Administration of Sub-anesthetic Dose of Ketamine and Electroconvulsive Treatment on Alternate Week Days in Patients with Treatment Resistant Depression: A Double Blind Placebo Controlled Trial.
Authors: Altinay M, Karne H, Anand A Abstract Introduction and Background: Patients with depression who fail to respond to at least two antidepressants in their current episode are considered to have Treatment Resistant Depression (TRD). ECT is an effective treatment of TRD but cognitive side effects limit its use. Ketamine elicits a rapid antidepressant response in sub-anesthetic repeated doses. ECT and ketamine may be modulating the glutamate system, therefore when administered in an interleaved fashion, they could have a synergistic effect. Methods: 15 TRD patients were recruited and 12 were included in the ...
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Impact of Gabapentin Adjunct use with Benzodiazepines for the Treatment of Alcohol Withdrawal in a Psychiatric Hospital.
Conclusion: Gabapentin was not shown to reduce as-needed BZD requirements in patients with a diagnosis of alcohol use disorder admitted for alcohol withdrawal. PMID: 30858636 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Paroxetine versus Vortioxetine for Depressive Symptoms in Postmenopausal Transition: A Preliminary Study.
Conclusions: Data are related to a small sample retrospectively assessed trough a 6-month observation period. Thus, the preliminary results need further research to be confirmed. PMID: 30858637 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

The Impact of Completing Medication Reconciliation and Depression Treatment History in an Outpatient Depression Clinic.
Conclusions: Telephone assessments conducted by pharmacy students prior to an initial depression clinic consultation was associated with higher consultation attendance, identified a large number of medication discrepancies, were successfully reviewed and received by clinicians, potentially saved clinician time, and influenced subsequent medication prescribing. PMID: 30858638 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Exercise as a Treatment for Schizophrenia: A Review.
This article will briefly review the clinical signs, symptoms and proposed etiologies of schizophrenia, and describe the current understanding of exercise programs as an effective treatment in patients with the disease. PMID: 30858639 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Thrombolytic Therapy in Cocaine Users with Ischemic Stroke: A Review of Current Practice.
Authors: Siniscalchi A, De Sarro G, Pacifici R, Pisani E, Sanguigni S, Gallelli L Abstract Alteplase is the main pharmacological treatment available for intravenous thrombolysis in patients with acute ischemic stroke. Endovascular treatment alone or add-on to intravenous thrombolysis is a valid approach in acute ischemic stroke with cerebral large vessel disease. The most common serious adverse reaction related to alteplase is the development of spontaneous intracerebral hemorrhage and the presence of cerebral small vessel disease may increase this risk, particularly in cocaine users, even if only few data have bee...
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Akathisia Induced by Abrupt Withdrawal of Risperidone: A Case Report.
Authors: Soundarrajan G, Chogtu B, Krishna V, Kamath G A, Murugesan M Abstract Akathisia is a common movement disorder that occurs as a consequence of antipsychotic therapy. However, its occurrence secondary to risperidone withdrawal has been reported rarely. Reporting of such rare adverse event gains profound importance because changing the antipsychotics is very common in long term management of affective disorders. Here, we report a 17-year-old female who on withdrawal of risperidone developed akathisia. Further, we also discuss already reported cases in literature in relation to the current case. PMID: 3085...
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

An Approach to the Pharmacotherapy of Neuroleptic Malignant Syndrome.
Authors: van Rensburg R, Decloedt EH Abstract Neuroleptic malignant syndrome is a rare, idiosyncratic emergency associated with exposure to dopamine antagonists, commonly antipsychotic drugs. The typical clinical picture consists of altered consciousness, muscular rigidity, fever, and autonomic instability. While the condition has generally been well described, the pathophysiology is still poorly understood. The importance of this case report is to highlight the lack of robust evidence-based treatment for this emergency. We submit an approach to the pharmacotherapy of neuroleptic malignant syndrome based on the ava...
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Cocaine-Induced Psychosis and Asenapine as Treatment: A Case Study.
We report a 38-years-old man with substance use disorders in methadone maintenance treatment who relapsed on cocaine use and presented CIPD that was satisfactorily treated with asenapine. It is important further research on CIPD management, especially on asenapine and other second-generation antipsychotics du to its possible role in its treatment. PMID: 30858643 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Promoting the Discussion of the Beneficial Effects of Ketamine to Treat Refractory Depression.
Discussion of the Beneficial Effects of Ketamine to Treat Refractory Depression. Psychopharmacol Bull. 2019 Feb 15;49(1):98-99 Authors: Ghosh P, Viswanath O PMID: 30858644 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Re: An Interesting Presentation About Cyclical Menstrual Psychosis with an Updated Review of Literature.
Authors: Almeida M, Burrell Ward H PMID: 30618469 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - January 9, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

A Perspective on Adolescent Chronic Pain Dismissal.
Authors: Peck J, Viswanath O PMID: 30618470 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - January 9, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

The Utilization of Atypical Antipsychotics in the Pain Medicine Physician's Armamentarium.
Authors: Viswanath O PMID: 30618471 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - January 9, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Induction of Psychosis by Cyclobenzaprine.
We report a case of psychosis induced by exposure to a commonly prescribed drug to treat muscle spasms and associated pain cyclobenzaprine (Flexeril®). Cyclobenzaprine is structurally very similar to tricyclic anti-depressants, such as amyltriptine. While it is well known that agitation caused by cyclobenzaprine is not an uncommon occurrence in the elderly, there have also been sporadic reports of significant psychosis in association with the use of cyclobenzaprine in younger patients. We report a case of reversible mania in a susceptible 44-year-old patient with a lengthy history of mild borderline personality and bip...
Source: Psychopharmacology Bulletin - January 9, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

A Case of Hyper Sexuality Probably Associated with Clozapine.
Conclusions: Clozapine's dopaminergic agonistic effects at the mesolimbic circuit may be responsible for this hypersexuality phenomenon. Poor understanding of the condition by the patient could lead to marital discord and suffering. WHO scale indicates clozapine as the probable cause of sexual dysfunction in our patient. PMID: 30618473 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - January 9, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Three-Year Naturalistic Study On Early Use Of Long-Acting Injectable Antipsychotics In First Episode Psychosis.
Conclusion: Early prescription of LAI-AP seems beneficial in FEP with poor prognostic factors. PMID: 30618474 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - January 9, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Cariprazine Augmentation to Antidepressant Therapy in Major Depressive Disorder: Results of a Randomized, Double-Blind, Placebo-Controlled Trial.
Authors: Earley WR, Guo H, Németh G, Harsányi J, Thase ME Abstract Cariprazine is an atypical antipsychotic currently under investigation as an adjunctive to antidepressant treatment (ADT) for patients with major depressive disorder (MDD). Here results of an 18- to 19-week randomized double-blind placebo-controlled Phase 3 study evaluating the efficacy of adjunctive cariprazine (1.5-4.5 mg/day[d]) with ADT in participants with previous inadequate response to ADT are presented. ADT response was assessed in an 8-week open-label period; inadequate responders were randomized (N = 530) to open-label ADT pl...
Source: Psychopharmacology Bulletin - January 9, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Retraction.
Authors: Abstract [This retracts the article on p. 8 in vol. 47.][This retracts the article on p. 17 in vol. 47, PMID: 28839336.]. PMID: 30618476 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - January 9, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Characterizing the Effects of Quetiapine in Military Post-Traumatic Stress Disorder.
Conclusions: Quetiapine demonstrated greater effect than placebo on several symptoms. The strongest response was seen on insomnia, which the highest significance level on the CAPS. The insomnia items of both the HAM-D and HAM-A also demonstrated improvement with quetiapine. These finding indicate quetiapine improved sleep measure. Insomnia can be a difficult problem to treat in PTSD patients, therefore quetiapine should be considered in difficult cases. PMID: 29713096 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - May 3, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

A Pilot Evaluating Clinical Pharmacy Services in an Ambulatory Psychiatry Setting.
Conclusion: While this study found no significant difference in the change in PHQ-9/GAD scores between groups, it demonstrated the need for enhanced utilization of measurement-based outcomes in the psychiatric setting. Pharmacists provide a range of services to patients and providers and can serve as key partners to enhance measurement-based care. PMID: 29713097 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - May 3, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Successful Management of Psychotropics Induced Stuttering Priapism with Pseudoephedrine in a Patient with Schizophrenia.
Authors: Thippaiah SM, Nagaraja S, Birur B, Pandurangi A Abstract Stuttering Priapism is a recurrent, persistent penile erection in the absence of sexual desire due to altered genital hemodynamics, affecting the arterial component (high flow, non-ischemic) or the veno-occlusive mechanism (low flow, ischemic). Both typical and atypical antipsychotics increase the risk for priapism with greater implications in typicals than atypicals. Prompt recognition and treatment are important as 40% to 50% of patients with stuttering priapism may develop an erectile dysfunction if left untreated. There are several case reports i...
Source: Psychopharmacology Bulletin - May 3, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Dosing and Monitoring: Children and Adolescents.
Authors: Hirsch GS PMID: 29713099 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - May 3, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Do Long-Acting Injectable Antipsychotics Prevent or Delay Hospital Readmission?
Conclusion: This study revealed the use of LAI antipsychotics in those with a history of medication non-adherence, particularly those with longer administration frequency, have potentially promising outcomes. PMID: 29713100 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - May 3, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

An Interesting Presentation About Cyclical Menstrual Psychosis with an Updated Review of Literature.
Authors: Thippaiah SM, Nagaraja S, Birur B, Cohen AW Abstract Cyclical menstrual psychosis is an uncommon, generally a self-limiting mental illness that occurs only in females. It is associated with other menstruation-related disorders and stressful psychogenic factors. Nonetheless, many cases remain unrecognized due to poor awareness of its presence. A young female who presented with psychotic and mood symptoms during each cycle of menstruation was admitted to the psychiatric inpatient unit. There was severe disruption in her activities of daily living and socio-occupational functioning. Treatment involved bio-psy...
Source: Psychopharmacology Bulletin - May 3, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Major Depressive Disorder Following Dermatomyositis: A Case Linking Depression with Inflammation.
Authors: Reddy A, Birur B, Shelton RC, Li L Abstract Major depressive disorder (MDD) is one of the most common psychiatric disorders. Recent studies have shown a strong association between MDD and peripheral inflammation, shown by a higher incidence of depression in patients with inflammatory diseases including rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and systemic lupus erythematosus. Dermatomyositis (DM), an idiopathic inflammatory connective tissue disease that is associated with inflammation, predominantly affects the skin and skeletal muscle. The association between DM and MDD in the...
Source: Psychopharmacology Bulletin - May 3, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

A Case of Concomitant Pseudocyesis and Couvade Syndrome Variant.
Authors: Thippaiah SM, George V, Birur B, Pandurangi A Abstract Per DSM-V, pseudocyesis is included under the category "other specified somatic symptom and related disorder" and is defined as a false belief of being pregnant that is associated with objective signs and reported symptoms of pregnancy. The male counterpart of pseudocyesis is Couvade syndrome, also called "sympathetic pregnancy" where a man experiences symptoms of pregnancy when his female partner is pregnant. There are extensive reports on pseudocyesis and Couvade syndrome in psychiatric literature but none with features of both, i...
Source: Psychopharmacology Bulletin - May 3, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Efficacy and Tolerability of Two Different Kinds of Titration of Paroxetine Hydrocloride Solution: an Observational Study.
Authors: Ielmini M, Poloni N, Caselli I, Bianchi L, Diurni M, Vender S, Callegari C Abstract Background: Depressive disorders are expected to be the second highest cause of morbidity in the world until few years. Moreover, patients with depression frequently show many side effects and low compliance to therapy. To find a more tolerated and more efficacy therapy is a growing need. Objective: This observational study investigates the efficacy, safety and tolerability of paroxetine hydrochloride comparing slow versus standard titration in a population affected by Depressive Disoders (according to DSM 5). Metho...
Source: Psychopharmacology Bulletin - May 3, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Progressive Non-familial Adult onset Cerebellar Degeneration: An Unusual Occurrence with Hashimoto's Thyroiditis.
We report a case of cerebellar atrophy in a 31 year old female whose detailed evaluation had revealed sub-clinical hypothyroidism secondary to autoimmune thyroiditis with a very high anti-TPO (anti-thyroid peroxidase) antibody levels. MRI (Magnetic Resonanace Imaging) of brain showed diffuse bilateral cerebellar atrophy. She was treated with thyroid hormone supplementation and after one year of follow up, cerebellar signs had disappeared completely with significant reduction in anti-TPO antibody levels. Imaging of the brain post one year of follow-up revealed normal cerebellum. Hence, we opine that thyroid dysfunction shou...
Source: Psychopharmacology Bulletin - May 3, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Risperidone Induced Isolated Thrombocytopenia: A Rare Adverse Event.
Authors: Bhattacharjee D, Yerrapragada D, Chogtu B, Thomson SR PMID: 29713106 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - May 3, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Major Depression Comorbid with Medical Conditions: Analysis of Quality of Life, Functioning, and Depressive Symptom Severity.
Authors: IsHak WW, Steiner AJ, Klimowicz A, Kauzor K, Dang J, Vanle B, Elzahaby C, Reid M, Sumner L, Danovitch I Abstract Background: The presence of Major Depressive Disorder (MDD) is often comorbid in patients with a variety of general medical conditions (GMCs) which could lead to less favorable outcomes. Objective: The goal of this analysis is to examine functional outcomes of QOL and functioning before and after antidepressant treatment among patients with MDD with and without GMCs. Methods: We performed a secondary analysis based on the STAR*D database. The analysis included two patient groups from the...
Source: Psychopharmacology Bulletin - February 1, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Effective Vortioxetine Dose Varies with Extent of Antidepressant Use Across Countries.
Conclusions: In countries with high antidepressant utilization, higher doses of vortioxetine were required, and obverse was true in countries with lower antidepressant utilization. These data support the hypothesis that tolerance to serotonin reuptake inhibition drives poor antidepressant response. PMID: 29382958 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - February 1, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

The Use of Complementary Alternative Medicine in Children and Adolescents with Autism Spectrum Disorder.
Authors: DeFilippis M Abstract Complementary alternative medicine (CAM) is used to a greater degree in children and adolescents with autism spectrum disorder (ASD), when compared to children and adolescents without this diagnosis. There is limited evidence supporting the use of many of these treatments in ASD, despite their popularity. Current FDA approved medications for ASD target associated behavioral symptoms of the diagnosis, not the core symptoms of social communication deficits and restricted/repetitive behaviors. These medications are also associated with concerning adverse effects. Evidence-based therapies...
Source: Psychopharmacology Bulletin - February 1, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

The Black Book of Psychotropic Dosing and Monitoring.
Authors: Schatzberg AF, Charles D PMID: 29382960 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - February 1, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Erratum.
Authors: Abstract [This corrects the article on p. 29 in vol. 47, PMID: 28936006.][This corrects the article on p. 29 in vol. 47, PMID: 28936006.]. PMID: 29382961 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - February 1, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Dextromethorphan in Cough Syrup: The Poor Man's Psychosis.
We report a noteworthy case of severe dextromethorphan use disorder with dextromethorphan-induced psychotic disorder in a 40-year-old Caucasian female, whose symptoms remitted only following treatment with a combination of an antipsychotic and mood stabilizer. While some states have begun to limit the quantity of DXM sold or restrict sales to individuals over 18-years of age, there is currently no federal ban or restriction on DXM. Abuse of DXM, a readily available and typically inexpensive agent that is not detected on a standard urine drug screen, may be an under-recognized cause of substance-induced psychosis. It is imp...
Source: Psychopharmacology Bulletin - January 5, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Escitalopram Induced SIADH in an Elderly Female: A Case Study.
Authors: Vidyasagar S, Rao K, Verma M, Tripuraneni AD, Patil N, Bhattacharjee D Abstract Hyponatraemia is a well-established and potentially, a life-threatening adverse effect of selective serotonin receptor uptake inhibitors (SSRI). However, its occurrence secondary to syndrome of inappropriate antidiuretic hormone secretion (SIADH) with escitalopram, has been reported extremely sporadically. The reporting of such rare, but life-threatening adverse effects of escitalopram assumes immense significance in light of the fact that SSRIs presently form the mainstay of treatment of depressive disorders. Here, we report a...
Source: Psychopharmacology Bulletin - January 5, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Persisting Psychosocial Impairments in Adults Being Treated with Medication for Attention Deficit/Hyperactivity Disorder.
Authors: Brown TE, Flood E, Sarocco P, Atkins N, Khachatryan A PMID: 28936004 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - September 24, 2017 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Unmet Medication Coverage Needs among Adults with Attention Deficit/Hyperactivity Disorder (ADHD).
Authors: Brown TE, Flood E, Sarocco P, Atkins N, Khachatryan A PMID: 28936005 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - September 24, 2017 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

A Phase-1, 6-Month Open-Label, Dose-Ranging Pharmacokinetic Study in Stabilized Patients with Schizophrenia Following Risperidone Implant.
Authors: Dammerman R, Kim S, Adera M, Schwarz A PMID: 28936006 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - September 24, 2017 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

A Phase 1, Open-Label, Single Dose Pharmacokinetic Study in Stabilized Patients with Schizophrenia Following Risperidone Implant.
Authors: Dammerman R, Kim S, Adera M, Schwarz A PMID: 28936007 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - September 24, 2017 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Physical Activity Diminishes Symptomatic Decline in Chronic Schizophrenia: A Systematic Review.
Authors: Tarpada SP, Morris MT Abstract Physical activity has been shown to positively influence a number of parameters in chronic schizophrenia, including cognition, social well being, and quality of life. Here, we present a systematic review of randomized controlled trials reporting on reduction of positive and negative symptoms using PANSS grading after the implementation of a physical activity protocol. Review of 64 articles yielded 6 relevant to our discussion. We found that physical activity significantly improved aggregate total PANSS score as well as positive symptoms PANSS score. While negative PANSS score...
Source: Psychopharmacology Bulletin - September 24, 2017 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Collaborative Care in Ambulatory Psychiatry: Content Analysis of Consultations to a Psychiatric Pharmacist.
CONCLUSIONS: This is a preliminary analysis that provides information about how psychiatry residents, attending physicians, and advanced practice nurse practitioners at our health system utilize a psychiatric pharmacist. This collaborative relationship may have implications for the future of psychiatric care delivery. PMID: 28936009 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - September 24, 2017 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Dextromethorphan in Cough Syrup: The Poor Man's Psychosis.
We report a noteworthy case of severe dextromethorphan use disorder with dextromethorphan-induced psychotic disorder in a 40-year-old Caucasian female, whose symptoms remitted only following treatment with a combination of an antipsychotic and mood stabilizer. While some states have begun to limit the quantity of DXM sold or restrict sales to individuals over 18-years of age, there is currently no federal ban or restriction on DXM. Abuse of DXM, a readily available and typically inexpensive agent that is not detected on a standard urine drug screen, may be an under-recognized cause of substance-induced psychosis. It is imp...
Source: Psychopharmacology Bulletin - September 24, 2017 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Escitalopram Induced SIADH in an Elderly Female: A Case Study.
Authors: Vidyasagar S, Rao K, Verma M, Tripuraneni AD, Patil N, Bhattacharjee D Abstract Hyponatraemia is a well-established and potentially, a life-threatening adverse effect of selective serotonin receptor uptake inhibitors (SSRI). However, its occurrence secondary to syndrome of inappropriate antidiuretic hormone secretion (SIADH) with escitalopram, has been reported extremely sporadically. The reporting of such rare, but life-threatening adverse effects of escitalopram assumes immense significance in light of the fact that SSRIs presently form the mainstay of treatment of depressive disorders. Here, we report a...
Source: Psychopharmacology Bulletin - September 24, 2017 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Baseline Demographics and Characteristics From a Paliperidone Palmitate Study in Subjects with Recent-Onset Schizophrenia or Schizophreniform Disorder.
Authors: Brown B, Alphs L, Turkoz I, Yue Y PMID: 28839335 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - August 27, 2017 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Correlation of Caregiver Burden and Baseline Characteristics of Caregivers and Patients in Their Care with Recent-Onset Psychosis: The FIRST Study.
Authors: Mancevski B, Gogate J, Ashcroft K, Tardieu K, Kim E PMID: 28839336 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - August 27, 2017 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

A Phase-1 Study Comparing Pharmacokinetic and Safety Profiles of Three Different Dose Intervals of Aripiprazole Lauroxil.
CONCLUSION: AL allows for a range of dose/dose-interval combinations. The PK results from this study show that a dosing interval of every 8 weeks for the 1064 mg dose resulted in aripiprazole concentrations within the established therapeutic window for AL. There was no safety signal directing any particular concern to any of the three doses/dose intervals studied. All patients continued their primary antipsychotics without any apparent tolerability issue arising from the addition of the AL injections. The results of this study show that 1064 mg AL may be suitable for a 2-month dose interval. The three doses/dose intervals ...
Source: Psychopharmacology Bulletin - August 27, 2017 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Metabolic and Endocrine Profiles During 1-Year Treatment of Outpatients with Schizophrenia with Aripiprazole Lauroxil.
CONCLUSION: Long-term treatment with AL in outpatients with schizophrenia was associated with a modest lowering of serum prolactin for both genders and relatively modest changes in average weight, fasting glucose, and HbA1c values. There appeared to be little net change in lipid parameters. This presentation extends a recently published report on the short-term metabolic and endocrine effects of AL over a period of 12 weeks. The present study increased the follow-up period to more than a year and was careful to use the first exposure to AL as the baseline. Limitations include lack of a comparison group and difficulty disen...
Source: Psychopharmacology Bulletin - August 27, 2017 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Single Dose and Repeat Once-Daily Dose Safety, Tolerability and Pharmacokinetics of Valbenazine in Healthy Male Subjects.
Authors: Luo R, Bozigian H, Jimenez R, Loewen G, O'Brien CF Abstract Valbenazine (VBZ) is a vesicular monoamine transporter 2 (VMAT2) inhibitor approved for the treatment of tardive dyskinesia. The safety, tolerability and pharmacokinetics of VBZ following single and repeat once-daily (QD) dosing were evaluated in 2 randomized, single-center, double-blind studies in healthy male subjects. In the first study, 2 cohorts of 8 subjects were administered single doses (SD) of placebo (PBO; N = 2/period) or VBZ (N = 6/period; 1, 2, 5, or 12.5 mg for Cohort 1 and 12.5, 25, 50, or 75 mg for Cohort 2) using a sequential esca...
Source: Psychopharmacology Bulletin - August 27, 2017 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Efficacy of Valbenazine (NBI-98854) in Treating Subjects with Tardive Dyskinesia and Mood Disorder.
CONCLUSION: Sustained TD improvements were found in subjects with a mood disorder who received up to 48 weeks of VBZ, with TD reverting toward baseline severity when assessed 4 weeks after treatment withdrawal. Together with results from SCHZ subjects and the long-term safety profile (presented separately), these results indicate that long-term VBZ can be beneficial for managing TD regardless of psychiatric diagnosis. PMID: 28839340 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - August 27, 2017 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research