Patient Response Trajectories in Major Depressive Disorder.
Conclusions: The presence of fast-, slow- and non-responder classes has a clear clinical relevance for guiding treatment decisions; individual patients can be classified by the change in their MADRS score from baseline at 2 or 4 weeks. PMID: 33012870 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - October 7, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

The Use of Prazosin in Treatment of Drug Dreams in Adolescents with Substance Use Disorder: Two Case Reports.
Authors: Aggarwal A, Lindegaard V Abstract ~ Nightmares are psychologically distressing events that may cause significant effects on mental health, physical well-being and overall quality of life, in addition to their negative impact on quality and duration of sleep. Drug dreams are a variant of nightmares and a known phenomenon in addiction medicine, and have been studied as a potential causative factor in relapse of substance use. Recent studies have noted that addictive behaviors and drug dreams share a similar neurobiological pathway, and that certain neurotransmitters, most notably those of the noradrenergic s...
Source: Psychopharmacology Bulletin - October 7, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Lumateperone for the Treatment of Schizophrenia.
Authors: Edinoff A, Wu N, deBoisblanc C, Feltner CO, Norder M, Tzoneva V, Kaye AM, Cornett EM, Kaye AD, Viswanath O, Urits I Abstract Introduction: Schizophrenia is a severe psychotic disorder that is diagnosed by the presence of hallucinations or delusions along with disorganized speech, disorganized thought, or negative symptoms that are present for at least six months. Roughly 1 in 10,000 people a year are diagnosed with this psychiatric disorder. It is a chronic disorder requiring a lifetime of treatment of which antipsychotics have been the mainstay of this treatment. First-generation antipsychotics have dysto...
Source: Psychopharmacology Bulletin - October 7, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Asenapine Transdermal Patch for the Management of Schizophrenia.
Authors: Zhou M, Derakhshanian S, Rath A, Bertrand S, DeGraw C, Barlow R, Menard A, Kaye AM, Hasoon J, Cornett EM, Kaye AD, Viswanath O, Urits I Abstract Purpose of Review: This is a comprehensive review of the literature regarding the use of asenapine for the treatment of schizophrenia (SZ) in adults. It covers an introduction, epidemiology, risk factors, pathophysiology, and current treatment modalities regarding SZ, provides a background on the mechanism of action of asenapine, and then reviews the existing evidence for use of asenapine in both its sublingual and transdermal formulation in the treatment of SZ. ...
Source: Psychopharmacology Bulletin - October 7, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Cariprazine to Treat Schizophrenia and Bipolar Disorder in Adults.
Authors: Edinoff A, Ruoff MT, Ghaffar YT, Rezayev A, Jani D, Kaye AM, Cornett EM, Kaye AD, Viswanath O, Urits I Abstract Purpose of Review: Antipsychotics are the standard of care when it comes to the treatment of Schizophrenia, and they are often used in Bipolar as well. Their use can come with adverse effects such as extrapyramidal movements, metabolic complications as well as cardiovascular complications such as a prolonged QT interval. Treatment for these side effects ranges from the treatment of the complications up to the cessation of the medication, which could come at the expense of the user's stability. Bo...
Source: Psychopharmacology Bulletin - October 7, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Efficacy and Tolerability of Lamotrigine in Borderline Personality Disorder: A Systematic Review and Meta-Analysis.
Conclusions: Our results suggest there is limited data regarding efficacy of lamotrigine in BPD. There was no consistent evidence of lamotrigine's efficacy for the core symptom domains of BPD. Future studies should focus on examining targeted domains of BPD to clarify sub-phenotypes and individualized treatment for patients with BPD. PMID: 33012875 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - October 7, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

An Update on the Efficacy and Tolerability of Oral Ketamine for Major Depression: A Systematic Review and Meta-Analysis.
Authors: Nuñez NA, Joseph B, Pahwa M, Seshadri A, Prokop LJ, Kung S, Schak KM, Vande Voort JL, Frye MA, Singh B Abstract Background: Intravenous Ketamine has shown robust antidepressant efficacy although other routes of administration are currently needed. We conducted a systematic review and meta-analysis of studies evaluating the efficacy and tolerability of oral ketamine for depression. Methods: A comprehensive search of major electronic databases from inception to April 2020 was performed. Studies of oral ketamine for depression, from case series to randomized clinical trials, were eligible. Randomiz...
Source: Psychopharmacology Bulletin - October 7, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Autism Spectrum Disorder Screening at 18-36 Months in Infants with Moderate and Severe Neonatal Encephalopathy: Is Routine Screening Required?
Conclusion: Our results showed that the risk of ASD increases in infants with moderate and severe NE, and this relationship should be considered in long-term clinical follow-ups. PMID: 32733108 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - August 1, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Impact of Recent Methamphetamine Use on Vancomycin Clearance.
Conclusion: Recent methamphetamine use may increase vancomycin clearance. Larger prospective trials with protocolized vancomycin dosing strategies are needed to further elucidate the impact of methamphetamine use on attainment of goal vancomycin troughs in addition to the potential impact on vancomycin clearance. PMID: 32733109 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - August 1, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Assesment of Risk Factors for Tardive Dyskinesia.
Conclusion: Advancing age seemed to be the most significant risk factor in the development of TD. Clinicians need to be cautious about TD when prescribing APD for elderly patients. PMID: 32733110 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - August 1, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Impact of Polymorphism of CYP2D6 on Equilibrium Concentration of Duloxetine in Patients Suffering from Major Depressive Disorder.
This study enrolled 118 patients with recurrent depressive disorder (average age - 40.6±17.1 years). Therapy included duloxetine in an average daily dose of 103.7±37.1 mg per day. Treatment efficacy was assessed using the international psychometric scales. Therapy safety was assessed using the UKU Side-Effect Rating Scale. For genotyping we performed the real-time polymerase chain reaction (PCR Real-time). Therapeutic drug monitoring has been performed using HPLC-MS/MS. Results: Our findings revealed the statistically significant results in terms of the treatment efficacy evaluation (HAMD scores at the en...
Source: Psychopharmacology Bulletin - August 1, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

The Influence of Concentration of Micro-RNA hsa-miR-370-3p and CYP2D6*4 on Equilibrium Concentration of Mirtazapine in Patients With Major Depressive Disorder.
The objective of our study was to investigate the influence of 1846G>A polymorphism of the CYP2D6 gene on the concentration/dose indicator of mirtazapine, using findings on enzymatic activity of CYP2D6 (as evaluated by the 6M-THBC/pinoline ratio measurement) and on CYP2D6 expression level obtained by measuring the hsa-miR-370-3p plasma levelsin patients suffering from recurrent depressive disorder. Material and Methods: Our study included 192 patients with major depressive disorder (age - 41.4 ± 15.6 years). Treatment regimen included mirtazapine in an average daily dose of 37.4 ± 13.5 mg per week. Tre...
Source: Psychopharmacology Bulletin - August 1, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

A Comprehensive Update of Lofexidine for the Management of Opioid Withdrawal Symptoms.
Authors: Urits I, Patel A, Zusman R, Virgen CG, Mousa M, Berger AA, Kassem H, Jung JW, Hasoon J, Kaye AD, Viswanath O Abstract Purpose of Review: This is a comprehensive review of the literature regarding the use of Lofexidine for opiate withdrawal symptoms. It covers the background and necessity of withdrawal programs and the management of withdrawal symptoms and then covers the existing evidence of the use of Lofexidine for this purpose. Recent Findings: Opiate abuse leads to significant pain and suffering. However, withdrawal is difficult and often accompanied by withdrawal symptoms and renewed cravings. The...
Source: Psychopharmacology Bulletin - August 1, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Naldemedine for the Use of Management of Opioid Induced Constipation.
Authors: Urits I, Patel A, Kiernan HC, Clay CJ, Monteferrante N, Jung JW, Berger AA, Kassem H, Hasoon J, Kaye AD, Kaye AM, Viswanath O Abstract Purpose of Review: Opioid medications are a pillar of acute and chronic analgesia, though their use is often accompanied by side-effects, such as opioid-induced constipation. Unfortunately, tolerance rarely develops to this untoward side effect. This review presents the background, evidence, and indications for the use of Naldemedine (Brand name Symproic 0.2 mg tablets) to treat opioid-induced constipation. Recent Findings: Opioids are often used for the treatment of ac...
Source: Psychopharmacology Bulletin - August 1, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Use of Clozapine in the General Hospital.
Authors: Mustafa FA Abstract Patients with treatment-resistant schizophrenia receiving clozapine therapy are at risk of potentially serious complications in the general hospital setting, due to the complex pharmacokinetic and pharmacodynamic profile of clozapine. We summarize common clinical challenges that face clinicians who care for clozapine patients in the general hospital, and make recommendations based on the available literature and clinical experience. Early collaborative management between consultation-liaison psychiatry and other clinical teams in the general hospital is paramount to improve clinical out...
Source: Psychopharmacology Bulletin - August 1, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Sequential Multiple Assignment Randomized Treatment (SMART) for Bipolar Disorder at Any Phase of Illness and at least Mild Symptom Severity.
Conclusions: The efficacy of lithium and divalproex as monotherapy was modest. Adjunctive lamotrigine and quetiapine to either one was well-tolerated and equally effective in reducing bipolar symptomatology, but adjunctive therapy should be initiated as early as possible when depression symptoms are present. PMID: 32508363 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - June 10, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Demographic Variation in the Use of Prazosin for Treatment of Sleep Disturbance in Combat Veterans with PTSD.
Conclusion: Prazosin is prescribed for PTSD-SD to a diverse clinical population with multiple comorbidities and concurrent medications and is characterized by poor adherence and sub-optimal dosing. Future work should clarify the efficacy of prazosin for subgroups of veterans with PTSD-SD, notably women and racial/ethnic minorities. PMID: 32508364 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - June 10, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Antiepileptic Drugs and Bone Health: Current Concepts.
Authors: Siniscalchi A, Murphy S, Cione E, Piro L, Sarro G, Gallelli L Abstract Chronic use of antiepileptic drugs (AEDs) can induce the development of adverse effects on bone metabolism. In epileptic patients treated with AED, the monitoring of biochemical markers of bone turnover, such as the measurement of serum 25 (OH) vitamin D, bone mineral density, before the beginning of the treatment and during the follow-up is not routinely required. In the future, monitoring of biochemical markers in epileptic patients treated with AED may help us for adequate prevention therapy. PMID: 32508365 [PubMed - in process] ...
Source: Psychopharmacology Bulletin - June 10, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

ASD with the Bor Syndrome: A Case Report.
Authors: Yaylaci F, Sahbudak B, Citli S, Kilit N PMID: 32508366 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - June 10, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Case Report: A Case of Intellectual Disability with Inappropriate and Challenging Sexual Behavior that was Treated with GNRH Analogues.
Authors: Yaylacı F, Gül A Abstract Intellectual Disability starts within the course of developmental stages and covers both intellectual and adaptive deficiencies in conceptual, social and applied fields. Individuals with intellectual disability experience many difficulties in social life due to challenging and inappropriate sexual behaviour. Suchdifficulties need to be addressed, reduced or treated. Traditional treatments often fail to treat and improve suchbehavior. Alternative treatment options need to be explored with studies conducted in this field. With this paper, we aimed to show and touch on alternat...
Source: Psychopharmacology Bulletin - June 10, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Cannabis Use and its Association with Psychological Disorders.
Authors: Urits I, Gress K, Charipova K, Li N, Berger AA, Cornett EM, Hasoon J, Kassem H, Kaye AD, Viswanath O Abstract Purpose of Review: This is a comprehensive review of the association between cannabis use and psychological disorders. It reviews the latest and seminal evidence that is available and attempts to conclude the strength of such association. Recent Findings: Cannabis is a flowering plant with psychoactive properties, attributed to cannabinoids that naturally occur within the plant. These act through the CB1 and CB2 receptors to inhibit GABA and glutamate release, as well through other forms of neu...
Source: Psychopharmacology Bulletin - June 10, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Asenapine in the Treatment of Bipolar Depression.
Conclusions: While this is a very small sample, asenapine appears to have a beneficial effect on both depression and anxiety in depressed bipolar I patients compared to treatment with placebo. Due to the large fraction of subjects with the short form, the hypothesis that the SF-5HTTR might increase asenapine response could not be adequately tested. PMID: 32214517 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 29, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

The Effect of Organic Lithium Salts on Plasma 8-Hydroxy-2'-Deoxyguanosine in Bipolar Patients In Vitro.
Conclusion: Lithium pyruvate reduces oxidative DNA damage in the blood of BD patients in vitro, demonstrating the potential of this compound to function not only as a mood stabilizer, but also as an antioxidant and cytoprotector. PMID: 32214518 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 29, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Psychiatric Prescribing Patterns for Depression Treatment in an Outpatient Depression Clinic.
Conclusion: Healthcare providers observed in this study follow depression treatment guidelines and ensure medications are given an adequate trial. PMID: 32214519 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 29, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Efficacy of Low-Dose Aripiprazole for Treatment of Psychotic Symptoms in a Patient with 22q11.2 Deletion Syndrome.
Conclusions: In the present situation delusional ideas are no longer mentioned, but a cognitive deduction is found. Aripiprazole can be an effective pharmacological solution for the psychotic symptoms in patients suffering from 22q11DS. PMID: 32214520 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 29, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Spontaneous Ejaculation Induced with Atomoxetine.
Authors: Yaylacı F, Şahbudak B, Küçük Ö Abstract Attention Deficit-Hyperactivity Disorder is one of the most common psychiatric disorders of childhood, characterized by attention deficit, hyperactivity and impulsivity. The most effective treatment in ADHD is drug treatment. Stimulant and nonstimulant drug treatments are preferentially used. Atomoxetine is one of the nonstimulant treatments. Although sexual side effects of atomoxetine in adults are reported, there is limited knowledge about sexual side effects in children and adolescents. In this case report, we aimed to describe an adolescen...
Source: Psychopharmacology Bulletin - March 29, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Carotid Artery Dissection Induced Acute Tongue Swelling in a Cocaine User.
We report a 42-year old men who presented to our observation with acute tongue swelling and atrophy of left side of tongue from a hypoglossal nerve injury. A magnetic resonance imaging revealed a denervation of the left half of the tongue from a hypoglossal nerve injury due to left extracranial internal carotid artery (ICA) dissection, without evidence of ischemic stroke. The urine toxicology screen test revealed a positivity for cocaine. This case report suggest to perform in young patient a toxicological drug screening test in presence of ICA dissection with hypoglossal nerve injury and an acute tongue swelling. However ...
Source: Psychopharmacology Bulletin - March 29, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Misdiagnosis of Catatonia.
Authors: Mustafa FA, Nayar A PMID: 32214523 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 29, 2020 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Identifying Predictors of Primary Adherence to Second Generation Long-Acting Injectable Antipsychotics Following Discharge from an Acute Inpatient Psychiatry Unit.
Conclusions: Primary adherence and medication persistence to second generation LAI antipsychotics following hospital discharge is low with approximately 60% of patients not receiving another injection. Clinicians should consider outpatient medication adherence before initiating a second-generation LAI antipsychotic during hospitalization. Efforts should be made to facilitate adherence to LAI antipsychotics during transition of care from inpatient to outpatient settings. PMID: 31308578 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - July 18, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Oral Antipsychotic Versus Long-Acting Injections Antipsychotic in Schizophrenia Spectrum Disorder: a Mirror Analysis in a Real-World Clinical Setting.
Authors: Poloni N, Ielmini M, Caselli I, Lucca G, Gasparini A, Gasparini A, Lorenzoli G, Callegari C Abstract Despite mixed results found in literature, long-acting injectable antipsychotics (LAIs) should offer better efficacy and tolerability, compared to oral antipsychotics due to improved adherence and more stable pharmacokinetics. From this perspective, authors evaluated 153 patients, diagnosed with Schizophrenia Spectrum Disorder and residing in the province of Varese (Italy), in order to compare oral antipsychotics' and LAIs' efficacy in terms of accesses to emergency room, number and length of hospitalizatio...
Source: Psychopharmacology Bulletin - July 18, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Revisiting Lithium: Utility for Behavioral Stabilization in Adolescents and Adults with Autism Spectrum Disorder.
Conclusions: Lithium carbonate is a viable, efficacious and well tolerated alternative to various neuroleptics and other psychotropic medications for use as a mood stabilizer for patients with ASD. PMID: 31308580 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - July 18, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Improved Efficacy of Pregabalin by Restoring Plasma Vitamin D Levels in Migraine: a Case Report.
We report a 46-year old woman affected by migraine, anxiety and mild depressive mood (MSQ score: 24; BDI score: 34; VAS score: 8) that partially improved with pregabalin treatment (VAS: 5). Laboratory findings documented low serum levels of vitamin D (25-hydroxy-vitamin D: 12 ng/mL; normal range: 20-100 ng/mL; 1-25 di-hydroxy-vitamin D: 19 ng/mL, normal range: 25-66 ng/mL). The treatment with 10,000 UI vitamin D during pregabalin therapy induced an improvement of clinical symptoms (pain, anxiety and depression) and of the quality of life. This case report suggest that in chronic migraine patient with anxiety and mild mood ...
Source: Psychopharmacology Bulletin - July 18, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Delayed-Onset Toxicity in an Adolescent Case Following Attempted Suicide with an Overdose of Paliperidone Intake.
Authors: Yaylacı F, Küçük Ö, Erkuran HÖ Abstract Paliperidone is a relatively novel atypical antipsychotic drug that is currently used to treat schizophrenia in adolescents and adults. The drug was generated by combining the active metabolite of risperidone, 9-hydroxyrisperidone, with osmotic controlled-release oral administration system (OROS) technology. Due to its specific design, the drug has been identified as a different form, albeit an active metabolite of risperidone. Such distinction mainly manifests itself during pharmacokinetic processes, because paliperidone is not affected b...
Source: Psychopharmacology Bulletin - July 18, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Successful Resolution of Prominent Somatic Delusions Following Bi-temporal Electroconvulsive Therapy in a patient with Treatment-Resistant Schizoaffective Disorder.
Authors: Cohen JL, Vu MT, Beg MA, Sivaraman S, Birur B Abstract Somatic delusions occur in a variety of psychiatric disorders including schizophrenia, major depressive disorder, and bipolar disorder. Somatization is associated with lower quality of life and greater risk for suicide. Treatment of somatic delusions is extremely challenging. Here we report an interesting case of severe somatic delusions in a 48-year-old African-American female with a long history of treatment resistant schizoaffective disorder, with multiple somatic complaints surrounding constipation, pregnancy, jaw pain, body aches, vaginal itch, ma...
Source: Psychopharmacology Bulletin - July 18, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Serum Concentration of Paliperidone Palmitate Administered Every 3 Weeks.
We report two cases of off-label use resulting in serum paliperidone levels greatly exceeding the recommended therapeutic window. A 20- and 31-year-old male were treated with 150 mg IM paliperidone palmitate/21 days. After one and two years, blood drug concentrations were 240 nmol/l and 610 nmol/l, respectively. Neither patient exhibited major adverse effects. Thus paliperidone serum levels greatly in excess of recommended targets can be well tolerated, although we urge caution with off-label use of paliperidone palmitate as it is not always the most appropriate way to achieve the control of schizophrenia. PMID: 313085...
Source: Psychopharmacology Bulletin - July 18, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Involuntary Facial Twitching in a Patient with Schizophrenia on Treatment with Long Acting Injectable Olanzapine.
Authors: Mustafa FA, Nayar A PMID: 31308585 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - July 18, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Administration of Sub-anesthetic Dose of Ketamine and Electroconvulsive Treatment on Alternate Week Days in Patients with Treatment Resistant Depression: A Double Blind Placebo Controlled Trial.
Authors: Altinay M, Karne H, Anand A Abstract Introduction and Background: Patients with depression who fail to respond to at least two antidepressants in their current episode are considered to have Treatment Resistant Depression (TRD). ECT is an effective treatment of TRD but cognitive side effects limit its use. Ketamine elicits a rapid antidepressant response in sub-anesthetic repeated doses. ECT and ketamine may be modulating the glutamate system, therefore when administered in an interleaved fashion, they could have a synergistic effect. Methods: 15 TRD patients were recruited and 12 were included in the ...
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Impact of Gabapentin Adjunct use with Benzodiazepines for the Treatment of Alcohol Withdrawal in a Psychiatric Hospital.
Conclusion: Gabapentin was not shown to reduce as-needed BZD requirements in patients with a diagnosis of alcohol use disorder admitted for alcohol withdrawal. PMID: 30858636 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Paroxetine versus Vortioxetine for Depressive Symptoms in Postmenopausal Transition: A Preliminary Study.
Conclusions: Data are related to a small sample retrospectively assessed trough a 6-month observation period. Thus, the preliminary results need further research to be confirmed. PMID: 30858637 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

The Impact of Completing Medication Reconciliation and Depression Treatment History in an Outpatient Depression Clinic.
Conclusions: Telephone assessments conducted by pharmacy students prior to an initial depression clinic consultation was associated with higher consultation attendance, identified a large number of medication discrepancies, were successfully reviewed and received by clinicians, potentially saved clinician time, and influenced subsequent medication prescribing. PMID: 30858638 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Exercise as a Treatment for Schizophrenia: A Review.
This article will briefly review the clinical signs, symptoms and proposed etiologies of schizophrenia, and describe the current understanding of exercise programs as an effective treatment in patients with the disease. PMID: 30858639 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Thrombolytic Therapy in Cocaine Users with Ischemic Stroke: A Review of Current Practice.
Authors: Siniscalchi A, De Sarro G, Pacifici R, Pisani E, Sanguigni S, Gallelli L Abstract Alteplase is the main pharmacological treatment available for intravenous thrombolysis in patients with acute ischemic stroke. Endovascular treatment alone or add-on to intravenous thrombolysis is a valid approach in acute ischemic stroke with cerebral large vessel disease. The most common serious adverse reaction related to alteplase is the development of spontaneous intracerebral hemorrhage and the presence of cerebral small vessel disease may increase this risk, particularly in cocaine users, even if only few data have bee...
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Akathisia Induced by Abrupt Withdrawal of Risperidone: A Case Report.
Authors: Soundarrajan G, Chogtu B, Krishna V, Kamath G A, Murugesan M Abstract Akathisia is a common movement disorder that occurs as a consequence of antipsychotic therapy. However, its occurrence secondary to risperidone withdrawal has been reported rarely. Reporting of such rare adverse event gains profound importance because changing the antipsychotics is very common in long term management of affective disorders. Here, we report a 17-year-old female who on withdrawal of risperidone developed akathisia. Further, we also discuss already reported cases in literature in relation to the current case. PMID: 3085...
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

An Approach to the Pharmacotherapy of Neuroleptic Malignant Syndrome.
Authors: van Rensburg R, Decloedt EH Abstract Neuroleptic malignant syndrome is a rare, idiosyncratic emergency associated with exposure to dopamine antagonists, commonly antipsychotic drugs. The typical clinical picture consists of altered consciousness, muscular rigidity, fever, and autonomic instability. While the condition has generally been well described, the pathophysiology is still poorly understood. The importance of this case report is to highlight the lack of robust evidence-based treatment for this emergency. We submit an approach to the pharmacotherapy of neuroleptic malignant syndrome based on the ava...
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Cocaine-Induced Psychosis and Asenapine as Treatment: A Case Study.
We report a 38-years-old man with substance use disorders in methadone maintenance treatment who relapsed on cocaine use and presented CIPD that was satisfactorily treated with asenapine. It is important further research on CIPD management, especially on asenapine and other second-generation antipsychotics du to its possible role in its treatment. PMID: 30858643 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Promoting the Discussion of the Beneficial Effects of Ketamine to Treat Refractory Depression.
Discussion of the Beneficial Effects of Ketamine to Treat Refractory Depression. Psychopharmacol Bull. 2019 Feb 15;49(1):98-99 Authors: Ghosh P, Viswanath O PMID: 30858644 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 16, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Re: An Interesting Presentation About Cyclical Menstrual Psychosis with an Updated Review of Literature.
Authors: Almeida M, Burrell Ward H PMID: 30618469 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - January 9, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

A Perspective on Adolescent Chronic Pain Dismissal.
Authors: Peck J, Viswanath O PMID: 30618470 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - January 9, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

The Utilization of Atypical Antipsychotics in the Pain Medicine Physician's Armamentarium.
Authors: Viswanath O PMID: 30618471 [PubMed - in process] (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - January 9, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Induction of Psychosis by Cyclobenzaprine.
We report a case of psychosis induced by exposure to a commonly prescribed drug to treat muscle spasms and associated pain cyclobenzaprine (Flexeril®). Cyclobenzaprine is structurally very similar to tricyclic anti-depressants, such as amyltriptine. While it is well known that agitation caused by cyclobenzaprine is not an uncommon occurrence in the elderly, there have also been sporadic reports of significant psychosis in association with the use of cyclobenzaprine in younger patients. We report a case of reversible mania in a susceptible 44-year-old patient with a lengthy history of mild borderline personality and bip...
Source: Psychopharmacology Bulletin - January 9, 2019 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research