Short course gamma tocopherol did not mitigate effects of ozone on airway inflammation in asthmatics.
Authors: Burbank AJ, Hernandez ML, Robinette C, Wang T, Zhou H, Alexis N, Bennett WD, Peden DB PMID: 32727225 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - July 31, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Numerical modeling of nanoparticle deposition in realistic monkey airway and human airway models: a comparative study.
CONCLUSIONS: The results of this study can contribute to the research involving extrapolation of inhalation toxicology studies, from monkeys to humans. PMID: 32729366 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - July 31, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Estimates of carbon nanotube deposition in the lung: improving quality and robustness.
Authors: Wright MD, Buckley AJ, Smith R Abstract Carbon nanotube (CNT) in vivo inhalation studies are increasingly providing estimates of the quantity of material deposited in the lung, generally estimated using standard formulae and pulmonary deposition models. These models have typically been developed and validated using data from studies using sphere-like particles. Given the importance of particle morphology to pulmonary deposition, the appropriateness of such an approach was explored to identify any potential limitations. Aerosolized CNT particles typically form 'fiber-like' and/or 'broadly spherical' ag...
Source: Inhalation Toxicology - July 23, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Exploration of therapeutic role of montelukast and dexamethasone combination against paraquat induced inhalational toxicity.
Conclusions: Given the advantage of therapeutic synergism activity of MON and DXM, it may be used in the prophylaxis of PQ-intoxication following clinical trials. PMID: 32597253 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - July 1, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Absence of mesothelioma risk maintained in an expanded international cohort of cosmetic talc miners and millers.
Conclusions: Despite the recent finding of one case of mesothelioma in the Vermont cohort (a case unlikely related to talc exposure), we continue to conclude that the epidemiological evidence from the cosmetic talc miner/miller cohort studies does not support the hypothesis that cosmetic talc exposures are associated with an increased risk of pleural mesothelioma. PMID: 32571118 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - June 24, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Airborne particulate matter from goat farm increases acute allergic airway responses in mice.
Authors: Liu D, Wagner JG, Mariman R, Harkema JR, Gerlofs-Nijland ME, Pinelli E, Folkerts G, Cassee FR, Vandebriel RJ Abstract Background: Inhalation exposure to biological particulate matter (BioPM) from livestock farms may provoke exacerbations in subjects suffering from allergy and asthma. The aim of this study was to use a murine model of allergic asthma to determine the effect of BioPM derived from goat farm on airway allergic responses.Methods: Fine (
Source: Inhalation Toxicology - June 24, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Transfer of metals in the liquids of electronic cigarettes.
Conclusions: There is a transfer of metals from the heating coils to the e-liquids. This transfer depends on the e-liquid composition and on the boiling temperature. PMID: 32538207 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - June 17, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

The impact of allergies and smoking status on nasal mucosa of hypertrophied turbinates - an immunohistologic analysis.
Conclusion: The coexistence of an allergic background and smoking alters known immunologic responses within the nasal mucosa. Smoking may have an immunosuppressive role in the nasal mucosa in both innate and humoral immune systems. PMID: 32530330 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - June 14, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Acute neuroradiological, behavioral, and physiological effects of nose-only exposure to vaporized cannabis in C57BL/6 mice.
Conclusions: Quantified physiological, behavioral, and neurological responses served as validation for our mouse model of cannabis inhalation. Animal models of aerosol exposure will be instrumental for uncovering the health outcomes of chronic cannabis use. PMID: 32475185 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - June 3, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

A review of pulmonary toxicity studies of nanocellulose.
Authors: Sai T, Fujita K Abstract In recent years, nanocellulose (NC) obtained by defibrating cellulose to the nanometer level has been developed, and its development for various applications, e.g. as an additive for cosmetics and as a component of structural elements, is progressing. However, because NC has unique physico-chemical properties that are not found in conventional nanomaterials, particularly when inhaled, there are concerns about unexpected effects on organisms. This review summarizes the progress of in vivo experiments on the effects of NC on the respiratory system by inhalation. In addition, thi...
Source: Inhalation Toxicology - May 30, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Impact on rats from acute intratracheal inhalation exposures to WTC dusts.
Conclusions: These results provide further support for our longstanding hypothesis that the WTC dusts could potentially have acted as direct inducers of many of the health effects that have been seen in the exposed FR. PMID: 32448006 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - May 27, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Physical and elemental analysis of Middle East sands from recent combat zones.
Conclusions: These data demonstrate significant differences in Iraq and Afghanistan sand particle size and characteristics. Middle East sands contained elevated levels of elements that have been associated with respiratory disease versus control site sand, suggesting the potential of sand/dust storm exposure to promote adverse respiratory symptoms. Data also demonstrate the potential for variation based on geographical region or site of exposure. The data generated provide baseline information that will be valuable in designing future exposure studies. PMID: 32448007 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - May 27, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Associations of HMGB1 gene polymorphisms with risk of coal workers' pneumoconiosis susceptibility in Chinese Han population.
The objective of the study was to determine the association between HMGB1 polymorphisms and CWP in Chinese Han population.Methods: The genotypes of HMGB1 gene rs1045411, rs2249825, rs1412125 and rs1360485 in 340 CWP patients and 312 healthy controls were determined and serum HMGB1 levels were detected.Results: Our finding showed that the HMGB1 rs1360485 G allele increased the risk of CWP in comparison with A allele (P = 0.005). HMGB1 rs1360485 GG genotype as well as AG+GG genotype increased the risk of CWP in comparison with AA genotype (P = 0.010, P = 0.025, respectively). Four ha...
Source: Inhalation Toxicology - May 17, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Chemical characterization of marijuana blunt smoke by non-targeted chemical analysis.
Conclusion: This study shows the power and utility of GC × GC-TOFMS as a methodology for non-targeted chemical analysis to identify new chemical exposures in blunt MSS and to provide data to guide further investigations of blunt MSS. PMID: 32408835 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - May 17, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Independent roles of beta-adrenergic and glucocorticoid receptors in systemic and pulmonary effects of ozone.
Conclusions: In summary, 1) activating βAR, even with GR inhibition, exacerbated and inhibiting βAR, even with GR activation, attenuated ozone-induced pulmonary effects; and 2) activating GR exacerbated ozone systemic effects, but with βAR inhibition, this exacerbation was less remarkable. These data suggest the independent roles of βAR in pulmonary and dependent roles of βAR and GR in systemic effects of ozone. PMID: 32366144 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - May 7, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Development of chronic lung injury and pulmonary fibrosis in mice following acute exposure to nitrogen mustard.
Conclusions: We conclude that the mouse represents a useful model of NM-induced acute lung injury and chronic pulmonary fibrosis, the latter driven by the overexpression of TGF-β, p-ERK, and P-HSP90. This model may prove useful in the pre-clinical development of antidotes and other countermeasures. PMID: 32362214 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - May 5, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Changes at global and site-specific DNA methylation of MLH1 gene promoter induced by waterpipe smoking in blood lymphocytes and oral epithelial cells.
Authors: Sabi SH, Khabour OF, Alzoubi KH, Cobb CO, Eissenberg T Abstract Objective: Cigarette tobacco smoking has been shown to cause cancer through different mechanisms that include epigenetic modulation of tumor-suppressor genes. In the present study, the association between global and MLH1 gene promoter methylation and waterpipe tobacco smoking was investigated. Materials and Methods: Blood lymphocytes and oral epithelium were sampled from 150 pure waterpipe smokers and 150 never-smokers from Jordan. Methylation assessment was performed using the methylation-specific PCR technique for MLH1 gene and ELISA for glo...
Source: Inhalation Toxicology - April 24, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Impairment of endothelial progenitor cells function in patient with mustard gas intoxication.
Conclusions: SM exposure resulted in decreased proliferation and migration of EPCs, which was associated with decreased tubule formation and angiogenic factors. PMID: 32312128 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - April 22, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Acute changes in lung function following controlled exposure to cookstove air pollution in the subclinical tests of volunteers exposed to smoke (STOVES) study.
Conclusions: Patterns suggesting short-term decreases in lung function follow from exposure to cookstove air pollution even for stove exposures with low PM2.5 levels. PMID: 32297528 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - April 18, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Low powered variable voltage E-Cigarette batteries under perform at higher power settings.
Conclusion: Studies seeking to associate VV EC power with psychological, physiological or toxicological effects should measure the actual power supplied or else a negative bias is likely to be observed in trials above 8.5 watts. PMID: 32279591 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - April 15, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Global optimization of the Michaelis-Menten parameters using physiologically-based pharmacokinetic (PBPK) modeling and chloroform vapor uptake data in F344 rats.
Conclusion: In summary, this work should help toxicologists interested in optimization techniques understand the overall process employed when calibrating metabolic parameters in a PBPK model with inhalation data. PMID: 32241199 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - April 5, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Determination of the relative contribution of the non-dissolved fraction of ZnO NP on membrane permeability and cytotoxicity.
Conclusions: These studies demonstrate the ability of intact ZnO NP to induce membrane permeability and cytotoxicity without the contribution of dissolved Zn2+, suggesting that ZnO NP toxicity does not necessarily depend upon Zn2+. The stability of ZnO NP inside the phagolysosomes suggests that LMP is the result of the toxic effect of intact ZnO NP on phagolysosomal membranes. PMID: 32216500 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - March 29, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Occupational exposure to carbon fibers impregnated with epoxy resins and evaluation of their respirability.
Conclusions: Despite the evidence of occupational exposure to low concentrations of CFR, the absence of such fibers in the EBC in the exposed workers confirms their non-respirability, as expected based on their aerodynamic diameter. PMID: 32197573 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - March 22, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

TDZD-8 alleviates delayed neurological sequelae following acute carbon monoxide poisoning involving tau protein phosphorylation.
Conclusions: The therapeutic effect of TDZD-8 in alleviating DNS caused by acute CO poisoning is related to the inactivation of Tau by intensifying the level of GSK-3β phosphorylation. PMID: 32188325 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - March 21, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Physiological responses to cisplatin using a mouse hypersensitivity model.
Authors: Lehmann DM, Williams WC Abstract Background: The physiological mechanisms underlying the development of respiratory hypersensitivity to cisplatin (CDDP) are not well-understood. It has been suggested that these reactions are likely the result of type I hypersensitivity, but other explanations are plausible and the potential for CDDP to induce type I hypersensitivity responses has not been directly evaluated in an animal model. Objectives and Methods: To investigate CDDP hypersensitivity, mice were topically sensitized through application of CDDP before being challenged by oropharyngeal aspiration (OPA) wit...
Source: Inhalation Toxicology - March 21, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Expert workshop on the hazards and risks of poorly soluble low toxicity particles.
Authors: Driscoll KE, Borm PJA Abstract 'Lung particle overload' refers to the impaired lung particle clearance and increased particle retention occurring with high lung doses of poorly soluble low toxicity (PSLT) particles. In rats, lung particle overload is associated with inflammation, epithelial hyperplasia, and, in extreme cases, lung cancer. While the human relevance of rat lung tumors occurring under overload has been questioned, recent regulatory decisions have considered these outcomes evidence of possible human hazard. To better understand the state-of-the-science on PSLT toxicology, an Expert Workshop wa...
Source: Inhalation Toxicology - March 11, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

No pathogenic responses in rat lung upon exposure to ground granulated blast furnace slag (GGBS).
Authors: Dillon K, Jochims K, Gerigk U, Jost F, Kobesen H, Bialucha R Abstract Objective: Granulated blast furnace slag (GBS) is a by-product of the manufacture of iron by thermochemical reduction in a blast furnace. Blast furnace slag is generated at temperatures above 1500 °C. If the liquid slag is quenched very rapidly with water, a glassy slag is generated (GBS). It is used - after grinding
Source: Inhalation Toxicology - March 5, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

A systematic review of the health effects associated with the inhalation of particle-filtered and whole diesel exhaust.
Conclusions: Overall, the results from this systematic review demonstrate that exposure to different components in diesel exhaust can have distinct and independent health effects. Thus, to better inform human health risk assessments, future studies aimed at elucidating the health effects from diesel exhaust should include exposure to both particle-filtered and whole diesel exhaust. PMID: 32100584 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - February 28, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Mouse pulmonary dose- and time course-responses induced by exposure to nitrogen-doped multi-walled carbon nanotubes.
Conclusions: These data indicate nitrogen doping of MWCNT decreases their bioactivity, as reflected with lower in vitro and in vivo toxicity inflammation and lung disease. The lower activation of the NLRP3 inflammasome may be responsible. Abbreviations: NDMWCNT: nitrogen-doped multi-walled carbon nanotubes; MWCNT: multi-walled carbon nanotubes; TEM: transmission electron microscopy; HRTEM: high resolution transmission electron microscopy; IL-1ß: interleukin-1ß; DM: dispersion medium; WLL: whole lung lavage; IL-18: interleukin-18; GSD: geometric standard deviation; XPS: X-ray photoelectron spectroscopy...
Source: Inhalation Toxicology - February 8, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

PBPK modeling characterization of potential acute impairment effects from inhalation of ethanol during e-cigarette use.
Conclusions: The approach used in this study, combining a validated PBPK model for a toxicant with peer-reviewed topographical parameters, can serve as a screening-level exposure assessment useful for evaluation of the safety of e-liquid formulations. Abbreviations: BAC: blood alcohol concentration; e-cigarette: electronic cigarette; e-liquid: e-cigarette liquid or propylene glycol and/or vegetable glycerin-based liquid; HS-GC-FID: headspace gas chromatography with flame-ionization detection; HS-GC-MS: headspace gas chromatography-mass spectrometry; PBPK: physiologically based pharmacokinetic; Cair: puff concentration expr...
Source: Inhalation Toxicology - February 5, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Incorporation of in  vitro metabolism data and physiologically based pharmacokinetic modeling in a risk assessment for chloroprene.
Discussion and conclusions: The revised chloroprene PBPK model is based on the best available science, including new test animal in vivo validation, updated literature review and a Markov-Chain Monte Carlo analysis to assess parameter uncertainty. Relying on both mouse and human metabolism data also provides an important advancement in the use of quantitative in vitro to in vivo extrapolation (QIVIVE). Inclusion of the best available science is especially important when deriving a toxicity value based on species extrapolation for the potential carcinogenicity of a reactive metabolite. PMID: 31992090 [PubMed - as suppli...
Source: Inhalation Toxicology - January 31, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Behavior-based yield for electronic cigarette users of different strength eliquids based on natural environment topography.
Conclusions: Evidence was provided for topography as a compensatory mechanism. Use of low nicotine strength eliquids can increase TPM, which can lead to increase in HPHC. Regulatory review of new products should consider natural use topography and realistic use exposures to nicotine, TPM and HPHCs. PMID: 31994941 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - January 31, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Time-course transcriptomic alterations reflect the pathophysiology of polyhexamethylene guanidine phosphate-induced lung injury in rats.
Conclusion: The results of transcriptomic analysis were consistent with lung histopathology results. These findings indicated that exposure-time-specific changes in gene expression closely reflected time-dependent pathological changes in PHMG-P-induced lung injury. PMID: 31971030 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - January 25, 2020 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Letter concerning: Occupational exposures to cosmetic talc and risk of mesothelioma: an updated pooled cohort and statistical power analysis with consideration of latency period by Gary M. Marsh et  al. (Inhal Toxicol. 2019 Aug 5:1-11. doi:10.1080/08958378.2019.1645768).
Letter concerning: Occupational exposures to cosmetic talc and risk of mesothelioma: an updated pooled cohort and statistical power analysis with consideration of latency period by Gary M. Marsh et al. (Inhal Toxicol. 2019 Aug 5:1-11. doi:10.1080/08958378.2019.1645768). Inhal Toxicol. 2019 Dec 24;:1-3 Authors: Finkelstein MM PMID: 31874570 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - December 26, 2019 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Cultivation and aerosolization of Stachybotrys chartarum for modeling pulmonary inhalation exposure.
This study aimed to develop a method of S. chartarum aerosolization to better model inhalation exposures. Materials and methods: An acoustical generator system (AGS) was previously developed and utilized to aerosolize and deliver fungal spores to mice housed in a multi-animal nose-only exposure chamber. In this study, methods for cultivating, heat-inactivating, and aerosolizing two macrocyclic trichothecene-producing strains of S. chartartum using the AGS are described. Results and discussion: In addition to conidia, acoustical generation of one strain of S. chartarum resulted in the aerosolization of fungal fragments (
Source: Inhalation Toxicology - December 26, 2019 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Secondhand smoke as a risk factor for attention deficit hyperactivity disorder in children.
Conclusion: In conclusion, there is a significant association between ADHD in the examined sample of children and exposure to SHS. Serum cotinine is a biomarker reflecting current exposure to SHS but it is not a reliable indicator of past and long-term exposure to SHS. PMID: 31874576 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - December 26, 2019 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Particle and organic vapor emissions from children's 3-D pen and 3-D printer toys.
Authors: Yi J, Duling MG, Bowers LN, Knepp AK, LeBouf RF, Nurkiewicz TR, Ranpara A, Luxton T, Martin SB, Burns DA, Peloquin DM, Baumann EJ, Virji MA, Stefaniak AB Abstract Objective: Fused filament fabrication "3-dimensional (3-D)" printing has expanded beyond the workplace to 3-D printers and pens for use by children as toys to create objects.Materials and methods: Emissions from two brands of toy 3-D pens and one brand of toy 3-D printer were characterized in a 0.6 m3 chamber (particle number, size, elemental composition; concentrations of individual and total volatile organic compounds (TVOC)). ...
Source: Inhalation Toxicology - December 26, 2019 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Response to Marsh, G. M., Ierardi, A. M., Benson, S. M., & Finley, B. L. (2019). Occupational exposures to cosmetic talc and risk of mesothelioma: an updated pooled cohort and statistical power analysis with consideration of latency period. Inhalation toxicology, 31(6), 213-223.
Response to Marsh, G. M., Ierardi, A. M., Benson, S. M., & Finley, B. L. (2019). Occupational exposures to cosmetic talc and risk of mesothelioma: an updated pooled cohort and statistical power analysis with consideration of latency period. Inhalation toxicology, 31(6), 213-223. Inhal Toxicol. 2019 Dec 17;:1-2 Authors: Madigan D, Egilman D, Finkelstein MM, Tran T, Yimam M PMID: 31847624 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - December 20, 2019 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Response to letters regarding "Occupational exposures to cosmetic talc and risk of mesothelioma: an updated pooled cohort and statistical power analysis with consideration of latency period".
Response to letters regarding "Occupational exposures to cosmetic talc and risk of mesothelioma: an updated pooled cohort and statistical power analysis with consideration of latency period". Inhal Toxicol. 2019 Dec 18;:1-5 Authors: Marsh GM, Ierardi AM, Benson SM, Finley BL PMID: 31851545 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - December 20, 2019 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Autoimmune markers for progression of Libby amphibole lamellar pleural thickening.
Conclusion: The data support the hypothesis that progressive LPT is associated with immunological findings that may serve as an initial screen for progressive LPT. PMID: 31814459 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - December 10, 2019 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Effects of sevoflurane on reproductive function of male rats and its main mechanism of action.
Discussion and conclusions: Sevoflurane induces disorders of spermatogenesis and causes testicular injury. The underlying mechanism may be related to the imbalance of sex hormones in the hypothalamic-pituitary-gonadal axis. PMID: 31805798 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - December 8, 2019 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

A custom-built low-cost chamber for exposing rodents to e-cigarette aerosol: practical considerations.
Conclusions: Our low-cost exposure chamber can be used in animal experimental studies of the health effects of e-cigarettes. Our model allows estimating design parameters such as chamber volume, air exchange rate, and puff period. PMID: 31797690 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - December 6, 2019 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Pulmonary toxicity induced by exposure to phthalates, an experimental study.
Conclusion: DEHP has a toxic effect on the lung tissues, which after its withdrawal did not improve completely. PMID: 31777295 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - November 30, 2019 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Characterization of an aerosol generation system to assess inhalation risks of aerosolized nano-enabled consumer products.
In this study, we developed a fully automated aerosol generation system to examine the aerosol properties of four aerosolized nano-enabled cosmetics using real-time monitoring and sampling instrumentation. Physicochemical characterization of aerosols was conducted using scanning electron microscopy coupled with energy dispersive x-ray spectroscopy (SEM-EDX). Characterization and calibration of animal exposure pods coupled to the system were also performed by measuring and comparing particle concentrations between pods.Results and Discussion: Results show peak emissions are shade dependent and varied between 12,000-22,000 p...
Source: Inhalation Toxicology - November 30, 2019 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Bedding-generated particulate matter: implications for rodent studies.
CONCLUSIONS: These results indicate that standard laboratory housing conditions can expose rodents to substantial levels of PM2.5. Bedding-generated PM has potential implications as an environmental agent in rodent studies. PMID: 31762350 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - November 26, 2019 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Surface area- and mass-based comparison of fine and ultrafine nickel oxide lung toxicity and augmentation of allergic response in an ovalbumin asthma model.
Conclusions: Collectively, these findings suggest that although NiO surface area correlates best with acute pulmonary injury and inflammation following respiratory exposure, other physico-chemical properties may contribute to the modulation of immune responses in the lung. PMID: 31707870 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - November 13, 2019 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Assessment of the physicochemical properties of chrysotile-containing brake debris pertaining to toxicity.
Conclusions: The long, free, respirable chrysotile fibers were present in BD, yet were of low bio-durability; incubation in artificial lysosomal fluid led to destruction of free fibers. PMID: 31690138 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - November 8, 2019 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Characterization and cytotoxicity assessment of nargile smoke using dynamic exposure.
Conclusions: The presented data clearly indicated significant in vitro cytotoxicity, genotoxicity and apoptosis/necrosis associated with a 60-min single session of nargile smoking. PMID: 31665951 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - November 3, 2019 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Correction.
Authors: PMID: 31615272 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - October 17, 2019 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Prevention of crystalline silica-induced inflammation by the anti-malarial hydroxychloroquine.
Conclusions: Our findings suggest that hydroxychloroquine blocks LMP and can significantly decrease cSiO2-induced toxicity in vitro. HCQ may be a promising treatment for prevention of cSiO2-induced lung damage. PMID: 31556748 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - September 27, 2019 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research