Heart failure in chronic kidney disease – Cardiology Basics
Heart failure in chronic kidney disease – Cardiology Basics
Prevalence of both heart failure and chronic kidney disease (CKD) are increasing as the population is aging globally. Hence heart failure in chronic kidney disease is seen more often. Presence of CKD in heart failure increases morbidity and mortality. Though there is increasing use of effective medications and special devices like cardiac resynchronization therapy in heart failure patients in general, those with CKD have not been benefited well.
CKD is defined as abnormalities of kidney structure or function, present for >3 months, with implications for h...
Source: Cardiophile MD - October 21, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Important blood tests in relation to the heart – Cardiology Basics
Important blood tests in relation to the heart – Cardiology Basics
Here are some important blood tests in relation to the heart. Normal ranges of some of these tests may vary between labs.
Cholesterol is a type of fat found in the blood and has a role in the development of atherosclerosis in the coronary arteries as well as other arteries. Desirable value of total cholesterol in blood is less than 200 milligrams per decilitre.
Triglycerides is another type of fat found in the blood. Desirable value is less than 150 milligrams per decilitre. Very high levels of triglycerides carry a risk of pancreatitis. Calorie restr...
Source: Cardiophile MD - October 11, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
InterWell Health Enhances Capabilities to Transform Kidney Care with Addition of Acumen Physician Solutions
Leading Electronic Health Record and Practice Management Software for Nephrology Practices will Accelerate Care Coordination for People Living with Chronic Kidney Disease
InterWell Health, the nation’s premier, physician-centric value-based kidney care provider, has enhanced its ability to transform kidney care with the addition of Acumen Physician Solutions (Acumen), a former division of Fresenius Medical Care North America.
Acumen is the leading provider of electronic health record (EHR) and patient management software designed especially for nephrologists caring for people living with chronic kidney dise...
Source: EMR and HIPAA - October 7, 2022 Category: Information Technology Authors: Healthcare IT News Tags: EMR-EHR Health IT Company Healthcare IT Acumen Acumen Epic Connect Acumen Physician Solutions Chronic Kidney Disease CKD Electronic Health Record Fresenius Medical Care North America Health IT Acquisitions Healthcare M&A InterWell Source Type: blogs
Finerenone, a non-steroidal MRA
Finerenone is a nonsteroidal, selective mineralocorticoid receptor antagonist. Finerenone is thought to have lower risk of hyperkalemia and renal issues compared to other MRAs. It has been shown to reduce albuminuria in patients with chronic kidney disease and type 2 diabetes mellitus. FInerenone in reducing kiDnEy faiLure and dIsease prOgression in Diabetic Kidney Disease (FIDELIO-DKD) study evaluated the renal and cardiovascular outcomes in patients with CKD and type 2 diabetes mellitus. 5734 patients with CKD and type 2 diabetes were randomized to finerenone or placebo. All patients were on renin-angiotensin system blo...
Source: Cardiophile MD - September 24, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
DIAMOND trial: Patiromer for management of hyperkalemia in HFrEF
Patiromer is a nonabsorbed potassium binder used in the treatment of hyperkalemia. Earlier it was tested in patients with chronic kidney disease who were receiving inhibitors of the renin-angiotensin-aldosterone system (RAAS). It was found that patiromer treatment was associated with a decrease in serum potassium levels compared to placebo and a reduction in the recurrence of hyperkalemia [1].
DIAMOND trial was designed to evaluate patiromer for the management of hyperkalemia in patients receiving RAAS inhibitors for heart failure with reduced ejection fraction (HFrEF) [2]. 1195 patients with RAAS inhibitor related ...
Source: Cardiophile MD - September 24, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Commentators and Journalists Weigh In On Digital Health And Related Privacy, Safety, Social Media And Security Matters. Lots Of Interesting Perspectives - August 30, 2022.
This article explores thekey functions of the CISC as outlined on its website.-----https://www.smh.com.au/politics/federal/living-standards-at-risk-without-big-data-and-artificial-intelligence-20220823-p5bbyt.htmlLiving standards at risk without big data and artificial intelligenceByShane WrightAugust 23, 2022 — 10.30pmAustralian living standards could slip behind those of other countries if the government and businesses fail to use and analyse data or take advantage of new technologies such as artificial intelligence, the Productivity Commission has warned.As part of its broader examination of ways to lift the nation â€...
Source: Australian Health Information Technology - August 30, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Weekly Australian Health IT Links – 22 August, 2022.
Here are a few I have come across the last week or so. Note: Each link is followed by a title and a few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment.General Comment-----This week we seem to have more in the way of State-Based initiatives as well as the usual rubbish info sessions from the ADHA.Also the usual from of NBN news and news of #myHR Rule 42 – which I had never heard of!-----https://www.australianageingagenda.com.au/contributors/opinion/critical-staff-shortages-affect-more-than-frontli...
Source: Australian Health Information Technology - August 22, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Assessing Heart Function and Fluid Status with Cardiac Scales: Interview with John Lipman, CEO, and Corey Centen, Founder, Bodyport
Bodyport, a medtech company based in San Francisco, developed the Bodyport Cardiac Scale, a set of weighing scales that can non-invasively assess fluid status and heart function. The scales can detect these signals through the feet when a patient steps onto the device. The technology is intended to be convenient and requires only 20 seconds each morning, and should easily lend itself to integration into a daily routine. Â Â
The device can transmit the data on cardiac hemodynamic parameters to clinicians through cellular networks, and uses AI-based algorithms to identify a variety of hemodynamic biomarkers to aid in ear...
Source: Medgadget - July 29, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Cardiology Exclusive Bodyport Source Type: blogs
Fight Aging! Newsletter, June 27th 2022
In conclusion, this study confirms that innate immune training can be induced in aging healthy individuals as well as critically ill sepsis patients. We found that innate immune training can be induced regardless of age and there was no substantive difference in the immune trained phenotype as a function of age. We employed β-glucan as our immune training stimulus. The ability of glucan to induce the trained phenotype suggests that it may be possible to pharmacologically induce the immune trained phenotype in aging human immunocytes.
Sitting Time Correlates with Mortality Risk
https://www.fightaging.org/archi...
Source: Fight Aging! - June 26, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Age-Related Arterial Calcification in the Context of Stroke
Calcification in arteries is an age-related malfunction of cell behavior, in which cells in blood vessel walls inappropriately take on some of the behaviors of bone cells called osteoblasts. These errant cells deposit calcium structures characteristic of bone tissue into the extracellular matrix, and that is in turn disruptive of tissue properties, particularly to the elasticity needed for constriction and dilation of blood vessels. In effect, blood vessels, and other structures such as heart valves that are subject to calcification, are slowly turning into bone. This causes cardiovascular dysfunctions that, given time, wi...
Source: Fight Aging! - June 20, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, May 23rd 2022
In conclusion, remofuscin activates the lysosome-to-nucleus pathway in C. elegans, thereby increasing the expression levels of xenobiotic detoxification genes resulted in extending their lifespan.
Naked Mole-Rat Skin Shows Fewer Signs of Aging
https://www.fightaging.org/archives/2022/05/naked-mole-rat-skin-shows-fewer-signs-of-aging/
Naked mole-rats exhibit a maximum life span that is many times longer than is the case for similarly sized mammals. Further, they are negligibly senescent, showing few age-related declines in function across much of that lengthy life span. That includes maintenance of stem ...
Source: Fight Aging! - May 22, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senescent Cell Extracellular Vesicles in Vascular Calcification
A growing body of evidence implicates the presence of senescent cells in the development of vascular calcification. Calcification arises as cells in blood vessel walls inappropriately take on the characteristics of bone cells. Senescent cells produce inflammatory signaling that contributes to these and other detrimental changes, and much of that signaling is carried in extracellular vesicles, membrane-wrapped packages of molecules that pass between cells in tissue. The direct solution to this problem is targeted removal of senescent cells, via senolytic therapies, but that isn't stopping researchers from mapping the way in...
Source: Fight Aging! - May 16, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 28th 2022
In conclusion, as BMI and waist circumference are related to elevations of immune markers in the IL-6 pathway, chronic inflammation might be an important mediator of the relationship between BMI and frailty.
Fat Tissue Becomes Dysfunctional with Age as Mitochondria Falter
https://www.fightaging.org/archives/2022/02/fat-tissue-becomes-dysfunctional-with-age-as-mitochondria-falter/
Mitochondria are effectively power plants, hundreds of them working in every cell to produce chemical energy store molecules to power cellular processes. Mitochondrial function declines with age, unfortunately, for underlying r...
Source: Fight Aging! - February 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
GSK3 β Overexpression and Cellular Senescence in the Aging Kidney
Senescent cells accumulate with age, a growing imbalance between pace of creation and pace of clearance. The majority of senescent cells come into being as cells reach the Hayflick limit on replication, and survive for only a short time before succumbing to programmed cell death or immune system activity. But senescent cells can be created by injury, inflammation, and other forms of damage as well. Senescent cells secrete pro-growth, inflammatory signals. This is useful in the short term as a way to help the body clear up damage or potentially cancerous cells, but when sustained over the long term it is highly disruptive t...
Source: Fight Aging! - February 25, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, February 21st 2022
In conclusion, clinical trials targeting aging in humans have shown promising but limited results on biomarkers so far.
Mycobacterium Vaccae Immunization as an Anti-Inflammatory Strategy
https://www.fightaging.org/archives/2022/02/mycobacterium-vaccae-immunization-as-an-anti-inflammatory-strategy/
In today's open access paper, researchers discuss immunization with Mycobacterium vaccae as an approach to reduce the inflammatory overactivity of the aged immune system. Researchers have made some initial inroads into studying the way in which this bacteria can alter the function of the immune system, and her...
Source: Fight Aging! - February 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
