Use of osteopathic manipulative treatment for low back pain patients with and without pain medication history.
Conclusion: Both groups showed significant decreases in overall pain, and this similar effect in each group may indicate a lack of need for medications when OMT is used. Additional research on efficacy of OMT in this patient population is needed with larger, multicenter, randomized trials.
PMID: 33512387 [PubMed - as supplied by publisher] (Source: Journal of the American Osteopathic Association)
Source: Journal of the American Osteopathic Association - January 30, 2021 Category: Complementary Medicine Tags: J Am Osteopath Assoc Source Type: research
Storage of urine specimens in point of care (POC) urine drug testing cups reduces concentrations of many drugs
ConclusionExposure of urine specimens to POC urine drug testing strips reduces the concentration of several drugs measured by LCMS method. (Source: Clinica Chimica Acta)
Source: Clinica Chimica Acta - September 4, 2019 Category: Laboratory Medicine Source Type: research
Storage of urine specimens in point of care (POC) urine drug testing cups reduces concentrations of many drugs.
CONCLUSION: Exposure of urine specimens to POC urine drug testing strips reduces the concentration of several drugs measured by LCMS method.
PMID: 31491368 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - September 2, 2019 Category: Chemistry Authors: Haidari M, Mansani S, Ponds D, Romero L, Cobb C, Alsaab S Tags: Clin Chim Acta Source Type: research
The Prevalence of Beers Criteria Medication Use and Associations with Falls in Geriatric Patients at a Level 1 Trauma Center.
Abstract
The Beers Criteria for Potentially Inappropriate Medication (PIM) use is a list of medications with multiple risks in older patients. Approximately 24 per cent use rate is reported in prior studies. Our objective was to determine the local PIM use and subsequent fall risk in geriatric trauma patients. We conducted a retrospective analysis of PIM use in all geriatric patients evaluated at our Level 1 trauma center between 2014 and 2017. Patients were identified from our trauma database. Pre-admission medication use was determined through medication reconciliation from our electronic medical record ...
Source: The American Surgeon - July 31, 2019 Category: Surgery Authors: Walker BS, Collier BR, Bower KL, Lollar DI, Faulks ER, Matos M, Nussbaum MS, Hamill ME Tags: Am Surg Source Type: research
Late stage Pd-catalyzed C-H bond functionalization: A powerful tool for the one step access to arylated Cyproheptadine and cyclobenzaprine derivatives
Publication date: September 2019Source: Catalysis Communications, Volume 129Author(s): Dhieb Atoui, Haoran Li, Ridha Ben Salem, Thierry Roisnel, Elsa Caytan, Jean-François Soulé, Henri DoucetAbstractThe reactivity of Cyproheptadine and Cyclobenzaprine in Pd-catalyzed arylation via C-H bond functionalizations was investigated. From Cyproheptadine using aryl bromides as aryl sources and 5 mol% of a palladium catalyst, the C10-arylated Cyproheptadine derivatives were regioselectively obtained. The highest yields were obtained with electron-rich aryl bromides, but the reaction tolerated useful functional groups on the aryl...
Source: Catalysis Communications - July 24, 2019 Category: Chemistry Source Type: research
Green analytical chromatographic assay method for quantitation of cyclobenzaprine in tablets, spiked human urine and in-vitro dissolution test.
Abstract
Cyclobenzaprine hydrochloride, a skeletal muscle relaxant has been determined using an ecofriendly micellar HPLC method in its pure form and tablets. The chromatographic determination was performed using C8 monolithic column (100mm×4.6mm i.d., 5μm particle size) and micellar eluent which was composed of sodium dodecyl sulfate (0.15M), n-propanol (15%), 0.02M orthophosphoric acid (pH 4.5) and 0.3% triethylamine using UV detection of effluent was set at 225nm. The calibration plot showed good linearity over concentration range from 2-40μg/mL. The assay results were statistically validated for lin...
Source: Annales Pharmaceutiques Francaises - July 7, 2019 Category: Drugs & Pharmacology Authors: Walash MI, El Abass Mohamed SA Tags: Ann Pharm Fr Source Type: research
Late stage Pd-catalyzed CH bond functionalization: A powerful tool for the one step access to arylated Cyproheptadine and cyclobenzaprine derivatives
Publication date: Available online 29 May 2019Source: Catalysis CommunicationsAuthor(s): Dhieb Atoui, Haoran Li, Ridha Ben Salem, Thierry Roisnel, Elsa Caytan, Jean-François Soulé, Henri DoucetAbstractThe reactivity of Cyproheptadine and Cyclobenzaprine in Pd-catalyzed arylation via CH bond functionalizations was investigated. From Cyproheptadine using aryl bromides as aryl sources and 5 mol% of a palladium catalyst, the C10-arylated Cyproheptadine derivatives were regioselectively obtained. The highest yields were obtained with electron-rich aryl bromides, but the reaction tolerated useful functional groups on the ary...
Source: Catalysis Communications - May 29, 2019 Category: Chemistry Source Type: research
Evaluation of the impact of preoperative use of dexamethasone and cyclobenzaprine in surgical extraction of lower third molars on trismus by electromyographic analysis
ConclusionThe results suggest that dexamethasone and cyclobenzaprine may be useful as an adjuvant in the prevention of motor dysfunctions in third molar surgery. (Source: Oral and Maxillofacial Surgery)
Source: Oral and Maxillofacial Surgery - May 21, 2019 Category: ENT & OMF Source Type: research
Compounded Topical Pain Creams to Treat Localized Chronic Pain: A Randomized Controlled Trial.
Conclusion: Compounded pain creams were not better than placebo creams, and their higher costs compared with approved compounds should curtail routine use.
Primary Funding Source: Centers for Rehabilitation Sciences Research, Defense Health Agency, U.S. Department of Defense.
PMID: 30716769 [PubMed - as supplied by publisher] (Source: Pain Physician)
Source: Pain Physician - February 5, 2019 Category: Anesthesiology Authors: Brutcher RE, Kurihara C, Bicket MC, Moussavian-Yousefi P, Reece DE, Solomon LM, Griffith SR, Jamison DE, Cohen SP Tags: Ann Intern Med Source Type: research
Induction of Psychosis by Cyclobenzaprine.
We report a case of psychosis induced by exposure to a commonly prescribed drug to treat muscle spasms and associated pain cyclobenzaprine (Flexeril®). Cyclobenzaprine is structurally very similar to tricyclic anti-depressants, such as amyltriptine. While it is well known that agitation caused by cyclobenzaprine is not an uncommon occurrence in the elderly, there have also been sporadic reports of significant psychosis in association with the use of cyclobenzaprine in younger patients. We report a case of reversible mania in a susceptible 44-year-old patient with a lengthy history of mild borderline personality and bipola...
Source: Psychopharmacology Bulletin - January 9, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research
Investigative Drug Compounds/Therapies
*Differential treatment effects of TNX- 102 SL, a sublingual formulation of cyclobenzaprine, on dissociative symptoms of derealization and depersonalization in a military-related PTSD population: retrospective analysis of a double-blind randomized study** Presenters: Sullivan GM Affiliations: Tonix Pharmaceuticals, Inc Objective: Dissociative symptoms are associated with trauma disorders including posttraumatic stress disorder (PTSD). This is retrospective analysis […]
The post Investigative Drug Compounds/Therapies appeared first on Innovations in Clinical Neuroscience. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - October 26, 2018 Category: Neuroscience Tags: Adverse Events in Psychiatry Brief Report Source Type: research
Co-prescription of Strong CYP1A2 Inhibitors and the Risk of Tizanidine-Associated Hypotension: A Retrospective Cohort Study.
In conclusion, CYP1A2 inhibition increases the risk of hypotensive episodes associated with the use of tizanidine in routine clinical practice. This article is protected by copyright. All rights reserved.
PMID: 30223305 [PubMed - as supplied by publisher] (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - September 17, 2018 Category: Drugs & Pharmacology Authors: Chaugai S, Dickson AL, Shuey MM, Feng Q, Barker KA, Wei WQ, Luther JM, Stein CM, Chung CP Tags: Clin Pharmacol Ther Source Type: research
