Selecting an Individualized Treatment Approach: The Predictive Value of Erotic Stimulation and Nocturnal Erections for Efficacy of Tadalafil and Cure in Patients With Erectile Dysfunction
ConclusionRigiscan was able to predict the efficacy of daily tadalafil accurately and efficiently. Its diagnostic value was at maximum when DOEE60 ≥17.75 min of NPTR in tadalafil responders and DOEE ≥ 4.125 min of AVSS in cured patients. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - June 29, 2022 Category: Endocrinology Source Type: research

Small scale in vitro method to determine a potential bioequivalent equilibrium solubility range for fed human intestinal fluid
This study demonstrates that it is possible to assess the fed intestinal equilibrium solubility envelope using the nine media recipes obtained from a multi-dimensional analysis of fed HIF. The derivation of the nine media compositions coupled with the results in this study indicate that the solubility results are more likely to reflect the fed intestinal solubility envelope than previous DoE studies and highlight that the system is worthy of further investigation.PMID:35718078 | DOI:10.1016/j.ejpb.2022.06.005 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - June 19, 2022 Category: Drugs & Pharmacology Authors: Maria In ês Silva Ibrahim Khadra Kate Pyper Gavin W Halbert Source Type: research

Small scale in vitro method to determine a potential bioequivalent equilibrium solubility range for fed human intestinal fluid
This study demonstrates that it is possible to assess the fed intestinal equilibrium solubility envelope using the nine media recipes obtained from a multi-dimensional analysis of fed HIF. The derivation of the nine media compositions coupled with the results in this study indicate that the solubility results are more likely to reflect the fed intestinal solubility envelope than previous DoE studies and highlight that the system is worthy of further investigation.PMID:35718078 | DOI:10.1016/j.ejpb.2022.06.005 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - June 19, 2022 Category: Drugs & Pharmacology Authors: Maria In ês Silva Ibrahim Khadra Kate Pyper Gavin W Halbert Source Type: research

Small scale in vitro method to determine a potential bioequivalent equilibrium solubility range for fed human intestinal fluid
This study demonstrates that it is possible to assess the fed intestinal equilibrium solubility envelope using the nine media recipes obtained from a multi-dimensional analysis of fed HIF. The derivation of the nine media compositions coupled with the results in this study indicate that the solubility results are more likely to reflect the fed intestinal solubility envelope than previous DoE studies and highlight that the system is worthy of further investigation.PMID:35718078 | DOI:10.1016/j.ejpb.2022.06.005 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - June 19, 2022 Category: Drugs & Pharmacology Authors: Maria In ês Silva Ibrahim Khadra Kate Pyper Gavin W Halbert Source Type: research

Small scale in vitro method to determine a potential bioequivalent equilibrium solubility range for fed human intestinal fluid
This study demonstrates that it is possible to assess the fed intestinal equilibrium solubility envelope using the nine media recipes obtained from a multi-dimensional analysis of fed HIF. The derivation of the nine media compositions coupled with the results in this study indicate that the solubility results are more likely to reflect the fed intestinal solubility envelope than previous DoE studies and highlight that the system is worthy of further investigation.PMID:35718078 | DOI:10.1016/j.ejpb.2022.06.005 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - June 19, 2022 Category: Drugs & Pharmacology Authors: Maria In ês Silva Ibrahim Khadra Kate Pyper Gavin W Halbert Source Type: research

Sex-specific effects of daily tadalafil on diabetic heart kinetics in RECOGITO, a randomized, double-blind, placebo-controlled trial
Sci Transl Med. 2022 Jun 15;14(649):eabl8503. doi: 10.1126/scitranslmed.abl8503. Epub 2022 Jun 15.ABSTRACTCyclic GMP-phosphodiesterase type 5 (PDE5) inhibition has been shown to counteract maladaptive cardiac changes triggered by diabetes in some but not all studies. We performed a single-center, 20-week, double-blind, randomized, placebo-controlled trial (NCT01803828) to assess sex differences in cardiac remodeling after PDE5 inhibition in patients with diabetic cardiomyopathy. A total of 122 men and women (45 to 80 years) with long-duration (>3 years) and well-controlled type 2 diabetes mellitus (T2DM; HbA1c < 86 m...
Source: Molecular Medicine - June 15, 2022 Category: Molecular Biology Authors: Riccardo Pofi Elisa Giannetta Tiziana Feola Nicola Galea Federica Barbagallo Federica Campolo Roberto Badagliacca Biagio Barbano Federica Ciolina Giuseppe Defeudis Tiziana Filardi Franz Sesti Marianna Minnetti Carmine D Vizza Patrizio Pasqualetti Pierluig Source Type: research

High-throughput screening in combination with a cohort study for iodothyronine deiodinases
In conclusion, we completed HTS for DIOs and obtained attractive hit compounds. Our cohort study revealed the clinical significance of ritodrine, sildenafil, and TKIs. We hope our unique method will contribute to analyzing various targets and lists of hit compounds will promote understanding of DIOs.PMID:35695766 | DOI:10.1210/endocr/bqac090 (Source: Endocrinology)
Source: Endocrinology - June 13, 2022 Category: Endocrinology Authors: Ichiro Yamauchi Yoriko Sakane Yukiko Okuno Taku Sugawa Takuro Hakata Haruka Fujita Kentaro Okamoto Daisuke Taura Takafumi Yamashita Keisho Hirota Yohei Ueda Toshihito Fujii Akihiro Yasoda Nobuya Inagaki Source Type: research

High-throughput screening in combination with a cohort study for iodothyronine deiodinases
In conclusion, we completed HTS for DIOs and obtained attractive hit compounds. Our cohort study revealed the clinical significance of ritodrine, sildenafil, and TKIs. We hope our unique method will contribute to analyzing various targets and lists of hit compounds will promote understanding of DIOs.PMID:35695766 | DOI:10.1210/endocr/bqac090 (Source: Endocrinology)
Source: Endocrinology - June 13, 2022 Category: Endocrinology Authors: Ichiro Yamauchi Yoriko Sakane Yukiko Okuno Taku Sugawa Takuro Hakata Haruka Fujita Kentaro Okamoto Daisuke Taura Takafumi Yamashita Keisho Hirota Yohei Ueda Toshihito Fujii Akihiro Yasoda Nobuya Inagaki Source Type: research

Regular Use of Erectile Dysfunction Drugs Associated With Eye Problems
Regular use of phosphodiesterase type 5 inhibitors (PDE5Is) for erectile dysfunction was associated with increased risks of serous retinal detachment (SRD), retinal vascular occlusion (RVO), and ischemic optic neuropathy (ION) among older US men in a large observational study. PDE5Is are among the most prescribed medication classes in the US and include avanafil (Stendra), sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra). (Source: JAMA)
Source: JAMA - June 7, 2022 Category: General Medicine Source Type: research

Role of ADMA/DDAH-1 and iNOS/eNOS signaling in the gastroprotective effect of tadalafil against indomethacin-induced gastric injury
Biomed Pharmacother. 2022 Jun;150:113026. doi: 10.1016/j.biopha.2022.113026. Epub 2022 Apr 28.ABSTRACTNon-steroidal anti-inflammatory drugs (NSAIDs)-induced gastric ulcers represent a significant clinical concern and adversely affect the quality of life. Inducible nitric oxide synthase/endothelial nitric oxide synthase (iNOS/eNOS) and asymmetric dimethylarginine/ dimethylarginine dimethylaminohydrolase-1 (ADMA/DDAH-1) signaling are key players in gastric ulcer pathogenesis. This work was planned to explore the role of iNOS/eNOS and ADMA/DDAH-1 signaling in rats with indomethacin-induced gastric ulcer, as potential pathways...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 5, 2022 Category: Drugs & Pharmacology Authors: Yasmin T Mohamed Ibrahim A Naguib Ali A Abo-Saif Mohammed H Elkomy Badrah S Alghamdi Wafaa R Mohamed Source Type: research

Comment on: Comparison of the efficacy of the early LI-SWT plus daily tadalafil with daily tadalafil only as penile rehabilitation for postprostatectomy erectile dysfunction
International Journal of Impotence Research, Published online: 02 June 2022; doi:10.1038/s41443-022-00588-yComment on: Comparison of the efficacy of the early LI-SWT plus daily tadalafil with daily tadalafil only as penile rehabilitation for postprostatectomy erectile dysfunction (Source: International Journal of Impotence Research)
Source: International Journal of Impotence Research - June 2, 2022 Category: Urology & Nephrology Authors: Caner Baran Mehmet Gokhan Culha Source Type: research

Erectile function outcomes following surgical treatment of ischemic priapism
CONCLUSION: According to our study, delayed management exceeding 48 h, fibrosis and the necessity of a surgical distal shunt are three independent factors affecting erectile function after treatment of ischemic priapism.PMID:35638068 | PMC:PMC9142696 | DOI:10.1016/j.amsu.2022.103696 (Source: Annals of Medicine)
Source: Annals of Medicine - May 31, 2022 Category: Internal Medicine Authors: Moez Rahoui Yassine Ouanes Chaker Kays Bibi Mokhtar Kheireddine Mrad Dali Ahmed Sellami Sami Ben Rhouma Yassine Nouira Source Type: research

Integration of Transcriptomics and Metabolomics Reveals the Antitumor Mechanism Underlying Tadalafil in Colorectal Cancer
In this study, we assessed the anti-tumor activity of tadalafil in human colorectal cancer cells. A systematic perspective of the tadalafil-induced anti-tumor mechanism was provided by the integration of transcriptomics and metabolomics. We found that differentially expressed genes (DEGs) were mainly involved in microRNAs in cancer, purine metabolism, glycosphingolipid biosynthesis, arginine biosynthesis, and amino acid metabolism. Amino acid metabolism, especially alanine, aspartate, and glutamate metabolism was the most of the differentially accumulated metabolites (DAMs) through the analysis of metabolomics. The conjoin...
Source: Frontiers in Pharmacology - May 27, 2022 Category: Drugs & Pharmacology Source Type: research

The Phosphodiesterase Inhibitor Tadalafil Promotes Splenic Retention of Plasmodium falciparum Gametocytes in Humanized Mice
The persistence of erythrocytes infected with Plasmodium falciparum gametocytes in the bloodstream is closely related to the modulation of their mechanical properties. New drugs that increase the stiffness of infected erythrocytes may thus represent a novel approach to block malaria parasite transmission. The phosphodiesterase inhibitor tadalafil has been shown to impair the ability of infected erythrocytes to circulate in an in vitro model for splenic retention. Here, we used a humanized mouse model to address in vivo the effect of tadalafil on the circulation kinetics of mature gametocyte-infected erythrocytes. We show t...
Source: Frontiers in cellular and infection microbiology - May 25, 2022 Category: Microbiology Source Type: research

Structured solubility behaviour in bioequivalent fasted simulated intestinal fluids
Eur J Pharm Biopharm. 2022 May 20:S0939-6411(22)00098-4. doi: 10.1016/j.ejpb.2022.05.010. Online ahead of print.ABSTRACTDrug solubility in intestinal fluid is a key parameter controlling absorption after the administration of a solid oral dosage form. To measure solubility in vitro simulated intestinal fluids have been developed, but there are multiple recipes and the optimum is unknown. This situation creates difficulties during drug discovery and development research. A recent study characterised sampled fasted intestinal fluids using a multidimensional approach to derive nine bioequivalent fasted intestinal media that c...
Source: European Journal of Pharmaceutics and Biopharmaceutics - May 23, 2022 Category: Drugs & Pharmacology Authors: Qamar Abuhassan Ibrahim Khadra Kate Pyper Patrick Augustijns Joachim Brouwers Gavin W Halbert Source Type: research