Free Universal School Meals: A Crucial Public Health and Social Justice Move for California and the Nation
Expanding Universal School Meals for All is a massive win for public health and social justice. California is now the first state to provide free breakfast and lunch to all public school students for the next two years. Thank you to Senator Nancy Skinner (D-Berkeley) and the School Meals for All Coalition of more than 200 nonprofits, supported by philanthropist and real food advocate Kat Taylor, for championing this policy.
As a pediatrician and a school district food service director, we know that nutritious school food is one of the most powerful levers to safeguard children’s health. Why? Kids can often get 50-1...
Source: Conversations with Dr Greene - August 16, 2021 Category: Child Development Authors: Alan Greene MD Tags: Dr. Greene's Blog School Lunch School Melas Schoolage Nutrition Source Type: blogs
Fight Aging! Newsletter, August 16th 2021
In conclusion, cancer survivors, especially older individuals, demonstrate greater odds of and accelerated functional decline, suggesting that cancer and/or its treatment may alter aging trajectories.
Linking Particulate Air Pollution and Dementia in a Small Region of the US
https://www.fightaging.org/archives/2021/08/linking-particulate-air-pollution-and-dementia-in-a-small-region-of-the-us/
It is fairly settled that evident particulate air pollution, such as daily exposure to smoke from wood-fueled cooking fires, has a strongly detrimental effect on long-term health. The mechanisms involved are inflam...
Source: Fight Aging! - August 15, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Insilico Medicine Targeting Kidney Fibrosis
Insilico Medicine works on cost reduction and acceleration of existing small molecule drug discovery approaches via machine learning and other forms of automation. While starting out as an aging-focused company, their primary goal at this stage, steered by their investors, is to sell the software platforms they produce to the pharmaceutical industry. Their in-house drug development programs serve as marketing for this goal. Those they chose to publicize are somewhat senotherapeutic in nature at the present time, focused on clearance or suppression of senescent cells to treat fibrosis. A range of evidence suggests that sene...
Source: Fight Aging! - August 11, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, August 9th 2021
In conclusion, the present study supports that some age-related diseases as well as education are causally related to longevity and highlights several new targets for achieving longevity, including management of venous thromboembolism, appropriate intake of sugar, and control of body fat. Our results warrant further studies to elucidate the underlying mechanisms of these reported causal associations.
Pol III Inhibition Extends Longevity in Short-Lived Species
https://www.fightaging.org/archives/2021/08/pol-iii-inhibition-extends-longevity-in-short-lived-species/
As this paper notes, Pol III is downstrea...
Source: Fight Aging! - August 8, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Ability of Calorie Restriction to Aid in Kidney Regeneration Falters with Age
The practice of calorie restriction (also known as dietary restriction) improves health and slows aging. This occurs to a greater degree in short-lived species than in our own comparatively long-lived species, but nonetheless, the benefits are evident. Researchers here discuss the evidence for calorie restriction to be protective of kidney function, but for that protection to decline with age. This is an interesting perspective on calorie restriction, one that I haven't see much mentioned in the past. Very little of our biochemistry and function escapes aging, and we might expect near any measurable aspect of physiology an...
Source: Fight Aging! - August 2, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, June 21st 2021
This study showed that the leakage of this mitochondrial nucleic material may occur as a result of mitochondrial dysfunction, which may involve genetic mutations in genes encoding mitochondrial proteins or incomplete degradation of mitochondrial dsDNA in the lysosome - which is a 'degradation factory' of the cell. Upon the leakage into the cytoplasm, this undegraded dsDNA is detected by a 'foreign' DNA sensor of the cytoplasm (IFI16) which then triggers the upregulation of mRNAs encoding for inflammatory proteins."
Using a PD zebrafish model (gba mutant), the researchers demonstrated that a combination of PD-like ph...
Source: Fight Aging! - June 20, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Accelerated Epigenetic Age Correlates with Worse Kidney Function
Kidney function is very important to long-term health, influencing the operation of other organs. This is well illustrated by research into klotho, a longevity associated gene that appears to primarily function in the kidney, yet improves numerous measures of cognitive and cardiovascular aging when highly expressed. Here, researchers show that epigenetic age acceleration, in which epigenetic age is higher than chronological age, is associated with worse kidney function. Epigenetic age is in effect an assessment of cellular reactions to the aged tissue environment of damage, dysfunction, and altered signaling, and it is int...
Source: Fight Aging! - June 15, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, June 7th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - June 6, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Oisin Biotechnologies Seeks to Treat Chronic Kidney Disease with Senolytic Suicide Gene Therapy
Oisin Biotechnologies is one of the older startup biotech companies in the still young and growing longevity industry. The company develops a programmable suicide gene therapy platform, initially targeted at the selective destruction of senescent cells and cancerous cells. Of interest in a recent press release regarding funding is the note that their senolytic program will be used to treat chronic kidney disease. Other groups are running human trials of the dasatinib and quercetin combination as a treatment for chronic kidney disease. Positive data there will help Oisin Biotechnologies, in the sense that it will further va...
Source: Fight Aging! - June 3, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Senolytic Treatment Reverses Age-Related Loss of Kidney Regeneration in Mice
Senescent cells accumulate with age and cause a great deal of harm in the aged body. Their numbers are not thought to be very high in most tissues, perhaps a few percent of all cells by late life, but senescent cells secrete a potent mix of signals that has a widespread disruptive effect. This signaling spurs chronic inflammation and causes malfunctioning of the normal processes of tissue regeneration and maintenance, amongst other issues. In organs like the kidney, this results in a lack of resilience to injury, increased fibrosis, and eventually chronic kidney disease. Researchers have shown that senolytic treatment to d...
Source: Fight Aging! - June 2, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Will U.S. health care match Native Americans ’ treatment of chronic kidney disease?
For years, hypertension has dominated the health care field, afflicting 45 percent of all adult Americans. Another disease that has gained renown in the world of health care is diabetes, afflicting 10.5 percent of the U.S. population. Health care professionals have allocated untold assets to minimize the impact such diseases pose. Yet, the relative obscurity and lackRead more …Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - May 30, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/donald-voltz-and-eric-tran" rel="tag" > Donald Voltz, MD and Eric Tran < /a > < /span > Tags: Conditions Nephrology Source Type: blogs
Fight Aging! Newsletter, May 31st 2021
In conclusion, iMSC-sEVs could rejuvenate the senescence of NPCs and attenuate the development of IVDD.
Cell Signaling via Exosomes in the Development of Vascular Calcification
https://www.fightaging.org/archives/2021/05/cell-signaling-via-exosomes-in-the-development-of-vascular-calcification/
Vascular calcification is a feature of aging, a process in which cells in the blood vessel wall take on inappropriate identities and activities that are more appropriate to bone tissue. Evidence of recent years implicates chronic inflammation and the presence of senescent cells in this process. Senescent cells cau...
Source: Fight Aging! - May 30, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Targeting Senescent Cells to Reverse the Aging of the Kidneys
Senescent cells accumulate with age and cause a wide range of pathologies. They contribute in some way to near all of the common, ultimately fatal age-related conditions. Senescent cells secrete a mix of signals that produces chronic inflammation, disrupts tissue maintenance to encourage fibrosis, and changes the behavior of other cells for the worse in numerous ways. It is the signaling that allows the comparatively small fraction of senescent cells in any given aged tissue to cause such widespread harm.
Destroying senescent cells in a targeted fashion via the use of senolytic therapies has shown great promise in a...
Source: Fight Aging! - May 28, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, May 17th 2021
This study is consistent with previous evidence showing that inflammaging, or age-related inflammation, is naturally heightened in the nervous system. Moreover, the authors disproved their hypothesis that anti-inflammatory microglia-specific genes are responsible for the elevated inflammatory response in aged brains since the expression of anti-inflammatory mediators was elevated in middle-aged brains following infection. Thus, the cause for the increase in pro-inflammatory genes remains to be elucidated.
Mixed Results in Animal Studies of Gene Therapy Targeting Axonal Regrowth
https://www.fightaging.org/archi...
Source: Fight Aging! - May 16, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Age-Related Loss of Kidney Function Correlates with Dementia Risk
The relationship between age-related kidney failure and neurodegeneration is interesting to consider in the context of research into the longevity-associated gene klotho. Overexpression of klotho slows aging, while loss of expression accelerates aging. Klotho also affects cognitive decline; more klotho slows age-related neurodegeneration. Klotho, however, appears to act in the kidney, not the brain. This is a point of emphasis on the importance of the kidneys to long term health; loss of kidney function leads to deterioration of tissue function throughout the body, due to the failure to clear waste products from the bloods...
Source: Fight Aging! - May 12, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
