Efficacy and safety of rademikibart (CBP-201), a next-generation monoclonal antibody targeting IL-4R α, in adults with moderate-to-severe atopic dermatitis: a phase 2 randomized trial (CBP-201-WW001)
CONCLUSION: Rademikibart was efficacious and well tolerated at Q2W and Q4W intervals. Q4W dosing is a more convenient frequency than approved for current therapies.PMID:38157942 | DOI:10.1016/j.jaci.2023.11.924 (Source: Herpes)
Source: Herpes - December 29, 2023 Category: Infectious Diseases Authors: Jonathan I Silverberg Bruce Strober Brian Feinstein Jinhua Xu Emma Guttman-Yassky Eric L Simpson Pauline Li Malinda Longphre Jing Song Jiawang Guo Jang Yun Belinda Williams Wubin Pan Selwyn Ho Ra úl Collazo Zheng Wei Source Type: research
A fractional modeling approach for the transmission dynamics of measles with double-dose vaccination
This study examines a SEIVR compartmental model in the caputo sense using a double dose of vaccine to simulate the measles outbreak. The reproduction number R0 and model properties are both thoroughly examined. Both the local and global stabilities of the proposed model are determined for R0 less and greater than 1. To achieve the model's global stability, the Lyapunov function is used while the existence and uniqueness of the proposed model are demonstrated In addition to the calculated and fitted biological parameters, the forward sensitivity indices for R0 are also obtained. Simulations of the proposed fractional order ...
Source: Computer Methods in Biomechanics and Biomedical Engineering - December 27, 2023 Category: Biomedical Engineering Authors: Muhammad Farhan Zahir Shah Rashid Jan Saeed Islam Mansoor H Alshehri Zhi Ling Source Type: research
Epinastine Cream: A Novel Once-Daily Therapeutic Agent for Allergic Conjunctivitis
Journal of Ocular Pharmacology and Therapeutics, Ahead of Print. (Source: Journal of Ocular Pharmacology and Therapeutics)
Source: Journal of Ocular Pharmacology and Therapeutics - December 27, 2023 Category: Opthalmology Authors: Naoki Ogura Koushi Fujisawa Masatomo Kato Source Type: research
Impact of black soot emissions on public health in Niger Delta, Nigeria: understanding the severity of the problem
Inhal Toxicol. 2023 Dec 25:1-13. doi: 10.1080/08958378.2023.2297698. Online ahead of print.ABSTRACTRivers State, Niger Delta, Nigeria often referred to as the 'treasure bed of the nation' is the seat of crude oil production activities with the accompanying environmental degradation. The severity of the environmental pollution and contaminated air quality took a new turn for the worse in November 2016, when the residents of Port Harcourt city, Rivers State, a major oil producing State experienced for the first time, aerosol deposition of plumes of black soot. This systematic review paper is aimed at quantifying the severity...
Source: Inhalation Toxicology - December 25, 2023 Category: Respiratory Medicine Authors: Osazuwa Clinton Ekhator Fortune Chiemelie Orish Ernest O Nnadi Daprim Samuel Ogaji Success Isuman Orish Ebere Orisakwe Source Type: research
Atopic Dermatitis and the Risk of Infection in End-Stage Renal Disease
Conclusions: Overall, after controlling for demographic and clinical covariates and adjusting for person-years-at-risk, AD was associated with an increased risk for some, but not all, infections within the population of patients with ESRD.PMID:38138248 | DOI:10.3390/medicina59122145 (Source: Herpes)
Source: Herpes - December 23, 2023 Category: Infectious Diseases Authors: Rushan I Momin Stephanie L Baer Jennifer L Waller Lufei Young Sarah Tran Varsha Taskar Wendy B Bollag Source Type: research
Atopic Dermatitis and the Risk of Infection in End-Stage Renal Disease
Conclusions: Overall, after controlling for demographic and clinical covariates and adjusting for person-years-at-risk, AD was associated with an increased risk for some, but not all, infections within the population of patients with ESRD.PMID:38138248 | PMC:PMC10744789 | DOI:10.3390/medicina59122145 (Source: Herpes)
Source: Herpes - December 23, 2023 Category: Infectious Diseases Authors: Rushan I Momin Stephanie L Baer Jennifer L Waller Lufei Young Sarah Tran Varsha Taskar Wendy B Bollag Source Type: research
Frequency of feline herpesvirus 1 (FHV-1) in domestic cats from Campo Grande, MS, Brazil
An Acad Bras Cienc. 2023 Dec 15;95(suppl 2):e20221010. doi: 10.1590/0001-3765202320221010. eCollection 2023.ABSTRACTFeline herpesvirus type 1 (HVF-1) is the infectious agent of feline viral rhinotracheitis. The main clinical signs are cough, nasal and eye discharge, fever, conjunctivitis and sneezing. Although the occurrence of the virus is known in some regions of Brazil, in Campo Grande, Mato Grosso do Sul (MS), there is no epidemiological information about its frequency. Thus, this study aimed to determine the frequency of feline herpesvirus type 1 in the region, and to evaluate its possible association with clinical an...
Source: An Acad Bras Cienc - December 21, 2023 Category: Science Authors: Juliany B Cavalheiro J éssica T Echeverria Carlos A N Ramos Veronica J Babo-Terra Source Type: research
Frequency of feline herpesvirus 1 (FHV-1) in domestic cats from Campo Grande, MS, Brazil
An Acad Bras Cienc. 2023 Dec 15;95(suppl 2):e20221010. doi: 10.1590/0001-3765202320221010. eCollection 2023.ABSTRACTFeline herpesvirus type 1 (HVF-1) is the infectious agent of feline viral rhinotracheitis. The main clinical signs are cough, nasal and eye discharge, fever, conjunctivitis and sneezing. Although the occurrence of the virus is known in some regions of Brazil, in Campo Grande, Mato Grosso do Sul (MS), there is no epidemiological information about its frequency. Thus, this study aimed to determine the frequency of feline herpesvirus type 1 in the region, and to evaluate its possible association with clinical an...
Source: An Acad Bras Cienc - December 21, 2023 Category: Science Authors: Juliany B Cavalheiro J éssica T Echeverria Carlos A N Ramos Veronica J Babo-Terra Source Type: research
