Rheumatology: What You May Have Missed in 2023
Ann Intern Med. 2024 Apr 16. doi: 10.7326/M24-0678. Online ahead of print.ABSTRACTMany patients with rheumatologic conditions receive care from physicians other than rheumatologists. Here we note key findings from 6 studies in rheumatology published in 2023 that offer valuable insights for internal medicine specialists and subspecialists outside of rheumatology. The first study investigated the effect of low-dose glucocorticoids on patients with rheumatoid arthritis (RA) over 2 years and challenged existing perceptions about the risks of glucocorticoids in this setting. The second study focused on the updated guideline for...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Kafaf Jalali Lisa A Mandl Source Type: research
Rheumatology: What You May Have Missed in 2023
Ann Intern Med. 2024 Apr 16. doi: 10.7326/M24-0678. Online ahead of print.ABSTRACTMany patients with rheumatologic conditions receive care from physicians other than rheumatologists. Here we note key findings from 6 studies in rheumatology published in 2023 that offer valuable insights for internal medicine specialists and subspecialists outside of rheumatology. The first study investigated the effect of low-dose glucocorticoids on patients with rheumatoid arthritis (RA) over 2 years and challenged existing perceptions about the risks of glucocorticoids in this setting. The second study focused on the updated guideline for...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Kafaf Jalali Lisa A Mandl Source Type: research
Rheumatology: What You May Have Missed in 2023
Ann Intern Med. 2024 Apr 16. doi: 10.7326/M24-0678. Online ahead of print.ABSTRACTMany patients with rheumatologic conditions receive care from physicians other than rheumatologists. Here we note key findings from 6 studies in rheumatology published in 2023 that offer valuable insights for internal medicine specialists and subspecialists outside of rheumatology. The first study investigated the effect of low-dose glucocorticoids on patients with rheumatoid arthritis (RA) over 2 years and challenged existing perceptions about the risks of glucocorticoids in this setting. The second study focused on the updated guideline for...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Kafaf Jalali Lisa A Mandl Source Type: research
Comparative Risk of Injury with Concurrent Use of Opioids and Skeletal Muscle Relaxants
In conclusion, the relative injury rate associated with different SMRs used concurrently with the three most dispensed opioids appears to vary depending on the specific opioid and the order of combination initiation. If confirmed by future studies, clinicians should consider the varying injury rates when prescribing SMRs to individuals using hydrocodone, oxycodone, and tramadol.PMID:38482733 | DOI:10.1002/cpt.3248 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - March 14, 2024 Category: Drugs & Pharmacology Authors: Cheng Chen Sean Hennessy Colleen M Brensinger Todd A Miano Warren B Bilker Sascha Dublin Sophie P Chung John R Horn Anika Tiwari Charles E Leonard Source Type: research
Comparative Risk of Injury with Concurrent Use of Opioids and Skeletal Muscle Relaxants
In conclusion, the relative injury rate associated with different SMRs used concurrently with the three most dispensed opioids appears to vary depending on the specific opioid and the order of combination initiation. If confirmed by future studies, clinicians should consider the varying injury rates when prescribing SMRs to individuals using hydrocodone, oxycodone, and tramadol.PMID:38482733 | DOI:10.1002/cpt.3248 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - March 14, 2024 Category: Drugs & Pharmacology Authors: Cheng Chen Sean Hennessy Colleen M Brensinger Todd A Miano Warren B Bilker Sascha Dublin Sophie P Chung John R Horn Anika Tiwari Charles E Leonard Source Type: research
On the Tip of Our Tongue: Sublingual Cyclobenzaprine and Fibromyalgia
South Med J. 2024 Mar;117(3):172-173. doi: 10.14423/SMJ.0000000000001645.NO ABSTRACTPMID:38428940 | DOI:10.14423/SMJ.0000000000001645 (Source: Southern Medical Journal)
Source: Southern Medical Journal - March 1, 2024 Category: General Medicine Authors: Malvika Lall Christopher D Jackson Source Type: research
Multifactorial Dependence of Muscle Relaxant Efficacy in Lower Back Pain
We read with interest the article by Abril et al., who reported a study on the efficacy of seven skeletal muscle relaxants (SMRs) for lower back pain (LBP) (1). Four randomized controlled trials were retrospectively pooled and analyzed together for efficacy and adverse-effect profiles of baclofen, metaxalone, tizanidine, diazepam, orphenadrin e, methocarbamol, and cyclobenzaprine compared with placebo and whether efficacy was related to age, sex, or baseline LBP-related functional impairment, as assessed by the Roland-Morris Disability Questionnaire (RMDQ) (1). (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - November 17, 2023 Category: Emergency Medicine Authors: Josef Finsterer, Fulvio A. Scorza Tags: Letter to the Editor Source Type: research
Pharmacologic Management of Cancer-Related Pain in Pregnant Patients
The objective of this review is to provide clinicians with an understanding of pain experienced by pregnant patients with cancer and medications that may be used to help manage cancer-related pain. Nociceptive pain results from damage to somatic or visceral tissues that may be directly caused by cancer. This type of pain can be managed in pregnant patients using acetaminophen and/or nonsteroidal antiinflammatory drugs as first-line agents. In nociceptive pain not managed by non-opioid analgesics, buprenorphine is recommended for those requiring chronic opioids to help manage their pain. Neuropathic pain that results from d...
Source: Drugs - June 22, 2023 Category: Drugs & Pharmacology Source Type: research
Baclofen and the Risk of Encephalopathy: A Real-World, Active-Comparator Cohort Study
To quantify the risk of encephalopathy associated with oral baclofen compared with other muscle relaxants —tizanidine or cyclobenzaprine. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 5, 2023 Category: Internal Medicine Authors: Y. Joseph Hwang, Alex R. Chang, Daniel J. Brotman, Lesley A. Inker, Morgan E. Grams, Jung-Im Shin Tags: Original Article Source Type: research
51-Year-Old Woman With Fever, Cough, and Myalgias
A 51-year-old woman presented to the emergency department (ED) during the summertime with a 2-day history of fever up to 39.2 °C, nonproductive cough, myalgias, and nausea without associated diarrhea or vomiting. Her medical comorbidities included nicotine dependence with a 20-pack-year smoking history, common variable immune deficiency, quiescent multiple sclerosis not receiving immunomodulatory therapy, heart failure wi th preserved ejection fraction, hypertension, and fibromyalgia. Medications at the time of presentation were nortriptyline, cyclobenzaprine, aspirin, and duloxetine. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - March 1, 2023 Category: Internal Medicine Authors: Jack McHugh, Ryan Khodadadi, Priya Sampathkumar Tags: Residents ’ clinic Source Type: research
Temporomandibular Disorders: Rapid Evidence Review
Am Fam Physician. 2023 Jan;107(1):52-58.ABSTRACTTemporomandibular disorders affect between 5% and 12% of the population and present with symptoms such as headache, bruxism, pain at the temporomandibular joint, jaw popping or clicking, neck pain, tinnitus, dizziness, decreased hearing, and hyperacuity to sound. Common signs on physical examination include tenderness of the pterygoid muscles, temporomandibular joints, and temporalis muscles, and malocclusion of the jaw and crepitus. The diagnosis is based on history and physical examination; however, use of computed tomography or magnetic resonance imaging is recommended if ...
Source: American Family Physician - January 23, 2023 Category: Primary Care Authors: Eric M Matheson Joli D Fermo Russell S Blackwelder Source Type: research
Temporomandibular Disorders: Rapid Evidence Review
Am Fam Physician. 2023 Jan;107(1):52-58.ABSTRACTTemporomandibular disorders affect between 5% and 12% of the population and present with symptoms such as headache, bruxism, pain at the temporomandibular joint, jaw popping or clicking, neck pain, tinnitus, dizziness, decreased hearing, and hyperacuity to sound. Common signs on physical examination include tenderness of the pterygoid muscles, temporomandibular joints, and temporalis muscles, and malocclusion of the jaw and crepitus. The diagnosis is based on history and physical examination; however, use of computed tomography or magnetic resonance imaging is recommended if ...
Source: Pain Physician - January 23, 2023 Category: Anesthesiology Authors: Eric M Matheson Joli D Fermo Russell S Blackwelder Source Type: research
