Modulation of SIRT1 expression improves erectile function in aged rats
Asian J Androl. 2022 Feb 18. doi: 10.4103/aja202199. Online ahead of print.ABSTRACTSilent information regulator 2-related enzyme 1 (SIRT1) is an aging-related protein activated with aging. Herein, we evaluated the role of SIRT1 in aging-related erectile dysfunction. The expression of SIRT1 was modulated in aged Sprague-Dawley rats following intragastric administration of resveratrol (Res; 5 mg kg-1), niacinamide (NAM; 500 mg kg-1) or Res (5 mg kg-1) + tadalafil (Tad; phosphodiesterase-5 [PDE5] inhibitor; 5 mg kg-1) for 8 weeks. Then, we determined erectile function by the ratio of intracavernosal pressure (ICP)/mean system...
Source: Asian Journal of Andrology - March 1, 2022 Category: Urology & Nephrology Authors: Wen Yu Jing Wang Yu-Tian Dai Bin Wang Yang Xu Qing-Qiang Gao Zhi-Peng Xu Source Type: research

Modulation of SIRT1 expression improves erectile function in aged rats
Asian J Androl. 2022 Feb 18. doi: 10.4103/aja202199. Online ahead of print.ABSTRACTSilent information regulator 2-related enzyme 1 (SIRT1) is an aging-related protein activated with aging. Herein, we evaluated the role of SIRT1 in aging-related erectile dysfunction. The expression of SIRT1 was modulated in aged Sprague-Dawley rats following intragastric administration of resveratrol (Res; 5 mg kg-1), niacinamide (NAM; 500 mg kg-1) or Res (5 mg kg-1) + tadalafil (Tad; phosphodiesterase-5 [PDE5] inhibitor; 5 mg kg-1) for 8 weeks. Then, we determined erectile function by the ratio of intracavernosal pressure (ICP)/mean system...
Source: Asian Journal of Andrology - March 1, 2022 Category: Urology & Nephrology Authors: Wen Yu Jing Wang Yu-Tian Dai Bin Wang Yang Xu Qing-Qiang Gao Zhi-Peng Xu Source Type: research

Modulation of SIRT1 expression improves erectile function in aged rats
Asian J Androl. 2022 Feb 18. doi: 10.4103/aja202199. Online ahead of print.ABSTRACTSilent information regulator 2-related enzyme 1 (SIRT1) is an aging-related protein activated with aging. Herein, we evaluated the role of SIRT1 in aging-related erectile dysfunction. The expression of SIRT1 was modulated in aged Sprague-Dawley rats following intragastric administration of resveratrol (Res; 5 mg kg-1), niacinamide (NAM; 500 mg kg-1) or Res (5 mg kg-1) + tadalafil (Tad; phosphodiesterase-5 [PDE5] inhibitor; 5 mg kg-1) for 8 weeks. Then, we determined erectile function by the ratio of intracavernosal pressure (ICP)/mean system...
Source: Asian Journal of Andrology - March 1, 2022 Category: Urology & Nephrology Authors: Wen Yu Jing Wang Yu-Tian Dai Bin Wang Yang Xu Qing-Qiang Gao Zhi-Peng Xu Source Type: research

Effects of sildenafil and tadalafil on skin flap viability
This study suggested positive results with the use of sildenafil and tadalafil as adjuvant drugs in skin flap viability. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - February 16, 2022 Category: Dermatology Source Type: research

The PASTIS trial: Testing tadalafil for possible use in vascular cognitive impairment
DISCUSSION: This trial did not identify a significant treatment effect of single-administration tadalafil on subcortical CBF. To detect treatment effects may require different dosing regimens.PMID:35135037 | DOI:10.1002/alz.12559 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - February 8, 2022 Category: Psychiatry Authors: Mathilde M H Pauls Lauren R Binnie Philip Benjamin Shai Betteridge Brian Clarke Mohani-Preet K Dhillon Rita Ghatala Fearghal A H Hainsworth Franklyn A Howe Usman Khan Christina Kruuse Jeremy B Madigan Barry Moynihan Bhavini Patel Anthony C Pereira Egill R Source Type: research

Evaluation of Neutrophil Dynamics Change by Protective Effect of Tadalafil After Renal Ischemia/Reperfusion Using In Vivo Real-time Imaging
Conclusions. Use of a novel technique contributed to elucidation of neutrophil dynamics after reperfusion. Tadalafil has a potential for inhibiting neutrophil infiltration in renal IRI. (Source: Transplantation)
Source: Transplantation - February 1, 2022 Category: Transplant Surgery Tags: Original Basic Science Source Type: research

Positive Predictors for Response to Ambrisentan Combination Therapy in Pulmonary Arterial Hypertension
Int Heart J. 2022;63(1):99-105. doi: 10.1536/ihj.21-497.ABSTRACTThe AMBITION study (NCT01178073) provided the first long-term clinical evidence for initial combination therapy with ambrisentan and tadalafil in patients with pulmonary arterial hypertension (PAH). Nevertheless, predictors of treatment response were not assessed.To identify predictors for response to initial combination therapy, we examined data from 302 patients with PAH (World Health Organization Functional Class II or III) who received initial combination therapy from the modified intention-to-treat population of the AMBITION study (n = 605). A responder w...
Source: International Heart Journal - January 31, 2022 Category: Cardiology Authors: Masaru Hatano Kohtaro Abe George Koike Tomohiko Takahashi Grant Tunmer David G Kiely Source Type: research