Tadalafil Attenuates Angiotensin II-Induced Extracellular Matrix Remodeling in Cardiac Fibroblasts Through TGF- & #946;1/Smad3 Signaling Pathway
(Source: Journal of Biomedical Nanotechnology)
Source: Journal of Biomedical Nanotechnology - August 11, 2023 Category: Nanotechnology Authors: Ye, Wenyi Huang, Junling Yang, Jun Wang, Ling Dai, Jin Wang, Xiao Tags: research-article Source Type: research
Cost-effectiveness analysis of selexipag for the combined treatment of pulmonary arterial hypertension
Conclusion: In China, adding selexipag may not be cost-effective for patients with PAH who failed to control their condition after combined treatment of ERA and PDE5i. Results of the analysis can aid discussions on the value and position of selexipag for the combined treatment of PAH. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - August 11, 2023 Category: Drugs & Pharmacology Source Type: research
A pilot phase Ib study to evaluate tadalafil to overcome immunosuppression during chemoradiotherapy for IDH-wild-type glioblastoma
CONCLUSIONS: Concurrent tadalafil is well tolerated during chemoradiotherapy for GBM. Tadalafil is associated with a reduction of peripheral MDSCs after chemoradiotherapy and increased CD8 T-cell proliferation and activation.PMID:37554225 | PMC:PMC10406429 | DOI:10.1093/noajnl/vdad088 (Source: Cancer Control)
Source: Cancer Control - August 9, 2023 Category: Cancer & Oncology Authors: Subhajit Ghosh Tanner M Johanns Milan G Chheda Eric Liu Omar Butt Christopher Abraham Shahed Badiyan Yi Huang David DeNardo Albert H Kim Dennis Hallahan Dinesh Thotala Jiayi Huang Source Type: research
Effect of phosphodiesterase ‐5 inhibition on SystEmic Right VEntricular size and function. A multicentre, double‐blind, randomized, placebo‐controlled trial: SERVE
ConclusionsIn this trial in adults with systemic right ventricles, right ventricular systolic function, exercise capacity and neuro-hormonal activation remained stable over a 3-year follow-up period. No significant treatment effect of tadalafil was observed. Further research is needed to find effective treatment for improvement of ventricular function in adults with systemic right ventricles. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - August 8, 2023 Category: Cardiology Authors: Matthias Greutmann,
Daniel Tobler,
Reto Engel,
Dik Heg,
Christian Mueller,
Andr é Frenk,
Harald Gabriel,
Tobias Rutz,
Ronny R. Buechel,
Matthias Willhelm,
Lukas Trachsel,
Michael Freese,
Francisco Javier Ruperti‐Repilado,
Emanuela Valsangi Tags: Research Article Source Type: research
E-209 Comparative analysis of the vasodilatory effects of enteral nimodipine and tadalafil in an animal model of cerebral vasospasm
ConclusionCerebral vasospasm could leave neurologic deficit or sequelae even after proper treatment. Therefore, prevention is important. Tadalafil showed preventive effect against cerebral vasospasm and vasodilative effect similar to that of nimodipine. Therefore, tadalafil could be considered an alternative preventive treatment of cerebral vasospasm.Disclosures J. Lim: 1; C; Chungnam National University Hospital(No. 2019-CF-032 and No. 2021-2129-01), National Research Foundation (No.2022-0222-01) of Korea. K. Jung: None. H. Byoun: None. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Lim, J., Jung, K., Byoun, H. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research
Improvement in Endothelial Function in men taking phosphordiesterase type 5 inhibitors for erectile dysfunction
CONCLUSIONS: Erectile dysfunction and endothelial dysfunction are risk factors for cardiovascular disease. Our study showed that PDE5i improved endothelial function and erectile dysfunction (with a significant correlation). Improving endothelial function could be the mechanism that leads to a reduction in cardiovascular events and death in men with erectile dysfunction treated with PDE5i.PMID:37506991 | DOI:10.1016/j.amjmed.2023.07.010 (Source: Atherosclerosis)
Source: Atherosclerosis - July 28, 2023 Category: Cardiology Authors: Konstantinovsky Alex Kuchersky Nina Kridin Khakaf Blum Arnon Source Type: research
Retraction Note: Roflumilast and tadalafil improve learning and memory deficits in intracerebroventricular A β1-42 rat model of Alzheimer's disease through modulations of hippocampal cAMP/cGMP/BDNF signaling pathway
Pharmacol Rep. 2023 Jul 21. doi: 10.1007/s43440-023-00511-2. Online ahead of print.NO ABSTRACTPMID:37477845 | DOI:10.1007/s43440-023-00511-2 (Source: Pharmacological Reports)
Source: Pharmacological Reports - July 21, 2023 Category: Drugs & Pharmacology Authors: Noorul Hasan Saima Zameer Abul Kalam Najmi Suhel Parvez Mohammad Shahar Yar Mohd Akhtar Source Type: research
Retraction Note: Roflumilast and tadalafil improve learning and memory deficits in intracerebroventricular A β1-42 rat model of Alzheimer's disease through modulations of hippocampal cAMP/cGMP/BDNF signaling pathway
Pharmacol Rep. 2023 Jul 21. doi: 10.1007/s43440-023-00511-2. Online ahead of print.NO ABSTRACTPMID:37477845 | DOI:10.1007/s43440-023-00511-2 (Source: Pharmacological Reports)
Source: Pharmacological Reports - July 21, 2023 Category: Drugs & Pharmacology Authors: Noorul Hasan Saima Zameer Abul Kalam Najmi Suhel Parvez Mohammad Shahar Yar Mohd Akhtar Source Type: research
Retraction Note: Roflumilast and tadalafil improve learning and memory deficits in intracerebroventricular A β1-42 rat model of Alzheimer's disease through modulations of hippocampal cAMP/cGMP/BDNF signaling pathway
Pharmacol Rep. 2023 Jul 21. doi: 10.1007/s43440-023-00511-2. Online ahead of print.NO ABSTRACTPMID:37477845 | DOI:10.1007/s43440-023-00511-2 (Source: Pharmacological Reports)
Source: Pharmacological Reports - July 21, 2023 Category: Drugs & Pharmacology Authors: Noorul Hasan Saima Zameer Abul Kalam Najmi Suhel Parvez Mohammad Shahar Yar Mohd Akhtar Source Type: research
Retraction Note: Roflumilast and tadalafil improve learning and memory deficits in intracerebroventricular A β1-42 rat model of Alzheimer's disease through modulations of hippocampal cAMP/cGMP/BDNF signaling pathway
Pharmacol Rep. 2023 Jul 21. doi: 10.1007/s43440-023-00511-2. Online ahead of print.NO ABSTRACTPMID:37477845 | DOI:10.1007/s43440-023-00511-2 (Source: Pharmacological Reports)
Source: Pharmacological Reports - July 21, 2023 Category: Drugs & Pharmacology Authors: Noorul Hasan Saima Zameer Abul Kalam Najmi Suhel Parvez Mohammad Shahar Yar Mohd Akhtar Source Type: research
Retraction Note: Roflumilast and tadalafil improve learning and memory deficits in intracerebroventricular A β1-42 rat model of Alzheimer's disease through modulations of hippocampal cAMP/cGMP/BDNF signaling pathway
Pharmacol Rep. 2023 Jul 21. doi: 10.1007/s43440-023-00511-2. Online ahead of print.NO ABSTRACTPMID:37477845 | DOI:10.1007/s43440-023-00511-2 (Source: Pharmacological Reports)
Source: Pharmacological Reports - July 21, 2023 Category: Drugs & Pharmacology Authors: Noorul Hasan Saima Zameer Abul Kalam Najmi Suhel Parvez Mohammad Shahar Yar Mohd Akhtar Source Type: research
Retraction Note: Roflumilast and tadalafil improve learning and memory deficits in intracerebroventricular A β1-42 rat model of Alzheimer's disease through modulations of hippocampal cAMP/cGMP/BDNF signaling pathway
Pharmacol Rep. 2023 Jul 21. doi: 10.1007/s43440-023-00511-2. Online ahead of print.NO ABSTRACTPMID:37477845 | DOI:10.1007/s43440-023-00511-2 (Source: Pharmacological Reports)
Source: Pharmacological Reports - July 21, 2023 Category: Drugs & Pharmacology Authors: Noorul Hasan Saima Zameer Abul Kalam Najmi Suhel Parvez Mohammad Shahar Yar Mohd Akhtar Source Type: research
Retraction Note: Roflumilast and tadalafil improve learning and memory deficits in intracerebroventricular A β1-42 rat model of Alzheimer's disease through modulations of hippocampal cAMP/cGMP/BDNF signaling pathway
Pharmacol Rep. 2023 Jul 21. doi: 10.1007/s43440-023-00511-2. Online ahead of print.NO ABSTRACTPMID:37477845 | DOI:10.1007/s43440-023-00511-2 (Source: Pharmacological Reports)
Source: Pharmacological Reports - July 21, 2023 Category: Drugs & Pharmacology Authors: Noorul Hasan Saima Zameer Abul Kalam Najmi Suhel Parvez Mohammad Shahar Yar Mohd Akhtar Source Type: research
Spectroscopic determination of hydrophobic adulterant tadalafil by aptasensor based ellipsometry
In this study, we propose an aptasensor based on ellipsometry for the detection of PDE5 inhibitors. To enhance the detection specificity for PDE5 inhibitors, we designed an aptamer with a hydrophobic pocket that incorporates a guanine base-rich region and a three-way junction. This design is particularly effective considering the poor aqueous solubility of PDE5 inhibitors. Preliminary results demonstrate that tadalafil detection in various media can be achieved within the range of 1-2000 ng/mL. The limit of detection for the active compound of tadalafil is as low as 1.82 ng/mL.PMID:37454513 | DOI:10.1016/j.talanta.2023.124...
Source: Talanta - July 16, 2023 Category: Chemistry Authors: İlknur Üstündağ Mustafa Oguzhan Caglayan Source Type: research
