A Discussion of the Biochemistry of Cardiac Fibrosis
Fibrosis is a malfunction of tissue maintenance, in which excessive amounts of extracellular matrix structure are created, forming scar-like features that disrupt normal tissue function. Fibrosis is a feature of aging and can rise to the level of life-threatening issue in organs such as the lung, liver, kidneys, and heart. This is particularly the case because there are no truly effective therapies to treat fibrosis; it is an inexorable condition that leads towards organ failure. Progress towards the reversal of fibrosis has been slow, unfortunately, despite the comparatively recent discovery that senescent cells appear to...
Source: Fight Aging! - January 31, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Monogram Health Closes $375M Growth Capital Raise to Support Continued Expansion of Innovative In-Home Kidney and Polychronic Care Model
Milestone funding from leading strategic and financial investors will help accelerate company’s mission to measurably improve outcomes for patients living with polychronic conditions, including chronic kidney and end-stage renal disease
Monogram Health, a value-based specialty provider of in-home evidence-based care and benefit management services for patients living with polychronic conditions, including chronic kidney and end-stage renal disease, today announced it has closed on $375 million of new funding. This milestone growth funding round included investments from leading strategic investors CVS Health, Cigna Ventu...
Source: EMR and HIPAA - January 18, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Communication and Patient Experience Health IT Company Healthcare IT Telemedicine and Remote Monitoring Affordability BofA Securities Chronic Kidney Disease Cigna Ventures Cravath CVS Health Disease Management Frist Cressey Ventures Source Type: blogs
The SenNet Consortium Intends to Map Senescent Cells Throughout the Human Lifespan
As noted last year, the NIH is setting up the SenNet program to fill in some of the larger gaps in the present detail-level knowledge of the role of senescent cells in aging. The goal is to better steer the numerous efforts presently underway to develop improved senolytic therapies that clear senescent cells from old tissues, thereby producing rapid rejuvenation. Senolytic therapies have produced promising results in animal studies, and the potential for this class of treatment to significantly improve late life health in humans is an attractive prospect.
Multiple lines of evidence suggest that senescent cells (Sn...
Source: Fight Aging! - December 29, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, December 26th 2022
This article on senolytic therapies to selectively remove senescent cells in old tissues is in part a matter of Unity Biotechnology talking up their position. The company suffered from first mover disadvantage in bringing senolytic drugs into clinical development. The field has made progress very rapidly over the last decade, and startups founded even just a couple of years after Unity's launch benefited from greater knowledge and a selection of better technologies to work with. Still, one can be talking up one's position and also be right. The accumulation of senescent cells is profoundly harmful, a significant contributi...
Source: Fight Aging! - December 25, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
On the Aging of the Kidneys
The longevity-associated gene klotho is known to act in kidney tissue, in ways that are protective of cell function in the aging environment of damage and inflammation. One of the conclusions that might be drawn from the extended life span produced by increased klotho expression in animal studies is that declining kidney function is an important aspect of aging. If the kidneys are not efficiently clearing waste from the bloodstream, and otherwise providing their contribution to bodily function, then all organs suffer as a result. Faster loss of kidney function means a faster decline into disease and mortality.
The...
Source: Fight Aging! - December 23, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Cautious Industry View of the Promise of Senolytics
This article on senolytic therapies to selectively remove senescent cells in old tissues is in part a matter of Unity Biotechnology talking up their position. The company suffered from first mover disadvantage in bringing senolytic drugs into clinical development. The field has made progress very rapidly over the last decade, and startups founded even just a couple of years after Unity's launch benefited from greater knowledge and a selection of better technologies to work with. Still, one can be talking up one's position and also be right. The accumulation of senescent cells is profoundly harmful, a significant contributi...
Source: Fight Aging! - December 22, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, December 19th 2022
In conclusion, p16 deletion or p16 positive cell clearance could be a novel strategy preventing long term HFD-induced skin aging.
Association of LDL-Cholesterol with Mortality
https://www.fightaging.org/archives/2022/12/association-of-ldl-cholesterol-with-mortality/
Researchers here report on a study of LDL-cholesterol and mortality risk in older people. As they note, data on this topic is conflicted once one moves beyond the matter of cardiovascular disease. Over a lifetime, higher LDL-cholesterol makes it easier to reach the tipping point at which cholesterol deposited in blood vessel walls produces e...
Source: Fight Aging! - December 18, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Struggle to Deal with the Presently Incurable Issues of Aging
The struggles and sufferings of the old are largely conducted behind the curtain, not talked about all that much in the public sphere. How does one manage the last phase of life for a failing, complex machine that cannot be repaired, only coaxed into a slightly slower decline? As it turns out, a fair amount of not thinking about it is involved: on the part of younger people, and particularly on the part of research and development institutions that do not wish to be burdened with the very complex, interacting nature of late life age-related diseases. New treatments and adjustments to the standard of care are rarely formall...
Source: Fight Aging! - December 16, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, December 5th 2022
In conclusion, the PAAIs examined (i.e. mTOR loss of function, Ghrhr loss of function, intermittent fasting-based version of dietary restriction) often influenced age-sensitive traits in a direct way and not by slowing age-dependent change. Previous studies often failed to include young animals subjected to PAAI to account for age-independent PAAI effects. However, any study not accounting for such age-independent intervention effects will be prone to overestimate the extent to which an intervention delays the effects of aging on the phenotypes studied. This can result in a considerable bias of our view on how modifiable a...
Source: Fight Aging! - December 4, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Vascular Smooth Muscle Cells Become Prone to Altered Behavior with Age
The altered signaling environment in aged tissue produces changes in cell behavior, some of which is adaptive and helpful, and some of which is maladaptive and harmful. In some cases the same process can be one or the other depending on context. Cellular senescence, for example, is helpful in the contexts of cancer suppression and regeneration from injury, but only up until the point at which senescent cells are no longer removed as rapidly as they are created, at which point their continued, unrelenting pro-growth, pro-inflammatory signaling contributes to many of the forms of tissue dysfunction observed in aging.
...
Source: Fight Aging! - December 2, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Interactions Between the Aging Immune System and Aging Kidney
Researchers here discuss the ways in which the aging of the immune system influences the aging of the kidney, such as through disruption of the normal participation of immune cells in tissue maintenance and repair. With age the immune system falls into a state of chronic inflammation, and unresolved inflammatory signaling is disruptive to the structure and operation of tissues throughout the body. The kidney is but one example of how this contributes to the declines of aging.
With the steady increase in the number of elderly individuals globally, age-related diseases emerge as a major challenge to health care work...
Source: Fight Aging! - November 28, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 21st 2022
In this study researchers added new insight, showing that high-intensity aerobic exercise, which derives its energy from sugar, can reduce the risk of metastatic cancer by as much as 72%. If so far the general message to the public has been 'be active, be healthy', now researchers can explain how aerobic activity can maximize the prevention of the most aggressive and metastatic types of cancer.
The study combined an animal model in which mice were trained under a strict exercise regimen, with data from healthy human volunteers examined before and after running. The human data, obtained from an epidemiological study ...
Source: Fight Aging! - November 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Klotho Promotes Autophagy to Slow Vascular Calcification
Klotho is one of the few robustly determined longevity genes capable of altering life span in both directions in mice. A reduced expression of klotho shortens life span, while increased klotho levels lengthen life. Klotho has been shown to improve cognitive function, but investigation to date has suggested that it primarily functions in the kidney, and that kidney function mediates effects elsewhere in the body.
Today's open access paper is focused instead on the relationship between klotho and vascular calcification. Prior research on this topic has focused on the relationship between klotho and FGF23, but here the...
Source: Fight Aging! - November 15, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
High Blood Pressure Can Lead to Kidney Damage
Conclusion
A potential outcome of hypertension is damage to blood vessels and organs such as the kidneys. In addition, a delay in receiving treatment increases the risk of waste fluid build-up, which elevates the chance of complications and, ultimately, renal failure.
If your doctor has diagnosed you with hypertension, you might be recommended adaptations to your lifestyle and medications. It’s vital to take prescription drugs as indicated and attend follow-ups as scheduled to check blood pressure.
References
“High Blood Pressure & Kidney Disease.” National Institute of Diabetes and Digestive and Kidney...
Source: The EMT Spot - November 8, 2022 Category: Emergency Medicine Authors: Michael Kutryk Tags: Guides Blood Pressure Source Type: blogs
What are BNP and NT-proBNP tests? Cardiology Basics
BNP and NT-proBNP tests are used for detection of heart failure. When the heart fails, there is stretching of the ventricles which leads to release of BNP from the myocardium. Pro BNP is the precursor of BNP, which is cleaved by enzymes to NT-proBNP and BNP. BNP stands for brain natriuretic peptide or B-type natriuretic peptide. BNP is biologically active while NT-proBNP is not. NT stands for amino terminal of the protein.
NT-proBNP has a longer plasma half life than BNP. Hence levels of NT-proBNP are more stable. Thus, it can reflect the stretching of the left ventricle, over the previous 12 hours. This is the reas...
Source: Cardiophile MD - October 28, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
