Riding the Wave: Risk Factors for Acute Kidney Injury in Patients Receiving Ptcy with Hyperhydration

Post-transplant cyclophosphamide has gained widespread use as GVHD prophylaxis due to superior outcomes in overall survival as well as decreased rate of acute and chronic GVHD as compared to ATG and methotrexate-based GVHD prophylaxis. To avoid the risk of hemorrhagic cystitis associated with cyclophosphamide, various hyperhydration protocols have been used to dilute acrolein, the toxic metabolite excreted in the urine. These protocols vary from 3-6L of IV hydration per day +/- diuresis and may carry risk of volume overload and renal .
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 221 Source Type: research