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Effects of Low-Dose Tadalafil in a Patient with Biventricular Heart Failure: A Case Report
Tohoku J Exp Med. 2023 Mar 9. doi: 10.1620/tjem.2023.J020. Online ahead of print.NO ABSTRACTPMID:36889738 | DOI:10.1620/tjem.2023.J020 (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - March 8, 2023 Category: Research Authors: Shoko Kono Jinya Takahashi Koutatsu Shimozono Jun Kumanomido Norikazu Inoguchi Shoichiro Nohara Naoki Itaya Takaharu Nakayoshi Yoshihiro Fukumoto Source Type: research

Molecules, Vol. 28, Pages 2402: Deep Eutectic Liquids as a Topical Vehicle for Tadalafil: Characterisation and Potential Wound Healing and Antimicrobial Activity
In conclusion, this work presents the design and application of a topical vehicle for TDF with novel biomedical applications. (Source: Molecules)
Source: Molecules - March 6, 2023 Category: Chemistry Authors: Bayan Alkhawaja Faisal Al-Akayleh Ashraf Al-Khateeb Jehad Nasereddin Bayan Y. Ghanim Albert Bolhuis Nisrein Jaber Mayyas Al-Remawi Nidal A. Qinna Tags: Article Source Type: research

Molecules, Vol. 28, Pages 2352: Development of a Rapid LC-MS/MS Method for Simultaneous Quantification of Donepezil and Tadalafil in Rat Plasma: Its Application in a Pharmacokinetic Interaction Study after Oral Administration in Rats
This study aimed to establish a simple and sensitive analytical method to simultaneously quantify donepezil (DPZ) and tadalafil (TAD) in rat plasma using lansoprazole (LPZ) as an internal standard (IS) by using liquid chromatography tandem mass spectrometry. The fragmentation pattern of DPZ, TAD, and IS was elucidated using multiple reaction monitoring in electrospray ionization positive ion mode for the quantification of precursor to production at m/z 380.1 &rarr; 91.2 for DPZ, m/z 390.2 &rarr; 268.1 for TAD, and m/z 370.3 &rarr; 252.0 for LPZ. The extracted DPZ and TAD from plasma using acetonitri...
Source: Molecules - March 3, 2023 Category: Chemistry Authors: Jiyoung Yoon Doowon Choi Wang-Seob Shim Sanghee Choi Yeo Jin Choi Soo-Heui Paik Kyung-Tae Lee Tags: Article Source Type: research

Is there a new role for oral therapy to treat peyronie’s disease? Commentary on Daily low-dose tadalafil may reduce the penile curvature progression rate in patients with acute Peyronie’s Disease: a retrospective comparative analysis
International Journal of Impotence Research, Published online: 24 February 2023; doi:10.1038/s41443-023-00684-7Is there a new role for oral therapy to treat peyronie’s disease? Commentary on Daily low-dose tadalafil may reduce the penile curvature progression rate in patients with acute Peyronie’s Disease: a retrospective comparative analysis (Source: International Journal of Impotence Research)
Source: International Journal of Impotence Research - February 24, 2023 Category: Urology & Nephrology Authors: Matthew Ziegelmann Source Type: research

Inhibition of phosphodiesterase 5A by tadalafil improves SIRT1 expression and activity in insulin-resistant podocytes
Cell Signal. 2023 Feb 6:110622. doi: 10.1016/j.cellsig.2023.110622. Online ahead of print.ABSTRACTA decrease in intracellular levels of 3',5'-cyclic guanosine monophosphate (cGMP) has been implicated in the progression of diabetic nephropathy. Hyperglycemia significantly inhibits cGMP-dependent pathway activity in the kidney, leading to glomerular damage and proteinuria. The enhancement of activity of this pathway that is associated with an elevation of cGMP levels may be achieved by inhibition of the cGMP specific phosphodiesterase 5A (PDE5A) using selective inhibitors, such as tadalafil. Hyperglycemia decreased the insul...
Source: Cellular Signalling - February 8, 2023 Category: Cytology Authors: Dorota Rogacka Patrycja Rachubik Irena Audzeyenka Tomasz Kulesza Maria Szrejder Dorota My ślińska Stefan Angielski Agnieszka Piwkowska Source Type: research

Analysis of a maternal health medicines pipeline database 2000-2021: New candidates for the prevention and treatment of fetal growth restriction
CONCLUSION: Aspirin, L-arginine and vitamin D are promising, high potential preventative agents for fetal growth restriction. Based on the medicines pipeline, new pharmacological agents for fetal growth restriction are unlikely to emerge in the near future.PMID:36655375 | DOI:10.1111/1471-0528.17392 (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - January 19, 2023 Category: OBGYN Authors: Shao Lim Annie R A McDougall Maya Goldstein Andrew Tuttle Roxanne Hastie Stephen Tong Anne Ammerdorffer Sara Rushwan Christina Ricci A Metin Gulmezoglu Joshua P Vogel Source Type: research

Sexual dysfunction therapeutic approaches in patients with multiple sclerosis: a systematic review
ConclusionThe management of sexual dysfunction in PwMS needs to be further investigated. A team of healthcare professionals should be involved in the management of SD in order to address not only the primary (MS-related) SD symptoms but the secondary and tertiary as well. The main limitations that were identified in the existing literature were related to MS disease features, sample characteristics and evaluation tools and batteries. (Source: Neurological Sciences)
Source: Neurological Sciences - December 31, 2022 Category: Neurology Source Type: research

Development of a detector tube for screening tadalafil and its analogues in adulterated sexual enhancement products
In this study, a Td detector tube for the rapid detection of Tds was developed based on the color change reaction between sulfuric acid and Tds. The specificity of this test method was evaluated using 13 Tds, all of which elicited positive results. Additionally, 30 commonly found adulterants in dietary supplements, 11 active pharmaceutical ingredients of psychotropic drugs and 18 food ingredients were tested and obtained no false-positive results, except levomepromazine. The test tube accurately detected the presence or absence of Tds in 54 commercially available products. The visual detection limit was 2 –50 and 5–20 ...
Source: Drug Testing and Analysis - December 16, 2022 Category: Drugs & Pharmacology Authors: Yoko Ichikawa ‐Kaji, Fujio Ishizawa, Rei Nishiyama, Hajime Tachikawa, Nozomi Uemura, Yuka Moriuchi, Yi‐Yang Hsiao, Takako Moriyasu, Toshinari Suzuki, Yoichiro Takahashi, Akiko Inomata Tags: RESEARCH ARTICLE Source Type: research