Lower Mitochondrial DNA Copy Number Produces Disease-Related Epigenetic Changes in the Nucleus
Epigenetic marks on nuclear DNA, such as DNA methylation, control the expression of specific genes, and thus the mix of proteins being manufactured by a cell, and thus the behavior of that cell. Epigenetic marks are added and removed constantly in response to changing circumstances inside and outside a cell, and differ between cell types, but some of these marks are quite characteristic of the altered environment of an aged tissue. So much so that epigenetic clocks have been established to produce quite accurate assessments of chronological age, and more importantly biological age, a representation of the burden of molecul...
Source: Fight Aging! - October 14, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, October 12th 2020
We report that FMT from aged donors led to impaired spatial learning and memory in young adult recipients, whereas anxiety, explorative behaviour, and locomotor activity remained unaffected.
This was paralleled by altered expression of proteins involved in synaptic plasticity and neurotransmission in the hippocampus. Also, a strong reduction of bacteria associated with short-chain fatty acids (SCFAs) production (Lachnospiraceae, Faecalibaculum, and Ruminococcaceae) and disorders of the CNS (Prevotellaceae and Ruminococcaceae) was observed. Finally, the detrimental effect of FMT from aged donors on the CNS was confir...
Source: Fight Aging! - October 11, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Klotho in Aging and the Failing Kidney
Klotho is one of the few longevity-associated genes with robustly demonstrated effects in both directions: reduce its expression and life span is reduced, increase its expression and life span is increased. Klotho levels decline with age, and this decline is strongly associated with loss of cognitive function, but, interestingly, this may be a very indirect effect that exists due to klotho's influence over kidney function in aging. More klotho implies a slower decline in kidney function, and loss of kidney function is also shown to be a contributing factor in cognitive decline. Thus there is some interest in the research c...
Source: Fight Aging! - October 8, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Redefining Values in American Health Care
By RICHARD HOEHN, MD
Experts claim we could have been better prepared when the COVID-19 pandemic struck in early 2020. With an annual budget of $400-700 million, the Strategic National Stockpile (SNS) is designed to respond to chemical, biological, and other disasters. Its $8 billion inventory included 13,000 ventilators and a limited supply of personal protective equipment, N95 masks, and medical supplies. This left state and local governments scrambling as the COVID-19 pandemic accelerated and the capacity of many hospitals was overwhelmed.
Faced with immediate and visible death and suffering, leaders took drastic...
Source: The Health Care Blog - August 6, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Economics Health Policy Healthcare spending Richard Hoen Source Type: blogs
Fight Aging! Newsletter, July 13th 2020
In conclusion, sitting for prolonged periods of time without interruption is unfavorably associated with DBP and HDL cholesterol.
Exercise Slows Inappropriate Growth of Blood Vessels in a Mouse Model of Macular Degeneration
https://www.fightaging.org/archives/2020/07/exercise-slows-inappropriate-growth-of-blood-vessels-in-a-mouse-model-of-macular-degeneration/
Excessive growth of blood vessels beneath the retina is a proximate cause of blindness in conditions such as macular degeneration. Researchers here provide evidence for physical activity to be influential in the pace at which this process of tissu...
Source: Fight Aging! - July 12, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
MicroRNA-34a Promotes Vascular Cellular Senescence and Consequent Calcification
With the growing interest in the accumulation of senescent cells as an important cause of aging, and more funding flowing into this part of the field, researchers are uncovering numerous direct links between cellular senescence and age-related conditions. Senescent cells cause harm to tissues via their inflammatory secretions, the senescence-associated secretory phenotype (SASP). The SASP is damaging, but there are usually too few senescent cells, even in later life, to have a significant effect on tissue dysfunction through their localized actions. There may be exceptions to that rule, but the evidence to date strongly su...
Source: Fight Aging! - July 9, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Health in 2 Point 00, Episode 132 | Accolade IPO, Somatus, NexHealth, Tatch & more
Today on Health in 2 Point 00, Jess and I cover some big news! Accolade has filed its IPO, so on Episode 132 I give my take on this health care navigation service. We also cover Somatus getting $64 million for chronic kidney disease care, NexHealth raising $15 million, Tatch raising $4.25 million for sleep apnea diagnosis, Simply Speak raising a $1.1 million seed round, and optimize.health raising $3.5 million for its remote monitoring platform. —Matthew Holt (Source: The Health Care Blog)
Source: The Health Care Blog - July 6, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Health in 2 Point 00 Health Tech Health Technology Jessica DaMassa Matthew Holt Accolade digital health IPO NexHealth optimize.health Simply Speak Somatus Tatch Source Type: blogs
Ventilator rationing is guided by rules that could worsen health inequities
Imagine there are two individuals who have been admitted to a hospital due to COVID-19, and both desperately need ventilators. One is a 60-year-old with a heart condition, and another is a 63-year-old with chronic kidney disease. Because of resource constraints, you have to decide which patient will be able to receive a ventilator. Both […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - May 28, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/vishal-s-arora" rel="tag" > Vishal S. Arora, MD < /a > < /span > Tags: Conditions COVID-19 coronavirus Hospital-Based Medicine Infectious Disease Source Type: blogs
A Vigilante in Statistical Badlands
This study, for instance, attributes a patient’s waitlist/transplant outcome to the very last dialysis facility the patient was associated with. In epidemiology speak, this means the causal inference authors are trying to draw between for-profit status and good transplant outcomes is subject to time-varying confounding. As an example, if one is seeking an association between testosterone levels and risk of a heart attack, using the last testosterone level available would be a poor way of doing this study because testosterone levels are known to vary over time. The same applies to dialysis facilities. Patients chan...
Source: The Health Care Blog - May 25, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Physicians Eric Weinhandl JAMA medical research public health Public Policy public policy research Source Type: blogs
Reducing your risk of changes in thinking following surgery
Cognition is an important function of the brain that enables us to acquire and process information, to enhance our understanding of thoughts, experiences, and our senses. Any condition that affects our ability to think, reason, memorize, or be attentive affects our cognitive ability. Some cognitive decline is a normal part of aging, but there are many things you can do to prevent or forestall cognitive changes as you age, including when planning for surgery.
Older adults are having more surgical procedures
As our population ages and medicine and healthcare advances, more older adults are likely to develop serious condition...
Source: Harvard Health Blog - May 22, 2020 Category: Consumer Health News Authors: Subramaniam Balachundhar, MD, MPH, FASA Tags: Healthy Aging Managing your health care Memory Neurological conditions Prevention Surgery Source Type: blogs
Here ’s What Loneliness Can Do to You During COVID-19
“The loneliest moment in someone’s life is when they are watching their whole world fall apart, and all they can do is stare blankly.” – F. Scott Fitzgerald
Loneliness is never easy to endure, yet during times of mandatory social isolation and distancing, such as millions of Americans are experiencing during the COVID-19 pandemic, it can be particularly damaging. Among its many effects, loneliness can exacerbate and bring upon a host of mental and physical conditions.
Social Isolation and Loneliness May Increase Inflammation
A study by researchers at the University of Surrey and Brunel University London found a pot...
Source: World of Psychology - May 14, 2020 Category: Psychiatry & Psychology Authors: Suzanne Kane Tags: Self-Help coronavirus COVID-19 Loneliness social distancing Source Type: blogs
Fight Aging! Newsletter, April 27th 2020
In conclusion, our study demonstrated that Nrf2 deficiency promoted the increasing trend of autophagy during aging in skeletal muscle. Nrf2 deficiency and increasing age may cause excessive autophagy in skeletal muscle, which can be a potential mechanism for the development of sarcopenia.
To What Degree is Chondrocyte Hypertrophy in Osteoarthritis Due to Cellular Senescence?
https://www.fightaging.org/archives/2020/04/to-what-degree-is-chondrocyte-hypertrophy-in-osteoarthritis-due-to-cellular-senescence/
Senescent cells are large. They do not replicate, that function is disabled, but it is as if they go...
Source: Fight Aging! - April 26, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Chronic Kidney Disease Accelerates Many Aspects of Aging, Such as Cardiovascular Disease Risk
Chronic kidney disease is an unpleasant condition. There is little that can be done for patients at the present time, though there is hope that senolytic drugs might be able to turn back the fibrosis characteristic of the condition. The kidneys are important to the correct function of tissues throughout the body, and consequently chronic kidney disease accelerates the degenerative aging of many other organs, including the cardiovascular system and brain. Finding ways to restore kidney function in older patients would be a big deal.
Chronic kidney disease (CKD) is a systemic pathology that affects approximately 10%...
Source: Fight Aging! - April 21, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Quantifying the Effects of a Healthy Lifestyle on Later Risk of Age-Related Disease
It is no big secret that maintaining a healthier lifestyle will extend the time spent free from age-related disease and generally improve the experience of later life. In this day and age, and now that the very harmful practice of smoking is waning somewhat, the practice of maintaining better health largely means resisting the siren call of excess calories and consequent excess weight. The presence of visceral fat tissue in excessive amounts accelerates the aging process. Staying slim over the course of life thus pays off down the line. If you instead choose to damage yourself in this way, the inevitable result is an earli...
Source: Fight Aging! - March 18, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Evidence for Loss of Capillary Density to be Important in Heart Disease
Loss of capillary density, and thus flow of blood through tissues, is a known feature of aging, though the causes of this change in tissue maintenance are far from completely explored. It is proposed to be quite important in loss of tissue function, particularly in organs with high metabolic demands, such as muscle and the brain. Researchers here provide evidence to suggest that this loss of capillary density is a noteworthy mediating mechanism linking the age-related impairment of heart function with the presence of chronic kidney disease. The latter is already known to correlate with impaired capillary structure in the h...
Source: Fight Aging! - February 12, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
