Rare occurrence of ovarian choriocarcinoma: ultrasound evaluation
AbstractChoriocarcinoma of the ovary is a rare, highly malignant tumor showing malignant trophoblastic cells and produces human chorionic gonadotropins. It can be classified as gestational and non-gestational choriocarcinoma. Non-gestational choriocarcinoma is extremely rare. Treatment is Methotrexate-based chemotherapy for the gestational type. This case study is a rare case of ovarian choriocarcinoma managed by surgical resection, followed by methotrexate-based chemotherapy, and aimed to evaluate the ultrasound characteristics of ovarian choriocarcinoma and how to arrive at the diagnosis. In cases with an elevated serum ...
Source: Journal of Ultrasound - February 26, 2024 Category: Radiology Source Type: research
Metastatic choriocarcinoma to the heart and lung with successful multimodal management
AbstractCardiac tumors continue to be one of the most uncommon primary tumors. Secondary cardiac tumors are rare and occur in difficult instances. A multidisciplinary team is required for diagnosis and management. Within this case study, we present a 24-year-old female patient who experienced dyspnea and was diagnosed as having metastatic heart and lung choriocarcinoma that was effectively managed with heart surgery and chemotherapy. (Source: Indian Journal of Thoracic and Cardiovascular Surgery)
Source: Indian Journal of Thoracic and Cardiovascular Surgery - February 19, 2024 Category: Cardiovascular & Thoracic Surgery Source Type: research
Establishment and comparison of human term placenta-derived trophoblast cells
In this study, we describe the development of a human-term placenta-derived cytotrophoblast immortalized cell line (hPTCCTB) derived from the basal plate. hPTCCTB cells are comparable to their primary cells of origin in terms of morphology, marker expression, and functional responses. We demonstrate that these can transform into syncytiotrophoblast and extravillous trophoblasts. We also compared the hPTCCTB cells to immortalized chorionic trophoblasts (hFM-CTC), trophoblasts of the chorionic plate, and BeWo cells, choriocarcinoma cell lines of conventional use. hPTCCTB and hFM-CTCs displayed more similarity to each other t...
Source: Biology of Reproduction - February 8, 2024 Category: Reproduction Medicine Authors: Manuel S Vidal Enkhtuya Radnaa Natasha Vora Kamil Khanipov Cristina Antich Marc Ferrer Rheanna Urrabaz-Garza Jeena E Jacob Ramkumar Menon Source Type: research
Establishment and comparison of human term placenta-derived trophoblast cells
In this study, we describe the development of a human-term placenta-derived cytotrophoblast immortalized cell line (hPTCCTB) derived from the basal plate. hPTCCTB cells are comparable to their primary cells of origin in terms of morphology, marker expression, and functional responses. We demonstrate that these can transform into syncytiotrophoblast and extravillous trophoblasts. We also compared the hPTCCTB cells to immortalized chorionic trophoblasts (hFM-CTC), trophoblasts of the chorionic plate, and BeWo cells, choriocarcinoma cell lines of conventional use. hPTCCTB and hFM-CTCs displayed more similarity to each other t...
Source: Reproductive Biology - February 8, 2024 Category: Reproduction Medicine Authors: Manuel S Vidal Enkhtuya Radnaa Natasha Vora Kamil Khanipov Cristina Antich Marc Ferrer Rheanna Urrabaz-Garza Jeena E Jacob Ramkumar Menon Source Type: research
Molecular profiling of gestational trophoblastic neoplasia: Identifying therapeutic targets
CONCLUSIONS: The high rate of PD-L1 positivity in this real-world database and reported in prior literature support continued clinical trial development evaluating immunotherapy for treatment of GTN. Other potential targeted treatments identified include Wee1, PARP and MEK inhibitors based on molecular alterations in TP53, HRR genes, and RTK-RAS pathways respectively.PMID:38301309 | DOI:10.1016/j.ygyno.2024.01.033 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 1, 2024 Category: Cancer & Oncology Authors: Leah McNally Sharon Wu Kurt Hodges Matt Oberley John J Wallbillich Nathaniel L Jones Thomas J Herzog Premal H Thaker Angeles Alvarez Secord Marilyn Huang Source Type: research
Valproic acid elevates HIF-1 α-mediated CGB expression and suppresses glucose uptake in BeWo cells
J Toxicol Sci. 2024;49(2):69-77. doi: 10.2131/jts.49.69.ABSTRACTPlacental dysfunction can disrupt pregnancy. However, few studies have assessed the effects of chemical-induced toxicity on placental function. Here, we examined the effects of valproic acid (VPA) as a model chemical on production of hormones and on glucose uptake in human choriocarcinoma cell line BeWo. Cells were treated with forskolin to differentiate into syncytiotrophoblasts, which were then treated with VPA for 72 hr. Real-time RT-PCR analysis showed that VPA significantly increased the mRNA expression of chorionic gonadotropin β (CGB), a hormone that i...
Source: Journal of Toxicological Sciences - January 31, 2024 Category: Toxicology Authors: Go Kitahara Kazuma Higashisaka Yurina Nakamoto Rena Yamamoto Wakako Okuno Momoe Serizawa Yuji Sakahashi Hirofumi Tsujino Yuya Haga Yasuo Tsutsumi Source Type: research
