A Pilot Study to Explore the Effect of Long Acting Injectable Antipsychotics on Aggression
CONCLUSION: The switch from an oral antipsychotic to a LAI antipsychotic did not appear to significantly increase or decrease incidents of aggression or self-injurious behavior, but seemed to decrease the number of restraints/seclusions required.PMID:38449470 | PMC:PMC10913868 (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 7, 2024 Category: Psychiatry & Psychology Authors: Tiffany M Hopkins O Greg Deardorff Yifei Liu Megan G Trout Roger W Sommi Niels C Beck Source Type: research
A Comprehensive Review of Solriamfetol to Treat Excessive Daytime Sleepiness
Psychopharmacol Bull. 2024 Mar 4;54(1):65-86.ABSTRACTPURPOSE OF REVIEW: This is a comprehensive review of the literature regarding the use of Solriamfetol for excessive daytime sleepiness. It covers the background and current therapeutic approaches to treating excessive daytime sleepiness, the management of common comorbidities, and the existing evidence investigating the use of Solriamfetol for this purpose.RECENT FINDINGS: Excessive daytime sleepiness leads to worse quality of life, a medical sequela and significant economic cost. There are multiple phenotypes of excessive daytime sleepiness depending on the comorbidity ...
Source: Psychopharmacology Bulletin - March 7, 2024 Category: Psychiatry & Psychology Authors: Mitchell C Fuller Samuel Carlson Haley Pysick Vince Berry Andrew Tondryk Hayden Swartz Elyse M Cornett Adam M Kaye Omar Viswanath Ivan Urits Alan D Kaye Source Type: research
A Phase 2 Open Label Study of Efficacy, Safety, and Tolerability of SLS-002 (Intranasal Racemic Ketamine) in Adults with MDD at Imminent Risk of Suicide
CONCLUSIONS: The results of this open label study support the continued development of SLS-002. The randomized double-blind placebo-controlled part two of this trial was recently completed.PMID:38449472 | PMC:PMC10913863 (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 7, 2024 Category: Psychiatry & Psychology Authors: Timothy Whitaker Kimberly F Farrand Michael E Thase Source Type: research
Duration of Untreated Illness in Obsessive-Compulsive Disorder and its Associated Factors
CONCLUSION: The present study highlighted a considerable delay before OCD patients received effective treatment. Although many intractable cultural and socioeconomic factors were tested, the strongest associations were found to be unemployment and marital status.PMID:38449473 | PMC:PMC10913869 (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 7, 2024 Category: Psychiatry & Psychology Authors: Anas Ibn Auf Abdelgadir Osman Source Type: research
New-Onset Prolonged Psychosis Following Synthetic Cannabinoid Use in an Older Patient: A Case Report
We present a clinical case report of a 51-year-old African American female with no known psychiatric history who was admitted to the inpatient psychiatric unit after reported paranoia and altered mental status for the preceding six days. During hospitalization, she exhibited disorganization, persecutory delusions, extreme agitation, and bizarre behaviors that included the concealment of a set of stolen keys in her vagina, necessitating an ethics consult. After consideration of differentials, the patient was diagnosed with substance-induced psychotic disorder secondary to SC. The patient was stabilized on 3 mg Risperidone a...
Source: Psychopharmacology Bulletin - March 7, 2024 Category: Psychiatry & Psychology Authors: Ahmed Alhassan Srihari R Prahad Bradley G Burk Rachel E Fargason Badari Birur Source Type: research
A Comprehensive Review of Lemborexant to Treat Insomnia
Psychopharmacol Bull. 2024 Mar 4;54(1):43-64.ABSTRACTPURPOSE OF REVIEW: This is a comprehensive review of the literature regarding Lemborexant for the treatment of insomnia. It covers the background and management of insomnia and then reviews the body of existing evidence evaluating the use of Lemborexant for this purpose.RECENT FINDINGS: Insomnia leads to significant decreased in quality of life and economic burden due to decreased workplace performance and increased health care costs. Insomnia manifests as a single common pathway of hyperarousal due to a highly complex network of interactions between activation of the sy...
Source: Psychopharmacology Bulletin - March 7, 2024 Category: Psychiatry & Psychology Authors: Mitchell C Fuller Samuel F Carlson Chris Grant Vince Berry Marko Ivancich Elyse M Cornett Adam M Kaye Omar Viswanath Ivan Urits Sahar Shekoohi Alan D Kaye Source Type: research
Pregabalin Adjuventia Helped Risperidone-Induced Extrapyramidal Syndrome and Augmented Antipsychotic Response in an Adolescent with Schizophrenia
Psychopharmacol Bull. 2024 Mar 4;54(1):40-42.ABSTRACTHere, authors report on an interesting case of early-onset of schizophrenia where adjunctive pregabalin alleviated risperidone-induced pseudoparkinsonism, helped with insomnia and agitation and boosted antipsychotic response with great tolerability. We wager that gabapentenoids can be a viable option in the niche of psychopharmacotherapy of schizophrenia in CAP population.PMID:38449476 | PMC:PMC10913867 (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 7, 2024 Category: Psychiatry & Psychology Authors: Ahmed Naguy Saxby Pridmore Bibi Alamiri Source Type: research
A Pilot Study to Explore the Effect of Long Acting Injectable Antipsychotics on Aggression
CONCLUSION: The switch from an oral antipsychotic to a LAI antipsychotic did not appear to significantly increase or decrease incidents of aggression or self-injurious behavior, but seemed to decrease the number of restraints/seclusions required.PMID:38449470 | PMC:PMC10913868 (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 7, 2024 Category: Psychiatry & Psychology Authors: Tiffany M Hopkins O Greg Deardorff Yifei Liu Megan G Trout Roger W Sommi Niels C Beck Source Type: research
A Comprehensive Review of Solriamfetol to Treat Excessive Daytime Sleepiness
Psychopharmacol Bull. 2024 Mar 4;54(1):65-86.ABSTRACTPURPOSE OF REVIEW: This is a comprehensive review of the literature regarding the use of Solriamfetol for excessive daytime sleepiness. It covers the background and current therapeutic approaches to treating excessive daytime sleepiness, the management of common comorbidities, and the existing evidence investigating the use of Solriamfetol for this purpose.RECENT FINDINGS: Excessive daytime sleepiness leads to worse quality of life, a medical sequela and significant economic cost. There are multiple phenotypes of excessive daytime sleepiness depending on the comorbidity ...
Source: Psychopharmacology Bulletin - March 7, 2024 Category: Psychiatry & Psychology Authors: Mitchell C Fuller Samuel Carlson Haley Pysick Vince Berry Andrew Tondryk Hayden Swartz Elyse M Cornett Adam M Kaye Omar Viswanath Ivan Urits Alan D Kaye Source Type: research
A Phase 2 Open Label Study of Efficacy, Safety, and Tolerability of SLS-002 (Intranasal Racemic Ketamine) in Adults with MDD at Imminent Risk of Suicide
CONCLUSIONS: The results of this open label study support the continued development of SLS-002. The randomized double-blind placebo-controlled part two of this trial was recently completed.PMID:38449472 | PMC:PMC10913863 (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 7, 2024 Category: Psychiatry & Psychology Authors: Timothy Whitaker Kimberly F Farrand Michael E Thase Source Type: research
Duration of Untreated Illness in Obsessive-Compulsive Disorder and its Associated Factors
CONCLUSION: The present study highlighted a considerable delay before OCD patients received effective treatment. Although many intractable cultural and socioeconomic factors were tested, the strongest associations were found to be unemployment and marital status.PMID:38449473 | PMC:PMC10913869 (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 7, 2024 Category: Psychiatry & Psychology Authors: Anas Ibn Auf Abdelgadir Osman Source Type: research
New-Onset Prolonged Psychosis Following Synthetic Cannabinoid Use in an Older Patient: A Case Report
We present a clinical case report of a 51-year-old African American female with no known psychiatric history who was admitted to the inpatient psychiatric unit after reported paranoia and altered mental status for the preceding six days. During hospitalization, she exhibited disorganization, persecutory delusions, extreme agitation, and bizarre behaviors that included the concealment of a set of stolen keys in her vagina, necessitating an ethics consult. After consideration of differentials, the patient was diagnosed with substance-induced psychotic disorder secondary to SC. The patient was stabilized on 3 mg Risperidone a...
Source: Psychopharmacology Bulletin - March 7, 2024 Category: Psychiatry & Psychology Authors: Ahmed Alhassan Srihari R Prahad Bradley G Burk Rachel E Fargason Badari Birur Source Type: research
A Comprehensive Review of Lemborexant to Treat Insomnia
Psychopharmacol Bull. 2024 Mar 4;54(1):43-64.ABSTRACTPURPOSE OF REVIEW: This is a comprehensive review of the literature regarding Lemborexant for the treatment of insomnia. It covers the background and management of insomnia and then reviews the body of existing evidence evaluating the use of Lemborexant for this purpose.RECENT FINDINGS: Insomnia leads to significant decreased in quality of life and economic burden due to decreased workplace performance and increased health care costs. Insomnia manifests as a single common pathway of hyperarousal due to a highly complex network of interactions between activation of the sy...
Source: Psychopharmacology Bulletin - March 7, 2024 Category: Psychiatry & Psychology Authors: Mitchell C Fuller Samuel F Carlson Chris Grant Vince Berry Marko Ivancich Elyse M Cornett Adam M Kaye Omar Viswanath Ivan Urits Sahar Shekoohi Alan D Kaye Source Type: research
Pregabalin Adjuventia Helped Risperidone-Induced Extrapyramidal Syndrome and Augmented Antipsychotic Response in an Adolescent with Schizophrenia
Psychopharmacol Bull. 2024 Mar 4;54(1):40-42.ABSTRACTHere, authors report on an interesting case of early-onset of schizophrenia where adjunctive pregabalin alleviated risperidone-induced pseudoparkinsonism, helped with insomnia and agitation and boosted antipsychotic response with great tolerability. We wager that gabapentenoids can be a viable option in the niche of psychopharmacotherapy of schizophrenia in CAP population.PMID:38449476 | PMC:PMC10913867 (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 7, 2024 Category: Psychiatry & Psychology Authors: Ahmed Naguy Saxby Pridmore Bibi Alamiri Source Type: research
A Pilot Study to Explore the Effect of Long Acting Injectable Antipsychotics on Aggression
CONCLUSION: The switch from an oral antipsychotic to a LAI antipsychotic did not appear to significantly increase or decrease incidents of aggression or self-injurious behavior, but seemed to decrease the number of restraints/seclusions required.PMID:38449470 | PMC:PMC10913868 (Source: Psychopharmacology Bulletin)
Source: Psychopharmacology Bulletin - March 7, 2024 Category: Psychiatry & Psychology Authors: Tiffany M Hopkins O Greg Deardorff Yifei Liu Megan G Trout Roger W Sommi Niels C Beck Source Type: research
