Beyond Erectile Dysfunction: cGMP-Specific Phosphodiesterase 5 Inhibitors for Other Clinical Disorders
Annu Rev Pharmacol Toxicol. 2022 Oct 7. doi: 10.1146/annurev-pharmtox-040122-034745. Online ahead of print.ABSTRACTCyclic guanosine monophosphate (cGMP), an important intracellular second messenger, mediates cellular functional responses in all vital organs. Phosphodiesterase 5 (PDE5) is one of the 11 members of the cyclic nucleotide phosphodiesterase (PDE) family that specifically targets cGMP generated by nitric oxide-driven activation of the soluble guanylyl cyclase. PDE5 inhibitors, including sildenafil and tadalafil, are widely used for the treatment of erectile dysfunction, pulmonary arterial hypertension, and certai...
Source: Pharmacological Reviews - October 7, 2022 Category: Drugs & Pharmacology Authors: Arun Samidurai Lei Xi Anindita Das Rakesh C Kukreja Source Type: research
Beyond Erectile Dysfunction: cGMP-Specific Phosphodiesterase 5 Inhibitors for Other Clinical Disorders
Annu Rev Pharmacol Toxicol. 2022 Oct 7. doi: 10.1146/annurev-pharmtox-040122-034745. Online ahead of print.ABSTRACTCyclic guanosine monophosphate (cGMP), an important intracellular second messenger, mediates cellular functional responses in all vital organs. Phosphodiesterase 5 (PDE5) is one of the 11 members of the cyclic nucleotide phosphodiesterase (PDE) family that specifically targets cGMP generated by nitric oxide-driven activation of the soluble guanylyl cyclase. PDE5 inhibitors, including sildenafil and tadalafil, are widely used for the treatment of erectile dysfunction, pulmonary arterial hypertension, and certai...
Source: Annual Review of Pharmacology and Toxicology - October 7, 2022 Category: Drugs & Pharmacology Authors: Arun Samidurai Lei Xi Anindita Das Rakesh C Kukreja Source Type: research
Beyond Erectile Dysfunction: cGMP-Specific Phosphodiesterase 5 Inhibitors for Other Clinical Disorders
Annu Rev Pharmacol Toxicol. 2022 Oct 7. doi: 10.1146/annurev-pharmtox-040122-034745. Online ahead of print.ABSTRACTCyclic guanosine monophosphate (cGMP), an important intracellular second messenger, mediates cellular functional responses in all vital organs. Phosphodiesterase 5 (PDE5) is one of the 11 members of the cyclic nucleotide phosphodiesterase (PDE) family that specifically targets cGMP generated by nitric oxide-driven activation of the soluble guanylyl cyclase. PDE5 inhibitors, including sildenafil and tadalafil, are widely used for the treatment of erectile dysfunction, pulmonary arterial hypertension, and certai...
Source: Pharmacological Reviews - October 7, 2022 Category: Drugs & Pharmacology Authors: Arun Samidurai Lei Xi Anindita Das Rakesh C Kukreja Source Type: research
Beyond Erectile Dysfunction: cGMP-Specific Phosphodiesterase 5 Inhibitors for Other Clinical Disorders
Annu Rev Pharmacol Toxicol. 2022 Oct 7. doi: 10.1146/annurev-pharmtox-040122-034745. Online ahead of print.ABSTRACTCyclic guanosine monophosphate (cGMP), an important intracellular second messenger, mediates cellular functional responses in all vital organs. Phosphodiesterase 5 (PDE5) is one of the 11 members of the cyclic nucleotide phosphodiesterase (PDE) family that specifically targets cGMP generated by nitric oxide-driven activation of the soluble guanylyl cyclase. PDE5 inhibitors, including sildenafil and tadalafil, are widely used for the treatment of erectile dysfunction, pulmonary arterial hypertension, and certai...
Source: Annual Review of Pharmacology and Toxicology - October 7, 2022 Category: Drugs & Pharmacology Authors: Arun Samidurai Lei Xi Anindita Das Rakesh C Kukreja Source Type: research
Beyond Erectile Dysfunction: cGMP-Specific Phosphodiesterase 5 Inhibitors for Other Clinical Disorders
Annu Rev Pharmacol Toxicol. 2022 Oct 7. doi: 10.1146/annurev-pharmtox-040122-034745. Online ahead of print.ABSTRACTCyclic guanosine monophosphate (cGMP), an important intracellular second messenger, mediates cellular functional responses in all vital organs. Phosphodiesterase 5 (PDE5) is one of the 11 members of the cyclic nucleotide phosphodiesterase (PDE) family that specifically targets cGMP generated by nitric oxide-driven activation of the soluble guanylyl cyclase. PDE5 inhibitors, including sildenafil and tadalafil, are widely used for the treatment of erectile dysfunction, pulmonary arterial hypertension, and certai...
Source: Annual Review of Pharmacology and Toxicology - October 7, 2022 Category: Drugs & Pharmacology Authors: Arun Samidurai Lei Xi Anindita Das Rakesh C Kukreja Source Type: research
Beyond Erectile Dysfunction: cGMP-Specific Phosphodiesterase 5 Inhibitors for Other Clinical Disorders
Annu Rev Pharmacol Toxicol. 2022 Oct 7. doi: 10.1146/annurev-pharmtox-040122-034745. Online ahead of print.ABSTRACTCyclic guanosine monophosphate (cGMP), an important intracellular second messenger, mediates cellular functional responses in all vital organs. Phosphodiesterase 5 (PDE5) is one of the 11 members of the cyclic nucleotide phosphodiesterase (PDE) family that specifically targets cGMP generated by nitric oxide-driven activation of the soluble guanylyl cyclase. PDE5 inhibitors, including sildenafil and tadalafil, are widely used for the treatment of erectile dysfunction, pulmonary arterial hypertension, and certai...
Source: Annual Review of Pharmacology and Toxicology - October 7, 2022 Category: Drugs & Pharmacology Authors: Arun Samidurai Lei Xi Anindita Das Rakesh C Kukreja Source Type: research
Beyond Erectile Dysfunction: cGMP-Specific Phosphodiesterase 5 Inhibitors for Other Clinical Disorders
Annu Rev Pharmacol Toxicol. 2022 Oct 7. doi: 10.1146/annurev-pharmtox-040122-034745. Online ahead of print.ABSTRACTCyclic guanosine monophosphate (cGMP), an important intracellular second messenger, mediates cellular functional responses in all vital organs. Phosphodiesterase 5 (PDE5) is one of the 11 members of the cyclic nucleotide phosphodiesterase (PDE) family that specifically targets cGMP generated by nitric oxide-driven activation of the soluble guanylyl cyclase. PDE5 inhibitors, including sildenafil and tadalafil, are widely used for the treatment of erectile dysfunction, pulmonary arterial hypertension, and certai...
Source: Annual Review of Pharmacology and Toxicology - October 7, 2022 Category: Drugs & Pharmacology Authors: Arun Samidurai Lei Xi Anindita Das Rakesh C Kukreja Source Type: research
Beyond Erectile Dysfunction: cGMP-Specific Phosphodiesterase 5 Inhibitors for Other Clinical Disorders
Annu Rev Pharmacol Toxicol. 2022 Oct 7. doi: 10.1146/annurev-pharmtox-040122-034745. Online ahead of print.ABSTRACTCyclic guanosine monophosphate (cGMP), an important intracellular second messenger, mediates cellular functional responses in all vital organs. Phosphodiesterase 5 (PDE5) is one of the 11 members of the cyclic nucleotide phosphodiesterase (PDE) family that specifically targets cGMP generated by nitric oxide-driven activation of the soluble guanylyl cyclase. PDE5 inhibitors, including sildenafil and tadalafil, are widely used for the treatment of erectile dysfunction, pulmonary arterial hypertension, and certai...
Source: Annual Review of Pharmacology and Toxicology - October 7, 2022 Category: Drugs & Pharmacology Authors: Arun Samidurai Lei Xi Anindita Das Rakesh C Kukreja Source Type: research
Beyond Erectile Dysfunction: cGMP-Specific Phosphodiesterase 5 Inhibitors for Other Clinical Disorders
Annu Rev Pharmacol Toxicol. 2022 Oct 7. doi: 10.1146/annurev-pharmtox-040122-034745. Online ahead of print.ABSTRACTCyclic guanosine monophosphate (cGMP), an important intracellular second messenger, mediates cellular functional responses in all vital organs. Phosphodiesterase 5 (PDE5) is one of the 11 members of the cyclic nucleotide phosphodiesterase (PDE) family that specifically targets cGMP generated by nitric oxide-driven activation of the soluble guanylyl cyclase. PDE5 inhibitors, including sildenafil and tadalafil, are widely used for the treatment of erectile dysfunction, pulmonary arterial hypertension, and certai...
Source: Annual Review of Pharmacology and Toxicology - October 7, 2022 Category: Drugs & Pharmacology Authors: Arun Samidurai Lei Xi Anindita Das Rakesh C Kukreja Source Type: research
Beyond Erectile Dysfunction: cGMP-Specific Phosphodiesterase 5 Inhibitors for Other Clinical Disorders
Annu Rev Pharmacol Toxicol. 2022 Oct 7. doi: 10.1146/annurev-pharmtox-040122-034745. Online ahead of print.ABSTRACTCyclic guanosine monophosphate (cGMP), an important intracellular second messenger, mediates cellular functional responses in all vital organs. Phosphodiesterase 5 (PDE5) is one of the 11 members of the cyclic nucleotide phosphodiesterase (PDE) family that specifically targets cGMP generated by nitric oxide-driven activation of the soluble guanylyl cyclase. PDE5 inhibitors, including sildenafil and tadalafil, are widely used for the treatment of erectile dysfunction, pulmonary arterial hypertension, and certai...
Source: Annual Review of Pharmacology and Toxicology - October 7, 2022 Category: Drugs & Pharmacology Authors: Arun Samidurai Lei Xi Anindita Das Rakesh C Kukreja Source Type: research
Beyond Erectile Dysfunction: cGMP-Specific Phosphodiesterase 5 Inhibitors for Other Clinical Disorders
Annu Rev Pharmacol Toxicol. 2022 Oct 7. doi: 10.1146/annurev-pharmtox-040122-034745. Online ahead of print.ABSTRACTCyclic guanosine monophosphate (cGMP), an important intracellular second messenger, mediates cellular functional responses in all vital organs. Phosphodiesterase 5 (PDE5) is one of the 11 members of the cyclic nucleotide phosphodiesterase (PDE) family that specifically targets cGMP generated by nitric oxide-driven activation of the soluble guanylyl cyclase. PDE5 inhibitors, including sildenafil and tadalafil, are widely used for the treatment of erectile dysfunction, pulmonary arterial hypertension, and certai...
Source: Annual Review of Pharmacology and Toxicology - October 7, 2022 Category: Drugs & Pharmacology Authors: Arun Samidurai Lei Xi Anindita Das Rakesh C Kukreja Source Type: research
Beyond Erectile Dysfunction: cGMP-Specific Phosphodiesterase 5 Inhibitors for Other Clinical Disorders
Annu Rev Pharmacol Toxicol. 2022 Oct 7. doi: 10.1146/annurev-pharmtox-040122-034745. Online ahead of print.ABSTRACTCyclic guanosine monophosphate (cGMP), an important intracellular second messenger, mediates cellular functional responses in all vital organs. Phosphodiesterase 5 (PDE5) is one of the 11 members of the cyclic nucleotide phosphodiesterase (PDE) family that specifically targets cGMP generated by nitric oxide-driven activation of the soluble guanylyl cyclase. PDE5 inhibitors, including sildenafil and tadalafil, are widely used for the treatment of erectile dysfunction, pulmonary arterial hypertension, and certai...
Source: Annual Review of Pharmacology and Toxicology - October 7, 2022 Category: Drugs & Pharmacology Authors: Arun Samidurai Lei Xi Anindita Das Rakesh C Kukreja Source Type: research
Epinephrine/tadalafil
(Source: Reactions Weekly)
Source: Reactions Weekly - October 1, 2022 Category: Drugs & Pharmacology Source Type: research
Identification of antiparasitic drug targets using a multi-omics workflow in the acanthocephalan model
CONCLUSIONS: The combination of genomics, transcriptomics, and proteomics led to a broadly applicable procedure for the cost- and time-saving identification of candidate target proteins in parasites. The ligands predicted to bind can now be further evaluated for their suitability in the control of acanthocephalans. The workflow has been deposited at the Galaxy workflow server under the URL tinyurl.com/yx72rda7 .PMID:36180835 | DOI:10.1186/s12864-022-08882-1 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - September 30, 2022 Category: Genetics & Stem Cells Authors: Hanno Schmidt Katharina Mauer Manuel Glaser Bahram Sayyaf Dezfuli S ören Lukas Hellmann Ana L úcia Silva Gomes Falk Butter Rebecca C Wade Thomas Hankeln Holger Herlyn Source Type: research
Efficacy and safety of dutasteride with tadalafil add-on therapy in patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia
To evaluate the efficacy and safety of add-on therapy with the phosphodiesterase type 5 inhibitor tadalafil in Japanese men with lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) tr... (Source: BMC Research Notes)
Source: BMC Research Notes - September 5, 2022 Category: Research Authors: Daisuke Gotoh, Kazumasa Torimoto, Yosuke Morizawa, Shunta Hori, Yasushi Nakai, Makito Miyake and Kiyohide Fujimoto Tags: Research note Source Type: research
