MALAT1 modulates trophoblast phenotype via miR-101-3p/VEGFA axis
Arch Biochem Biophys. 2023 Jul 10:109692. doi: 10.1016/j.abb.2023.109692. Online ahead of print.ABSTRACTPreeclampsia is a potentially life-threatening condition that can arise due to poor placentation and consequent abnormal uterine spiral artery remodeling. Abnormal placentation, in turn, is associated with aberrant trophoblast cell proliferation and apoptosis. Here, we investigated the lncRNA MALAT1 in trophoblast proliferation during early-onset preeclampsia (ePE). MALAT1 levels were examined in placental tissue samples from ePE patients and control patients. The effects and underlying mechanism of MALAT1 on proliferati...
Source: Archives of Biochemistry and Biophysics - July 12, 2023 Category: Biochemistry Authors: Qin Li Shuo Li Jin Ding Bo Pang Ranran Li Hui Cao Li Ling Source Type: research
MALAT1 modulates trophoblast phenotype via miR-101-3p/VEGFA axis
Arch Biochem Biophys. 2023 Jul 10:109692. doi: 10.1016/j.abb.2023.109692. Online ahead of print.ABSTRACTPreeclampsia is a potentially life-threatening condition that can arise due to poor placentation and consequent abnormal uterine spiral artery remodeling. Abnormal placentation, in turn, is associated with aberrant trophoblast cell proliferation and apoptosis. Here, we investigated the lncRNA MALAT1 in trophoblast proliferation during early-onset preeclampsia (ePE). MALAT1 levels were examined in placental tissue samples from ePE patients and control patients. The effects and underlying mechanism of MALAT1 on proliferati...
Source: Archives of Biochemistry and Biophysics - July 12, 2023 Category: Biochemistry Authors: Qin Li Shuo Li Jin Ding Bo Pang Ranran Li Hui Cao Li Ling Source Type: research
MALAT1 modulates trophoblast phenotype via miR-101-3p/VEGFA axis
Arch Biochem Biophys. 2023 Jul 10:109692. doi: 10.1016/j.abb.2023.109692. Online ahead of print.ABSTRACTPreeclampsia is a potentially life-threatening condition that can arise due to poor placentation and consequent abnormal uterine spiral artery remodeling. Abnormal placentation, in turn, is associated with aberrant trophoblast cell proliferation and apoptosis. Here, we investigated the lncRNA MALAT1 in trophoblast proliferation during early-onset preeclampsia (ePE). MALAT1 levels were examined in placental tissue samples from ePE patients and control patients. The effects and underlying mechanism of MALAT1 on proliferati...
Source: Archives of Biochemistry and Biophysics - July 12, 2023 Category: Biochemistry Authors: Qin Li Shuo Li Jin Ding Bo Pang Ranran Li Hui Cao Li Ling Source Type: research
Endoscopic manifestations of jejunal choriocarcinoma
Rev Esp Enferm Dig. 2023 Jun 14. doi: 10.17235/reed.2023.9714/2023. Online ahead of print.ABSTRACTChoriocarcinoma, a malignant tumor deriving from the trophoblastic tissue, is mostly associated with adverse pregnancy. Early metastasis is very common in patient with choriocarcinoma, but the cases of intestinal metastasis are definitely rare. Herein, we reported a case of jejunal choriocarcinoma revealed by endoscopy. Segmental resection of the jejunum as well as biopsy of liver nodules were performed. The patient was classified as super high-risk choriocarcinoma and received chemotherapy and surgical treatment. Unfortunatel...
Source: Revista Espanola de Enfermedades Digestivas - June 14, 2023 Category: Gastroenterology Authors: Yan Wang Lei Diao Pei-Pei Zhang Xi Chen Source Type: research
Pure testicular choriocarcinoma with gastrointestinal metastasis and paraneoplastic symptoms: a case report
Pure testicular choriocarcinoma is a rare type of non-seminomatous germ cell tumor extremely poor prognostic with the tendency to bleed at the metastatic site. At the time of the diagnosis, 70% of patients hav... (Source: BMC Urology)
Source: BMC Urology - June 3, 2023 Category: Urology & Nephrology Authors: Negin Namavari, Lohrasb Taheri, Farhang Hooshmand, Mohammad H. Dousthaghi and Vahid Rahmanian Tags: Case Report Source Type: research
GSE233281 LncRNA Tuna is activated in cadmium-induced placental insufficiency and drives the NRF2-mediated oxidative stress response [human Jeg3]
Contributors : Mark D Simmers ; Dereje D Jima ; Yoshiaki Tsuji ; Michael CowleySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCadmium (Cd) is a toxic heavy metal found throughout the environment and one of the top ten toxicants of major public health concern identified by the World Health Organization.InuteroCd exposure causes fetal growth restriction, malformation, and spontaneous abortion; however, the mechanisms by which Cd impacts these outcomes are poorly understood. Cd accumulates in the placenta, suggesting that these negative outcomes may be a consequence of disrupted place...
Source: GEO: Gene Expression Omnibus - May 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE233252 LncRNA Tuna is activated in cadmium-induced placental insufficiency and drives the NRF2-mediated oxidative stress response [mouse]
Contributors : Mark D Simmers ; Dereje D Jima ; Yoshiaki Tsuji ; Michael CowleySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCadmium (Cd) is a toxic heavy metal found throughout the environment and one of the top ten toxicants of major public health concern identified by the World Health Organization.InuteroCd exposure causes fetal growth restriction, malformation, and spontaneous abortion; however, the mechanisms by which Cd impacts these outcomes are poorly understood. Cd accumulates in the placenta, suggesting that these negative outcomes may be a consequence of disrupted place...
Source: GEO: Gene Expression Omnibus - May 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
HIF-1 α contributes to metastasis in choriocarcinoma by regulating DEC1 expression
ConclusionHIF-1 α contributed to EMT and metastasis through activation of canonical β-catenin signalling in choriocarcinoma and this process was dependent on DEC1. This study provides a new mechanism of HIF-1α in choriocarcinoma and suggests that intervention with DEC1 might be a promising therapeutic choice for choriocarcinoma. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 30, 2023 Category: Cancer & Oncology Source Type: research
Challenging gestational trophoblastic disease cases and mimics: An exemplar for the management of rare tumours
CONCLUSION: The National GTD service could be an exemplar for the management of rare tumours (such as cholangiocarcinoma) in our jurisdiction which could benefit from a similar constellation of supports. Our study demonstrates the importance of a nominated national clinical lead, dedicated nurse navigator support, registration of cases and networking. The impact of our service would be greater if registration was mandatory rather than voluntary. Such a measure would also ensure equity of access for patients to the service, assist in quantifying the need for resourcing and facilitate research to improve outcomes.PMID:372247...
Source: Reproductive Biology - May 24, 2023 Category: Reproduction Medicine Authors: M Hamid C M Joyce H K Carroll C Kenneally S Mulcahy Mary-Kate O'Neill J Coulter S O'Reilly Source Type: research
