Nitrergic inhibition of sympathetic arteriolar constrictions in the female rodent urethra
J Physiol. 2024 Apr 24. doi: 10.1113/JP285583. Online ahead of print.ABSTRACTDuring the urine storage phase, tonically contracting urethral musculature would have a higher energy consumption than bladder muscle that develops phasic contractions. However, ischaemic dysfunction is less prevalent in the urethra than in the bladder, suggesting that urethral vasculature has intrinsic properties ensuring an adequate blood supply. Diameter changes in rat or mouse urethral arterioles were measured using a video-tracking system. Intercellular Ca2+ dynamics in arteriolar smooth muscle (SMCs) and endothelial cells were visualised usi...
Source: The Journal of Physiology - April 24, 2024 Category: Physiology Authors: Hikaru Hashitani Retsu Mitsui Yuuna Hirai Hidekazu Tanaka Kyoko Miwa-Nishimura Source Type: research
Nitrergic inhibition of sympathetic arteriolar constrictions in the female rodent urethra
J Physiol. 2024 Apr 24. doi: 10.1113/JP285583. Online ahead of print.ABSTRACTDuring the urine storage phase, tonically contracting urethral musculature would have a higher energy consumption than bladder muscle that develops phasic contractions. However, ischaemic dysfunction is less prevalent in the urethra than in the bladder, suggesting that urethral vasculature has intrinsic properties ensuring an adequate blood supply. Diameter changes in rat or mouse urethral arterioles were measured using a video-tracking system. Intercellular Ca2+ dynamics in arteriolar smooth muscle (SMCs) and endothelial cells were visualised usi...
Source: The Journal of Physiology - April 24, 2024 Category: Physiology Authors: Hikaru Hashitani Retsu Mitsui Yuuna Hirai Hidekazu Tanaka Kyoko Miwa-Nishimura Source Type: research
Which PDE5 inhibitor is the most effective in the treatment of erectile dysfunction in men with spinal cord injury? A systematic review and network meta ‐analysis
Discussion and conclusionWithin the grading of comparison network, tadalafil appeared to be the best PDE5i in the treatment of SCI-related ED. Further focused studies are warranted to confirm these findings and define optimal doses and duration of therapy. (Source: Andrology)
Source: Andrology - March 31, 2024 Category: Urology & Nephrology Authors: Daniele Tienforti,
Giorgio Felzani,
Alfonso Boris Di Pasquale,
Arcangelo Barbonetti Tags: ORIGINAL ARTICLE Source Type: research
Resolution of Severe Portopulmonary Hypertension With Inhaled Treprostinil and Liver Transplantation
This report presents a case of severe portopulmonary hypertension that resolved with a conservative therapeutic regimen of tadalafil, macitentan, and inhaled treprostinil, which ultimately enabled successful liver transplantation. There was no recurrence of pulmonary hypertension after transplantation, and the patient was weaned off most pulmonary arterial hypertension therapies. This case report is the first to provide evidence that inhaled treprostinil is a safe and effective alternative to continuous intravenous prostacyclins in portopulmonary hypertension.PMID:38483473 | DOI:10.14503/THIJ-23-8209 (Source: Texas Heart Institute Journal)
Source: Texas Heart Institute Journal - March 14, 2024 Category: Cardiology Authors: Alex J Chang Choon Hwa Goh Source Type: research
Resolution of Severe Portopulmonary Hypertension With Inhaled Treprostinil and Liver Transplantation
This report presents a case of severe portopulmonary hypertension that resolved with a conservative therapeutic regimen of tadalafil, macitentan, and inhaled treprostinil, which ultimately enabled successful liver transplantation. There was no recurrence of pulmonary hypertension after transplantation, and the patient was weaned off most pulmonary arterial hypertension therapies. This case report is the first to provide evidence that inhaled treprostinil is a safe and effective alternative to continuous intravenous prostacyclins in portopulmonary hypertension.PMID:38483473 | DOI:10.14503/THIJ-23-8209 (Source: Texas Heart Institute Journal)
Source: Texas Heart Institute Journal - March 14, 2024 Category: Cardiology Authors: Alex J Chang Choon Hwa Goh Source Type: research
Resolution of Severe Portopulmonary Hypertension With Inhaled Treprostinil and Liver Transplantation
This report presents a case of severe portopulmonary hypertension that resolved with a conservative therapeutic regimen of tadalafil, macitentan, and inhaled treprostinil, which ultimately enabled successful liver transplantation. There was no recurrence of pulmonary hypertension after transplantation, and the patient was weaned off most pulmonary arterial hypertension therapies. This case report is the first to provide evidence that inhaled treprostinil is a safe and effective alternative to continuous intravenous prostacyclins in portopulmonary hypertension.PMID:38483473 | DOI:10.14503/THIJ-23-8209 (Source: Texas Heart Institute Journal)
Source: Texas Heart Institute Journal - March 14, 2024 Category: Cardiology Authors: Alex J Chang Choon Hwa Goh Source Type: research
Resolution of Severe Portopulmonary Hypertension With Inhaled Treprostinil and Liver Transplantation
This report presents a case of severe portopulmonary hypertension that resolved with a conservative therapeutic regimen of tadalafil, macitentan, and inhaled treprostinil, which ultimately enabled successful liver transplantation. There was no recurrence of pulmonary hypertension after transplantation, and the patient was weaned off most pulmonary arterial hypertension therapies. This case report is the first to provide evidence that inhaled treprostinil is a safe and effective alternative to continuous intravenous prostacyclins in portopulmonary hypertension.PMID:38483473 | DOI:10.14503/THIJ-23-8209 (Source: Texas Heart Institute Journal)
Source: Texas Heart Institute Journal - March 14, 2024 Category: Cardiology Authors: Alex J Chang Choon Hwa Goh Source Type: research
Single-dose Tadalafil Reduces Opening Urethral Pressure: A Randomized, Double-blind, Placebo-controlled, Crossover Trial in Healthy Women
ConclusionsA single dose of 40 mg tadalafil moderately reduced urethral pressure in healthy women, without affecting voiding parameters. The clinical implications of this are yet to be determined. (Source: International Urogynecology Journal and Pelvic Floor Dysfunction)
Source: International Urogynecology Journal and Pelvic Floor Dysfunction - March 8, 2024 Category: OBGYN Source Type: research
Single-dose Tadalafil Reduces Opening Urethral Pressure: A Randomized, Double-blind, Placebo-controlled, Crossover Trial in Healthy Women
ConclusionsA single dose of 40 mg tadalafil moderately reduced urethral pressure in healthy women, without affecting voiding parameters. The clinical implications of this are yet to be determined. (Source: International Urogynecology Journal)
Source: International Urogynecology Journal - March 8, 2024 Category: OBGYN Source Type: research
Evaluating the management trends for priapism and assessing the risk of priapism after in-office intracavernosal injections: a cross-sectional analysis
We describe the management trends of patients suffering from any priapism and evaluate the risks of developing priapism after intracavernosal injections (ICI) performed in office. We queried TriNetX for two separate male adult cohorts - those presenting with any priapism based on International Classification of Disease code, N48.3 (priapism) and those who underwent ICI in office based on Current Procedural Terminology code, 54235 (injection of corpora cavernosa with pharmacologic agent[s]). We evaluated treatment options for these patients after any priapism and described demographic risks for developing priapism after ICI...
Source: Cell Research - March 6, 2024 Category: Cytology Authors: Joon Yau Leong Zachary J Prebay David Ebbott Michael Li Paul H Chung Source Type: research
Evaluation of efficacy and safety profile of tadalafil 5 mg daily dose in the tablet form versus oral dispersible film in men with mild-to-moderate erectile dysfunction: a comparative placebo-controlled study
ConclusionODF tadalafil 5 mg is an effective, tolerable, and safe formulation that can be used in patients with mild-to-moderate ED. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 4, 2024 Category: Urology & Nephrology Source Type: research
A multi-modal approach to investigate Desmodium gangeticum's influence on stress-induced male infertility: In vivo, in vitro, and in silico assessments
Biomed Pharmacother. 2024 Mar 1;173:116358. doi: 10.1016/j.biopha.2024.116358. Online ahead of print.ABSTRACTPhysical and psychological stress has an inverse relation with male libido and sperm quality. The present study investigates the potential fertility-enhancing properties of Desmodium gangeticum (DG) root extracts in male Wister rats subjected to immobilization-induced stress (SIMB). DG roots were extracted using n-hexane (HEDG), chloroform (CEDG), and water (AEDG). In the pilot study, aphrodisiac protentional was investigated at two doses (125 and 250 mg kg-1) of each extract. In the main study, the HEDG and AEDG at...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 2, 2024 Category: Drugs & Pharmacology Authors: Yahya S Alqahtani Vijay R Chidrawar Shruti Shiromwar Sudarshan Singh Rahul Maheshwari Havagiray Chitme Naresh Babu Chilamakuru Popat Mohite Ahmed M Aljameeli Masood Medleri Khateeb Source Type: research
Treatment of sexual dysfunction induced by hyperprolactinemia accompanied by reduced luteinizing hormone levels: A case report
In this study, we aimed to present the case of a 35-year-old male patient with sexual dysfunction. The treatment process and physical and laboratory examination results were recorded. Before treatment, the PRL and LH levels in this patient were 31.27 ng/mL and 1.62 mIU/mL, respectively. The International Index of Erectile Function-5 (IIEF-5) score was initially 14 points. After regular treatment with low doses of bromocriptine and tadalafil, the hormonal disorder was corrected (PRL: 11.16 ng/mL and LH: 2.28 mIU/mL) and sexual function w as recovered (IIEF-5: 23 points). This case report suggested a sufficient expo...
Source: Clinical Case Reports - February 29, 2024 Category: General Medicine Authors: Tao Liu,
Chao Jia,
Yan Li Tags: CASE REPORT Source Type: research
Novel drug therapy of acute hepatic failure induced in rats by a combination of tadalafil and Lepidium sativum
Hepatocyte death and a systemic inflammatory response are the outcome of a complex chain of events mediated by numerous inflammatory cells and chemical mediators. The point of this study was to find out if tad... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - February 27, 2024 Category: Complementary Medicine Authors: Mahmoud S. Sabra, Ahmed A. Mohammed, Khaled M. Ahmed Hassanein, Ahmed A. N. Ahmed, Dalia Hassan and Ebtsam S. Abdel-lah Tags: Research Source Type: research
Treatment of pulmonary arterial hypertension in patients with connective tissue diseases: a systematic review and meta-analysis
AbstractThe evidence for the treatment of connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH) mostly depends on subgroup or post hoc analysis of randomized controlled trials (RCTs). Thus, we performed a meta-analysis of RCTs that reported outcomes for CTD-PAH. PubMed and EMBASE were searched for CTD-PAH treatment. The selected outcomes were functional class (FC) change, survival rates, 6-min walk distance (6-MWD), clinical worsening (CW), N-terminal prohormone BNP (NT-proBNP), pulmonary vascular resistance (PVR), mean pulmonary arterial pressure (mPAP), right atrial pressure (RAP), and cardiac in...
Source: Internal and Emergency Medicine - February 20, 2024 Category: Emergency Medicine Source Type: research
