Rebecca Jennings, Rakhee Vaidya, Mary B Seegars, Sarada Krishnamurthy, Jonathan Lambird, Dianna S. Howard Tags: 221 Source Type: research
Incidence and Nature of BK and Adenovirus Infections in Post-Transplant Cyclophosphamide-Based Adult Allogeneic Hematopoietic Cell Transplant
Post-transplantation cyclophosphamide (PTCy) has been widely adopted to reduce graft-vs-host disease (GvHD) sufficiently to permit HLA haplotype disparate allogeneic hematopoietic cell transplantation (HCT). PTCy has been associated with increased risk of viral infections. Our objectives were to evaluate the frequency& severity of viremia and hemorrhagic cystitis (HC) due to adenovirus (ADV) and BK polyoma virus (BKV) and the associated mortality by day 180 post-HCT (D180) in a large single institution cohort of adult patients (pts) who received PTCy. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Parastoo B. Dahi, Yuxuan Li, Brian C. Shaffer, Boglarka Gyurkocza, Han Gyuri, Ann A. Jakubowski, Yeon Joo Lee, Dr. Richard J. Lin, Esperanza B. Papadopoulos, Ioannis Politikos, Gunjan L. Shah, Roni Tamari, Miguel-Angel Perales, Sergio A. Giralt, Genovefa Tags: 615 Source Type: research
Continuous Infusion Vs Intermittent Bolus Mesna with Post-Transplant Cyclophosphamide Following Hematopoietic Stem Cell Transplantation
Post-transplant cyclophosphamide (PTCy) is an effective strategy used in the prevention of graft-vs-host-disease (GVHD) during hematopoietic stem cell transplantation (HCT). Hemorrhagic cystitis (HC) is a major complication associated with high-dose cyclophosphamide in 10-40% of patients [Urology; 100:16-19]. Sodium 2-mercaptoethanesulfonate (MESNA) binds and inactivates acrolein in the urinary tract, preventing tissue injury. While international guidelines endorse MESNA, there is no consensus regarding the optimal method of administration with high-dose cyclophosphamide (J Clin Oncol.2002;20:2895 –2903). (Source: Biolog...
Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Lindsay Orton, Katie S. Gatwood, Eden Biltibo, Andrew Jallouk, James H. Jerkins, Reena V Jayani, Dr. Bhagirathbhai Dholaria, Tae K Kon Kim, Bipin N. Savani, Leena Choi, Elizabeth McNeer, Adetola A. Kassim Tags: 149 Source Type: research
Pelvic Floor Therapy and Initial Interventions for Pelvic Floor Dysfunction in Gynecologic Malignancies
AbstractPurpose of ReviewThis review provides evidence-based updates for the first-line management approaches for pelvic floor disorders in patients with gynecologic malignancies, as well as important provider considerations when referring for pelvic floor physical therapy.Recent FindingsCurrently, there is strong evidence to recommend pelvic floor muscle training as initial treatment for urinary incontinence and for pelvic organ prolapse; some evidence to recommend a more targeted pelvic floor muscle training program for fecal incontinence; and mostly expertise-based evidence to recommend vaginal gels or estrogen to aid w...
Source: Current Oncology Reports - January 31, 2024 Category: Cancer & Oncology Source Type: research
Concomitant Use of Sodium-Glucose Cotransporter 2 Inhibitors and Overactive Bladder Drugs and the Risk of Urinary Tract Infection
This study found a similar risk of UTIs in concomitant users of SGLT-2i and DPP-4i (weighted HR 1.08, 95% confidence interval: 0.88-1.32) with OAB drugs. In the second cohort, 2,387 and 280 new-users of SGLT-2i and GLP-1RA with OAB drugs were identified, respectively. Initiation of SGLT-2i while on OAB treatment was not associated with increased risk of UTI (0.89, 0.50-1.60), compared with initiation of GLP-1RA. These results show that the concomitant use of SGLT-2i with OAB drugs was not associated with an increased risk of UTI compared with the concomitant use of DPP-4i or GLP-1RA with OAB drugs.PMID:38284421 | DOI:10.10...
Source: Clinical Pharmacology and Therapeutics - January 29, 2024 Category: Drugs & Pharmacology Authors: Sungho Bea Hyesung Lee Sohee Park Young Min Cho Won Suk Choi Katsiaryna Bykov Ju-Young Shin Source Type: research
Hypertension and urologic chronic pelvic pain syndrome: An analysis of MAPP-I data
Urologic chronic pelvic pain syndrome (UCPPS), which includes interstitial cystitis/bladder pain syndrome (IC/BPS) and chronic prostatitis (CP/CPPS), is associated with increased voiding frequency, nocturia, a... (Source: BMC Urology)
Source: BMC Urology - January 28, 2024 Category: Urology & Nephrology Authors: Rosalynn R.Z. Conic, Terrie Vasilopoulos, Karthik Devulapally, Rene Przkora, Andrew Dubin, Kimberly T. Sibille and Aaron D. Mickle Tags: Research Source Type: research
β-Sitosterol Alleviates the Proliferation and Migration of Cystitis Glandularis-Associated Cells by Targeting HMGCR to Induce NLRP3-Dependent Pyroptosis
CONCLUSIONS: β-sitosterol alleviates the proliferation and migration of CG-associated cells by targeting HMGCR to induce NLRP3-dependent pyroptosis. These findings confirmed the therapeutic effect of β-sitosterol on treating CG.PMID:38273755 | DOI:10.24976/Discov.Med.202436180.14 (Source: Discovery Medicine)
Source: Discovery Medicine - January 26, 2024 Category: Research Authors: Dandan Qiu Lingling Gao Shuo Zhang Yan Zhu Gang Lin Source Type: research
