Insights into cAMP-dependent molecular mechanisms regulating expression and function of LGALS16 gene in choriocarcinoma JEG-3 cells
Cell Biol Int. 2024 Mar;48(3):378-385. doi: 10.1002/cbin.12128. Epub 2024 Jan 11.ABSTRACTThe human choriocarcinoma cell line JEG-3 offers a valuable model to study galectin-16 gene (LGALS16) expression and functions in the context of placental cell differentiation and cancer cell biology. Recent evidence indicates that cAMP-mediated signaling pathways might be responsible for the upregulation of LGALS16; however, the underlying mechanisms are unknown. Here, we employed biochemical inhibitors of the cAMP cascade and CRISPR/Cas9 engineered cells to assess regulatory patterns and associations between cAMP-induced trophoblast ...
Source: Cell Biology International - January 12, 2024 Category: Cytology Authors: Jennifer D Kaminker Ahmad G Butt Hailey Killeen Alexander V Timoshenko Source Type: research
Intracardiac metastasis of gestational choriocarcinoma: a case report and literature review
Gestational trophoblastic neoplasia (GTN) with intracardiac metastasis is rare, and here we reported a patient with intracardiac metastasis of high-risk and refractory gestational choriocarcinoma and reviewed ... (Source: BMC Pregnancy and Childbirth)
Source: BMC Pregnancy and Childbirth - January 2, 2024 Category: OBGYN Authors: Yu Gu, Haoran Zheng, Xiaowei Xue, Dan Wang, Hongyan Cheng, Liju Zong and Yang Xiang Tags: Case Report Source Type: research
