Incidence and Nature of BK and Adenovirus Infections in Post-Transplant Cyclophosphamide-Based Adult Allogeneic Hematopoietic Cell Transplant

Post-transplantation cyclophosphamide (PTCy) has been widely adopted to reduce graft-vs-host disease (GvHD) sufficiently to permit HLA haplotype disparate allogeneic hematopoietic cell transplantation (HCT). PTCy has been associated with increased risk of viral infections. Our objectives were to evaluate the frequency& severity of viremia and hemorrhagic cystitis (HC) due to adenovirus (ADV) and BK polyoma virus (BKV) and the associated mortality by day 180 post-HCT (D180) in a large single institution cohort of adult patients (pts) who received PTCy.

Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Parastoo B. Dahi, Yuxuan Li, Brian C. Shaffer, Boglarka Gyurkocza, Han Gyuri, Ann A. Jakubowski, Yeon Joo Lee, Dr. Richard J. Lin, Esperanza B. Papadopoulos, Ioannis Politikos, Gunjan L. Shah, Roni Tamari, Miguel-Angel Perales, Sergio A. Giralt, Genovefa Tags: 615 Source Type: research