The effects of prophylactic tadalafil use on VEGF expression in the rabbit model of steroid-induced femoral head avascular necrosis
CONCLUSION: This study has shown us that femoral head osteonecrosis can be reliably induced with LPS and corticosteroid, as described in the literature. Prophylactic tadalafil use did not decrease the occurrence of osteonecrosis significantly. However, it significantly increased VEGF expression in the femoral head independent of the effects of steroids and LPS.PMID:37850239 | DOI:10.5152/j.aott.2023.22188 (Source: Acta Orthopaedica et Traumatologica Turcica)
Source: Acta Orthopaedica et Traumatologica Turcica - October 18, 2023 Category: Orthopaedics Authors: Emre Özmen Hazal İzol Özmen Sezen Atasoy Menduh Dursun Bilge Bilgi ç Ahmet Salduz Source Type: research
The effects of prophylactic tadalafil use on VEGF expression in the rabbit model of steroid-induced femoral head avascular necrosis
CONCLUSION: This study has shown us that femoral head osteonecrosis can be reliably induced with LPS and corticosteroid, as described in the literature. Prophylactic tadalafil use did not decrease the occurrence of osteonecrosis significantly. However, it significantly increased VEGF expression in the femoral head independent of the effects of steroids and LPS.PMID:37850239 | DOI:10.5152/j.aott.2023.22188 (Source: Acta Orthopaedica)
Source: Acta Orthopaedica - October 18, 2023 Category: Orthopaedics Authors: Emre Özmen Hazal İzol Özmen Sezen Atasoy Menduh Dursun Bilge Bilgi ç Ahmet Salduz Source Type: research
The effects of prophylactic tadalafil use on VEGF expression in the rabbit model of steroid-induced femoral head avascular necrosis
CONCLUSION: This study has shown us that femoral head osteonecrosis can be reliably induced with LPS and corticosteroid, as described in the literature. Prophylactic tadalafil use did not decrease the occurrence of osteonecrosis significantly. However, it significantly increased VEGF expression in the femoral head independent of the effects of steroids and LPS.PMID:37850239 | DOI:10.5152/j.aott.2023.22188 (Source: Acta Orthopaedica et Traumatologica Turcica)
Source: Acta Orthopaedica et Traumatologica Turcica - October 18, 2023 Category: Orthopaedics Authors: Emre Özmen Hazal İzol Özmen Sezen Atasoy Menduh Dursun Bilge Bilgi ç Ahmet Salduz Source Type: research
The effects of prophylactic tadalafil use on VEGF expression in the rabbit model of steroid-induced femoral head avascular necrosis
CONCLUSION: This study has shown us that femoral head osteonecrosis can be reliably induced with LPS and corticosteroid, as described in the literature. Prophylactic tadalafil use did not decrease the occurrence of osteonecrosis significantly. However, it significantly increased VEGF expression in the femoral head independent of the effects of steroids and LPS.PMID:37850239 | DOI:10.5152/j.aott.2023.22188 (Source: Acta Orthopaedica)
Source: Acta Orthopaedica - October 18, 2023 Category: Orthopaedics Authors: Emre Özmen Hazal İzol Özmen Sezen Atasoy Menduh Dursun Bilge Bilgi ç Ahmet Salduz Source Type: research
Application of a modified vascular blocking technique in intrafascial nerve-sparing laparoscopic radical prostatectomy
CONCLUSION: INLRP via modified vascular blocking showed the advantages of desirable intraoperative bleeding control and postoperative tumor control, restoration of urinary continence and relatively satisfactory recovery of erectile function. However, due to the small sample size, short follow-up time and lack of control, our findings need to be further verified by more clinical studies.PMID:37846830 (Source: Cancer Control)
Source: Cancer Control - October 17, 2023 Category: Cancer & Oncology Authors: Si-Hai Shao Yue-Fan Shen An-Ping Xiang Xu-Feng Shen Source Type: research
Evidence for benefits and risks of tadalafil as a non-prescription medicine: review and evaluation using the Group Delphi technique to achieve consensus amongst clinical experts
An evidence-based consensus meeting was held with urologists, a pharmacist and a cardiologist to perform a structured benefit-risk analysis of reclassifying tadalafil, a phosphodiesterase type 5 (PDE5) inhibitor for treatment of erectile dysfunction (ED), to be available without prescription in Germany. As per the Brass process endorsed by regulatory authorities, an evidence-based Brass value tree was developed, which identified the incremental benefits and risks that should be considered above the safety and efficacy evidence required for prescription medicines. During the Group Delphi consensus meeting, the expert panel ...
Source: Frontiers in Pharmacology - October 9, 2023 Category: Drugs & Pharmacology Source Type: research
Electrospun polyvinyl alcohol/Withania somnifera extract nanofibers incorporating tadalafil-loaded nanoparticles for diabetic ulcers
Nanomedicine, Ahead of Print. (Source: Future Medicine: Nanomedicine)
Source: Future Medicine: Nanomedicine - October 6, 2023 Category: Nanotechnology Authors: Asmaa M Elsherbini Sally A Sabra Shimaa A Rashed Doaa A Abdelmonsif Medhat Haroun Thanaa I Shalaby Source Type: research
Electrospun polyvinyl alcohol/Withania somnifera extract nanofibers incorporating tadalafil-loaded nanoparticles for diabetic ulcers
Nanomedicine, Ahead of Print. (Source: Nanomedicine)
Source: Nanomedicine - October 6, 2023 Category: Nanotechnology Authors: Asmaa M Elsherbini Sally A Sabra Shimaa A Rashed Doaa A Abdelmonsif Medhat Haroun Thanaa I Shalaby Source Type: research
Real-World Treatment Patterns Among Patients with Connective Tissue Disorder-Related Pulmonary Arterial Hypertension in the United States: A Retrospective Claims-Based Analysis
CONCLUSIONS: Treatment patterns were generally similar between the CTD + PAH and PAH cohorts, although combination therapy was more frequent in the CTD + PAH cohort. Both cohorts may benefit from broader use of all available PAH treatment classes, including combination therapy. Considering the life-threatening nature of PAH, our findings also highlight the need to address the low persistence rates with PAH therapies regardless of etiology.PMID:37728697 | DOI:10.1007/s12325-023-02658-z (Source: Adv Data)
Source: Adv Data - September 20, 2023 Category: Epidemiology Authors: Therese Sargent Yuen Tsang Sumeet Panjabi Vienica Funtanilla Hayley D Germack Marjolaine Gauthier-Loiselle Ameur M Manceur Martin Cloutier Patrick Lefebvre Source Type: research
Real-World Treatment Patterns Among Patients with Connective Tissue Disorder-Related Pulmonary Arterial Hypertension in the United States: A Retrospective Claims-Based Analysis
CONCLUSIONS: Treatment patterns were generally similar between the CTD + PAH and PAH cohorts, although combination therapy was more frequent in the CTD + PAH cohort. Both cohorts may benefit from broader use of all available PAH treatment classes, including combination therapy. Considering the life-threatening nature of PAH, our findings also highlight the need to address the low persistence rates with PAH therapies regardless of etiology.PMID:37728697 | DOI:10.1007/s12325-023-02658-z (Source: Adv Data)
Source: Adv Data - September 20, 2023 Category: Epidemiology Authors: Therese Sargent Yuen Tsang Sumeet Panjabi Vienica Funtanilla Hayley D Germack Marjolaine Gauthier-Loiselle Ameur M Manceur Martin Cloutier Patrick Lefebvre Source Type: research
Long-term effects of combination treatment comprising low-intensity extracorporeal shockwave therapy and tadalafil for patients with erectile dysfunction: a retrospective study
International Journal of Impotence Research, Published online: 29 August 2023; doi:10.1038/s41443-023-00757-7Long-term effects of combination treatment comprising low-intensity extracorporeal shockwave therapy and tadalafil for patients with erectile dysfunction: a retrospective study (Source: International Journal of Impotence Research)
Source: International Journal of Impotence Research - August 29, 2023 Category: Urology & Nephrology Authors: Yurdaer Kaynak Ilan Gruenwald Source Type: research
Pretreatment with tadalafil attenuates cardiotoxicity induced by combretastatin A4 disodium phosphate in rats
In this study, we focused on the fact that phosphodiesterase (PDE) 5 inhibitors dilate the heart and peripheral blood vessels and aimed to investigate whether co-administration of tadalafil, a PDE5 inhibitor, can attenuate cardiotoxicity without altering the antitumor effect of CA4DP. To investigate cardiotoxicity, CA4DP and/or tadalafil were administered to rats, and blood pressure, echocardiography, histopathology, and cGMP concentration in the myocardium were examined. Administration of CA4DP increased systolic blood pressure, decreased cardiac function, lowered cGMP levels in the myocardium, and led to necrosis of myoc...
Source: Journal of Toxicologic Pathology - August 14, 2023 Category: Toxicology Authors: Yoshiyasu Nagashima Ryota Tochinai Shin-Ichi Sekizawa Daiki Kato Takayuki Nakagawa Yoshiharu Tsuru Yasuko Tatewaki Tatsushi Mutoh Yasuyuki Taki Masayoshi Kuwahara Source Type: research
