Temporomandibular Disorders: Rapid Evidence Review
Am Fam Physician. 2023 Jan;107(1):52-58.ABSTRACTTemporomandibular disorders affect between 5% and 12% of the population and present with symptoms such as headache, bruxism, pain at the temporomandibular joint, jaw popping or clicking, neck pain, tinnitus, dizziness, decreased hearing, and hyperacuity to sound. Common signs on physical examination include tenderness of the pterygoid muscles, temporomandibular joints, and temporalis muscles, and malocclusion of the jaw and crepitus. The diagnosis is based on history and physical examination; however, use of computed tomography or magnetic resonance imaging is recommended if ...
Source: American Family Physician - January 23, 2023 Category: Primary Care Authors: Eric M Matheson Joli D Fermo Russell S Blackwelder Source Type: research
Temporomandibular Disorders: Rapid Evidence Review
Am Fam Physician. 2023 Jan;107(1):52-58.ABSTRACTTemporomandibular disorders affect between 5% and 12% of the population and present with symptoms such as headache, bruxism, pain at the temporomandibular joint, jaw popping or clicking, neck pain, tinnitus, dizziness, decreased hearing, and hyperacuity to sound. Common signs on physical examination include tenderness of the pterygoid muscles, temporomandibular joints, and temporalis muscles, and malocclusion of the jaw and crepitus. The diagnosis is based on history and physical examination; however, use of computed tomography or magnetic resonance imaging is recommended if ...
Source: American Family Physician - January 23, 2023 Category: Primary Care Authors: Eric M Matheson Joli D Fermo Russell S Blackwelder Source Type: research
Temporomandibular Disorders: Rapid Evidence Review
Am Fam Physician. 2023 Jan;107(1):52-58.ABSTRACTTemporomandibular disorders affect between 5% and 12% of the population and present with symptoms such as headache, bruxism, pain at the temporomandibular joint, jaw popping or clicking, neck pain, tinnitus, dizziness, decreased hearing, and hyperacuity to sound. Common signs on physical examination include tenderness of the pterygoid muscles, temporomandibular joints, and temporalis muscles, and malocclusion of the jaw and crepitus. The diagnosis is based on history and physical examination; however, use of computed tomography or magnetic resonance imaging is recommended if ...
Source: Pain Physician - January 23, 2023 Category: Anesthesiology Authors: Eric M Matheson Joli D Fermo Russell S Blackwelder Source Type: research
Temporomandibular Disorders: Rapid Evidence Review
Am Fam Physician. 2023 Jan;107(1):52-58.ABSTRACTTemporomandibular disorders affect between 5% and 12% of the population and present with symptoms such as headache, bruxism, pain at the temporomandibular joint, jaw popping or clicking, neck pain, tinnitus, dizziness, decreased hearing, and hyperacuity to sound. Common signs on physical examination include tenderness of the pterygoid muscles, temporomandibular joints, and temporalis muscles, and malocclusion of the jaw and crepitus. The diagnosis is based on history and physical examination; however, use of computed tomography or magnetic resonance imaging is recommended if ...
Source: American Family Physician - January 23, 2023 Category: Primary Care Authors: Eric M Matheson Joli D Fermo Russell S Blackwelder Source Type: research
Temporomandibular Disorders: Rapid Evidence Review
Am Fam Physician. 2023 Jan;107(1):52-58.ABSTRACTTemporomandibular disorders affect between 5% and 12% of the population and present with symptoms such as headache, bruxism, pain at the temporomandibular joint, jaw popping or clicking, neck pain, tinnitus, dizziness, decreased hearing, and hyperacuity to sound. Common signs on physical examination include tenderness of the pterygoid muscles, temporomandibular joints, and temporalis muscles, and malocclusion of the jaw and crepitus. The diagnosis is based on history and physical examination; however, use of computed tomography or magnetic resonance imaging is recommended if ...
Source: American Family Physician - January 23, 2023 Category: Primary Care Authors: Eric M Matheson Joli D Fermo Russell S Blackwelder Source Type: research
Energy metabolism as a target for cyclobenzaprine: A drug candidate against Visceral Leishmaniasis
This study aimed to define the role of energy metabolism as a target for the leishmanicidal mechanisms of CBP. Methodology to assess CBP leishmanicidal mechanism variation of intracellular ATP levels using living Leishmania transfected with a cytoplasmic luciferase. Induction of plasma membrane permeability by assessing depolarization with DiSBAC(2)3 and entrance of the vital dye SYTOX® Green. Mitochondrial depolarization by rhodamine 123 accumulation. Mapping target site within the respiratory chain by oxygen consumption rate. Reactive oxygen species (ROS) production using MitoSOX. Morphological changes by transmission e...
Source: Bioorganic Chemistry - July 16, 2022 Category: Chemistry Authors: Marta Lopes Lima Maria A Abeng ózar Eduardo Caio Torres-Santos Samanta Etel Treiger Borborema Joanna Godzien Ángeles López-Gonzálvez Coral Barbas Luis Rivas Andre Gustavo Tempone Source Type: research
Energy metabolism as a target for cyclobenzaprine: A drug candidate against Visceral Leishmaniasis
This study aimed to define the role of energy metabolism as a target for the leishmanicidal mechanisms of CBP. Methodology to assess CBP leishmanicidal mechanism variation of intracellular ATP levels using living Leishmania transfected with a cytoplasmic luciferase. Induction of plasma membrane permeability by assessing depolarization with DiSBAC(2)3 and entrance of the vital dye SYTOX® Green. Mitochondrial depolarization by rhodamine 123 accumulation. Mapping target site within the respiratory chain by oxygen consumption rate. Reactive oxygen species (ROS) production using MitoSOX. Morphological changes by transmission e...
Source: Bioorganic Chemistry - July 16, 2022 Category: Chemistry Authors: Marta Lopes Lima Maria A Abeng ózar Eduardo Caio Torres-Santos Samanta Etel Treiger Borborema Joanna Godzien Ángeles López-Gonzálvez Coral Barbas Luis Rivas Andre Gustavo Tempone Source Type: research
Examination of multiple drug arrests reported to the Maine Diversion Alert Program
ConclusionThe misuse of opioids, both alone and in conjunction with another drug, deserves continued surveillance. In addition, common prescription drugs with less appreciated misuse potential, especially carisoprodol, amitriptyline, and quetiapine, require greater attention for their ability to enhance the effects of other drugs. (Source: Forensic Science, Medicine, and Pathology)
Source: Forensic Science, Medicine, and Pathology - May 26, 2022 Category: Forensic Medicine Source Type: research
Does Virtual Reality Feedback at Infra-Low Frequency Improve Centralized Pain With Comorbid Insomnia While Mitigating Risks for Sedative Use Disorder?: A Case Report
This case report concerns a patient with clinically diagnosed moderate-severe insomnia secondary to chronic lower back pain and sciatica, previously treated with hydrocodone, naproxen, cyclobenzaprine and nightly diazepam. He underwent a trial of 20 sessions of virtual reality neurofeedback therapy (VR-NFB) at infra-low frequency, and by the end of 20 sessions achieved sustained analgesia and consequently, a complete resolution of his pain-related insomnia. Follow-up at 1 year confirmed his improvements were sustained, and he maintained his abstinence from sedatives, as observed on the Prescription Monitoring Program for c...
Source: Frontiers in Human Neuroscience - May 18, 2022 Category: Neuroscience Source Type: research
Examination of multiple drug arrests reported to the Maine Diversion Alert Program
ConclusionThe misuse of opioids, both alone and in conjunction with another drug, deserves continued surveillance. In addition, common prescription drugs with less appreciated misuse potential, especially carisoprodol, amitriptyline, and quetiapine, require greater attention for their ability to enhance the effects of other drugs. (Source: Forensic Science, Medicine, and Pathology)
Source: Forensic Science, Medicine, and Pathology - January 30, 2022 Category: Forensic Medicine Source Type: research
6-Nitrodopamine is an endogenous mediator of rat isolated epididymal vas deferens contractions induced by electric-field stimulation
Eur J Pharmacol. 2021 Oct 1:174544. doi: 10.1016/j.ejphar.2021.174544. Online ahead of print.ABSTRACT6-nitrodopamine (6-ND) is released from human umbilical cord vessels and modulates vascular reactivity by acting as a dopamine antagonist. Here we investigate whether 6-ND is released by the rat isolated vas deferens and its effect on this tissue. Dopamine, noradrenaline, adrenaline and 6-ND levels were quantified in rat isolated vas deferens by LC-MS-MS. Electric-field stimulation (EFS) and concentration-response curves to 6-ND, noradrenaline, dopamine and adrenaline were performed in the absence and in the presence (30 mi...
Source: European Journal of Pharmacology - October 4, 2021 Category: Drugs & Pharmacology Authors: Jos é Britto-Júnior Luiz Ximenes Andr é Ribeiro Adriano Fregonesi Rafael Campos Luiz Ricardo de Almeida Kiguti Fab íola Z Mónica Edson Antunes Gilberto De Nucci Source Type: research
Upper Extremity Superficial Vein Thromboses Presenting as Acute Neck Pain in a Young and Healthy Male: A Case Report
DISCUSSION: UESVT events are rare and can be challenging to identify. This case report describes a unique presentation of acute neck pain caused by underlying UESVTs in an otherwise healthy and active young male.LEVEL OF EVIDENCE: Level 4.PMID:34123537 | PMC:PMC8169024 | DOI:10.26603/001c.23429 (Source: Physical Therapy)
Source: Physical Therapy - June 14, 2021 Category: Physiotherapy Authors: Kristen L Zosel Max K Dummar Benjamin G Adams Nancy C Henderson Richard B Westrick Source Type: research
Upper Extremity Superficial Vein Thromboses Presenting as Acute Neck Pain in a Young and Healthy Male: A Case Report
DISCUSSION: UESVT events are rare and can be challenging to identify. This case report describes a unique presentation of acute neck pain caused by underlying UESVTs in an otherwise healthy and active young male.LEVEL OF EVIDENCE: Level 4.PMID:34123537 | PMC:PMC8169024 | DOI:10.26603/001c.23429 (Source: Physical Therapy)
Source: Physical Therapy - June 14, 2021 Category: Physiotherapy Authors: Kristen L Zosel Max K Dummar Benjamin G Adams Nancy C Henderson Richard B Westrick Source Type: research
Upper Extremity Superficial Vein Thromboses Presenting as Acute Neck Pain in a Young and Healthy Male: A Case Report
DISCUSSION: UESVT events are rare and can be challenging to identify. This case report describes a unique presentation of acute neck pain caused by underlying UESVTs in an otherwise healthy and active young male.LEVEL OF EVIDENCE: Level 4.PMID:34123537 | PMC:PMC8169024 | DOI:10.26603/001c.23429 (Source: Physical Therapy)
Source: Physical Therapy - June 14, 2021 Category: Physiotherapy Authors: Kristen L Zosel Max K Dummar Benjamin G Adams Nancy C Henderson Richard B Westrick Source Type: research
Surgical Treatment of Upper Extremity Segmental Myoclonus in an Adolescent with Chiari Malformation and Cervicothoracic Syrinx
We report a pediatric patient who presented with upper extremity myoclonus and was found to have CM-1 and a complex septated cervicothoracic syrinx eccentric to the left.Case Presentation: A 12-year-old female presented with 6 months of headaches and upper extremity paresthesias who subsequently developed a left upper extremity segmental myoclonus after a fall. MRI demonstrated a CM-1 and a large complex cervicothoracic syrinx with a midline and left paracentral cavities. Her myoclonus was nonepileptic and refractory to clonazepam, cyclobenzaprine, and gabapentin. She underwent an intradural Chiari decompression and durapl...
Source: Pediatric Neurosurgery - May 11, 2021 Category: Neurosurgery Source Type: research
