Daily low-dose tadalafil may reduce the penile curvature progression rate in patients with acute Peyronie’s disease: a retrospective comparative analysis
International Journal of Impotence Research, Published online: 13 December 2022; doi:10.1038/s41443-022-00651-8Daily low-dose tadalafil may reduce the penile curvature progression rate in patients with acute Peyronie’s disease: a retrospective comparative analysis (Source: International Journal of Impotence Research)
Source: International Journal of Impotence Research - December 13, 2022 Category: Urology & Nephrology Authors: Lorenzo Spirito Celeste Manfredi Roberto La Rocca Luigi Napolitano Antonio Di Girolamo Marco Capece Francesco Trama Carmine Sciorio Ioannis Sokolakis Massimiliano Creta Davide Arcaniolo Source Type: research
Tadalafil increases the antitumor activity of 5-FU through inhibiting PRMT5-mediated glycolysis and cell proliferation in colorectal cancer
ConclusionsOur data indicates that PRMT5 promoted colorectal cancer proliferation partially through activating glycolysis and may be a potential target for colorectal cancer therapy. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - December 6, 2022 Category: Cancer & Oncology Source Type: research
EE251 A Budget Impact Analysis of the Introduction of Generics Ambrisentan and Tadalafil for the Treatment of Pulmonary Arterial Hypertension in Greece
The purpose of this study was to estimate the potential budget impact of the introduction and uptake of generics of Ambrisentan and Tadalafil for the treatment of Pulmonary Arterial Hypertension (PAH) in Greece. (Source: Value in Health)
Source: Value in Health - December 1, 2022 Category: International Medicine & Public Health Authors: N Nomikos, I Kyriopoulos, K Athanasakis Source Type: research
Central Serous Chorioretinopathy Associated with Tadalafil
In conclusion, prescribing physicians should be aware of tadalafil’s ability to decrease vision and cause CSCR. The addition of CSCR to the list of tadalafil’s side effects should also be considered.Case Rep Ophthalmol 2022;13:1008 –1011 (Source: Case Reports in Ophthalmology)
Source: Case Reports in Ophthalmology - November 28, 2022 Category: Opthalmology Source Type: research
Terahertz spectroscopic detection of antifatigue illegal additives in health care product matrices
Tadalafil is an illegal additive in antifatigue supplements. It is often misused in various plant dietary supplements (BDS), resulting in ... (Source: Applied Optics)
Source: Applied Optics - November 15, 2022 Category: Physics Authors: Wu Pan Huiyun Xiao Haizhu Li Yongrui Li Bin Zhang Bowen Liu Longliang Yang Source Type: research
Inhibition of multidrug resistance proteins by MK571 restored the erectile function in obese mice through cGMP accumulation
ConclusionsThe MRPs inhibition by MK571 favored the accumulation of cGMP in the smooth muscle cells, thus improving the smooth muscle relaxation and the erectile function in obese mice.This article is protected by copyright. All rights reserved (Source: Andrology)
Source: Andrology - November 14, 2022 Category: Urology & Nephrology Authors: Mariana Gon çalves Oliveira,
Gabriela Reolon Passos,
Erick Toledo Gomes,
Guilherme Ruiz Leonardi,
Adriana Zapparoli,
Edson Antunes,
Fabiola Zakia Mónica Tags: ORIGINAL ARTICLE Source Type: research
Skin cancer signal associated with phosphodiesterase inhibitors: gaining insight through the FDA pharmacovigilance database
CONCLUSIONS: This study supports the association between sildenafil, tadalafil, and vardenafil with skin cancer signal in erectile dysfunction (ED) patients.PMID:36334066 | DOI:10.1080/14740338.2023.2145280 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - November 5, 2022 Category: Drugs & Pharmacology Authors: Jun-Wei Chow Ming-Ming Yan Hui Zhao Zi-Ran Li Qian Zhang Ming-Kang Zhong Xiao-Yan Qiu Source Type: research
Skin cancer signal associated with phosphodiesterase inhibitors: gaining insight through the FDA pharmacovigilance database
CONCLUSIONS: This study supports the association between sildenafil, tadalafil, and vardenafil with skin cancer signal in erectile dysfunction (ED) patients.PMID:36334066 | DOI:10.1080/14740338.2023.2145280 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - November 5, 2022 Category: Drugs & Pharmacology Authors: Jun-Wei Chow Ming-Ming Yan Hui Zhao Zi-Ran Li Qian Zhang Ming-Kang Zhong Xiao-Yan Qiu Source Type: research
Clinical study of comprehensive TCM therapy in the treatment of damp and hot stasis erectile dysfunction
This study will provide preliminary evidence for the efficacy and safety of traditional Chinese medicine integrated therapy in the treatment of damp-heat stasis ED. In addition, it also provides a basis for the clinical application of Chinese medicine comprehensive therapy and the construction of Chinese medicine andrology rehabilitation system.
Trial registration:
Chinese clinical trial registration identifier, ChiCTR2200062016, registered on July 19, 2022. (Source: Medicine)
Source: Medicine - October 28, 2022 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research
Cancers, Vol. 14, Pages 4965: High Neutrophil-to-Lymphocyte Ratio Facilitates Cancer Growth & mdash;Currently Marketed Drugs Tadalafil, Isotretinoin, Colchicine, and Omega-3 to Reduce It: The TICO Regimen
Cancers, Vol. 14, Pages 4965: High Neutrophil-to-Lymphocyte Ratio Facilitates Cancer Growth—Currently Marketed Drugs Tadalafil, Isotretinoin, Colchicine, and Omega-3 to Reduce It: The TICO Regimen
Cancers doi: 10.3390/cancers14194965
Authors:
Richard E. Kast
This paper presents remarkably uniform data showing that higher NLR is a robust prognostic indicator of shorter overall survival across the common metastatic cancers. Myeloid derived suppressor cells, the NLRP3 inflammasome, neutrophil extracellular traps, and absolute neutrophil count tend to all be directly related to the NLR. They, individually and...
Source: Cancers - October 10, 2022 Category: Cancer & Oncology Authors: Richard E. Kast Tags: Perspective Source Type: research
