Choriocarcinoma That Had Transferred to the Right Inferior Pulmonary Vein and Left Atrium: A Case Report
Altern Ther Health Med. 2024 Apr 5:AT10239. Online ahead of print.ABSTRACTHere, we present a case of choriocarcinoma with metastasis only to the right inferior pulmonary vein and heart, which is unusual, as the skipping of lung metastasis is extremely rare. The 34-year-old patient presented with cough and hemoptysis. The diagnosis was challenging due to the absence of gynecological abnormalities and elevated β-HCG levels, only revealing a cardiac mass upon imaging. While no abnormalities were found through gynecological ultrasound or gynecological examination, the serum human chorionic gonadotropin β subunit (β-HCG) lev...
Source: Alternative Therapies in Health and Medicine - April 6, 2024 Category: Complementary Medicine Authors: Fang Guan Mingjun Fan Wenlong Zhang Guoying Cui Source Type: research
Choriocarcinoma That Had Transferred to the Right Inferior Pulmonary Vein and Left Atrium: A Case Report
Altern Ther Health Med. 2024 Apr 5:AT10239. Online ahead of print.ABSTRACTHere, we present a case of choriocarcinoma with metastasis only to the right inferior pulmonary vein and heart, which is unusual, as the skipping of lung metastasis is extremely rare. The 34-year-old patient presented with cough and hemoptysis. The diagnosis was challenging due to the absence of gynecological abnormalities and elevated β-HCG levels, only revealing a cardiac mass upon imaging. While no abnormalities were found through gynecological ultrasound or gynecological examination, the serum human chorionic gonadotropin β subunit (β-HCG) lev...
Source: Alternative Therapies in Health and Medicine - April 6, 2024 Category: Complementary Medicine Authors: Fang Guan Mingjun Fan Wenlong Zhang Guoying Cui Source Type: research
Choriocarcinoma That Had Transferred to the Right Inferior Pulmonary Vein and Left Atrium: A Case Report
Altern Ther Health Med. 2024 Apr 5:AT10239. Online ahead of print.ABSTRACTHere, we present a case of choriocarcinoma with metastasis only to the right inferior pulmonary vein and heart, which is unusual, as the skipping of lung metastasis is extremely rare. The 34-year-old patient presented with cough and hemoptysis. The diagnosis was challenging due to the absence of gynecological abnormalities and elevated β-HCG levels, only revealing a cardiac mass upon imaging. While no abnormalities were found through gynecological ultrasound or gynecological examination, the serum human chorionic gonadotropin β subunit (β-HCG) lev...
Source: Alternative Therapies in Health and Medicine - April 6, 2024 Category: Complementary Medicine Authors: Fang Guan Mingjun Fan Wenlong Zhang Guoying Cui Source Type: research
Choriocarcinoma That Had Transferred to the Right Inferior Pulmonary Vein and Left Atrium: A Case Report
Altern Ther Health Med. 2024 Apr 5:AT10239. Online ahead of print.ABSTRACTHere, we present a case of choriocarcinoma with metastasis only to the right inferior pulmonary vein and heart, which is unusual, as the skipping of lung metastasis is extremely rare. The 34-year-old patient presented with cough and hemoptysis. The diagnosis was challenging due to the absence of gynecological abnormalities and elevated β-HCG levels, only revealing a cardiac mass upon imaging. While no abnormalities were found through gynecological ultrasound or gynecological examination, the serum human chorionic gonadotropin β subunit (β-HCG) lev...
Source: Alternative Therapies in Health and Medicine - April 6, 2024 Category: Complementary Medicine Authors: Fang Guan Mingjun Fan Wenlong Zhang Guoying Cui Source Type: research
Choriocarcinoma That Had Transferred to the Right Inferior Pulmonary Vein and Left Atrium: A Case Report
Altern Ther Health Med. 2024 Apr 5:AT10239. Online ahead of print.ABSTRACTHere, we present a case of choriocarcinoma with metastasis only to the right inferior pulmonary vein and heart, which is unusual, as the skipping of lung metastasis is extremely rare. The 34-year-old patient presented with cough and hemoptysis. The diagnosis was challenging due to the absence of gynecological abnormalities and elevated β-HCG levels, only revealing a cardiac mass upon imaging. While no abnormalities were found through gynecological ultrasound or gynecological examination, the serum human chorionic gonadotropin β subunit (β-HCG) lev...
Source: Alternative Therapies in Health and Medicine - April 6, 2024 Category: Complementary Medicine Authors: Fang Guan Mingjun Fan Wenlong Zhang Guoying Cui Source Type: research
Post molar choriocarcinoma with solitary renal metastasis in the absence of primary uterine tumor: a case report and review of the literature
ConclusionsUrological symptoms such as hematuria or spontaneous renal hemorrhage might be the only presentation of post molar choriocarcinoma with renal involvement. Thus, it can be beneficial to measure serum beta human chorionic gonadotropin levels among females of childbearing age who present with unexplained urological symptoms, especially if there is a history of prior hydatiform mole. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - March 30, 2024 Category: General Medicine Source Type: research
Case report: Molecular profiling facilitates the diagnosis of a challenging case of lung cancer with choriocarcinoma features
We present a 35-year female with lung cancer with choriocarcinoma features. Her disease involved the right lower lung, brain, and thoracic lymph nodes. The pathology from brain metastasis was reported as “metastatic choriocarcinoma” (a germ cell tumor) by local pathologists. She initiated carboplatin and etoposide, a regimen for choriocarcinoma. Subsequently, her case was assessed by pathologists from an academic cancer center, who gave the diagnosis of “adenocarcinoma with aberrant expression of β-hCG” and finally pathologists at our hospital, who gave the diagnosis of “poorly differentiated carcinoma with chor...
Source: Frontiers in Oncology - March 25, 2024 Category: Cancer & Oncology Source Type: research
Human seminal extracellular vesicles enhance endometrial receptivity through leukemia inhibitory factor
Endocrinology. 2024 Mar 22:bqae035. doi: 10.1210/endocr/bqae035. Online ahead of print.ABSTRACTSeminal extracellular vesicles (EVs) contain different subgroups which have diverse effects on sperm function. However, the effect of seminal EVs-especially its subgroups, on the endometrial receptivity was largely unknown. Here, we found that the seminal EVs could be divided into high-density EV (EV-H)、medium density EV (EV-M) and low-density EV (EV-L), after purification using iodixanol. Then we demonstrated that EV-H could promote the expression and secretion of leukemia inhibitor factor (LIF) in human endometrial cells. In ...
Source: Endocrinology - March 22, 2024 Category: Endocrinology Authors: Hanshu Wang Yu Lin Rongrong Chen Yu Zhu Hongqiang Wang Shengxian Li Lei Yu Kaishu Zhang Yujie Liu Tao Jing Fei Sun Source Type: research
Human seminal extracellular vesicles enhance endometrial receptivity through leukemia inhibitory factor
Endocrinology. 2024 Mar 22:bqae035. doi: 10.1210/endocr/bqae035. Online ahead of print.ABSTRACTSeminal extracellular vesicles (EVs) contain different subgroups which have diverse effects on sperm function. However, the effect of seminal EVs-especially its subgroups, on the endometrial receptivity was largely unknown. Here, we found that the seminal EVs could be divided into high-density EV (EV-H)、medium density EV (EV-M) and low-density EV (EV-L), after purification using iodixanol. Then we demonstrated that EV-H could promote the expression and secretion of leukemia inhibitor factor (LIF) in human endometrial cells. In ...
Source: Endocrinology - March 22, 2024 Category: Endocrinology Authors: Hanshu Wang Yu Lin Rongrong Chen Yu Zhu Hongqiang Wang Shengxian Li Lei Yu Kaishu Zhang Yujie Liu Tao Jing Fei Sun Source Type: research
Human seminal extracellular vesicles enhance endometrial receptivity through leukemia inhibitory factor
Endocrinology. 2024 Mar 22:bqae035. doi: 10.1210/endocr/bqae035. Online ahead of print.ABSTRACTSeminal extracellular vesicles (EVs) contain different subgroups which have diverse effects on sperm function. However, the effect of seminal EVs-especially its subgroups, on the endometrial receptivity was largely unknown. Here, we found that the seminal EVs could be divided into high-density EV (EV-H)、medium density EV (EV-M) and low-density EV (EV-L), after purification using iodixanol. Then we demonstrated that EV-H could promote the expression and secretion of leukemia inhibitor factor (LIF) in human endometrial cells. In ...
Source: Endocrinology - March 22, 2024 Category: Endocrinology Authors: Hanshu Wang Yu Lin Rongrong Chen Yu Zhu Hongqiang Wang Shengxian Li Lei Yu Kaishu Zhang Yujie Liu Tao Jing Fei Sun Source Type: research
Placental Trophoblast Cell Isolation from the Term Placenta
Methods Mol Biol. 2024;2781:131-142. doi: 10.1007/978-1-0716-3746-3_12.ABSTRACTMultiple cell lines have been utilized over time in studying placental biology. Still, most of them rely on choriocarcinoma cells or immortalized trophoblast cells that may not be entirely comparable with actual human placental trophoblast cells. Term placentas can be a source of primary villous trophoblasts. However, challenges remain in isolating them and maintaining them in extended culture. This manuscript describes our three-phase protocol utilizing enzymatic/mechanical digestion, modified Percoll gradient density separation, and immunopuri...
Source: Mol Biol Cell - March 19, 2024 Category: Molecular Biology Authors: Manuel Vidal Jr S Radnaa Enkhtuya Rheanna Urrabaz-Garza Ramkumar Menon Source Type: research
GSE261551 Case Report: Molecular Profiling Facilitates the Diagnosis of a Challenging Case of Lung Cancer with Choriocarcinoma Features
We present a 35-year female with lung cancer with choriocarcinoma features. Her disease involved the right lower lung, brain, and thoracic lymph nodes. The pathology from brain metastasis was reported as “metastatic choriocarcinoma” (a germ cell tumor) by local pathologists. She initiated carboplatin and etoposide, a regimen for choriocarcinoma. Subsequently, her case was assessed by pathologists from an academic cancer center, who gave the diagnosis of “adenocarcinoma with aberrant expression of β-hCG” and finally pathologists at our hospital, who gave the diagnosis of “poorly differentiated carcinoma with cho...
Source: GEO: Gene Expression Omnibus - March 14, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Case report: Metastatic choriocarcinoma in the second trimester of a viable pregnancy with successful delivery and outcome after chemotherapy
Metastatic choriocarcinoma during viable pregnancy is rare worldwide, and neonate survival following pregnancy termination in the second trimester is uncommon. Here, we report the successful delivery of a pregnancy by a patient with metastatic choriocarcinoma, who received three courses of etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine (EMA-CO) chemotherapy in the second trimester. After multidisciplinary discussions, she was administered paclitaxel and carboplatin (TC) chemotherapy. Regular contractions occurred during her first paclitaxel infusion, and a healthy infant was delivered by cesarean...
Source: Frontiers in Oncology - March 8, 2024 Category: Cancer & Oncology Source Type: research
Intracranial non-germinomatous germ cell tumors in children and adolescents: how can the experience from an uppermiddle-income country contribute to the worldwide effort to improve outcomes?
ConclusionsDespite the small number of patients, in our series, treatment with six cycles of chemotherapy and RTV with focal boost for localized disease (n=11) and ACST for identified slow responders (n=2) seem to be effective strategies contributing to the overall effort to improve outcomes of this group of patients. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 4, 2024 Category: Cancer & Oncology Source Type: research
Genetic and histological analysis intraplacental choriocarcinoma: a case report
We report on single case of intraplacental choriocarcinoma (IC) coexisting with feto-maternal hemorrhage from our hospital, a rare malignant tumor that occurs in the chorionic villous trophoblast. To investigate genetic and epigenetic changes to the carcinogenesis of IC, we employed cancer gene panel analysis and whole methylation analysis from a recent case of IC. By Short Tandem Repeats analysis, we confirmed that the tumor of present IC was derived from concurrent normal chorionic villous trophoblast cells. No mutation was found in 145 cancer-related genes. Meanwhile, amplification in MDM2 gene was observed. Furthermore...
Source: Molecular Medicine - February 29, 2024 Category: Molecular Biology Authors: Natsuko Takano Masashi Takamura Yosuke Mizuno Yumi Mizuno Shunsuke Tamaru Kohei Nakamura Hiroaki Soma Takeshi Kajihara Source Type: research
