Sequential Multiple Assignment Randomized Treatment (SMART) for Bipolar Disorder at Any Phase of Illness and at least Mild Symptom Severity.
Conclusions: The efficacy of lithium and divalproex as monotherapy was modest. Adjunctive lamotrigine and quetiapine to either one was well-tolerated and equally effective in reducing bipolar symptomatology, but adjunctive therapy should be initiated as early as possible when depression symptoms are present. PMID: 32508363 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - June 10, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Demographic Variation in the Use of Prazosin for Treatment of Sleep Disturbance in Combat Veterans with PTSD.
Conclusion: Prazosin is prescribed for PTSD-SD to a diverse clinical population with multiple comorbidities and concurrent medications and is characterized by poor adherence and sub-optimal dosing. Future work should clarify the efficacy of prazosin for subgroups of veterans with PTSD-SD, notably women and racial/ethnic minorities. PMID: 32508364 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - June 10, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Antiepileptic Drugs and Bone Health: Current Concepts.
Authors: Siniscalchi A, Murphy S, Cione E, Piro L, Sarro G, Gallelli L Abstract Chronic use of antiepileptic drugs (AEDs) can induce the development of adverse effects on bone metabolism. In epileptic patients treated with AED, the monitoring of biochemical markers of bone turnover, such as the measurement of serum 25 (OH) vitamin D, bone mineral density, before the beginning of the treatment and during the follow-up is not routinely required. In the future, monitoring of biochemical markers in epileptic patients treated with AED may help us for adequate prevention therapy. PMID: 32508365 [PubMed - in process] ...
Source: Psychopharmacology Bulletin - June 10, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

ASD with the Bor Syndrome: A Case Report.
Authors: Yaylaci F, Sahbudak B, Citli S, Kilit N PMID: 32508366 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - June 10, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Case Report: A Case of Intellectual Disability with Inappropriate and Challenging Sexual Behavior that was Treated with GNRH Analogues.
Authors: Yaylacı F, Gül A Abstract Intellectual Disability starts within the course of developmental stages and covers both intellectual and adaptive deficiencies in conceptual, social and applied fields. Individuals with intellectual disability experience many difficulties in social life due to challenging and inappropriate sexual behaviour. Suchdifficulties need to be addressed, reduced or treated. Traditional treatments often fail to treat and improve suchbehavior. Alternative treatment options need to be explored with studies conducted in this field. With this paper, we aimed to show and touch on alternat...
Source: Psychopharmacology Bulletin - June 10, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Cannabis Use and its Association with Psychological Disorders.
Authors: Urits I, Gress K, Charipova K, Li N, Berger AA, Cornett EM, Hasoon J, Kassem H, Kaye AD, Viswanath O Abstract Purpose of Review: This is a comprehensive review of the association between cannabis use and psychological disorders. It reviews the latest and seminal evidence that is available and attempts to conclude the strength of such association. Recent Findings: Cannabis is a flowering plant with psychoactive properties, attributed to cannabinoids that naturally occur within the plant. These act through the CB1 and CB2 receptors to inhibit GABA and glutamate release, as well through other forms of neu...
Source: Psychopharmacology Bulletin - June 10, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Asenapine in the Treatment of Bipolar Depression.
Conclusions: While this is a very small sample, asenapine appears to have a beneficial effect on both depression and anxiety in depressed bipolar I patients compared to treatment with placebo. Due to the large fraction of subjects with the short form, the hypothesis that the SF-5HTTR might increase asenapine response could not be adequately tested. PMID: 32214517 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 29, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

The Effect of Organic Lithium Salts on Plasma 8-Hydroxy-2'-Deoxyguanosine in Bipolar Patients In Vitro.
Conclusion: Lithium pyruvate reduces oxidative DNA damage in the blood of BD patients in vitro, demonstrating the potential of this compound to function not only as a mood stabilizer, but also as an antioxidant and cytoprotector. PMID: 32214518 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 29, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Psychiatric Prescribing Patterns for Depression Treatment in an Outpatient Depression Clinic.
Conclusion: Healthcare providers observed in this study follow depression treatment guidelines and ensure medications are given an adequate trial. PMID: 32214519 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 29, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Efficacy of Low-Dose Aripiprazole for Treatment of Psychotic Symptoms in a Patient with 22q11.2 Deletion Syndrome.
Conclusions: In the present situation delusional ideas are no longer mentioned, but a cognitive deduction is found. Aripiprazole can be an effective pharmacological solution for the psychotic symptoms in patients suffering from 22q11DS. PMID: 32214520 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 29, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Spontaneous Ejaculation Induced with Atomoxetine.
Authors: Yaylacı F, Şahbudak B, Küçük Ö Abstract Attention Deficit-Hyperactivity Disorder is one of the most common psychiatric disorders of childhood, characterized by attention deficit, hyperactivity and impulsivity. The most effective treatment in ADHD is drug treatment. Stimulant and nonstimulant drug treatments are preferentially used. Atomoxetine is one of the nonstimulant treatments. Although sexual side effects of atomoxetine in adults are reported, there is limited knowledge about sexual side effects in children and adolescents. In this case report, we aimed to describe an adolescen...
Source: Psychopharmacology Bulletin - March 29, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Carotid Artery Dissection Induced Acute Tongue Swelling in a Cocaine User.
We report a 42-year old men who presented to our observation with acute tongue swelling and atrophy of left side of tongue from a hypoglossal nerve injury. A magnetic resonance imaging revealed a denervation of the left half of the tongue from a hypoglossal nerve injury due to left extracranial internal carotid artery (ICA) dissection, without evidence of ischemic stroke. The urine toxicology screen test revealed a positivity for cocaine. This case report suggest to perform in young patient a toxicological drug screening test in presence of ICA dissection with hypoglossal nerve injury and an acute tongue swelling. However ...
Source: Psychopharmacology Bulletin - March 29, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Misdiagnosis of Catatonia.
Authors: Mustafa FA, Nayar A PMID: 32214523 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 29, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Identifying Predictors of Primary Adherence to Second Generation Long-Acting Injectable Antipsychotics Following Discharge from an Acute Inpatient Psychiatry Unit.
Conclusions: Primary adherence and medication persistence to second generation LAI antipsychotics following hospital discharge is low with approximately 60% of patients not receiving another injection. Clinicians should consider outpatient medication adherence before initiating a second-generation LAI antipsychotic during hospitalization. Efforts should be made to facilitate adherence to LAI antipsychotics during transition of care from inpatient to outpatient settings. PMID: 31308578 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - July 18, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Oral Antipsychotic Versus Long-Acting Injections Antipsychotic in Schizophrenia Spectrum Disorder: a Mirror Analysis in a Real-World Clinical Setting.
Authors: Poloni N, Ielmini M, Caselli I, Lucca G, Gasparini A, Gasparini A, Lorenzoli G, Callegari C Abstract Despite mixed results found in literature, long-acting injectable antipsychotics (LAIs) should offer better efficacy and tolerability, compared to oral antipsychotics due to improved adherence and more stable pharmacokinetics. From this perspective, authors evaluated 153 patients, diagnosed with Schizophrenia Spectrum Disorder and residing in the province of Varese (Italy), in order to compare oral antipsychotics' and LAIs' efficacy in terms of accesses to emergency room, number and length of hospitalizatio...
Source: Psychopharmacology Bulletin - July 18, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Revisiting Lithium: Utility for Behavioral Stabilization in Adolescents and Adults with Autism Spectrum Disorder.
Conclusions: Lithium carbonate is a viable, efficacious and well tolerated alternative to various neuroleptics and other psychotropic medications for use as a mood stabilizer for patients with ASD. PMID: 31308580 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - July 18, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Improved Efficacy of Pregabalin by Restoring Plasma Vitamin D Levels in Migraine: a Case Report.
We report a 46-year old woman affected by migraine, anxiety and mild depressive mood (MSQ score: 24; BDI score: 34; VAS score: 8) that partially improved with pregabalin treatment (VAS: 5). Laboratory findings documented low serum levels of vitamin D (25-hydroxy-vitamin D: 12 ng/mL; normal range: 20-100 ng/mL; 1-25 di-hydroxy-vitamin D: 19 ng/mL, normal range: 25-66 ng/mL). The treatment with 10,000 UI vitamin D during pregabalin therapy induced an improvement of clinical symptoms (pain, anxiety and depression) and of the quality of life. This case report suggest that in chronic migraine patient with anxiety and mild mood ...
Source: Psychopharmacology Bulletin - July 18, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Delayed-Onset Toxicity in an Adolescent Case Following Attempted Suicide with an Overdose of Paliperidone Intake.
Authors: Yaylacı F, Küçük Ö, Erkuran HÖ Abstract Paliperidone is a relatively novel atypical antipsychotic drug that is currently used to treat schizophrenia in adolescents and adults. The drug was generated by combining the active metabolite of risperidone, 9-hydroxyrisperidone, with osmotic controlled-release oral administration system (OROS) technology. Due to its specific design, the drug has been identified as a different form, albeit an active metabolite of risperidone. Such distinction mainly manifests itself during pharmacokinetic processes, because paliperidone is not affected b...
Source: Psychopharmacology Bulletin - July 18, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Successful Resolution of Prominent Somatic Delusions Following Bi-temporal Electroconvulsive Therapy in a patient with Treatment-Resistant Schizoaffective Disorder.
Authors: Cohen JL, Vu MT, Beg MA, Sivaraman S, Birur B Abstract Somatic delusions occur in a variety of psychiatric disorders including schizophrenia, major depressive disorder, and bipolar disorder. Somatization is associated with lower quality of life and greater risk for suicide. Treatment of somatic delusions is extremely challenging. Here we report an interesting case of severe somatic delusions in a 48-year-old African-American female with a long history of treatment resistant schizoaffective disorder, with multiple somatic complaints surrounding constipation, pregnancy, jaw pain, body aches, vaginal itch, ma...
Source: Psychopharmacology Bulletin - July 18, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Serum Concentration of Paliperidone Palmitate Administered Every 3 Weeks.
We report two cases of off-label use resulting in serum paliperidone levels greatly exceeding the recommended therapeutic window. A 20- and 31-year-old male were treated with 150 mg IM paliperidone palmitate/21 days. After one and two years, blood drug concentrations were 240 nmol/l and 610 nmol/l, respectively. Neither patient exhibited major adverse effects. Thus paliperidone serum levels greatly in excess of recommended targets can be well tolerated, although we urge caution with off-label use of paliperidone palmitate as it is not always the most appropriate way to achieve the control of schizophrenia. PMID: 313085...
Source: Psychopharmacology Bulletin - July 18, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Involuntary Facial Twitching in a Patient with Schizophrenia on Treatment with Long Acting Injectable Olanzapine.
Authors: Mustafa FA, Nayar A PMID: 31308585 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - July 18, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Administration of Sub-anesthetic Dose of Ketamine and Electroconvulsive Treatment on Alternate Week Days in Patients with Treatment Resistant Depression: A Double Blind Placebo Controlled Trial.
Authors: Altinay M, Karne H, Anand A Abstract Introduction and Background: Patients with depression who fail to respond to at least two antidepressants in their current episode are considered to have Treatment Resistant Depression (TRD). ECT is an effective treatment of TRD but cognitive side effects limit its use. Ketamine elicits a rapid antidepressant response in sub-anesthetic repeated doses. ECT and ketamine may be modulating the glutamate system, therefore when administered in an interleaved fashion, they could have a synergistic effect. Methods: 15 TRD patients were recruited and 12 were included in the ...
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Impact of Gabapentin Adjunct use with Benzodiazepines for the Treatment of Alcohol Withdrawal in a Psychiatric Hospital.
Conclusion: Gabapentin was not shown to reduce as-needed BZD requirements in patients with a diagnosis of alcohol use disorder admitted for alcohol withdrawal. PMID: 30858636 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Paroxetine versus Vortioxetine for Depressive Symptoms in Postmenopausal Transition: A Preliminary Study.
Conclusions: Data are related to a small sample retrospectively assessed trough a 6-month observation period. Thus, the preliminary results need further research to be confirmed. PMID: 30858637 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

The Impact of Completing Medication Reconciliation and Depression Treatment History in an Outpatient Depression Clinic.
Conclusions: Telephone assessments conducted by pharmacy students prior to an initial depression clinic consultation was associated with higher consultation attendance, identified a large number of medication discrepancies, were successfully reviewed and received by clinicians, potentially saved clinician time, and influenced subsequent medication prescribing. PMID: 30858638 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Exercise as a Treatment for Schizophrenia: A Review.
This article will briefly review the clinical signs, symptoms and proposed etiologies of schizophrenia, and describe the current understanding of exercise programs as an effective treatment in patients with the disease. PMID: 30858639 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Thrombolytic Therapy in Cocaine Users with Ischemic Stroke: A Review of Current Practice.
Authors: Siniscalchi A, De Sarro G, Pacifici R, Pisani E, Sanguigni S, Gallelli L Abstract Alteplase is the main pharmacological treatment available for intravenous thrombolysis in patients with acute ischemic stroke. Endovascular treatment alone or add-on to intravenous thrombolysis is a valid approach in acute ischemic stroke with cerebral large vessel disease. The most common serious adverse reaction related to alteplase is the development of spontaneous intracerebral hemorrhage and the presence of cerebral small vessel disease may increase this risk, particularly in cocaine users, even if only few data have bee...
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Akathisia Induced by Abrupt Withdrawal of Risperidone: A Case Report.
Authors: Soundarrajan G, Chogtu B, Krishna V, Kamath G A, Murugesan M Abstract Akathisia is a common movement disorder that occurs as a consequence of antipsychotic therapy. However, its occurrence secondary to risperidone withdrawal has been reported rarely. Reporting of such rare adverse event gains profound importance because changing the antipsychotics is very common in long term management of affective disorders. Here, we report a 17-year-old female who on withdrawal of risperidone developed akathisia. Further, we also discuss already reported cases in literature in relation to the current case. PMID: 3085...
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

An Approach to the Pharmacotherapy of Neuroleptic Malignant Syndrome.
Authors: van Rensburg R, Decloedt EH Abstract Neuroleptic malignant syndrome is a rare, idiosyncratic emergency associated with exposure to dopamine antagonists, commonly antipsychotic drugs. The typical clinical picture consists of altered consciousness, muscular rigidity, fever, and autonomic instability. While the condition has generally been well described, the pathophysiology is still poorly understood. The importance of this case report is to highlight the lack of robust evidence-based treatment for this emergency. We submit an approach to the pharmacotherapy of neuroleptic malignant syndrome based on the ava...
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Cocaine-Induced Psychosis and Asenapine as Treatment: A Case Study.
We report a 38-years-old man with substance use disorders in methadone maintenance treatment who relapsed on cocaine use and presented CIPD that was satisfactorily treated with asenapine. It is important further research on CIPD management, especially on asenapine and other second-generation antipsychotics du to its possible role in its treatment. PMID: 30858643 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Promoting the Discussion of the Beneficial Effects of Ketamine to Treat Refractory Depression.
Discussion of the Beneficial Effects of Ketamine to Treat Refractory Depression. Psychopharmacol Bull. 2019 Feb 15;49(1):98-99 Authors: Ghosh P, Viswanath O PMID: 30858644 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Re: An Interesting Presentation About Cyclical Menstrual Psychosis with an Updated Review of Literature.
Authors: Almeida M, Burrell Ward H PMID: 30618469 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - January 9, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

A Perspective on Adolescent Chronic Pain Dismissal.
Authors: Peck J, Viswanath O PMID: 30618470 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - January 9, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

The Utilization of Atypical Antipsychotics in the Pain Medicine Physician's Armamentarium.
Authors: Viswanath O PMID: 30618471 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - January 9, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Induction of Psychosis by Cyclobenzaprine.
We report a case of psychosis induced by exposure to a commonly prescribed drug to treat muscle spasms and associated pain cyclobenzaprine (Flexeril®). Cyclobenzaprine is structurally very similar to tricyclic anti-depressants, such as amyltriptine. While it is well known that agitation caused by cyclobenzaprine is not an uncommon occurrence in the elderly, there have also been sporadic reports of significant psychosis in association with the use of cyclobenzaprine in younger patients. We report a case of reversible mania in a susceptible 44-year-old patient with a lengthy history of mild borderline personality and bip...
Source: Psychopharmacology Bulletin - January 9, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

A Case of Hyper Sexuality Probably Associated with Clozapine.
Conclusions: Clozapine's dopaminergic agonistic effects at the mesolimbic circuit may be responsible for this hypersexuality phenomenon. Poor understanding of the condition by the patient could lead to marital discord and suffering. WHO scale indicates clozapine as the probable cause of sexual dysfunction in our patient. PMID: 30618473 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - January 9, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Three-Year Naturalistic Study On Early Use Of Long-Acting Injectable Antipsychotics In First Episode Psychosis.
Conclusion: Early prescription of LAI-AP seems beneficial in FEP with poor prognostic factors. PMID: 30618474 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - January 9, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Cariprazine Augmentation to Antidepressant Therapy in Major Depressive Disorder: Results of a Randomized, Double-Blind, Placebo-Controlled Trial.
Authors: Earley WR, Guo H, Németh G, Harsányi J, Thase ME Abstract Cariprazine is an atypical antipsychotic currently under investigation as an adjunctive to antidepressant treatment (ADT) for patients with major depressive disorder (MDD). Here results of an 18- to 19-week randomized double-blind placebo-controlled Phase 3 study evaluating the efficacy of adjunctive cariprazine (1.5-4.5 mg/day[d]) with ADT in participants with previous inadequate response to ADT are presented. ADT response was assessed in an 8-week open-label period; inadequate responders were randomized (N = 530) to open-label ADT pl...
Source: Psychopharmacology Bulletin - January 9, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Retraction.
Authors: Abstract [This retracts the article on p. 8 in vol. 47.][This retracts the article on p. 17 in vol. 47, PMID: 28839336.]. PMID: 30618476 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - January 9, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Characterizing the Effects of Quetiapine in Military Post-Traumatic Stress Disorder.
Conclusions: Quetiapine demonstrated greater effect than placebo on several symptoms. The strongest response was seen on insomnia, which the highest significance level on the CAPS. The insomnia items of both the HAM-D and HAM-A also demonstrated improvement with quetiapine. These finding indicate quetiapine improved sleep measure. Insomnia can be a difficult problem to treat in PTSD patients, therefore quetiapine should be considered in difficult cases. PMID: 29713096 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - May 3, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

A Pilot Evaluating Clinical Pharmacy Services in an Ambulatory Psychiatry Setting.
Conclusion: While this study found no significant difference in the change in PHQ-9/GAD scores between groups, it demonstrated the need for enhanced utilization of measurement-based outcomes in the psychiatric setting. Pharmacists provide a range of services to patients and providers and can serve as key partners to enhance measurement-based care. PMID: 29713097 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - May 3, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Successful Management of Psychotropics Induced Stuttering Priapism with Pseudoephedrine in a Patient with Schizophrenia.
Authors: Thippaiah SM, Nagaraja S, Birur B, Pandurangi A Abstract Stuttering Priapism is a recurrent, persistent penile erection in the absence of sexual desire due to altered genital hemodynamics, affecting the arterial component (high flow, non-ischemic) or the veno-occlusive mechanism (low flow, ischemic). Both typical and atypical antipsychotics increase the risk for priapism with greater implications in typicals than atypicals. Prompt recognition and treatment are important as 40% to 50% of patients with stuttering priapism may develop an erectile dysfunction if left untreated. There are several case reports i...
Source: Psychopharmacology Bulletin - May 3, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Dosing and Monitoring: Children and Adolescents.
Authors: Hirsch GS PMID: 29713099 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - May 3, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Do Long-Acting Injectable Antipsychotics Prevent or Delay Hospital Readmission?
Conclusion: This study revealed the use of LAI antipsychotics in those with a history of medication non-adherence, particularly those with longer administration frequency, have potentially promising outcomes. PMID: 29713100 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - May 3, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

An Interesting Presentation About Cyclical Menstrual Psychosis with an Updated Review of Literature.
Authors: Thippaiah SM, Nagaraja S, Birur B, Cohen AW Abstract Cyclical menstrual psychosis is an uncommon, generally a self-limiting mental illness that occurs only in females. It is associated with other menstruation-related disorders and stressful psychogenic factors. Nonetheless, many cases remain unrecognized due to poor awareness of its presence. A young female who presented with psychotic and mood symptoms during each cycle of menstruation was admitted to the psychiatric inpatient unit. There was severe disruption in her activities of daily living and socio-occupational functioning. Treatment involved bio-psy...
Source: Psychopharmacology Bulletin - May 3, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Major Depressive Disorder Following Dermatomyositis: A Case Linking Depression with Inflammation.
Authors: Reddy A, Birur B, Shelton RC, Li L Abstract Major depressive disorder (MDD) is one of the most common psychiatric disorders. Recent studies have shown a strong association between MDD and peripheral inflammation, shown by a higher incidence of depression in patients with inflammatory diseases including rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and systemic lupus erythematosus. Dermatomyositis (DM), an idiopathic inflammatory connective tissue disease that is associated with inflammation, predominantly affects the skin and skeletal muscle. The association between DM and MDD in the...
Source: Psychopharmacology Bulletin - May 3, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

A Case of Concomitant Pseudocyesis and Couvade Syndrome Variant.
Authors: Thippaiah SM, George V, Birur B, Pandurangi A Abstract Per DSM-V, pseudocyesis is included under the category "other specified somatic symptom and related disorder" and is defined as a false belief of being pregnant that is associated with objective signs and reported symptoms of pregnancy. The male counterpart of pseudocyesis is Couvade syndrome, also called "sympathetic pregnancy" where a man experiences symptoms of pregnancy when his female partner is pregnant. There are extensive reports on pseudocyesis and Couvade syndrome in psychiatric literature but none with features of both, i...
Source: Psychopharmacology Bulletin - May 3, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Efficacy and Tolerability of Two Different Kinds of Titration of Paroxetine Hydrocloride Solution: an Observational Study.
Authors: Ielmini M, Poloni N, Caselli I, Bianchi L, Diurni M, Vender S, Callegari C Abstract Background: Depressive disorders are expected to be the second highest cause of morbidity in the world until few years. Moreover, patients with depression frequently show many side effects and low compliance to therapy. To find a more tolerated and more efficacy therapy is a growing need. Objective: This observational study investigates the efficacy, safety and tolerability of paroxetine hydrochloride comparing slow versus standard titration in a population affected by Depressive Disoders (according to DSM 5). Metho...
Source: Psychopharmacology Bulletin - May 3, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Progressive Non-familial Adult onset Cerebellar Degeneration: An Unusual Occurrence with Hashimoto's Thyroiditis.
We report a case of cerebellar atrophy in a 31 year old female whose detailed evaluation had revealed sub-clinical hypothyroidism secondary to autoimmune thyroiditis with a very high anti-TPO (anti-thyroid peroxidase) antibody levels. MRI (Magnetic Resonanace Imaging) of brain showed diffuse bilateral cerebellar atrophy. She was treated with thyroid hormone supplementation and after one year of follow up, cerebellar signs had disappeared completely with significant reduction in anti-TPO antibody levels. Imaging of the brain post one year of follow-up revealed normal cerebellum. Hence, we opine that thyroid dysfunction shou...
Source: Psychopharmacology Bulletin - May 3, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Risperidone Induced Isolated Thrombocytopenia: A Rare Adverse Event.
Authors: Bhattacharjee D, Yerrapragada D, Chogtu B, Thomson SR PMID: 29713106 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - May 3, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research