The Effect of Phosphodiesterase-type 5 Inhibitors on Erectile Function: An Overview of Systematic Reviews
Conclusion: Although the efficacy and safety of PDE5 inhibitors, compared to placebo, is well-documented, the existing evidence comparing different PDE5 inhibitors is low. Therefore, high-quality, head-to-head, trials comparing different PDE5 inhibitors are necessary to determine their ideal dosage and formulation based on their safety and efficacy profile.Systematic Review Registration: PROSPERO, identifier [CRD42020216754]. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - September 7, 2021 Category: Drugs & Pharmacology Source Type: research

Penile Rehabilitation with Low-intensity Extracorporeal Shock Wave Therapy in Patients After Prostate Cancer Surgery. Early Physiological Changes and Postoperative Follow-up Outcomes
CONCLUSIONS: Combined using of tadalafil and Low-intensity Extracorporeal Shock Wave Therapy (Li-ESWT) are highly effective and safety to treatment erectile dysfunction and prevent urinary incontinence after prostate cancer surgery.PMID:34487369 | DOI:10.1111/ijcp.14804 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - September 6, 2021 Category: Cancer & Oncology Authors: Ayhan Karakose Yasin Yitgin Source Type: research

"Tunable and Cooperative Catalysis for Enantioselective Pictet-Spengler Reaction with Varied Nitrogen-Containing Heterocyclic Carboxaldehydes"
Angew Chem Int Ed Engl. 2021 Sep 6. doi: 10.1002/anie.202109694. Online ahead of print.ABSTRACT"Herein we report an organocatalytic enantioselective functionalization of heterocyclic carboxaldehyde via Pictet-Spengler reaction. Through careful pairing of novel squaramide and Broensted acid catalysts, our method tolerates a breadth of heterocycles, enabling preparation of a series of heterocycle conjugated beta-(tetrahydro)carboline in good yield and enantioselectivity. Careful selection of carboxylic acid co-catalyst is essential for toleration of a variety of regioisomeric heterocycles. Utility is demonstrated via the thr...
Source: Angewandte Chemie - September 6, 2021 Category: Chemistry Authors: Yuk-Cheung Chan Marcus H Sak Scott A Frank Scott J Miller Source Type: research

Tadalafil as a Risk Factor for Excessive Intra-operative Bleeding During Dermatologic Surgery
No abstract available (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - September 1, 2021 Category: Dermatology Tags: Communications Source Type: research

Pharmacokinetic and Bioequivalence Evaluation of 2 Tadalafil Tablets in Healthy Male Chinese Subjects Under Fasting and Fed Conditions
This study investigated the bioequivalence of generic and marketed formulations of 10-mg tadalafil tablets under fasted and fed conditions. This open-label, randomized, single-dose, 2-period crossover study included 53 healthy Chinese men (aged 20-43 years). Plasma samples were collected from 0.5  hours before treatment to 72 hours after each dose and analyzed using ultra-high-performance liquid chromatography coupled with tandem mass spectrometry. Pharmacokinetic parameters were calculated using noncompartmental analysis. Safety assessments were performed throughout the study. For the fas ted state, the 90% confidence i...
Source: Clinical Pharmacology in Drug Development - August 28, 2021 Category: Drugs & Pharmacology Authors: Rong Shao, Dan ‐dan Yang, Zou‐rong Ruan, Jin‐liang Chen, Yin Hu, Bo Jiang, Hong‐gang Lou Tags: Original Article Source Type: research

Tadalafil and bergapten mitigate streptozotocin-induced sporadic Alzheimer's disease in mice via modulating neuroinflammation, PI3K/Akt, Wnt/ β-catenin, AMPK/mTOR signaling pathways
In conclusion, this study offers novel insights on the neuroprotective effects of TAD or BG in the management of SAD as evidenced by improved cognitive function and histological architecture. This could be attributed to modulation of the crosstalk among PI3K/Akt/GSK-3β, PP2A, mTOR/autophagy, cGMP/PKG, and Wnt/β-catenin signaling cascades and mitigation of neuroinflammation.PMID:34428446 | DOI:10.1016/j.taap.2021.115697 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - August 24, 2021 Category: Toxicology Authors: Mohamed A Salem Barbara Budzy ńska Joanna Kowalczyk Nesrine S El Sayed Suzan M Mansour Source Type: research

Tadalafil and bergapten mitigate streptozotocin-induced sporadic Alzheimer's disease in mice via modulating neuroinflammation, PI3K/Akt, Wnt/ β-catenin, AMPK/mTOR signaling pathways
In conclusion, this study offers novel insights on the neuroprotective effects of TAD or BG in the management of SAD as evidenced by improved cognitive function and histological architecture. This could be attributed to modulation of the crosstalk among PI3K/Akt/GSK-3β, PP2A, mTOR/autophagy, cGMP/PKG, and Wnt/β-catenin signaling cascades and mitigation of neuroinflammation.PMID:34428446 | DOI:10.1016/j.taap.2021.115697 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - August 24, 2021 Category: Toxicology Authors: Mohamed A Salem Barbara Budzy ńska Joanna Kowalczyk Nesrine S El Sayed Suzan M Mansour Source Type: research

Small scale in vitro method to determine a bioequivalent equilibrium solubility range for fasted human intestinal fluid
This study demonstrates that it is possible to assess the fasted intestinal equilibrium solubility envelope using a small number of bioequivalent media recipes obtained from a multi-dimensional analysis of fasted HIF. The derivation of the nine bioequivalent SIF media coupled with the lower measured solubility range indicate that the solubility results are more likely to reflect the fasted intestinal solubility envelope than previous DoE studies and highlight that intestinal solubility is a range and not a single value.PMID:34419602 | DOI:10.1016/j.ejpb.2021.08.002 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - August 22, 2021 Category: Drugs & Pharmacology Authors: Qamar Abuhassan Ibrahim Khadra Kate Pyper Gavin W Halbert Source Type: research

Small scale in vitro method to determine a bioequivalent equilibrium solubility range for fasted human intestinal fluid
This study demonstrates that it is possible to assess the fasted intestinal equilibrium solubility envelope using a small number of bioequivalent media recipes obtained from a multi-dimensional analysis of fasted HIF. The derivation of the nine bioequivalent SIF media coupled with the lower measured solubility range indicate that the solubility results are more likely to reflect the fasted intestinal solubility envelope than previous DoE studies and highlight that intestinal solubility is a range and not a single value.PMID:34419602 | DOI:10.1016/j.ejpb.2021.08.002 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - August 22, 2021 Category: Drugs & Pharmacology Authors: Qamar Abuhassan Ibrahim Khadra Kate Pyper Gavin W Halbert Source Type: research

Small scale in vitro method to determine a bioequivalent equilibrium solubility range for fasted human intestinal fluid
This study demonstrates that it is possible to assess the fasted intestinal equilibrium solubility envelope using a small number of bioequivalent media recipes obtained from a multi-dimensional analysis of fasted HIF. The derivation of the nine bioequivalent SIF media coupled with the lower measured solubility range indicate that the solubility results are more likely to reflect the fasted intestinal solubility envelope than previous DoE studies and highlight that intestinal solubility is a range and not a single value.PMID:34419602 | DOI:10.1016/j.ejpb.2021.08.002 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - August 22, 2021 Category: Drugs & Pharmacology Authors: Qamar Abuhassan Ibrahim Khadra Kate Pyper Gavin W Halbert Source Type: research

Effects of phosphodiesterase V inhibition alone and in combination with BNP on cardiovascular and renal response to volume load in human preclinical diastolic dysfunction
The objective was to evaluate if phosphodiesterase V inhibition (PDEVI) alone or combination PDEVI plus B-type natriuretic peptide (BNP) administration will correct the impaired cardiorenal response to VL in PDD. A randomized double-blinded placebo-controlled cross-over study was conducted in 20  subjects with PDD, defined as left ventricular ejection fraction (LVEF)>50% with moderate or severe diastolic dysfunction by Doppler echocardiography and without HF diagnosis or symptoms. Effects of PDEVI with oral tadalafil alone and tadalafil plus subcutaneous (SC) BNP, administered prior to acute volume loading, were assess...
Source: Physiological Reports - August 18, 2021 Category: Physiology Authors: Siu ‐Hin Wan, Paul M. McKie, Joshua P. Slusser, John C. Burnett, David O. Hodge, Horng H. Chen Tags: ORIGINAL ARTICLE Source Type: research

Population Pharmacokinetics of Tadalafil in Pediatric Patients with Pulmonary Arterial Hypertension: A Combined Adult/Pediatric Model
ConclusionsA one-compartment model parameterized in terms ofF, absorption rate constant,CL/F, andV/F described the data well. The model demonstrated that plasma tadalafil concentrations in pediatric patients aged 2 to<  18 years were similar to those in adults at similar doses, and confirmed that dosing of 40 mg once daily in pediatric patients with a bodyweight ≥ 40 kg, and a dose of 20 mg once daily in patients with a body weight<  40 kg and aged ≥ 2 years are suitable for phase III evaluation.Trial Registration Number (Date of Registration)LVIG: ClinicalTrials.gov identifier: NCT01484431 (2 December 2011)....
Source: Clinical Pharmacokinetics - August 11, 2021 Category: Drugs & Pharmacology Source Type: research

Dermal Filler-Induced Vascular Occlusion Successfully Treated With Tadalafil, Hyaluronidase, and Aspirin
No abstract available (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - August 1, 2021 Category: Dermatology Tags: Communications Source Type: research